Regulation of the Phagocyte Respiratory Burst Oxidase by Protein Interactions

Cell transformation by the superoxide-generating oxidase Mox1

1999 • 1,457 citations

Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1

1991 • 961 citations

Cloning the gene for an inherited human disorder—chronic granulomatous disease—on the basis of its chromosomal location

1986 • 839 citations

The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactions

1998 • 820 citations

Regulation of Phagocyte Oxygen Radical Production by the GTP-Binding Protein Rac 2

1991 • 669 citations

Tetratrico peptide repeat interactions: to TPR or not to TPR?

1995 • 624 citations

Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

1993 • 587 citations

rac, a novel ras-related family of proteins that are botulinum toxin substrates

1989 • 585 citations

Deficiency of the Hematopoietic Cell-Specific Rho Family GTPase Rac2 Is Characterized by Abnormalities in Neutrophil Function and Host Defense

1999 • 568 citations

Assembly of the phagocyte NADPH oxidase: molecular interaction of oxidase proteins

1996 • 534 citations

Structure of the Rho Family GTP-Binding Protein Cdc42 in Complex with the Multifunctional Regulator RhoGDI

2000 • 494 citations

Human neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutation

2000 • 476 citations

Purified cytochrome b from human granulocyte plasma membrane is comprised of two polypeptides with relative molecular weights of 91,000 and 22,000.

1987 • 459 citations

Blockage of chemotactic peptide-induced stimulation of neutrophils by wortmannin as a result of selective inhibition of phosphatidylinositol 3-kinase.

1994 • 443 citations

Two cytosolic components of the human neutrophil respiratory burst oxidase translocate to the plasma membrane during cell activation.

1990 • 435 citations

Mutations in the X-linked and autosomal recessive forms of chronic granulomatous disease

1996 • 424 citations

The glycoprotein encoded by the X-linked chronic granulomatous disease locus is a component of the neutrophil cytochrome b complex

1987 • 405 citations

Two Cytosolic Neutrophil Oxidase Components Absent in Autosomal Chronic Granulomatous Disease

1988 • 401 citations

Cloning of a 67-kD Neutrophil Oxidase Factor with Similarity to a Noncatalytic Region of p60 ^c-src

1990 • 393 citations

Interaction of Rac with p67 ^phox and Regulation pf Phagocytic NADPH Oxidase Activity

1994 • 384 citations

Cytochrome b ₅₅₈ : the Flavin-Binding Component of the Phagocyte NADPH Oxidase

1992 • 384 citations

Cytochrome b-245 is a flavocytochrome containing FAD and the NADPH-binding site of the microbicidal oxidase of phagocytes

1992 • 351 citations

The particulate superoxide-forming system from human neutrophils. Properties of the system and further evidence supporting its participation in the respiratory burst.

1976 • 350 citations

The phosphorylation of the respiratory burst oxidase component p47phox during neutrophil activation. Phosphorylation of sites recognized by protein kinase C and by proline-directed kinases.

1994 • 342 citations

Recombinant 47-Kilodalton Cytosol Factor Restores NADPH Oxidase in Chronic Granulomatous Disease

1989 • 341 citations

Unsaturated fatty acids stimulate NADPH-dependent superoxide production by cell-free system derived from macrophages

1984 • 335 citations

Two Forms of Autosomal Chronic Granulomatous Disease Lack Distinct Neutrophil Cytosol Factors

1988 • 327 citations

Primary structure and unique expression of the 22-kilodalton light chain of human neutrophil cytochrome b.

1988 • 317 citations

Translocation of Rac correlates with NADPH oxidase activation. Evidence for equimolar translocation of oxidase components.

1993 • 316 citations

Activation of human neutrophil nicotinamide adenine dinucleotide phosphate, reduced (triphosphopyridine nucleotide, reduced) oxidase by arachidonic acid in a cell-free system.

1985 • 315 citations

Cloning of the cDNA and functional expression of the 47-kilodalton cytosolic component of human neutrophil respiratory burst oxidase.

