Genetic toxicity of some important epoxides

Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals.

1975 • 3,362 citations

Carcinogens are Mutagens: A Simple Test System Combining Liver Homogenates for Activation and Bacteria for Detection

1973 • 2,275 citations

[Organotropic carcinogenic effects of 65 various N-nitroso- compounds on BD rats].

1967 • 1,408 citations

Organotrope carcinogene Wirkungen bei 65 verschiedenen N-Nitroso-Verbindungen an BD-Ratten

1967 • 1,336 citations

Mechanisms Of Epoxide Reactions

1959 • 1,127 citations

Steric effects in organic chemistry

1957 • 1,102 citations

Arene Oxides: A New Aspect of Drug Metabolism

1974 • 1,043 citations

1990 Recommendations of the International Commission on Radiological Protection

1992 • 957 citations

Possible Relevance of O–6 Alkylation of Deoxyguanosine to the Mutagenicity and Carcinogenicity of Nitrosamines and Nitrosamides

1969 • 949 citations

A rapid in vivo test for chromosomal damage☆

1973 • 780 citations

Linear Free Energy Relationships.

1963 • 649 citations

Quantitative Correlation of Relative Rates. Comparison of Hydroxide Ion with Other Nucleophilic Reagents toward Alkyl Halides, Esters, Epoxides and Acyl Halides¹

1953 • 606 citations

Arene oxides and the NIH shift: The metabolism, toxicity and carcinogenicity of aromatic compounds

1972 • 593 citations

Detection of chemical mutagens by the dominant lethal assay in the mouse

1972 • 572 citations

Insecticides, Action and Metabolism.

1968 • 498 citations

Effects of Some Chemical Mutagens and Carcinogens on Nucleic Acids

1966 • 370 citations

The Organic Chemistry of Phosphorus

1967 • 348 citations

Hepatic epoxide hydrase. Structure-activity relations for substrates and inhibitors

1971 • 316 citations

Evaluation of genetic risks of alkylating agents: Tissue doses in the mouse from air contaminated with ethylene oxide

1974 • 313 citations

Some chemical aspects of dose-response relationships in alkylation mutagenesis

1974 • 284 citations

Fluorescent adenosine and cytidine derivatives

1972 • 283 citations

Interstrand cross-linking of DNA by difunctional alkylating agents

1967 • 278 citations

Evaluation of genetic risks of alkylating agents. II. Haemoglobin as a dose monitor

1976 • 265 citations

Aldehydes in biological systems

1977 • 259 citations

Biology of Radiation Carcinogenesis

1977 • 255 citations

“Safety” Testing of Carcinogenic Agents

1961 • 239 citations

Enzymatic Conjugation of Epoxides with Glutathione

1973 • 237 citations

LYSOGENY1

1953 • 235 citations

Handbook of mutagenicity test procedures

1978 • 229 citations

Epoxides of Carcinogenic Polycyclic Hydrocarbons Are Frameshift Mutagens

1972 • 225 citations

Chemical Mutagens in the Human Environment

1968 • 224 citations

The role of arene oxide-oxepin systems in the metabolism of aromatic substrates. III. Formation of 1,2-naphthalene oxide from naphthalene by liver microsomes

1968 • 222 citations

Carcinogenicity of epoxides, lactones, and peroxy compounds. II.

1965 • 211 citations

SPECIAL MICROBIOLOGICAL SYSTEMS. II. OBSERVATIONS ON CHEMICAL MUTAGENESIS IN MICROORGANISMS*

1958 • 202 citations

The Mutagenicity of Chemical Carcinogens: Correlations, Problems, and Interpretations

1971 • 201 citations

Genetic toxicology of benzene, toluene, xylenes and phenols

1978 • 192 citations

High mutagenicity and toxicity of a diol epoxide derived from benzo[a]pyrene

1976 • 188 citations

AN ENZYME CATALYSING THE CONJUGATION OF EPOXIDES WITH GLUTATHIONE

1965 • 188 citations

Environmental Mutagenic Hazards

1975 • 182 citations

The Effect of the Carbonyl and Related Groups on the Reactivity of Halides in SN2 Reactions

1964 • 179 citations

Mutagenicity of vinyl chloride, chloroethyleneoxide, chloroacetaldehyde and chloroethanol

1975 • 177 citations

Carcinogenic Risk Assessment

1977 • 174 citations

Reaction kinetics and biological action in barley of mono-functional methanesulfonic esters

1970 • 171 citations

Inactivation of bacteriophage T7 by mono- and difunctional sulphur mustards in relation to cross-linking and depurination of bacteriophage DNA

1969 • 166 citations

Induction of mitotic gene conversion by mutagens.

1971 • 165 citations

The mutagenicity of chloroethylene oxide, chloroacetaldehyde, 2-chloroethanol and chloroacetic acid, conceivable metabolites of vinyl chloride

1976 • 160 citations

Monitoring and risk assessment by means of alkyl groups in hemoglobin in persons occupationally exposed to ethylene oxide.

1978 • 154 citations

The Chemistry of Cytotoxic Alkylating Agents

1953 • 153 citations

Mode of Production of Chromosome Abnormalities by the Nitrogen Mustards The Possible Role of Cross-Linking

1949 • 153 citations

Carcinogenic Activity of Alkylating Agents2

1974 • 152 citations

Chemische Konstitution und carcinogene Wirkung bei Nitrosaminen

1961 • 152 citations

766. The alkylation of guanosine and guanylic acid

1961 • 150 citations

Mutability of different genetic loci in mammalian cells by metabolically activated carcinogenic polycyclic hydrocarbons.

1976 • 148 citations

A cohort study of mortality and cancer incidence in ethylene oxide production workers.

