The NADPH oxidase and chronic granulomatous disease

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

Biological Defense Mechanisms. THE PRODUCTION BY LEUKOCYTES OF SUPEROXIDE, A POTENTIAL BACTERICIDAL AGENT

1973 • 2,955 citations

Altered immune responses in mice lacking inducible nitric oxide synthase

1995 • 1,296 citations

The Biochemical Basis of Phagocytosis

1959 • 1,240 citations

Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1

1991 • 961 citations

Mouse model of X–linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production

1995 • 920 citations

Oxygen Metabolism and the Toxic Properties of Phagocytes

1980 • 886 citations

Cloning the gene for an inherited human disorder—chronic granulomatous disease—on the basis of its chromosomal location

1986 • 839 citations

Studies of the Metabolic Activity of Leukocytes from Patients with a Genetic Abnormality of Phagocytic Function*

1967 • 677 citations

The respiratory burst of phagocytic cells is associated with a rise in vacuolar pH

1981 • 429 citations

Cloning of a 67-kD Neutrophil Oxidase Factor with Similarity to a Noncatalytic Region of p60 ^c-src

1990 • 393 citations

Cytochrome b-245 is a flavocytochrome containing FAD and the NADPH-binding site of the microbicidal oxidase of phagocytes

1992 • 351 citations

Absence of both cytochrome b−245 subunits from neutrophils in X-linked chronic granulomatous disease

1987 • 324 citations

Absence of Cytochrome b_-245in Chronic Granulomatous Disease

1983 • 300 citations

p40phox, a third cytosolic component of the activation complex of the NADPH oxidase to contain src homology 3 domains

1993 • 295 citations

Stimulated neutrophils from patients with autosomal recessive chronic granulomatous disease fail to phosphorylate a Mr-44,000 protein

1985 • 286 citations

Biologically active lipids are regulators of Rac.GDI complexation.

1993 • 206 citations

Relationship of Glycolytic and Oxidative Metabolism to Particle Entry and Destruction in Phagocytosing Cells

1966 • 195 citations

Prenatal Diagnosis of Chronic Granulomatous Disease

1979 • 153 citations

Respiratory burst oxidase and three of four oxidase-related polypeptides are associated with the cytoskeleton of human neutrophils.

1991 • 148 citations

A structural model for the nucleotide binding domains of the flavocytochrome b_–245 β‐chain

1993 • 124 citations

Autosomal recessive chronic granulomatous disease caused by deletion at a dinucleotide repeat.

1991 • 119 citations

A point mutation in gp91-phox of cytochrome b558 of the human NADPH oxidase leading to defective translocation of the cytosolic proteins p47-phox and p67-phox.

1994 • 109 citations

156Pro-->Gln substitution in the light chain of cytochrome b558 of the human NADPH oxidase (p22-phox) leads to defective translocation of the cytosolic proteins p47-phox and p67-phox.

1994 • 107 citations

Activation of NADPH oxidase of human neutrophils involves the phosphorylation and the translocation of cytosolic p67phox

1993 • 101 citations

A Variant X-linked Chronic Granulomatous Disease Patient (X91+) with Partially Functional Cytochrome b

1995 • 66 citations

Restoration of superoxide generation to a chronic granulomatous disease- derived B-cell line by retrovirus mediated gene transfer

1992 • 57 citations

Identification of the defective NADPH‐oxidase component in Chronic Granulomatous Disease: a study of 57 European families

1992 • 42 citations

The bactericidal effects of the respiratory burst and the myeloperoxidase system isolated in neutrophil cytoplasts

1988 • 36 citations

Superoxide production by normal and chronic granulomatous disease (CGD) patient-derived EBV-transformed B cell lines measured by chemiluminescence-based assays

1992 • 32 citations

A Phenotype or Not: Targeting Genes in the Immune System

1992 • 21 citations

The bactericidal effects of the respiratory burst and the myeloperoxidase system isolated in neutrophil cytoplasts

1988 • 20 citations