1989 • 310 citations

Novel domains in NADPH oxidase subunits, sorting nexins, and PtdIns 3‐kinases: Binding partners of SH3 domains?

1996 • 304 citations

Absence of Cytochrome b_-245in Chronic Granulomatous Disease

1983 • 300 citations

p40phox, a third cytosolic component of the activation complex of the NADPH oxidase to contain src homology 3 domains

1993 • 295 citations

Molecular basis of chronic granulomatous disease [see comments]

1991 • 290 citations

Role of Src homology 3 domains in assembly and activation of the phagocyte NADPH oxidase.

1994 • 286 citations

Protein kinase C and the activation of the human neutrophil NADPH- oxidase

1987 • 268 citations

Subcellular localization of the superoxide-forming enzyme in human neutrophils.

1979 • 268 citations

Reconstitution of neutrophil NADPH oxidase activity in the cell-free system by four components: p67-phox, p47-phox, p21rac1, and cytochrome b-245.

1992 • 265 citations

Rac translocates independently of the neutrophil NADPH oxidase components p47phox and p67phox. Evidence for its interaction with flavocytochrome b558.

1994 • 260 citations

Characteristics of the cofactor requirements for the superoxide-generating NADPH oxidase of human polymorphonuclear leukocytes

1981 • 251 citations

Phosphorylation of neutrophil 47-kDa cytosolic oxidase factor. Translocation to membrane is associated with distinct phosphorylation events.

1990 • 248 citations

Association of a Ras-related protein with cytochrome b of human neutrophils

1989 • 248 citations

Guanine nucleotide exchange regulates membrane translocation of Rac/Rho GTP-binding proteins.

1994 • 245 citations

Phosphorylation of the Respiratory Burst Oxidase Subunit p47 as Determined by Two-dimensional Phosphopeptide Mapping

1996 • 241 citations

Tetratricopeptide Repeat (TPR) Motifs of p67 Participate in Interaction with the Small GTPase Rac and Activation of the Phagocyte NADPH Oxidase

1999 • 230 citations

Oxidation-reduction properties of the cytochrome b found in the plasma-membrane fraction of human neutrophils. A possible oxidase in the respiratory burst

1981 • 229 citations

Activation of the human neutrophil nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase by protein kinase C.

1985 • 216 citations

Regulation of the Neutrophil Respiratory Burst Oxidase

1998 • 209 citations

Gp91 ^phox is the heme binding subunit of the superoxide-generating NADPH oxidase

1998 • 198 citations

ABSENCE OF A NEWLY DESCRIBED CYTOCHROME b FROM NEUTROPHILS OF PATIENTS WITH CHRONIC GRANULOMATOUS DISEASE

1978 • 197 citations

The p67 Activation Domain Regulates Electron Flow from NADPH to Flavin in Flavocytochromeb 558

1999 • 194 citations

Assembly and Activation of the Phagocyte NADPH Oxidase

1996 • 184 citations

Activation of NADPH oxidase involves the dissociation of p21rac from its inhibitory GDP/GTP exchange protein (rhoGDI) followed by its translocation to the plasma membrane

1994 • 180 citations

Purification and characterization of Rac 2. A cytosolic GTP-binding protein that regulates human neutrophil NADPH oxidase.

1992 • 176 citations

Superoxide-forming enzyme from human neutrophils: evidence for a flavin requirement

1977 • 174 citations

Activation of the Leukocyte NADPH Oxidase by Phorbol Ester Requires the Phosphorylation of p47 on Serine 303 or 304

1998 • 173 citations

Phosphatidic acid as a second messenger in human polymorphonuclear leukocytes. Effects on activation of NADPH oxidase.

1991 • 165 citations

Regulation of the superoxide-generating NADPH oxidase by a small GTP-binding protein and its stimulatory and inhibitory GDP/GTP exchange proteins.