1979 • 144 citations

CARCINOGENIC EPOXIDES, LACTONES, AND HALO‐ETHERS AND THEIR MODE OF ACTION*

1969 • 139 citations

Leukemia in Workers Exposed to Ethylene Oxide

1979 • 136 citations

Human Chromosome Damage by Chemical Agents

1970 • 132 citations

464. The reactions of certain epoxides in aqueous solutions

1950 • 132 citations

Reaction of guanine with glyoxal, pyruvaldehyde, and kethoxal, and the structure of the acylguanines. Synthesis of N2-alkylguanines

1969 • 132 citations

MORPHOLOGICAL AND SOMATIC CHROMOSOMAL ABERRATIONS INDUCED BY PESTICIDES IN BARLEY (HORDEUM VULGARE)

1966 • 131 citations

Alkylation of DNA and proteins in mice exposed to vinyl chloride

1977 • 131 citations

Carcinogenicity of benzo[a]pyrene 4,5-, 7,8-, and 9,10-oxides on mouse skin.

1976 • 126 citations

Chemical mutagenesis in relation to the concept of the gene

1957 • 125 citations

MALE ANTIFERTILITY COMPOUNDS: U-5897 AS A RAT CHEMOSTERILANT

1970 • 123 citations

Mutagenic activity of styrene oxide (1,2-epoxyethylbenzene), a presumed styrene metabolite

1976 • 123 citations

VIABLE MUTANTS INDUCED IN BARLEY BY IONIZING RADIATIONS AND CHEMICAL MUTAGENS

2009 • 122 citations

Effects of ionizing radiation on the reproductive system

1965 • 122 citations

Evaluation of genetic risks of alkylating agents. III. Alkylation of haemoglobin after metabolic conversion of ethene to ethene oxide in vivo

1977 • 122 citations

KINETIC STUDIES ON ETHYLENE OXIDES

1929 • 121 citations

Hydrolysis of Substituted Ethylene Oxides in H₂O¹⁸ Solutions¹

1956 • 118 citations

INDUCTION OF ECERIFERUM MUTANTS IN BARLEY BY IONIZING RADIATIONS AND CHEMICAL MUTAGENS. II

2009 • 118 citations

Bioassay of 29 Alkylatlng Chemicals by the Pulmonary-Tumor Response In Strain A Mice

1966 • 117 citations

Qualitative Aspects of the Chemistry and Biology of Radiomimetic (Mutagenic) Substances

1951 • 116 citations

CARCINOGENIC ACTION OF ALKYLATING AGENTS

1958 • 116 citations

Acrolein

1978 • 115 citations

CHEMICALLY INDUCED MUTATIONS IN NEUROSPORA

1951 • 115 citations

The Formation of Persistent Toxic Chlorohydrins in Foodstuffs by Fumigation with Ethylene Oxide and with Propylene Oxide

1965 • 114 citations

Epoxide intermediates in microsomal oxidation of olefins to glycols.

1970 • 111 citations

Epoxides as Obligatory Intermediates in the Metabolism of Olefins to Glycols

1970 • 111 citations

Vinyl chloride exposure and human chromosome aberrations

1975 • 110 citations

CHROMOSOME ABERRATIONS IN WORKERS EXPOSED TO VINYL CHLORIDE

1975 • 110 citations

New Evidence on the Mode of Action of ‘Mitotic Poisons’

1949 • 110 citations

Diethyl Pyrocarbonate in Nucleic Acid Research

1976 • 108 citations

MALE ANTIFERTILITY COMPOUNDS: BIOLOGICAL PROPERTIES OF U-5897 AND U-15,646

1970 • 107 citations

Carcnogenicity of epoxides, lactones, and peroxy compounds. VI. Structure and carcinogenic activity.

1967 • 106 citations

Experimental Carcinogenicity and Acute Toxicity Of Representative Epoxides

1963 • 106 citations

Solubilization, purification, and properties of a hepatic epoxide hydrase

1971 • 105 citations

Chromosomal Aberrations Induced by Pesticides in Meiotic Cells of Barley

1967 • 103 citations

The Preparation and Properties of N-Hydroxyethyl Derivatives of Adenosine, Adenosine Triphosphate, and Nicotinamide Adenine Dinucleotide

1961 • 102 citations

Effects upon tumours of Various Haloalkylarylamines

1948 • 100 citations

A study on the mutagenic activity of styrene and styrene oxide.

1976 • 99 citations

An extragonadal male antifertility agent

1969 • 99 citations

The influence of radiomimetic substances on deoxyribonucleic acid synthesis and function studied in Escherichia coli / phage systems - III. Mutation of T 2 bacteriophage as a consequence of alkylation in vitro : the uniqueness of ethylation

1959 • 98 citations

Dose response at low doses of X-irradiation and MMS on the induction of micronuclei in mouse erythroblasts

1976 • 98 citations

Factors affecting the induction of micronuclei at low doses of X-rays, MMS and dimethylnitrosamine in mouse erythroblasts

1978 • 97 citations

Carbonium ion as ultimate carcinogen of polycyclic aromatic hydrocarbons

1975 • 97 citations

Mutagenicity of industrial compounds: Styrene and its possible metabolite styrene oxide

1976 • 94 citations

Quantitative Analysis of Dose-Response Data Obtained With Three Carcinogenic Hydrocarbons in Strain C3H Male Mice

1943 • 93 citations

Organic Peroxides, Hydrogen Peroxide, Epoxides, and Neoplasia

1963 • 92 citations

Estimating "safe" levels, a hazardous undertaking.

