Glial‐Neuronal Interactions in Alzheimer's Disease: The Potential Role of a ‘Cytokine Cycle’ in Disease Progression

Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy

2012 • 10,051 citations

Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease.

1989 • 1,752 citations

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1992 • 1,602 citations

The Role of Interleukin-1 in Disease

1993 • 967 citations

Interleukin-1 Stimulation of Astroglial Proliferation After Brain Injury

1985 • 855 citations

Complement activation by beta-amyloid in Alzheimer disease.

1992 • 804 citations

Cytokine production by human fetal microglia and astrocytes. Differential induction by lipopolysaccharide and IL-1 beta.

1993 • 789 citations

Alzheimer's Disease: A Central Role for Amyloid

1994 • 749 citations

Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E

1997 • 601 citations

Synergistic Effects of Traumatic Head Injury and Apolipoprotein-epsilon4 in Patients With Alzheimer's Disease

1995 • 588 citations

Interleukin-1 injected into mammalian brain stimulates astrogliosis and neovascularization

1988 • 587 citations

Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells.

1989 • 586 citations

Head Trauma as a Risk Factor for Alzheimer's Disease: A Collaborative Re-Analysis of Case-Control Studies

1991 • 582 citations

Inverse association of anti‐inflammatory treatments and Alzheimer's disease

1994 • 567 citations

Beta amyloid protein deposition in the brain after severe head injury: implications for the pathogenesis of Alzheimer's disease.

1994 • 563 citations

Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer beta/A4 amyloid protein precursor.

1992 • 557 citations

β-Amyloid precursor protein (βAPP) as a marker for axonal injury after head injury

1993 • 557 citations

Interleukin-1 Expression in Different Plaque Types in Alzheimerʼs Disease

1995 • 538 citations

The occult aftermath of boxing.

1990 • 522 citations

Apolipoprotein E ε4 allele is associated with deposition of amyloid β-protein following head injury

1995 • 488 citations

βA4 amyloid protein deposition in brain after head trauma

1991 • 465 citations

Delayed onset of Alzheimer's disease with nonsteroidal anti-inflammatory and histamine H2 blocking drugs

1995 • 460 citations

Nonsteroidal anti-inflammatory drugs in Alzheimer's disease

1995 • 442 citations

Glial cytokines in Alzheimer's disease: Review and pathogenic implications

1995 • 412 citations

Purification and characterization of a neurite extension factor from bovine brain.

1985 • 378 citations

Neurotrophic protein S100 beta stimulates glial cell proliferation.

1991 • 326 citations

Functions and mechanisms of interleukin 1 in the brain

1991 • 325 citations

Human immunodeficiency virus-infected macrophages produce soluble factors that cause histological and neurochemical alterations in cultured human brains.

1991 • 289 citations

Brain macrophages synthesize interleukin‐1 and interleukin‐1 mRNAs in vitro

1988 • 286 citations

Do nonsteroidal anti-inflammatory drugs decrease the risk for Alzheimer's disease?

1995 • 284 citations

In vivo and in vitro evidence supporting a role for the inflammatory cytokine interleukin-1 as a driving force in Alzheimer pathogenesis

1996 • 260 citations

Expression of amyloid precursor protein mRNAs in endothelial, neuronal and glial cells: modulation by interleukin-1

1992 • 250 citations

Growth control of cultured microglia

1992 • 250 citations

A4 Protein in Alzheimer's Disease: Primary and Secondary Cellular Events in Extracellular Amyloid Deposition

1989 • 236 citations

Gene Encoding the β Subunit of S100 Protein Is on Chromosome 21: Implications for Down Syndrome

1988 • 222 citations

Genetic susceptibility and head injury as risk factors for Alzheimer's disease among community‐dwelling elderly persons and their first‐degree relatives

1993 • 221 citations

Interleukin-1 beta attenuates excitatory amino acid-induced neurodegeneration in vitro: involvement of nerve growth factor

1995 • 214 citations

Increased S100β neurotrophic activity in Alzheimer's disease temporal lobe

1992 • 214 citations

Correlation of Astrocytic S100β Expression with Dystrophic Neurites in Amyloid Plaques of Alzheimerʼs Disease

