Carcinogenic Risk Assessment

Department of Health, Education, and Welfare

1976 • 4,071 citations

Animal scale-up

1973 • 389 citations

A mathematical model for the age distribution of cancer in man

1969 • 282 citations

The Age Distribution of Cancer: Implications for Models of Carcinogenesis

1971 • 242 citations

“Safety” Testing of Carcinogenic Agents

1961 • 239 citations

The Cancer Problem

1975 • 209 citations

RBE and the Primary Mechanism of Radiation Action

1971 • 158 citations

Resolution of dose-response toxicity data for chemicals requiring metabolic activation: Example?Vinyl chloride*1

1978 • 156 citations

Discrimination between alternative binary response models

1967 • 154 citations

A Biometrics Invited Paper. Estimation of "Safe Doses" in Carcinogenic Experiments

1977 • 134 citations

Estimation of risks of irreversible, delayed toxicity

1975 • 129 citations

Micronuclei in mouse bone-marrow cells. A simple in vivo model for the evaluation of drug-induced chromosomal aberrations

1974 • 125 citations

Confidence Intervals and Test of Hypotheses Concerning Dose Response Relations Inferred from Animal Carcinogenicity Data

1977 • 122 citations

Uncertainty estimates for low-dose-rate extrapolations of animal carcinogenicity data.

1977 • 105 citations

A Dose-Response Equation for the Invasion of Micro-Organisms

1953 • 99 citations

Quantitative Analysis of Dose-Response Data Obtained With Three Carcinogenic Hydrocarbons in Strain C3H Male Mice

1943 • 93 citations

Mechanisms of carcinogenesis: dose response.

1978 • 91 citations

Estimating "safe" levels, a hazardous undertaking.

1975 • 90 citations

Food and Drug Administration Advisory Committee on Protocols for Safety Evaluation: Panel on carcinogenesis report on cancer testing in the safety evaluation of food additives and pesticides *1, *2August, 1970

1971 • 82 citations

Chemical Carcinogens: How Dangerous Are Low Doses?

1978 • 77 citations

Extrapolation of experimental data from animals to man.

1976 • 64 citations

Carcinogenic effects of chronic exposure to very low levels of toxic substances.

1978 • 63 citations

Quantit Analysis: A Quantal Assay Refinement

1977 • 56 citations

The effects of small doses of ionizing radiation

1970 • 55 citations

A SIMPLE METHOD FOR DETECTING ENVIRONMENTAL CARCINOGENS AS MUTAGENS*

1976 • 52 citations

Chemical Carcinogens: The Scientific Basis for Regulation

1978 • 51 citations

Some classes of hit-theory models

1975 • 49 citations

Measuring the benefit of reduced exposure to environmental carcinogens

1975 • 47 citations

The effect of dose on cancer latency period.

1977 • 44 citations

Multi-hit kinetics of tumor formation, with special reference to experimental liver and human lung carcinogenesis and some gneral conclusions.

1977 • 39 citations

Age incidence curves for cancer.

1977 • 32 citations

Combination Effects in Chemical Carcinogenesis (Experimental Results)

1976 • 29 citations

Maximum Likelihood Estimation of Dose-Response Functions Subject to Absolutely Monotonic Constraints

1978 • 26 citations

Chemical Carcinogens in the Human Environment Problems and Quantitative Aspects

1976 • 24 citations

Application of Pharmacokinetic Principles in the Extrapolation of Animal Data to Humans

1976 • 23 citations

Determination of the “no-effect levels” of two pesticides, lindane and zineb, on the microsomal enzyme activities of rat liver

1977 • 21 citations

Best-estimate low-dose extrapolation of carcinogenicity data.

1978 • 19 citations

Repair Excision of Alkylated Bases from DNA <i>in vivo</i>

1976 • 18 citations

Some Examples of Dose-Response Studies in Chemical Carcinogenesis

1976 • 17 citations

Underestimation of chronic toxicities of food additives and chemicals: The bias of a phantom rule

1978 • 17 citations

Estimating cancer risks to a population.

1978 • 15 citations

The delaney clause and a scheme for rewarding good experimentation

1973 • 15 citations

A collaborative cytogenetics study to measure and minimize interlaboratory variation

1977 • 14 citations

Thresholds in Linear Dose-Response Models for Carcinogenesis

1961 • 13 citations

SAFE DOSE PROBLEM OF THE STATISTICIAN IN THE WORLD OF TRANS SCIENCE

1974 • 12 citations

DOSE‐RESPONSE RELATIONSHIP AND THRESHOLD CONCEPTS

1976 • 12 citations

Much ado about safety

1969 • 12 citations

Cancer in Humans: Exposures and Responses in a Real World

1976 • 10 citations

Biologic evidence for the existence of thesholds in chemical carcinogenesis.

1978 • 8 citations

Acceptable Risk and Practical Safety

1973 • 7 citations

STATISTICAL EXTRAPOLATION METHODS FOR ESTIMATING RISKS FROM ANIMAL DATA

1976 • 6 citations

Threshold Doses in Chemical Carcinogenesis

1976 • 5 citations

Balancing the Benefits and Risks of the Application of Science to Agriculture and Food Production

1976 • 4 citations

Benefit-Risk Decision Making and Food Safety

1976 • 4 citations

Low-Level Radiation: Predicting the Effects

1977 • 2 citations

An unbalanced experimental design for dose response studies.

1977 • 2 citations