1975 • 90 citations

Studies on Quantitative Radiation Biology

1961 • 90 citations

Industrial mutagens and potential mutagens I. Halogenated aliphatic derivatives

1976 • 90 citations

Mutagenicity of styrene and styrene oxide

1977 • 90 citations

Alkylation by propylene oxide of deoxyribonucleic acid, adenine, guanosine and deoxyguanylic acid

1972 • 89 citations

Kinetics and Mechanism of the Acid-catalyzed Hydrolysis of Substituted Ethylene Oxides¹

1956 • 89 citations

Carcinogenicity of Epoxides, Lactones, and Peroxy Compounds

1964 • 89 citations

Chemical modification of viral ribonucleic acid

1961 • 87 citations

Some general principles of mutagenicity screening and a possible framework for testing procedures.

1973 • 87 citations

Cytogenetic analysis of the action of carcinogens and tumour inhibitors inDrosophila melanogaster V. Differential genetic response to the alkylating mutagens and x-radiation

1956 • 87 citations

Evaluation of genetic risks of alkylating agents IV. Quantitative determination of alkylated amino acids in haemoglobin as a measure of the dose after treatment of mice with methyl methanesulfonate

1978 • 85 citations

Mutation induction in chinese hamster V79 cells by two vinyl chloride metabolites, chloroethylene oxide and 2‐chloroacetaldehyde

1975 • 84 citations

New Cytotoxic Agents with Tumour-Inhibitory Activity

1950 • 83 citations

FURTHER STUDIES ON CHEMICALLY INDUCED REVERSIONS AT THE ADENINE LOCUS OF NEUROSPORA

2010 • 83 citations

Occupational styrene exposure and chromosomal aberrations

1977 • 82 citations

Mutagenicity of polycyclic aromatic hydrocarbons

1977 • 82 citations

Radiobiological Effects of Low Doses: Implications for Radiological Protection

1977 • 82 citations

CYTOTOXIC AGENTS: IV, THE CARCINOGENIC ACTIONS OF SOME MONOFUNCTIONAL ETHYLENEIMINE DERIVATIVES

1954 • 81 citations

MALE ANTIFERTILITY COMPOUNDS: EFFICACY OF U-5897 IN PRIMATES (MACACAMULATTA)

1970 • 81 citations

Mutagenicity of isomeric diol-epoxides of benzo[a]pyrene and benz[a]anthracene in S. typhimurium TA98 and TA100 and in V79 Chinese hamster cells

1977 • 79 citations

Determination of the mutagenic activity to bacteriophage T4 of carcinogenic and noncarcinogenic compounds.

1970 • 79 citations

Carcinogenicity of Epoxides, Lactones, and Peroxy Compounds. IV. Tumor Response in Epithelial and Connective Tissue in Mice and Rats<xref ref-type="fn" rid="FN2">2</xref>

1966 • 79 citations

ALKYLATING AGENTS

1964 • 79 citations

Tumorigenic potential of Aldrin and Dieldrin for mice

1962 • 78 citations

Mutagenicity of butadiene and butadiene monoxide

1978 • 77 citations

CHEMICAL CARCINOGENS AND THEIR MODES OF ACTION

1958 • 76 citations

Binding of K-region epoxides and other derivatives of benz[a]anthracene and dibenz[a,h]anthracene to DNA, RNA and proteins of transformable cells

1972 • 76 citations

Studies on Quantitative Radiation Biology

1963 • 75 citations

High microsome-mediated mutagenicity of the 3,4-dihydrodiol of 7-methylbenz[a]anthracene in S. typhimurium TA 98

1977 • 74 citations

RECENT CONTRIBUTIONS TO THE PHARMACOLOGY OF BIS(2-HALOETHYL) AMINES AND SULFIDES

1950 • 73 citations

Metabolism of chloroethanol in the rat

1967 • 73 citations

INDUCED VARIATION IN A QUANTITATIVE CHARACTER IN BARLEY. MORPHOLOGY AND CYTOGENETICS OF ERECTOIDES MUTANTS

2009 • 71 citations

Metabolism of polycyclic compounds. 5. Formation of 1:2-dihydroxy-1:2-dihydronaphthalenes

1949 • 69 citations

The mutagenic potential of ethylene oxide using the dominant-lethal assay in rats

1977 • 69 citations

On the reaction kinetics and mutagenic activity of methylating and β-halogenoethylating gasoline additives

1974 • 68 citations

RADIOSTERILIZATION OF MEDICAL PRODUCTS.

1968 • 68 citations

PRODUCTIVE MUTATIONS INDUCED IN BARLEY BY IONIZING RADIATIONS AND CHEMICAL MUTAGENS

2009 • 68 citations

Reaction rates and biological action of alkylating agents preliminary report on bactericidal and mutagenic action in E. coli

1969 • 67 citations

An assay for phosphotriester formation in the reaction of alkylating agents with deoxyribosenucleic acid in vitro and in vivo

1976 • 67 citations

Mutagenicity of Epoxides of Polycyclic Hydrocarbons correlates with Carcinogenicity of Parent Hydrocarbons

1971 • 67 citations

Mutagenicity of chemical carcinogens in Neurospora crassa.

1972 • 66 citations

Gene elimination in carcinogenesis: reinterpretation of the somatic mutation theory.

