The Chemistry of Cytotoxic Alkylating Agents

Physical Organic Chemistry

1941 • 1,182 citations

Specific Group Reagents for Proteins.

1947 • 218 citations

Biochemical Research on Chemical Warfare Agents

1946 • 202 citations

Mode of Production of Chromosome Abnormalities by the Nitrogen Mustards The Possible Role of Cross-Linking

1949 • 153 citations

Some New Aspects of Mitotic Poisoning

1947 • 140 citations

464. The reactions of certain epoxides in aqueous solutions

1950 • 132 citations

Kinetics of Hydrolysis and Displacement Reactions of β,β′-Dichlorodiethyl Sulfide (Mustard Gas) and of β-Chloro-β″-hydroxydiethyl Sulfide (Mustard Chlorohydrin)

1949 • 129 citations

CHEMICAL REACTIONS OF THE NITROGEN MUSTARD GASES.¹ I. THE TRANSFORMATIONS OF METHYL-BIS(β-CHLOROETHYL)AMINE IN WATER

1946 • 123 citations

KINETIC STUDIES ON ETHYLENE OXIDES

1929 • 121 citations

Approaches to Tumor Chemotherapy

1948 • 113 citations

New Evidence on the Mode of Action of ‘Mitotic Poisons’

1949 • 110 citations

THE ACTION OF 1,2-EPOXIDES ON PROTEINS

1944 • 105 citations

Mechanism and kinetics of substitution at a saturated carbon atom

1941 • 104 citations

CHEMICAL REACTIONS OF THE NITROGEN MUSTARD GASES.¹ III. THE TRANSFORMATIONS OF ETHYL-BIS(β-CHLOROETHYL)AMINE IN WATER

1946 • 103 citations

Effects upon tumours of Various Haloalkylarylamines

1948 • 100 citations

The replacement reactions of β-β′-dichlorodiethyl sulphide and of some analogues in aqueous solution: the isolation of β-chloro-β′-hydroxy diethyl sulphide

1948 • 83 citations

New Cytotoxic Agents with Tumour-Inhibitory Activity

1950 • 83 citations

THE EFFECT OF NITROGEN MUSTARDS ON ENZYMES AND TISSUE METABOLISM

1948 • 71 citations

43. Aryl-2-halogenoalkylamines. Part I

1949 • 67 citations

The reaction of nucleic acids with mustard gas

1948 • 66 citations

Chromosome Alteration and Tumour Inhibition by Nitrogen Mustards: the Hypothesis of Cross-linking Alkylation

1950 • 63 citations

Kinetics and Mechanism of the Reactions of Tertiary β-Chloroethylamines in Solution. I. Methyl-bis-β-chloroethylamine¹

1947 • 59 citations

66. Reactions of ethylene oxides. Part II. Reactions with thioamides, thiols, and inorganic sulphur salts

1949 • 58 citations

Recent contributions to the pharmacology of bis(2-haloethyl) amines and sulfides.

1950 • 49 citations

Über Glykolester der Pektinsäure

1947 • 46 citations

Reaction Kinetics of Aliphatic Tertiary β-Chloroethylamines in Dilute Aqueous Solution. I. The Cyclization Process¹

1948 • 45 citations

CHEMICAL REACTIONS OF THE NITROGEN MUSTARD GASES.¹ V. THE REACTIONS OF THE NITROGEN MUSTARD GASES WITH PROTEIN CONSTITUENTS

1946 • 44 citations

BIOCHEMICAL RESEARCH AT OXFORD UPON MUSTARD GAS

1947 • 42 citations

420. Aryl-2-halogenoalkylamines. Part II

1949 • 41 citations

CHEMICAL REACTIONS OF THE NITROGEN MUSTARD GASES.¹ VI. THE REACTIONS OF THE NITROGEN MUSTARD GASES WITH CHEMICAL COMPOUNDS OF BIOLOGICAL INTEREST

1946 • 41 citations

Rearrangement of 1,2-Aminochloroalkanes

1947 • 40 citations

REACTION OF ENZYMES AND PROTEINS WITH MUSTARD GAS (BIS(ß-CHLOROETHYL)SULFIDE)

1946 • 39 citations

The Role of Neighboring Groups in Replacement Reactions. XV. Rates and Medium Effects in the Alcoholysis and Hydrolysis of α-Bromopropionate Ion. The Carboxylate Ion Group

1948 • 38 citations

670. The action of ionizing radiations and of radiomimetic substances on deoxyribonucleic acid. Part II. The effect of oxygen on the degradation of the nucleic acid by X-rays

1950 • 37 citations

Studies on mustard gas (ββ′-dichlorodiethyl sulphide) and some related compounds

1946 • 37 citations

REACTIONS OF β,β'-DICHLORO-ETHYL SULFIDE WITH AMINO COMPOUNDS

1925 • 34 citations

CXCVI.—The velocities of combination of sodium derivatives of phenols with olefine oxides

1914 • 34 citations

The hydration of ethylene oxide

1948 • 33 citations

Chemical reactions of mustard gas and related compounds.

