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2002 • 4,135 citations

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Diffusible, nonfibrillar ligands derived from Aβ _1–42 are potent central nervous system neurotoxins

1998 • 3,404 citations

RETRACTED ARTICLE: A specific amyloid-β protein assembly in the brain impairs memory

2006 • 2,741 citations

High-Level Neuronal Expression of Aβ_1–42in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation

2000 • 1,793 citations

Soluble Amyloid β Peptide Concentration as a Predictor of Synaptic Change in Alzheimer's Disease

1999 • 1,505 citations

Natural Oligomers of the Alzheimer Amyloid-β Protein Induce Reversible Synapse Loss by Modulating an NMDA-Type Glutamate Receptor-Dependent Signaling Pathway

2007 • 1,501 citations

Oligomeric and Fibrillar Species of Amyloid-β Peptides Differentially Affect Neuronal Viability

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Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.

1994 • 1,313 citations

Activation of microglial cells by β-amyloid protein and interferon-γ

1995 • 1,298 citations

The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases

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Plaque-independent disruption of neural circuits in Alzheimer’s disease mouse models

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Amyloid β-Protein Fibrillogenesis

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1993 • 1,035 citations

Alzheimer's disease-affected brain: Presence of oligomeric Aβ ligands (ADDLs) suggests a molecular basis for reversible memory loss

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Age-Dependent Changes in Brain, CSF, and Plasma Amyloid β Protein in the Tg2576 Transgenic Mouse Model of Alzheimer's Disease

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Essential involvement of interleukin-8 (IL-8) in acute inflammation

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Targeting small Aβ oligomers: the solution to an Alzheimer's disease conundrum?

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Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons.

1999 • 917 citations

Aβ Oligomers Induce Neuronal Oxidative Stress through an N-Methyl-D-aspartate Receptor-dependent Mechanism That Is Blocked by the Alzheimer Drug Memantine

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Some morphometric aspects of the brain in senile dementia of the alzheimer type

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Protofibrillar Intermediates of Amyloid β-Protein Induce Acute Electrophysiological Changes and Progressive Neurotoxicity in Cortical Neurons

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Amyloid β-Protein and the Genetics of Alzheimer's Disease

1996 • 794 citations

Glial‐Neuronal Interactions in Alzheimer's Disease: The Potential Role of a ‘Cytokine Cycle’ in Disease Progression

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β-Amyloid Stimulation of Microglia and Monocytes Results in TNFα-Dependent Expression of Inducible Nitric Oxide Synthase and Neuronal Apoptosis

2001 • 678 citations

Effects of secreted oligomers of amyloid β‐protein on hippocampal synaptic plasticity: a potent role for trimers

2006 • 602 citations

Paradigm shifts in Alzheimer's disease and other neurodegenerative disorders: The emerging role of oligomeric assemblies

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Amyloid beta oligomers induce impairment of neuronal insulin receptors

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Self-Assembly of Aβ_1-42into Globular Neurotoxins

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Amyloid β protein immunotherapy neutralizes Aβ oligomers that disrupt synaptic plasticity in vivo

2005 • 486 citations

Different Conformations of Amyloid β Induce Neurotoxicity by Distinct Mechanisms in Human Cortical Neurons

2006 • 484 citations

Morphology and Toxicity of Aβ-(1-42) Dimer Derived from Neuritic and Vascular Amyloid Deposits of Alzheimer's Disease

1996 • 482 citations

The Oligomerization of Amyloid β-Protein Begins Intracellularly in Cells Derived from Human Brain

2000 • 479 citations

Block of Long-Term Potentiation by Naturally Secreted and Synthetic Amyloid β-Peptide in Hippocampal Slices Is Mediated via Activation of the Kinases c-Jun N-Terminal Kinase, Cyclin-Dependent Kinase 5, and p38 Mitogen-Activated Protein Kinase as well as Metabotropic Glutamate Receptor Type 5