1970 • 66 citations

The lethal action of monofunctional and bifunctional alkylating agents on T7 coliphage

1969 • 66 citations

Toxicology and Carcinogenesis of Various Chemicals Used in the Preparation of Vaccines

1971 • 66 citations

Oxidation of styrene in liver microsomes

1969 • 65 citations

The Shape of the Dose-Response Curve for Radiation Carcinogenesis: Extrapolation to Low Doses

1977 • 64 citations

Chromosome Alteration and Tumour Inhibition by Nitrogen Mustards: the Hypothesis of Cross-linking Alkylation

1950 • 63 citations

The kinetics of the alkaline hydrolysis of phosphotriesters in DNA

1976 • 63 citations

Irradiation in the Epidemiology of Leukemia Among Adults<xref ref-type="fn" rid="FN2">2</xref>

1972 • 63 citations

DISTINGUISHED ACHIEVEMENT AWARD

1976 • 63 citations

Reaction of alkylating mutagens and carcinogens with nucleic acids: N-3 of guanine as a site of alkylation by N-methyl-N-nitrosourea and dimethyl sulphate

1972 • 63 citations

On the mutagenic action of dichlorvos

1972 • 62 citations

Antifertility Effects and Metabolism of α and epi-Chlorhydrins in the Rat

1969 • 62 citations

DIFFERENTIAL RESPONSE TO MUTAGENS AS STUDIED BY THE NEUROSPORA REVERSE MUTATION TEST

2010 • 62 citations

Metabolism of polycyclic compounds. 6. Conversion of phenanthrene into dihydroxydihydrophenanthrenes

1950 • 60 citations

COMPARATIVE STUDIES OF MONOEPOXIDES AS INDUCERS OF REVERSE MUTATIONS IN NEUROSPORA

1955 • 59 citations

The molecular basis for biological inactivation of nucleic acids. The action of methylating agents on the ribonucleic acid-containing bacteriophage R17

1974 • 59 citations

ON THE MUTAGENIC ACTION OF ALKANESULFONIC ESTERS IN BARLEY

2009 • 58 citations

On the oncogenic activity of ethylene oxide and propylene oxide in mice

1979 • 58 citations

Physicochemical changes produced in DNA after alkylation

1962 • 57 citations

Mutagenic effect of epichlorohydrin II. Analysis of chromosomal aberrations in lymphocytes of persons occupationally exposed to epichlorohydrin

1977 • 56 citations

Toxicity, hæmatological effects and anti-tumour activity of epoxides derived from disubstituted hexitols. Mode of action of mannitol myleran and dibromomannitol

1968 • 56 citations

Environmental factors in the origin of cancer and estimation of the possible hazard to man

1975 • 56 citations

Teratogenic effects of aldrin, dieldrin, and endrin in hamsters and mice

1974 • 55 citations

Toxicological approaches to the metabolites of Fusaria. 3. Acute toxicity of fusarenon-X.

1971 • 55 citations

THE MUTAGENIC EFFECTS OF IONIZING RADIATIONS AND REACTIVE ETHYLENE DERIVATIVES IN BARLEY

2010 • 55 citations

Toxicity Profile of Epichlorohydrin

1972 • 55 citations

Toxicity of propylene oxide determined on experimental animals.

1956 • 55 citations

Analysis of a case of mutagen specificity in Neurospora crassa

1968 • 54 citations

CYTOTOXIC AGENTS: II, BIS‐EPOXIDES AND RELATED COMPOUNDS

1951 • 54 citations

INDUCTION OF MITOTIC CROSSING-OVER IN ASPERGILLUS NIDULANS BY BIFUNCTIONAL ALKYLATING AGENTS

1963 • 53 citations

Dose-rate and Mutation Frequency after Irradiation of Mouse Spermatogonia

1972 • 53 citations

Effect of caffeine on chromosome damage induced by chemical mutagens and ionizing radiation in Vicia faba and Secale cereale

1974 • 53 citations

Induction of Lambda-Bacteriophage in Escherichia coli as a Screening Test for Potential Antitumor Agents

1964 • 53 citations

Specificity for spontaneous and induced forward mutation at several gene loci in Aspergillus nidulans

1969 • 52 citations

Cytogenetic analysis of the action of carcinogens and tumour inhibitors inDrosophila melanogasterI. 1:2, 3:4-diepoxybutane

1953 • 51 citations

Banding technique used for the detection of chromosomal aberrations induced by radiation and alkylating agents TEPA and epichlorohydrin

1976 • 51 citations

Kinetic studies of mutation induction by epoxides in Neurospora crassa

1968 • 51 citations

Correlation of the Nucleophilic Reactivity of Aliphatic Amines

1964 • 51 citations

Recent contributions to the pharmacology of bis(2-haloethyl) amines and sulfides.

1950 • 49 citations

Carcinogenicity of Halo-Ethers. II. Structure-Activity Relationships of Analogs of Bis(chloromethyl)ether<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref><xref ref-type="fn" rid="FN4">4</xref>

1972 • 49 citations

Further evidence of an essential difference between the genetical effects of mono- and bifunctional alkylating agents

1966 • 49 citations

The value of the mouse in carcinogenicity testing.

1972 • 49 citations

DISTRIBUTION OF [14C] -CHLOROHYDRIN IN MICE AND RATS

1972 • 49 citations

Effects of -chlorohydrin on the metabolism of testicular and epididymal spermatozoa of rams

1976 • 48 citations

ON THE MUTAGENIC ACTION OF ETHYLENE OXIDE AND DI-EPOXYBUTANE IN BARLEY

2010 • 48 citations

2-haloethanols: Mutagenicity and reactivity with DNA

1974 • 48 citations

Chemically Induced Mutation and Sterility in Barley.

1956 • 47 citations

Fate and metabolism of some mutagenic alkylating agents in the mouse I. Ethyl methanesulfonate and methyl methanesulfonate at sublethal dose in hybrid males

1970 • 47 citations

Chemical production of mutations inDrosophila: Comparison of techniques

1952 • 47 citations

The Role of Repair Mechanisms in the Variations of Ultraviolet and γ-Radiation Sensitivity during the Cell Cycle of Schizosaccharomyces pombe

1973 • 45 citations

Genetic Alterations at the Molecular Level in X-Ray Induced ad-3B Mutants of Neurospora crassa

1973 • 44 citations

On the mechanism of action of the alkylating agents. I. Interaction of alkylating agents with nucleic acids.

