Activation of latent transforming growth factor beta during Chlamydia trachomatis-induced murine pneumonia

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

1992 • 2,969 citations

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.

1993 • 1,941 citations

Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth.

1986 • 1,617 citations

Transforming growth factor-beta in disease: the dark side of tissue repair.

1992 • 1,126 citations

Natural inhibitor of transforming growth factor-β protects against scarring in experimental kidney disease

1992 • 984 citations

Transforming growth factor beta is an important immunomodulatory protein for human B lymphocytes.

1986 • 777 citations

Control of scarring in adult wounds by neutralising antibody to transforming growth factor β

1992 • 624 citations

Transforming growth factor beta specifically enhances IgA production by lipopolysaccharide-stimulated murine B lymphocytes.

1989 • 567 citations

Elevated expression of transforming growth factor-beta and proteoglycan production in experimental glomerulonephritis. Possible role in expansion of the mesangial extracellular matrix.

1990 • 555 citations

Persistent chlamydiae: from cell culture to a paradigm for chlamydial pathogenesis

1994 • 549 citations

Immunodetection and quantitation of the two forms of transforming growth factor‐beta (TGF‐β1 and TGF‐β2) secreted by cells in culture

1989 • 453 citations

Transforming Growth Factor-β in Leishmanial Infection: a Parasite Escape Mechanism

1992 • 439 citations

Transforming growth factor beta (TGF-?) in inflammation: A cause and a cure

1992 • 417 citations

Regulation of Trypanosoma cruzi infections in vitro and in vivo by transforming growth factor beta (TGF-beta).

1991 • 309 citations

Role of active and latent transforming growth factor β in bone formation

1994 • 295 citations

Activation of the bone-derived latent TGF beta complex by isolated osteoclasts

1989 • 281 citations

Active and latent forms of transforming growth factor beta activity in synovial effusions.

1989 • 258 citations

ELEVATED EXPRESSION OF TRANSFORMING GROWTH FACTOR BETA AND PROTEOGLYCAN PRODUCTION IN EXPERIMENTAL GLOMERULONEPHRITIS

1990 • 196 citations

Resolution of chlamydial genital infection in B-cell-deficient mice and immunity to reinfection

1988 • 175 citations

Characterization and autoregulation of latent transforming growth factor beta (TGF beta) complexes in osteoblast-like cell lines. Production of a latent complex lacking the latent TGF beta-binding protein.

1994 • 173 citations

Transforming growth factor-beta 1 (TGF-beta 1) and recombinant human tumor necrosis factor-alpha reciprocally regulate the generation of lymphokine-activated killer cell activity. Comparison between natural porcine platelet-derived TGF-beta 1 and TGF-beta 2, and recombinant human TGF-beta 1.

1988 • 168 citations

Resolution of murine chlamydial genital infection by the adoptive transfer of a biovar-specific, Th1 lymphocyte clone.

1993 • 166 citations

Transforming growth factor-beta inhibits the in vitro generation of lymphokine-activated killer cells and cytotoxic T cells

1988 • 155 citations

Phosphorylation of serine 985 negatively regulates the hepatocyte growth factor receptor kinase.

1994 • 154 citations

Pathogenesis of trachoma: the stimulus for inflammation.

1987 • 143 citations

Production of transforming growth factor-beta by Mycobacterium avium-infected human macrophages is associated with unresponsiveness to IFN-gamma.

1993 • 133 citations

Latent Forms of Transforming Growth Factor-β (TGFβ) Derived from Bone Cultures: Identification of a Naturally Occurring 100-kDa Complex with Similarity to Recombinant Latent TGFβ

1991 • 119 citations

Activation of Latent Transforming Growth Factor ß

1993 • 118 citations

A role in vivo for tumor necrosis factor alpha in host defense against Chlamydia trachomatis

1990 • 113 citations

Infertility after acute salpingitis with special reference to Chlamydia trachomatis

1983 • 106 citations

Mechanisms of fibrosis in coal workers' pneumoconiosis. Increased production of platelet-derived growth factor, insulin-like growth factor type I, and transforming growth factor beta and relationship to disease severity.

1994 • 95 citations

TGF-beta is important in determining the in vivo patterns of susceptibility or resistance in mice infected with Candida albicans.

1995 • 93 citations

Pathologic concentrations of interleukin 6 inhibit T cell responses via induction of activation of TGF‐β

1991 • 89 citations

Infection of murine macrophages with Toxoplasma gondii is associated with release of transforming growth factor beta and downregulation of expression of tumor necrosis factor receptors

1993 • 77 citations

γ‐Interferon‐Induced Activation of Latent Transforming Growth Factor‐β by Human Monocytes

1990 • 73 citations

Role in vivo for gamma interferon in control of pneumonia caused by Chlamydia trachomatis in mice

1988 • 69 citations

Distribution of transforming growth factor-beta 1, fibronectin, and smooth muscle actin in asbestos-induced pulmonary fibrosis in rats.

1994 • 66 citations

Cellular Immunity to the Mouse Pneumonitis Agent

1984 • 61 citations

Neutralization of transforming growth factor-beta 1 in a mouse model of immune-induced lung fibrosis.

1994 • 47 citations

Chlamydia trachomatis pneumonia induces in vivo production of interleukin-1 and -6

1992 • 44 citations

Detection of Active Form of Transforming Growth Factor‐β in Cerebrospinal Fluid of Patients with Glioma

1993 • 31 citations

Antibody in host defense against mouse pneumonitis agent (murine Chlamydia trachomatis)

1984 • 30 citations

Interferon in Recovery From Pneumonia Due to Chlamydia trachomatis in the Mouse

1987 • 27 citations

Controls for validation of relative reverse transcription--polymerase chain reaction assays.

1993 • 22 citations

Kinetics of chlamydial antigen processing and presentation to T cells by paraformaldehyde-fixed murine bone marrow-derived macrophages

1995 • 21 citations

Use of stock solutions to simplify mRNA quantitation by reverse transcription--PCR assays.

1993 • 15 citations

Differential modulation of lymphocyte proliferative responses and lymphokine secretion in mice during development of immunity to Chlamydia psittaci

1989 • 5 citations