The enkephalinase inhibitor thiorphan shows antinociceptive activity in mice

Design of Specific Inhibitors of Angiotensin-Converting Enzyme: New Class of Orally Active Antihypertensive Agents

1977 • 1,851 citations

High-affinity enkephalin-degrading peptidase in brain is increased after morphine

1978 • 652 citations

Mode of deactivation of the enkephalins by rat and human plasma and rat brain homogenates

1976 • 516 citations

[D-Ala ² ]-Met-Enkephalinamide: A Potent, Long-Lasting Synthetic Pentapeptide Analgesic

1976 • 466 citations

Carboxypeptidase A: A Protein and an Enzyme

1971 • 396 citations

Hyperalgesia Induced by Naloxone Follows Diurnal Rhythm in Responsivity to Painful Stimuli

1977 • 373 citations

DISTRIBUTION AND PROPERTIES OF ANGIOTENSIN CONVERTING ENZYME OF RAT BRAIN

1972 • 298 citations

Facilitation de r�actions nociceptives par la naloxone chez la souris et chez le rat

1974 • 295 citations

Antinociceptive activity of narcotic agonist and partial agonist analgesics and other agents in the tail-immersion test in mice and rats

1976 • 235 citations

Hydrolysis of enkephalin by cultured human endothelial cells and by purified peptidyl dipeptidase

1978 • 203 citations

Two distinct enkephalinases: Solubilization, partial purification and separation from angiotensin converting enzyme

1979 • 189 citations

Enkephalin catabolism in vitro and in vivo

1977 • 168 citations

On the role of endogenous opioid peptides: Failure of naloxone to influence shock escape threshold in the rat

1976 • 137 citations

The adsorption of enkephalin to porous polystyrene beads: A simple assay for enkephalin hydrolysis

1977 • 125 citations

On the degradation of enkephalins and endorphins by rat and mouse brain extracts

1977 • 124 citations

Design of potent and specific inhibitors of carboxypeptidases A and B

1979 • 117 citations

Regional distribution of a high-affinity enkephalin-degrading peptidase (‘enkephalinase’) and effects of lesions suggest localization in the vicinity of opiate receptors in brain

1979 • 116 citations

Ontogenesis of enkephalinergic systems in rat brain: Post-natal changes in enkephalin levels, receptors and degrading enzyme activities

1980 • 94 citations

The relationship between enkephalin degradation and opiate receptor occupancy.

1978 • 93 citations

Is ‘enkephalinase” identical with ‘angiotensin-converting enzyme’?

1979 • 91 citations

Inhibitory potency of various peptides on enkephalinase activity from mouse striatum

1979 • 71 citations

‘Enkephalinase’ is distinct from brain ‘angiostensin-converting enzyme’

1979 • 69 citations

Subcellular localisation of leucine-enkephalin-hydrolysing activity in rat brain

1977 • 62 citations

CHEMISTRY AND PHARMACOLOGY OF THE METHADOLS¹ AND ACETYLMETHADOLS²

1952 • 59 citations

Inhibition of in situ metabolism of [3H](met5)-enkephalin and potentiation of (met5)-enkephalin analgesia by captopril

1980 • 58 citations

Enkephalin degradation in mouse brain studied by a new H.P.L.C. method: Further evidence for the involvement of carboxydipeptidase

1979 • 56 citations

Intracerebral naloxone and the reaction to thermal noxious stimulation in the rat

1980 • 21 citations

Disappearance of energy-transfer as a tool for fluorimetric study of the degradation of enkephalins by aminopeptidase activity from mouse brain

1979 • 16 citations

DEGRADATION OF ENKEPHALIN BY TWO BRAIN ENZYMATIC ACTIVITIES

1980 • 9 citations

ENKEPHALINASE: PRELIMINARY CHARACTERIZATION AND COMPARISON WITH ANGIOTENSIN CONVERTING ENZYME

1980 • 8 citations

ONTOGENESIS OF ENKEPHALINERGIC SYSTEMS IN RAT BRAIN

1980 • 5 citations