1961 • 44 citations

Carcinogenicity of Epoxides, Lactones, and Peroxy Compounds. III. Biological Activity and Chemical Reactivity

1966 • 43 citations

The Pathology of Vinyl Chloride Exposed Mice

1976 • 42 citations

PROTEIN SYNTHESIS AND THE INDUCTION OF MUTATIONS IN ESCHERICHIA COLI BY ALKYLATING AGENTS

1960 • 42 citations

Genetic aspects of carcinogenesis

1971 • 42 citations

Studies on a recombination-deficient mutant of drosophila II. Response to X-rays and alkylating agents

1972 • 41 citations

Recent advances in basic mutation research

1977 • 41 citations

Interference with the Formation of a Nucleoprotein Complex by Radiomimetic Compounds

1952 • 40 citations

Post-testicular Antifertility Effects of Epichlorohydrin and 2,3-Epoxypropanol

1970 • 40 citations

Considerations of Some Current Concepts in Cancer Research

1975 • 40 citations

DIFFERENT TYPES OF STERILITY INDUCED IN BARLEY BY IONIZING RADIATIONS AND CHEMICAL MUTAGENS

2009 • 39 citations

Substitution at a saturated carbon atom. XII. Generality of the ion-pair mechanism of nucleophilic substitution

1969 • 38 citations

DIFFERENTIAL SENSITIVITY OF MOUSE SPERMATOGENESIS TO ALKYLATING AGENTS

1961 • 37 citations

Carcinogenicity of Epoxides, Lactones, and Peroxy Compounds. V. Subcutaneous Injection in Rats<xref ref-type="fn" rid="FN1">2</xref>

1967 • 37 citations

Evidence of an essential difference between the genetical effects of mono- and bi-functional alkylating agents

1964 • 37 citations

Comment on the mutagenic effectiveness of vinyl chloride metabolites

1976 • 37 citations

An international comparison of hygienic standards for chemicals in the work environment.

1975 • 36 citations

Induction of Lambda-Bacteriophage in Escherichia coli as a Screening Test for Potential Antitumor Agents1

1964 • 36 citations

Studies on a recombination-deficient mutant of drosophila

1969 • 36 citations

Epoxy derivatives of aromatic polycyclic hydrocarbons. The preparation and metabolism of epoxides related to 7,12-dimethylbenz[a]-anthracene

1973 • 36 citations

Mutagenicity of chemical carcinogens

1976 • 36 citations

Occupational Dermatitis Caused by Ethylene Oxide

1955 • 36 citations

Oxygenated fatty acids of oil from sunflower seeds after prolonged storage

1968 • 36 citations

Chloroplast Mutagenesis: Effect of N -Methyl- N ′-Nitro- N -Nitrosoguanidine and Some Other Agents on Euglena

1965 • 35 citations

The larvicidal activity of some 12,13-epoxytrichothec-9-enes

1975 • 35 citations

ORAL ANTIFERTILITY EFFECTS OF HALO PROPANEDIOL DERIVATIVES IN MALE RATS

1972 • 35 citations

Mycotoxins of possible importance in diseases of Canadian farm animals.

1975 • 35 citations

AN EFFICIENT CHEMICAL FOR THE INDUCTION OF STICKY CHROMOSOMES

2010 • 34 citations

Is Glycidol an Active Intermediate in the Antifertility Action of α-Chlorhydrin in Male Rats?

1970 • 34 citations

Exposure-Response Curve for Radiation-Induced Lung Tumors in the Mouse

1973 • 34 citations

High frequency of chromosome aberrations induced by DEB with caffeine posttreatment in Vicia faba var. minor

1971 • 34 citations

The influence of radiomimetic substances on deoxyribonucleic acid synthesis and function studied inEscherichia coli/phage systems - I. The nature of the inactivation ofT2 phagein vitroby certain alkylating agents

1959 • 33 citations

CYTOGENETIC ANALYSIS OF THE ACTION OF CARCINOGENS AND TUMOUR INHIBITORS IN DROSOPHILA MELANOGASTER. XI. MUTAGENIC EFFICIENCY OF THE MESYLOXY ESTERS ON THE SPERM IN RELATION TO MOLECULAR STRUCTURE

1961 • 32 citations

Nucleophilic Reactivity. Part II. Kinetics of Reactions of Methyl Perchlorate with Nucleophiles in Water.

1969 • 32 citations

Effects of beta-Hydroxyethylation and beta-Methoxyethylation on DNA in vitro.

1968 • 32 citations

Analysis of a case of mutagen specificity inNeurospora crassa

1970 • 32 citations

The effects of six years of mutagen testing on our attitude to the problems posed by it

1975 • 31 citations

The effect of storage on the frequency of translocations in Drosophila melanogaster

1970 • 31 citations

System for the evaluation of the risk from chemical mutagens for man: Basic principles and practical recommendations

1976 • 31 citations

On the reaction kinetics in water of 1,3-propane sultone and 1.4-butane sultone: A comparison of reaction rates and mutagenic activities of some alkylating agents

1976 • 31 citations

Radiation and Radiomimetic Chemicals

1964 • 31 citations

Chronic Toxicity or Ethylene Oxide

1964 • 30 citations

Metabolism of polycyclic compounds

1936 • 30 citations

Test of a possible correlation between cross-linking and chromosome breaking abilities of chemical mutagens

1961 • 30 citations

Ethylene oxide burns. A hospital outbreak involving 19 women.