1996 • 210 citations

Cytokine Regulation of Neuronal Survival

1992 • 209 citations

Glial-Neuronal Interactions in Alzheimer Disease

1997 • 207 citations

Selective induction of Kunitz-type protease inhibitor domain-containing amyloid precursor protein mRNA after persistent focal ischemia in rat cerebral cortex

1991 • 206 citations

S100β Stimulates Inducible Nitric Oxide Synthase Activity and mRNA Levels in Rat Cortical Astrocytes

1996 • 201 citations

S100 beta stimulates calcium fluxes in glial and neuronal cells.

1992 • 199 citations

Increased Neuronal β‐Amyloid Precursor Protein Expression in Human Temporal Lobe Epilepsy: Association with Interleukin‐1α Immunoreactivity

1994 • 196 citations

In vitro production of IL-6, IL-1 beta, and tumor necrosis factor-alpha by human embryonic microglial and neural cells.

1993 • 195 citations

S100β expression in Alzheimer's disease: Relation to neuropathology in brain regions

1994 • 193 citations

Astrocytosis and axonal proliferation in the hippocampus of S100b transgenic mice.

1994 • 183 citations

Microglial inter leukin‐1α expression in brain regions in Alzheimer's disease: correlation with neuritic plaque distribution

1995 • 181 citations

S100β protein expression in Alzheimer disease: Potential role in the pathogenesis of neuritic plaques

1994 • 179 citations

Brain interleukin-1 beta in Alzheimer's disease and vascular dementia.

1994 • 176 citations

Microglial interleukin-lα expression in human head injury: Correlations with neuronal and neuritic β-amyloid precursor protein expression

1994 • 169 citations

Expression of the Alzheimer amyloid-promoting factor antichymotrypsin is induced in human astrocytes by IL-1

1995 • 166 citations

Senile plaques in temporal lobe epilepsy

1994 • 159 citations

Human brain S100β and S100β mRNA expression increases with age: Pathogenic implications for Alzheimer's disease

1996 • 155 citations

Distribution of β‐amyloid protein in the brain following severe head injury

1995 • 145 citations

S100 is present in developing chicken neurons and schwann cell and promotes motor neuron survival in vivo

1992 • 145 citations

Antisense inhibition of glial S100 beta production results in alterations in cell morphology, cytoskeletal organization, and cell proliferation.

1990 • 136 citations

Overexpression of the Neurotrophic Cytokine S100β in Human Temporal Lobe Epilepsy

1995 • 125 citations

Development of senile plaques. Relationships of neuronal abnormalities and amyloid deposits.

1990 • 114 citations

Studies of the bacterial cell wall VI. Wall composition and sensitivity to lysozyme

1960 • 111 citations

Complete cerebral ischemia with short-term survival in rats induced by cardiac arrest. I. Extracellular accumulation of Alzheimer's β-amyloid protein precursor in the brain

1994 • 104 citations

Chapter 16 Molecular pathology of head trauma: altered βAPP metabolism and the aetiology of Alzheimer's disease

1993 • 89 citations

Increased apolipoprotein E ϵ4 in epilepsy with senile plaques

1997 • 86 citations

Increased numbers of βAPP-immunoreactive neurones in the entorhinal cortex after head injury

1994 • 72 citations

Alzheimer's disease: pathology to potential treatments?

1992 • 59 citations

Apolipoprotein E distribution among different plaque types in Alzheimer's disease: implications for its role in plaque progression

1996 • 43 citations

A decomposition product of a contaminant implicated in L-tryptophan eosinophilia myalgia syndrome affects spinal cord neuronal cell death and survival through stereospecific, maturation and partly interleukin-1-dependent mechanisms.

1993 • 33 citations

SUGGESTED LINKS BETWEEN DIFFERENT TYPES OF DEMENTIAS

1989 • 30 citations

Lesioning of the inferior olive using a ventral surgical approach

1997 • 10 citations

Apolipoprotein E: Emerging Story in the Pathogenesis of Alzheimer's Disease

1995 • 8 citations