NOXO1, Regulation of Lipid Binding, Localization, and Activation of Nox1 by the Phox Homology (PX) Domain

Cell transformation by the superoxide-generating oxidase Mox1

1999 • 1,457 citations

Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses

1993 • 1,148 citations

Killing activity of neutrophils is mediated through activation of proteases by K+ flux

2002 • 1,141 citations

Novel gp91 ^phox Homologues in Vascular Smooth Muscle Cells

2001 • 841 citations

Superoxide Production and Expression of Nox Family Proteins in Human Atherosclerosis

2002 • 838 citations

Oxidants from phagocytes: agents of defense and destruction

1984 • 803 citations

Homologs of gp91 phox : cloning and tissue expression of Nox3, Nox4, and Nox5

2001 • 794 citations

The superoxide-generating NADPH oxidase: structural aspects and activation mechanism

2002 • 753 citations

RECEPTORS AND PHOSPHOINOSITIDE-GENERATED SECOND MESSENGERS

1985 • 722 citations

The PX domains of p47phox and p40phox bind to lipid products of PI(3)K

2001 • 600 citations

Phagocytic activation of a luminol-dependent chemiluminescence in rabbit alveolar and peritoneal macrophages

1976 • 572 citations

Hydrogen peroxide mediates the cell growth and transformation caused by the mitogenic oxidase Nox1

2001 • 478 citations

Two Novel Proteins Activate Superoxide Generation by the NADPH Oxidase NOX1

2003 • 477 citations

Reactive oxygen generated by Nox1 triggers the angiogenic switch

2002 • 473 citations

Purified cytochrome b from human granulocyte plasma membrane is comprised of two polypeptides with relative molecular weights of 91,000 and 22,000.

1987 • 459 citations

Upregulation of Nox-Based NAD(P)H Oxidases in Restenosis After Carotid Injury

2002 • 449 citations

Mutations in the X-linked and autosomal recessive forms of chronic granulomatous disease

1996 • 424 citations

Molecular Basis of Phosphorylation-Induced Activation of the NADPH Oxidase

2003 • 393 citations

Novel Human Homologues of p47 and p67 Participate in Activation of Superoxide-producing NADPH Oxidases

2003 • 366 citations

Novel homologs of gp91phox

2000 • 356 citations

The phosphorylation of the respiratory burst oxidase component p47phox during neutrophil activation. Phosphorylation of sites recognized by protein kinase C and by proline-directed kinases.

1994 • 342 citations

Primary structure and unique expression of the 22-kilodalton light chain of human neutrophil cytochrome b.

1988 • 317 citations

Binding of the PX domain of p47phox to phosphatidylinositol 3,4-bisphosphate and phosphatidic acid is masked by an intramolecular interaction

2002 • 308 citations

Novel domains in NADPH oxidase subunits, sorting nexins, and PtdIns 3‐kinases: Binding partners of SH3 domains?

1996 • 304 citations

Nox/Duox family of nicotinamide adenine dinucleotide (phosphate) oxidases

2002 • 281 citations

Proteins Homologous to p47 and p67 Support Superoxide Production by NAD(P)H Oxidase 1 in Colon Epithelial Cells

2003 • 274 citations

NOX5 NAD(P)H oxidase regulates growth and apoptosis in DU 145 prostate cancer cells

2003 • 254 citations

Location, Location, Location: Membrane Targeting Directed by PX Domains

2001 • 237 citations

Mechanism for Phosphorylation-induced Activation of the Phagocyte NADPH Oxidase Protein p47

1999 • 221 citations

Phosphorylation of p47 ^phox directs phox homology domain from SH3 domain toward phosphoinositides, leading to phagocyte NADPH oxidase activation

2003 • 210 citations

The PX domain: a new phosphoinositide-binding module

2002 • 184 citations

Modulation of p47 ^PHOX activity by site-specific phosphorylation: Akt-dependent activation of the NADPH oxidase

2003 • 174 citations

Activation of the Leukocyte NADPH Oxidase by Phorbol Ester Requires the Phosphorylation of p47 on Serine 303 or 304

1998 • 173 citations

Solution structure of the PX domain, a target of the SH3 domain.

2001 • 165 citations

Phosphorylation of the Respiratory Burst Oxidase Subunit p67 during Human Neutrophil Activation

1997 • 154 citations

Phosphatidic acid and not diacylglycerol generated by phospholipase D is functionally linked to the activation of the NADPH oxidase by FMLP in human neutrophils

1990 • 151 citations

The NADPH oxidase and chronic granulomatous disease

1996 • 130 citations

Tumor necrosis factor alpha priming of phospholipase D in human neutrophils

1991 • 129 citations

The p40 and p47 PX Domains of NADPH Oxidase Target Cell Membranes via Direct and Indirect Recruitment by Phosphoinositides

2002 • 110 citations

Activation of NADPH oxidase of human neutrophils involves the phosphorylation and the translocation of cytosolic p67phox

1993 • 101 citations

The PX Domain as a Novel Phosphoinositide- Binding Module

2001 • 94 citations

The NADPH Oxidase Components p47phox and p40phox Bind to Moesin through Their PX Domain

2001 • 74 citations

Regulation of the Phagocyte Respiratory Burst Oxidase by Protein Interactions

2000 • 38 citations

The p47phox PX Domain

2002 • 19 citations

Protein kinases potentially capable of catalyzing the phosphorylation of p47-phox in normal neutrophils and neutrophils of patients with chronic granulomatous disease

1993 • 18 citations