1992 • 159 citations

Biosynthesis of the Phagocyte NADPH Oxidase Cytochromeb 558

1997 • 156 citations

Phosphorylation of the Respiratory Burst Oxidase Subunit p67 during Human Neutrophil Activation

1997 • 154 citations

NADPH Oxidase Activity Is Independent of p47

1996 • 154 citations

Rac “Insert Region” Is a Novel Effector Region That Is Implicated in the Activation of NADPH Oxidase, but Not PAK65

1996 • 151 citations

Dynamin binds to SH3 domains of phospholipase C gamma and GRB-2.

1994 • 151 citations

The cytosolic components of the respiratory burst oxidase exist as a M(r) approximately 240,000 complex that acquires a membrane-binding site during activation of the oxidase in a cell-free system.

1992 • 150 citations

The Cytosolic Component p47 Is Not a Sine Qua Non Participant in the Activation of NADPH Oxidase but Is Required for Optimal Superoxide Production

1996 • 150 citations

Mapping sites of interaction of p47-phox and flavocytochrome b with random-sequence peptide phage display libraries.

1995 • 148 citations

Post-translational processing of rac p21s is important both for their interaction with the GDP/GTP exchange proteins and for their activation of NADPH oxidase.

1992 • 147 citations

The subcellular distribution and some properties of the cytochrome b component of the microbicidal oxidase system of human neutrophils

1979 • 145 citations

Activation of p47 , a Cytosolic Subunit of the Leukocyte NADPH Oxidase

1998 • 141 citations

Mechanisms of NADPH oxidase activation: translocation of p40phox, Rac1 and Rac2 from the cytosol to the membranes in human neutrophils lacking p47phox or p67phox

1996 • 138 citations

Rac Binding to p67

1997 • 135 citations

The NADPH oxidase and chronic granulomatous disease

1996 • 130 citations

Characterization of the Interaction between RhoGDI and Cdc42Hs Using Fluorescence Spectroscopy

1996 • 129 citations

The superoxide-generating oxidase of leucocytes. NADPH-dependent reduction of flavin and cytochrome b in solubilized preparations

1984 • 128 citations

Characterization of neutrophil NADPH oxidase factors p47-phox and p67-phox from recombinant baculoviruses.

1991 • 124 citations

Assembly of the Human Neutrophil NADPH Oxidase Involves Binding of p67 and Flavocytochrome to a Common Functional Domain in p47

1996 • 124 citations

Membrane Association of Rac Is Required for High Activity of the Respiratory Burst Oxidase

1996 • 116 citations

Cytochrome b−245 of the Neutrophil Superoxide-generating System Contains Two Nonidentical Hemes

1995 • 114 citations

p40 Down-regulates NADPH Oxidase Activity through Interactions with Its SH3 Domain

1997 • 113 citations

Structural and catalytic properties of the solubilized superoxide-generating activity of human polymorphonuclear leukocytes. Solubilization, stabilization in solution, and partial characterization

1979 • 111 citations

Function of wild-type or mutant Rac2 and Rap1a GTPases in differentiated HL60 cell NADPH oxidase activation

1995 • 109 citations

p40 Is Phosphorylated on Threonine 154 and Serine 315 during Activation of the Phagocyte NADPH Oxidase

1998 • 109 citations

The membrane-associated component of the amphiphile-activated, cytosol-dependent superoxide-forming NADPH oxidase of macrophages is identical to cytochrome b559.

1991 • 106 citations

Role of p67-phox SH3 domains in assembly of the NADPH oxidase system.

1994 • 106 citations

Activation of NADPH oxidase of human neutrophils involves the phosphorylation and the translocation of cytosolic p67phox

1993 • 101 citations

Activation of the Phagocyte NADPH Oxidase Protein p47

1999 • 100 citations

Phosphatidic acid and diacylglycerol synergize in a cell-free system for activation of NADPH oxidase from human neutrophils.

1993 • 96 citations

Activated or dominant inhibitory mutants of Rap1A decrease the oxidative burst of Epstein-Barr virus-transformed human B lymphocytes.

