Enkephalin may mediate euphoria and drive-reduction reward

Identification of two related pentapeptides from the brain with potent opiate agonist activity

1975 • 3,780 citations

Immunohistochemical studies using antibodies to leucine-enkephalin: Initial observations on the nervous system of the rat

1976 • 767 citations

Analgesia from Electrical Stimulation in the Brainstem of the Rat

1971 • 751 citations

Analgesia induced in vivo by central administration of enkephalin in rat

1976 • 524 citations

Regional concentrations of noradrenaline and dopamine in rat brain

1976 • 518 citations

Opioid Peptides Endorphins in Pituitary and Brain

1976 • 518 citations

Catecholamine systems as the neural substrate for intracranial self-stimulation: a hypothesis

1974 • 383 citations

Some thoughts on the significance of enkephalin, the endogenous ligand

1975 • 270 citations

Evidence for analgesic activity of enkephalin in the mouse

1976 • 252 citations

Brain Stimulation Reward

2015 • 236 citations

Physical Dependence of Opiate-Like Peptides

1976 • 219 citations

Catecholamine-containing neurones and electrical self-stimulation: 2. A theoretical interpretation and some psychiatric implications

1973 • 218 citations

Opiate receptor affinities and behavioral effects of enkephalin: Structure-activity relationship of ten synthetic peptide analogues

1976 • 214 citations

Opiate receptor in normal and drug altered brain function*

1975 • 184 citations

Isolation and structure identification of a morphine-like peptide “enkephalin” in bovine brain

1976 • 152 citations

Noradrenergic role in the self-administration of morphine or amphetamine

1975 • 94 citations

EVIDENCE PERTAINING TO AN ENDOGENOUS MECHANISM OF PAIN INHIBITION IN THE CENTRAL NERVOUS SYSTEM

1976 • 64 citations

PEPTIDE TRANSMITTERS: A UNIFYING HYPOTHESIS FOR EUPHORIA, RESPIRATION, SLEEP, AND THE ACTION OF LITHIUM

1976 • 62 citations

Intraventricular self-administration of morphine in naive laboratory rats

1976 • 54 citations

Brain Stimulation Reward

2010 • 48 citations