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Correlations of synaptic and pathological markers with cognition of the elderly

1995 • 405 citations

Temporal Profile of Amyloid-β (Aβ) Oligomerization in an in Vivo Model of Alzheimer Disease

2005 • 370 citations

Identification of Microglial Signal Transduction Pathways Mediating a Neurotoxic Response to Amyloidogenic Fragments of β-Amyloid and Prion Proteins

1999 • 353 citations

Clusterin (apoJ) Alters the Aggregation of Amyloid β-Peptide (Aβ1-42) and Forms Slowly Sedimenting Aβ Complexes That Cause Oxidative Stress

1995 • 343 citations

Amyloid Fibrils Activate Tyrosine Kinase-Dependent Signaling and Superoxide Production in Microglia

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Microglia enhance β‐amyloid peptide‐induced toxicity in cortical and mesencephalic neurons by producing reactive oxygen species

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Aggregation-related toxicity of synthetic β-amyloid protein in hippocampal cultures

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Role of p38 and p44/42 mitogen‐activated protein kinases in microglia

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Soluble β-Amyloid_1-40Induces NMDA-Dependent Degradation of Postsynaptic Density-95 at Glutamatergic Synapses

2005 • 271 citations

β-Amyloid-Stimulated Microglia Induce Neuron Death via Synergistic Stimulation of Tumor Necrosis Factor α and NMDA Receptors

2005 • 236 citations

High-resolution Atomic Force Microscopy of Soluble Aβ42 Oligomers

2006 • 221 citations

Differential effects of oligomeric and fibrillar amyloid-β1–42 on astrocyte-mediated inflammation

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β-Amyloid-Induced Inflammation and Cholinergic Hypofunction in the Rat Brain in Vivo: Involvement of the p38MAPK Pathway

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Amyloid beta peptide potentiates cytokine secretion by interleukin-1 beta-activated human astrocytoma cells.

1995 • 176 citations

CD45 Opposes β-Amyloid Peptide-Induced Microglial Activation via Inhibition of p44/42 Mitogen-Activated Protein Kinase

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Rapid, concurrent alterations in pre- and postsynaptic structure induced by naturally-secreted amyloid-β protein

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Macrophage Colony-stimulating Factor Augments β-Amyloid-induced Interleukin-1, Interleukin-6, and Nitric Oxide Production by Microglial Cells

1998 • 117 citations

Membrane‐bound β‐amyloid oligomers are recruited into lipid rafts by a fyn‐dependent mechanism

2007 • 117 citations

Soluble Aβ oligomers ultrastructurally localize to cell processes and might be related to synaptic dysfunction in Alzheimer's disease brain

2004 • 109 citations

β‐Amyloid protein oligomers induced by metal ions and acid pH are distinct from those generated by slow spontaneous ageing at neutral pH

2003 • 106 citations

Immunoreactivity of CD45, a protein phosphotyrosine phosphatase, in Alzheimer's disease

1991 • 105 citations

Protease inhibitor coinfusion with amyloid beta-protein results in enhanced deposition and toxicity in rat brain.

1998 • 85 citations

β-Amyloid Protein Structure Determines the Nature of Cytokine Release From Rat Microglia

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Protease Inhibitor Coinfusion with Amyloid β-Protein Results in Enhanced Deposition and Toxicity in Rat Brain

1998 • 62 citations

Aβ peptide conformation determines uptake and interleukin-1α expression by primary microglial cells

2008 • 38 citations

Amyloid precursor protein cross‐linking stimulates beta amyloid production and pro‐inflammatory cytokine release in monocytic lineage cells

2006 • 36 citations

Amyloid β Protein (25‐35) Phosphorylates MARCKS Through Tyrosine Kinase‐Activated Protein Kinase C Signaling Pathway in Microglia

1999 • 33 citations

Amyloid-β fibril formation is not necessarily required for microglial activation by the peptides

2005 • 31 citations