1994 • 96 citations

Human neutrophil cytochrome b contains multiple hemes. Evidence for heme associated with both subunits.

1992 • 95 citations

Specificity of p47^phox SH3 Domain Interactions in NADPH Oxidase Assembly and Activation

1997 • 91 citations

The phagocyte 47-kilodalton cytosolic oxidase protein is an early reactant in activation of the respiratory burst.

1990 • 89 citations

Purification of cytochrome b-245 from human neutrophils

1984 • 88 citations

Phosphorylation of p22 Is Mediated by Phospholipase D-dependent and -independent Mechanisms

2000 • 88 citations

Resonance Raman and electron paramagnetic resonance structural investigations of neutrophil cytochrome b558

1991 • 84 citations

Cryptic Rac-binding and p21 -activated Kinase Phosphorylation Sites of NADPH Oxidase Component p67

1998 • 84 citations

Activation of the respiratory burst oxidase in neutrophils: On the role of membrane-derived second messengers, Ca++, and protein kinase C

1988 • 83 citations

Purification of the 260 kDa cytosolic complex involved in the Superoxide production of guinea pig neutrophils

1993 • 83 citations

Kinase-dependent Activation of the Leukocyte NADPH Oxidase in a Cell-free System

1997 • 81 citations

Purification and characterization of a third cytosolic component of the superoxide-generating NADPH oxidase of macrophages.

1991 • 78 citations

A Phosphatidic Acid-activated Protein Kinase and Conventional Protein Kinase C Isoforms Phosphorylate p22 , an NADPH Oxidase Component

1999 • 78 citations

Interactions between the Cytosolic Components p47 and p67 of the Human Neutrophil NADPH Oxidase That Are Not Required for Activation in the Cell-free System

1995 • 78 citations

p40phox participates in the activation of NADPH oxidase by increasing the affinity of p47phox for flavocytochrome b558

2000 • 76 citations

Consequences of weak interaction of rho GDI with the GTP-bound forms of rho p21 and rac p21.

1993 • 75 citations

Cytochrome b558 from (bovine) granulocytes. Partial purification from Triton X-114 extracts and properties of the isolated cytochrome.

1984 • 75 citations

Characterization of the Effector-specifying Domain of Rac Involved in NADPH Oxidase Activation

1995 • 74 citations

Anionic Amphiphile-independent Activation of the Phagocyte NADPH Oxidase in a Cell-free System by p47 and p67 , Both in C Terminally Truncated Forms

1998 • 72 citations

Evidence for a readily dissociable complex of p47phox and p67phox in cytosol of unstimulated human neutrophils.

1994 • 70 citations

The GDP-bound form of the small G protein Rac1 p21 is a potent activator of the superoxide-forming NADPH oxidase of macrophages.

1994 • 68 citations

The respiratory burst oxidase of human neutrophils. Guanine nucleotides and arachidonate regulate the assembly of a multicomponent complex in a semirecombinant cell-free system.

1993 • 67 citations

Calculation of substrate dissociation constants from steady-state isotope effects in enzyme-catalyzed reactions

1985 • 66 citations

The cytochrome b and flavin content and properties of the O2−-forming NADPH oxidase solubilized from activated neutrophils

1983 • 63 citations

The translocation of respiratory burst oxidase components from cytosol to plasma membrane is regulated by guanine nucleotides and diacylglycerol.

1992 • 61 citations

Mutational Analysis of Novel Effector Domains in Rac1 Involved in the Activation of Nicotinamide Adenine Dinucleotide Phosphate (Reduced) Oxidase

1998 • 60 citations

The activity of one soluble component of the cell-free NADPH:O2 oxidoreductase of human neutrophils depends on guanosine 5'-O-(3-thio)triphosphate.

1990 • 60 citations

Mechanism for phosphorylation-induced activation of the phagocyte NADPH oxidase protein p47phox

1999 • 60 citations

p67-phox enhances the binding of p47-phox to the human neutrophil respiratory burst oxidase complex.