1974 • 29 citations

Use of mutagens in the improvement of production strains of microorganisms

1971 • 29 citations

Relation Between Tumouricidal and Prophage-Inducing Action

1963 • 28 citations

The reactivity of radiomimetic compounds II

1958 • 28 citations

The formation of epoxides from cytotoxic polyol methanesulphonates under physiological conditions

1963 • 28 citations

An investigation into the mutagenic after-effect of butadiene diepoxide usingNeurospora crassa

1962 • 27 citations

Studies on the reaction kinetics of biologically active electrophilic reagents as a basis for risk estimates

1975 • 27 citations

Carcinogenesis by Cholesterol

1959 • 27 citations

The Biological Action of Mustards on Dormant Seeds of Barley and Wheat

1954 • 27 citations

Mutagenicity of ethylene chlorohydrin. Degradation product present in foods exposed to ethylene oxide

1974 • 27 citations

MUTATION INDUCTION BY DIFUNCTIONAL ALKYLATING AGENTS IN NEUROSPORA CRASSA

1975 • 26 citations

Chemical mutagenesis: biochemical and chemical points of view on mechanisms of action.

1960 • 26 citations

X-ray-induced dominant lethal mutations in male guinea-pigs, hamsters and rabbits

1970 • 26 citations

X-Irradiation Enhancement of Transformation by Benzo(a)Pyrene in Hamster Embryo Cells

1971 • 26 citations

COMPARATIVE EFFECTS OF CERTAIN CHEMICALS ON TRADESCANTIA CHROMOSOMES AS OBSERVED AT POLLEN TUBE MITOSIS

1954 • 26 citations

Prophage Inductive Efficiency of Alkylating Agents and Radiations

1975 • 26 citations

Kinetics of Reactions of Amines with Alkene Oxides

1969 • 25 citations

Note on the chromosome breaking activity of ethylene oxide and ethyleneimine

2009 • 25 citations

Direction of Ring Opening in the Reduction of p-Substituted Styrene Oxides with Lithium Borohydride

1954 • 25 citations

Mutagenic action of ethylene halogenhydrins

1969 • 25 citations

An Investigation of the Oncogenic Activity of Two Representative Epoxy Resins

1958 • 25 citations

INDUCTION OF LEAF SPOTS IN LEGUMINOUS PLANTS BY NUCLEOTOXIC AGENTS. I

2009 • 24 citations

Some Effects of Epoxy Compounds on the Blood

1961 • 24 citations

The Dose Dependence of Mutation Rates in the RAD Range, in the Light of Experiments with Higher Plants

1966 • 24 citations

Cytogenetic analysis of human chromosomes and its valu for the estimation of genetic risk

1976 • 23 citations

Reaction of DNA with glycidaldehyde. Isolation and identification of a deoxyguanosine reaction product.

1977 • 23 citations

Chemical mutagenesis : Biochemical and chemical points of view on mechanisms of action

1960 • 23 citations

The Lithium Aluminum Hydride Reduction of p-Substituted Stilbene Oxides

1954 • 23 citations

Mutagen specificity in the induction of mitotic crossing-over in Saccharomyces cerevisiae

1975 • 23 citations

Analysis of a case of mutagen specificity in Neurospora crassa

1970 • 22 citations

Studies on the male anti-fertility drug 3-chloro-1,2-propanediol

1973 • 22 citations

The Dose Dependence of Mutation Rates in the Rad Range, in the Light of Experiments with Higher Plants

1966 • 22 citations

On the association between lysogeny and carcinogenicity in nitroquinolines and related compounds

1968 • 22 citations

The effect of chelation on the production of chromatid aberrations in Vicia faba

1961 • 22 citations

DIEPOXYBUTANE AS A CHEMICAL MUTAGEN IN ZEA MAYS

1960 • 21 citations

Mutagenic effect of epichlorohydrin. I. Testing on human lymphocytes in vitro in comparison with TEPA

1976 • 21 citations

Ethylene Oxide Burns

1974 • 21 citations

Inactivation of the T7 coliphage by the diepoxybutane stereoisomers

1971 • 21 citations

A Mutagenic after-effect associated with ethylene oxide in Neurospora crassa

1968 • 20 citations

The mutagenic effect of low concentrations of ethylene oxide in air

2009 • 20 citations

Chloropropanol, A mutagenic residue resulting from propylene oxide sterilization

1975 • 19 citations

MUTAGENESIS IN VULGARE WHEAT

2009 • 19 citations

Induced mutation in plants: mechanisms and principles.

1960 • 19 citations

Induction of chromosomal aberrations and mutations with isomeric forms of L-threitol-1,4-bismethanesulfonate in plant materials

1969 • 19 citations

Differential Response of a Double Mutant–adenineless, Inositolless-in Neurospora Crassa to Combined Treatment by Ultra-violet Radiation and Chemicals

1959 • 19 citations

Inhibition of tumor induction in two-stage carcinogenesis on mouse skin.

1969 • 18 citations

Chemical mutagenesis in higher plants

1960 • 18 citations

Chemical mutagenesis in higher plants.

1960 • 18 citations

Multiple Tumors in Female Germfree Inbred Albino Mice Exposed to Bedding Treated With Ethylene Oxide<xref ref-type="fn" rid="FN2">2</xref>

1964 • 18 citations

Specificity in the photoreactivation of premutational damage induced in Neurospora crassa by ultraviolet

1967 • 18 citations

The Carcinogenic Effects of Single and Repeated Doses of 3,4-Benzpyrene

1960 • 17 citations

Assays for phosphotriester formation in the reaction of bacteriophage R17 with a group of alkylating agents

1975 • 17 citations

[Dominant lethal mutations in the offspring of irradiated male mice. 1. Studies of the dosage effect and the difference between whole-and part-body irradiation in meiotic and postmeiotic cell stages].