1946 • 33 citations

The action of mustard gas on ox cornea collagen

1947 • 32 citations

99. The chemistry of 2-chloroalkylamines. Part II. Reactions of tertiary 2-chloroalkylamines in water

1947 • 31 citations

Reaction of 3,4-Epoxy-1-butene with Methanol. Direction and Mechanism of Ring Opening

1946 • 31 citations

610. The preparation of some cytotoxic epoxides

1950 • 31 citations

Studies on mustard gas (ββ′-dichlorodiethyl sulphide) and some related compounds

1946 • 30 citations

A TRIAL OF $beta;-NAPHTHYLDI-2-CHLOROETHYLAMINE (R48) IN LEUKqMIA, HODGKIN'S DISEASE, AND ALLIED DISEASES

1950 • 30 citations

Biological Action of ‘Mustard Gas’ Compounds: Mutagenic Activity of beta-Chloroalkyl Amines and Sulphides

1950 • 30 citations

CHEMICAL REACTIONS OF MUSTARD GAS AND RELATED COMPOUNDS.¹ I. THE TRANSFORMATIONS OF MUSTARD GAS IN WATER. FORMATION AND PROPERTIES OF SULFONIUM SALTS DERIVED FROM MUSTARD GAS

1946 • 30 citations

Ueber den Einfluss des Wassers auf die Addition des Aethylenoxyds an Ammoniak und Amine

1899 • 30 citations

CHEMICAL REACTIONS OF MUSTARD GAS AND RELATED COMPOUNDS.¹ VII. THE CHEMISTRY OF BIS(β-CHLOROETHYL)-SULFONE, DIVINYL SULFONE AND DIVINYL SULFOXIDE

1946 • 30 citations

Radiomimetic Action of Sulphur and Nitrogen ‘Mustards’ on Deoxyribonucleic Acid

1950 • 25 citations

Biological Action of X-Rays, Nitrogen Mustards, Diepoxides and Peroxides

1950 • 25 citations

The Role of Neighboring Nitrogen.Atom in the Displacement Reaction; Rearrangement in the Hydrolysis of 1-Diethylamino-2-chloropropane

1947 • 25 citations

CHEMICAL REACTIONS OF MUSTARD GAS AND RELATED COMPOUNDS.¹ II. THE REACTION OF MUSTARD GAS WITH CARBOXYL GROUPS AND WITH THE AMINO GROUPS OF AMINO ACIDS AND PEPTIDES

1946 • 25 citations

671. The action of ionizing radiations and of radiomimetic substances on deoxyribonucleic acid. Part III. The molecular weights of deoxyribonucleic acid degraded by X-rays and by treatment with a “nitrogen mustard.”

1950 • 24 citations

Sulfapyrazine Precipitated in Cancer Tissue upon Repeated Glucose Injections

1950 • 24 citations

324. Anhydrides of polyhydric alcohols. Part XIV. Observations on the ring scission of 1 : 2-5 : 6-diepoxyhexane and 3 : 4-isopropylidene 1 : 2-5 : 6-dianhydromannitol

1950 • 23 citations

β-Propiolactone. IX. The Kinetics of Attack by Nucleophilic Reagents upon the Alcoholic Carbon of β-Propiolactone

1950 • 23 citations

Biological Action of ‘Mustard Gas’ Compounds: Mutagenic Activity of some ‘Mustard Gas’ Compounds

1950 • 22 citations

669. The action of ionizing radiations and of radiomimetic substances on deoxyribonucleic acid. Part I. The action of some compounds of the “mustard” type

1950 • 21 citations

75. The anhydrides of polyhydric alcohols. Part II. Derivatives of 1 : 2–5 : 6-dianhydro mannitol

1946 • 21 citations

Nouvele synthèse des pipérazines N-monoalcoylées (VIIième communication sur les bis-[β-halogénoéthyl]-amines)

1935 • 21 citations

Studies on mustard gas (ββ′-dichlorodiethyl sulphide) and some related compounds

1946 • 20 citations

Biological Action of ‘Mustard Gas’ Compounds: Production of Mutations by Monochloro-‘Mustards’

1950 • 20 citations

The effect of nitrogen mustards upon the ultraviolet absorption spectrum of thymonucleate, uracil and purines.