1994 • 58 citations

Reversible activation of NADPH oxidase in membranes of HL-60 human leukemic cells

1987 • 56 citations

Activation of the Leukocyte NADPH Oxidase by Protein Kinase C in a Partially Recombinant Cell-free System

1999 • 54 citations

Absolute requirement for GTP in activation of human neutrophil NADPH oxidase in a cell-free system: role of ATP in regenerating GTP.

1992 • 52 citations

Isoprenylation of the low molecular mass GTP-binding proteins rac 1 and rac 2: Possible role in membrane localization

1990 • 51 citations

Mechanisms of Regulating the Respiratory Burst in Leukocytes

1984 • 49 citations

The cytosolic subunit p67phox contains an NADPH-binding site that participates in catalysis by the leukocyte NADPH oxidase.

1996 • 49 citations

Ras effector-homolog region on Rac regulates protein associations in the neutrophil respiratory burst oxidase complex

1994 • 48 citations

Nucleoside triphosphate requirements for superoxide generation and phosphorylation in a cell-free system from human neutrophils. Sodium dodecyl sulfate and diacylglycerol activate independently of protein kinase C.

1991 • 47 citations

Actin Enhances the Activation of Human Neutrophil NADPH Oxidase in a Cell-free System

1997 • 47 citations

Mutagenesis of an Arginine- and Lysine-rich Domain in the gp91 Subunit of the Phagocyte NADPH-oxidase Flavocytochromeb 558

1999 • 45 citations

The major phosphorylation site of the NADPH oxidase component p67phox is Thr233

1999 • 44 citations

Cell-free translocation of recombinant p47-phox, a component of the neutrophil NADPH oxidase: effects of guanosine 5'-O-(3-thiotriphosphate), diacylglycerol, and an anionic amphiphile

1992 • 43 citations

Photoaffinity Labeling and Photoinactivation of the O2--Generating Oxidase of Neutrophils by an Azido Derivative of FAD

1995 • 42 citations

Reconstitution of Flavin-depleted Neutrophil Flavocytochrome b558 with 8-Mercapto-FAD and Characterization of the Flavin-reconstituted Enzyme

1995 • 40 citations

Reconstitution and characterization of the human neutrophil respiratory burst oxidase using recombinant p47-phox, p67-phox and plasma membrane

1992 • 39 citations

Cell-Free Activation of the Respiratory Burst Oxidase by Protein Kinase C

1995 • 36 citations

Phosphorylation of p67^phox in the neutrophil occurs in the cytosol and is independent of p47^phox

1999 • 31 citations

Cytosolic factors in bovine neutrophil oxidase activation. Partial purification and demonstration of translocation to a membrane fraction

1990 • 31 citations

Deactivation of neutrophil NADPH oxidase by actin-depolymerizing agents in a cell-free system

2000 • 31 citations

EPR signals of cytochrome b558 purified from porcine neutrophils.

1992 • 28 citations

Mechanisms of H2O2 formation by leukocytes

1975 • 26 citations

Stabilization of the superoxide-generating respiratory burst oxidase of human neutrophil plasma membrane by crosslinking with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide

1989 • 25 citations

GTP‐dependent and ‐independent activation of superoxide producing NADPH oxidase in a neutrophil cell‐free system

1989 • 21 citations

Phosphorylation Induces Conformational Changes in the Leukocyte NADPH Oxidase Subunit p47phox

1999 • 17 citations

Translocation of the 46 kDa Protein(s) in Response to Activation of NADPH Oxidase in Guinea Pig Polymorphonuclear Leukocytes1

1990 • 15 citations

Stoichiometry of O2 metabolism and NADPH oxidation of the cell-free latent oxidase reconstituted from cytosol and solubilized membrane from resting human neutrophils.

1993 • 7 citations

Introduction: Respiratory burst oxidase and its regulation

1988 • 4 citations

Cytochromeb₅₅₈: A flavocytochrome comprising the complete electron‐transporting apparatus of phagocyte NADPH oxidase

1994 • 2 citations