IL-12 is required for differentiation of pathogenic CD8+ T cell effectors that cause myocarditis

T cell receptor antagonist peptides induce positive selection

1994 • 2,818 citations

Antibodies to interleukin 12 abrogate established experimental colitis in mice.

1995 • 1,338 citations

Class I–restricted Cross-Presentation of Exogenous Self-Antigens Leads to Deletion of Autoreactive CD8+ T Cells

1997 • 719 citations

Constitutive class I-restricted exogenous presentation of self antigens in vivo.

1996 • 637 citations

Cardiac Failure in Transgenic Mice With Myocardial Expression of Tumor Necrosis Factor-α

1998 • 602 citations

Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12.

1995 • 560 citations

Chlamydia Infections and Heart Disease Linked Through Antigenic Mimicry

1999 • 419 citations

Isolation and characterization of the mouse cardiac myosin heavy chain genes

1991 • 331 citations

CD4+ T Cell Help Impairs CD8+ T Cell Deletion Induced by Cross-presentation of Self-Antigens and Favors Autoimmunity

1997 • 320 citations

From Infection to Autoimmunity

2001 • 314 citations

The role of CD8+ T lymphocytes in coxsackievirus B3-induced myocarditis

1995 • 263 citations

Dilated cardiomyopathy in homozygous myosin-binding protein-C mutant mice

1999 • 258 citations

Effects of IL-12 on immune responses to microbial infections: a key mediator in regulating disease outcome

1995 • 249 citations

An abnormal Ca2+ response in mutant sarcomere protein–mediated familial hypertrophic cardiomyopathy

2000 • 232 citations

Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis

2001 • 222 citations

Induction of ovalbumin-specific cytotoxic T cells by in vivo peptide immunization.

1989 • 220 citations

Interleukin-12 in infectious diseases

1997 • 214 citations

Interleukin 12 Protects from a T Helper Type 1–mediated Autoimmune Disease, Experimental Autoimmune Uveitis, through a Mechanism Involving Interferon γ, Nitric Oxide, and Apoptosis

1999 • 210 citations

Susceptibility to Myocarditis Is Dependent on the Response of αβ T Lymphocytes to Coxsackieviral Infection

1999 • 188 citations

Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis

2001 • 182 citations

Reduced incidence and severity of collagen‐induced arthritis in interleukin‐12‐deficient mice

1996 • 180 citations

Interleukin 12 and Interleukin 4 Control T Cell Adhesion to Endothelial Selectins through Opposite Effects on α1,3-fucosyltransferase VII Gene Expression

1998 • 173 citations

The tyrosine kinase p56lck is essential in coxsackievirus B3-mediated heart disease

2000 • 166 citations

Influence of C3 Deficiency on Atherosclerosis

2002 • 162 citations

Interleukin-12 Receptor/STAT4 Signaling Is Required for the Development of Autoimmune Myocarditis in Mice by an Interferon-γ–Independent Pathway

2001 • 148 citations

Linking immune-mediated arterial inflammation and cholesterol-induced atherosclerosis in a transgenic mouse model

2000 • 141 citations

Expression of Intestine-Specific Antigen Reveals Novel Pathways of CD8 T Cell Tolerance Induction

2000 • 138 citations

Dual Role of the IL-12/IFN-γ Axis in the Development of Autoimmune Myocarditis: Induction by IL-12 and Protection by IFN-γ

2001 • 134 citations

Peptide Antigen Priming of Naive, But Not Memory, CD8 T Cells Requires a Third Signal That Can Be Provided by IL-12

2002 • 130 citations

Generation of mucosal cytotoxic T cells against soluble protein by tissue-specific environmental and costimulatory signals

1998 • 122 citations

IL-12 Enhances CD8 T Cell Homeostatic Expansion

2001 • 121 citations

Recombinant Murine Interleukin-12 Facilitates Induction of Cardiac Myosin–Specific Type 1 Helper T Cells in Rats

1998 • 96 citations

Coxsackievirus-induced myocarditis is dependent on distinct immunopathogenic responses in different strains of mice.

1997 • 92 citations

Evidence for autoimmunity to myosin and other heart-specific autoantigens in patients with dilated cardiomyopathy and their relatives

1996 • 90 citations

Autoimmunity in Myocarditis: Relevance of Animal Models

1997 • 85 citations

Type 1 and Type 2 CD8+ Effector T Cell Subpopulations Promote Long-Term Tumor Immunity and Protection to Progressively Growing Tumor

2000 • 84 citations

IL-12-Independent Th1-Type Immune Responses to Respiratory Viral Infection: Requirement of IL-18 for IFN-γ Release in the Lung But Not for the Differentiation of Viral-Reactive Th1-Type Lymphocytes

2000 • 71 citations

CD8+ T CELL SUBSETS TC1 AND TC2 CAUSE DIFFERENT HISTOPATHOLOGIC FORMS OF MURINE CARDIAC ALLOGRAFT REJECTION1

2001 • 49 citations

Cardiac myosin-induced myocarditis: target recognition by autoreactive T cells requires prior activation of cardiac interstitial cells.

1996 • 45 citations

In vivo deposition of myosin-specific autoantibodies in the hearts of mice with experimental autoimmune myocarditis.

1992 • 44 citations

Expression of Immunoregulatory Cytokines by Recombinant Coxsackievirus B3 Variants Confers Protection against Virus-Caused Myocarditis

2001 • 44 citations

The role of sensitized T-cells in myocarditis and dilated cardiomyopathy

1996 • 42 citations

Review of Microbial Infections and the Immune Response to Cardiac Antigens

2000 • 40 citations

The use of carboxyfluorescein diacetate succinimidyl ester to determine the site, duration and cell type responsible for antigen presentation in vivo

1999 • 37 citations

The Transition from Viral to Autoimmune Myocarditis

2001 • 36 citations