1971 • 17 citations

Buffer catalysis in epoxide hydrolyses

1973 • 17 citations

THE MUTAGENIC ACTIVITY OF β-HYDROXYETHYL METHANESULFONATE, β-METHOXYETHYL METHANESULFONATE AND DIETHYL 1,3-PROPANEDISULFONATE

2009 • 16 citations

Activity of L-threitol-1,4-bismethanesulfonate on barley chromosomes in relation to chemical transformation during treatment

1967 • 16 citations

QUANTITATIVE STUDIES OF INDUCED MUTATIONS IN PEAS. V. CHLOROPHYLL MUTATIONS

1961 • 16 citations

Ethylene Glycol produced by Ethylene Oxide Sterilization and its Effect on Blood-clotting Factors in an Inbred Strain of Mice

1962 • 16 citations

Differential Mutagenic Activity of l(+) and d(−) Diepoxybutane

1963 • 16 citations

EFFECTS OF CHLORHYDRIN UPON THE FERTILITY OF SPERMATOZOA OF THE CAUDA EPIDIDYMIDIS OF THE RAT

1971 • 16 citations

Comparative Effects of certain Chemicals on Tradescantia Chromosomes as Observed at Pollen Tube Mitosis

1954 • 15 citations

Mechanism of inactivation of DNA and RNA bacteriophages by alkylating agents in vitro.

1966 • 15 citations

THE INFLUENCE OF TREATMENT CONDITIONS ON THE SELECTIVE MUTAGENIC ACTION OF DIEPOXYBUTANE IN <i>NEUROSPORA</i>

1968 • 15 citations

104. The mechanism of epoxide reactions. Part VII. The reactions of 1,2-epoxybutane, 3,4-epoxybut-1-ene, 1,2-epoxy-3-chloropropane, and 1,2-epoxy-3-methoxypropane with chloride ion in water under neutral and acidic conditions

1965 • 15 citations

Kinetics of the Reaction between Ethylene Chlorohydrin and Hydroxyl or Alkoxyl Ions in Mixed Solvents^1,2

1948 • 15 citations

Production of Chromatid Aberrations by Diepoxybutane and an Iron Chelator

1961 • 15 citations

A comparative study of induced reversions in Escherichia coli

1956 • 14 citations

The influence of some alkylating agents on the structure of DNA in vitro

1974 • 14 citations

Effect of carcinogens and other compounds on deoxyribonuclease

1967 • 14 citations

Long-Term Effects of Whole-Body Irradiation on Lymphocyte Homeostasis in the Mouse

1959 • 14 citations

Comparative effects of chemosterilants on spermatogenic stages in the house fly I. Induction of dominant lethal mutations in mature sperm and gonial cell death

1969 • 14 citations

Mutagenic action of epoxy compounds and several alcohols

1973 • 14 citations

Chromosomal aberrations induced by dialkylating agents in allium cepa root-tips and their relation to the mitotic cycle and DNA synthesis

1968 • 14 citations

Mutagen specificity at the ad-3A and inositol loci in Neurospora crassa

1969 • 14 citations

The manipulation of mutation-induction kinetics in Neurospora crassa

1973 • 14 citations

Effects of low doses by different types of radiation on the waxy locus in barley and maize

2009 • 14 citations

Chemical mutagenesis in E. coli B/R; the influence of repair systems for UV damage

1969 • 13 citations

MUTAGENIC ACTIVITY OF ISOMERIC FORMS OF DIEPOXYBUTANE IN MAIZE

1962 • 13 citations

Mutagen Specificity

1969 • 13 citations

Epoxide inhibition of alcohol dehydrogenases. Identification of modified cysteines in yeast alcohol dehydrogenase and demonstration of reversible and irreversible inhibition of liver alcohol dehydrogenase by styrene oxide

1977 • 13 citations

Induction of chromosome aberrations by X-rays and chemical mutagens in a desynaptic mutant and in wild-type barley

1970 • 13 citations

Interaction of an epoxide with yeast alcohol dehydrogenase. Evidence for binding and the modification of two active site cysteins by styrene oxide

1975 • 13 citations

The effect of a carcinogenic peroxide on DNA

1967 • 13 citations

Determination of Residual Ethylene Oxide in Methyl Methacrylate Polymer Powders by GLC

1972 • 13 citations

Natural non-nutrient substances in the food chain

1972 • 13 citations

Isolation and Determination of Chlorohydrins in Foods Fumigated with Ethylene Oxide or with Propylene Oxide

1968 • 12 citations

THE ACTION OF ACTINOMYCIN D AND DIEPOXYBUTANE ON RECOMBINATION OF TWO CLOSELY LINKED LOCI INHORDEUM

1969 • 12 citations

Effectiveness and efficiency of ethyl methanesulphonate and ethylene oxide for the induction of mutations in rice

1975 • 12 citations

THE CHEMISTRY OF ETHYLENE OXIDE: V. THE REACTION OF ETHYLENE OXIDE WITH HALIDE IONS IN NEUTRAL AND ACID SOLUTION

1952 • 12 citations

Effects of the epoxide hydrase inhibitor, 1,1,1-trichloropropane-2,3-oxide on the genetic activity of aflatoxin B1 metabolites in in vitro activation test systems

1978 • 11 citations

Proceedings: effect of alpha-chlorohydrin on the fertility of rams and on the metabolism of spermatozoa in vitro

1975 • 11 citations

Modifications of Nucleosides and Nucleotides. I. Reaction of Ethylene Oxide with Uridine and Uridylic Acid.