1946 • 20 citations

Chromosome Alteration and Tumour Inhibition by Nitrogen Mustards: the Hypothesis of Cross-linking Alkylation

1950 • 19 citations

Kinetics and Mechanism of Reactions of Tertiary β-Chloroethylamines in Solution. II. Ethyl-bis-β-chloroethylamine¹

1947 • 19 citations

10. New organic sulphur vesicants. Part IV. 1 : 2-Di-(2-chloroethylthio)ethane and its analogues

1948 • 17 citations

CHEMICAL REACTIONS OF MUSTARD GAS AND RELATED COMPOUNDS.¹ III. THE REACTION OF MUSTARD GAS WITH METHIONINE

1946 • 16 citations

CHEMICAL REACTIONS OF MUSTARD GAS AND RELATED COMPOUNDS.¹ V. THE CHEMICAL REACTIONS OF 1,2-BIS(β-CHLOROETHYLTHIO)ETHANE

1946 • 15 citations

CHEMICAL REACTIONS OF THE NITROGEN MUSTARD GASES.¹ IV. THE TRANSFORMATIONS OF TRIS(β-CHLOROETHYL)-AMINE IN WATER

1946 • 15 citations

The Reaction of Mustard Gas with Proteins

1947 • 14 citations

201. Some compounds related to the aromatic “nitrogen mustards.”

1950 • 14 citations

598. Aryl-2-halogenoalkylamines. Part VIII. A comparison of the stability of esters derived from some aryl-2-halogenoalkylamines with those obtained from other radiomimetic compounds

1950 • 14 citations

Chemical Studies on Vesicant-treated Proteins¹

1948 • 13 citations

Observations upon a compound of mustard gas and kerateine

1947 • 13 citations

XXXVII.—Synthetical experiments with ββ′-dichloroethyl sulphide

1920 • 12 citations

ACTION OF MUSTARD GAS (ββ'-DICHLORODIETHYLSULPHIDE) ON NUCLEOPROTEINS

1947 • 10 citations

CCCXXXIX.—The interaction of ββ′-dichlorodiethyl sulphide, sulphoxide, and sulphone with glycine ester and with potassium phthalimide

1923 • 9 citations

547. Aryl-2-halogenoalkylamines. Part III. The reactions of NN-di-2-chloroethyl-p-anisidine and β-naphthyldi-2-chloroethylamine in aqueous-acetone salt solutions

1949 • 9 citations

THE REACTION OF SUCROSE WITH ETHYLENE OXIDE¹

1948 • 9 citations

REACTIONS AND ANALYSIS OF β-CHLOROETHYL SULFIDE IN WATER¹

1947 • 8 citations

595. Aryl-2-halogenoalkylamines. Part V. The preparation of 1 : 4-di-substituted piperazines by the reaction of di-2-halogenoalkylamines with primary amines

1949 • 7 citations

162. Aryl-2-halogenoalkylamines. Part VI. Reactions with certain organic sulphur compounds

1950 • 7 citations

Observations on antisera against complexes of di-2-chloroethyl sulphide and protein

1949 • 7 citations

CHEMICAL REACTIONS OF NITROGEN MUSTARD GASES.¹ I. REACTIONS OF METHYL-BIS(β-CHLOROETHYL) AMINE WITH HEXAMETHYLENETETRAMINE

1947 • 7 citations

CHEMICAL REACTIONS OF MUSTARD GAS AND RELATED COMPOUNDS.¹ IV. CHEMICAL REACTIONS OF β-CHLOROETHYL-β'-HYDROXYETHYLSULFIDE

1946 • 6 citations

270. Aryl-2-halogenoalkylamines. Part VII. Some derivatives of 2-naphthyldi-2′-halogenoalkylamines

1950 • 6 citations

72. The influence of the sulphur atom on the reactivity of adjacent atoms or groups. Part VI. Aromatic side-chain and nuclear reactivity

1933 • 5 citations

Formation of a Tetrahydrofuran Derivative from Diallyl

1949 • 4 citations

594. Aryl-2-halogenoalkylamines. Part IV. The reactions of NN-di-2-chloroethyl-p-anisidine and β-naphthyldi-2-chloroethylamine in aqueous acetone solutions of amines

1949 • 4 citations

Studies on Acid Hydrolysates of Vesicant-treated Insulin¹

1948 • 4 citations

Studies of the Effect of Mustard-type Vesicants on the Phenol Color Reaction of Proteins¹

1948 • 3 citations