1963 • 11 citations

Analysis of a case of mutagen specificity in Neurospora crassa

1972 • 10 citations

CHARACTERISTICS OF PROGENY OF ETHYLENE OXIDE TREATED Clostridium botulinum TYPE 62A SPORES

1971 • 10 citations

Cross sensitivity to mono- and bifunctional alkylating agents of three radiation-sensitiveSaccharomyces mutants

1973 • 10 citations

Effects of Diglycidyl Ether on Blood of Animals

1961 • 10 citations

Hydroxyethylation of amino acids in plasma albumin with ethylene oxide

1963 • 9 citations

NEUTRON SCATTERING AND BIOLOGICAL STRUCTURES

1977 • 9 citations

Biological Effects of a Chemical Mutagen, Diepoxybutane, on Tomato

1960 • 9 citations

Induction of unusual tumors in vivo by rat fibroblasts treated with diepoxybutane.

1975 • 9 citations

The action on barley chromosomes of isopropyl, 2-hydroxyisopropyl, and 2-methoxyisopropyl methanesulfonates

1976 • 9 citations

Chromosome Breakage with Two Isomers of l-Threitol 1,4-bismethanesulphonate in Plants

1966 • 9 citations

The stabilisation of a transient mutagen-sensitive state in Neurospora by the protein synthesis inhibitor actidione

1973 • 9 citations

The rate of dominant lethals after low X-ray doses given to mouse spermatozoa

1967 • 8 citations

FURTHER TEST OF POSSIBLE CORRELATION BETWEEN CROSS- LINKING AND CHROMOSOME BREAKING ABILITIES OF CHEMICAL MUTAGENS

1964 • 8 citations

Kinetics and mechanism of the N₇‐hydroxyalkylation of guanosine

1973 • 8 citations

Analysis of the storage effect of diepoxybutane (DEB) in Neurospora crassa

1973 • 8 citations

Interaction of chromatid breaks induced by nitrosoguanidine in combination with some radiomimetics and X-rays

1969 • 8 citations

Diepoxybutane pretreatment effects of UV-inactivation and photoreactivation of Sacchoromyces cerevisiae

1969 • 8 citations

The effect of diepoxybutane on chromosomes of Vicia faba

1967 • 8 citations

Safety of ethylene oxide gas residuals, part i

1974 • 7 citations

Quantitative Mutagenesis by Chemicals and by Radiations: Prerequisites for the Establishment of Rad-Equivalences

1977 • 7 citations

Ethylene oxide sterilant residues.

1970 • 7 citations

The influence of radiomimetic substances on deoxyribonucleic acid synthesis and function studied in escherichia coli/phage systems - IV. Colony-forming ability and escherichia coli strain B and two of its mutants following alkylation

1959 • 7 citations

Photoreactivation of mutational damage produced by the interaction between DEB and UV in Neurospora

1971 • 7 citations

Extrapolation of carcinogenic risk from animal experiments in man.

1978 • 7 citations

Effects of some methanesulfonic esters on DNA and plant material : a chemical and biological study

1971 • 7 citations

Investigations into a reversal of diepoxybutane specificity in Neurospora crassa

1974 • 6 citations

A Note on the Shape of Shouldered Dose–response Curves

1977 • 6 citations

Hypothetical dose—Response curves for chronic exposures to mutagens or carcinogens subject to simple enzymatic detoxification in the mammalian body

1975 • 6 citations

Synthesis of 2-Hydroxyethyl Methanesulfonate.

1968 • 6 citations

The hydroxyethylation and subsequent hydrolysis of deoxyguanosine at pH 7 and 25°

1962 • 6 citations

Transfer of Protons between Bases of DNA

1964 • 5 citations

Effect of cycloheximide on protein and DNA synthesis and on the yields of chromosomal aberrations induced by DEB and ENU in vicia faba

1974 • 5 citations

Sizes of Population Needed to Detect an Increase in Disease Risk When the Levels of Risk in the Exposed and the Controls Are Specified

1975 • 5 citations

Sorption Processes in Gas Sterilization in the Medical Sector

1973 • 5 citations

The Synergistic Action of Antifertility Compounds in the Male Rat

1973 • 5 citations

Détermination et dosage de l'oxyde d'ethylène (oxirane) et de ses dérivés dans le pain traité par ce fumigant

1970 • 5 citations

Chromosome aberrations induced by DEB in 5-aminouracil synchronised root meristems of Vicia faba

1972 • 4 citations

Sorption Processes in Gas Sterilization in the Medical Sector

1973 • 4 citations

Effect of Various Types of Carcinogens on the Hatching of <italic>Artemia salina</italic> Eggs<xref ref-type="fn" rid="FN2">2</xref>

1970 • 4 citations

Chromosomenaberrationen, hervorgerufen durch Scopolaminum hydrobromatum

1967 • 4 citations

Analysis of the storage effect of nitrosoethylurethane (NEU) in Neurospora crassa

1973 • 4 citations

The interaction between diepoxybutane and ultraviolet light in yeast II. Experiments with UV-sensitive and resistant strains

1970 • 4 citations

Radiological protection

2012 • 4 citations

Untersuchungen �ber das Verhalten von �thylenoxid bei der Begasung von Lebensmitteln

1969 • 4 citations

Toxicologie chronique du pain conservé par l'oxyde d'éthylène (oxirane)

1970 • 3 citations

[Long-term toxicity study of bread treated with ethylene oxide (oxirane)].

1970 • 3 citations

Trennung der durch �thylenoxyd (�O) ? 1,2-14C derivatisierten Inhaltsstoffe von Kakao und Verteilung der Radioaktivit�t auf Stoffgruppen

1975 • 2 citations

The influence of solvent composition on the rates of E2 elimination and similar reactions in alcohol–water mixtures

1967 • 2 citations

Modification of alkylating agent-induced mutation frequencies inBacillus subtilis

1971 • 2 citations

Lowest Common Denominators

1969 • 1 citations

Aberrations de Structure Chromosomique Induites par le L-diépoxybutane ChezVicia Fabaen Relation Avec le Cycle Mitotique

1969 • 1 citations

Deleted Work

1955 • 0 citations