From Infection to Autoimmunity

Approaching the Asymptote? Evolution and Revolution in Immunology

1989 • 3,079 citations

Phylogenetic Perspectives in Innate Immunity

1999 • 2,478 citations

REGULATION OF IMMUNE RESPONSES BY TGF-β

1998 • 1,908 citations

The Instructive Role of Innate Immunity in the Acquired Immune Response

1996 • 1,731 citations

C3d of Complement as a Molecular Adjuvant: Bridging Innate and Acquired Immunity

1996 • 1,172 citations

Abrogation of TGFβ Signaling in T Cells Leads to Spontaneous T Cell Differentiation and Autoimmune Disease

2000 • 970 citations

Myocarditis

2000 • 923 citations

Natural Interferon α/β–Producing Cells Link Innate and Adaptive Immunity

2000 • 867 citations

Cutting Edge: Cross-Talk Between Cells of the Innate Immune System: NKT Cells Rapidly Activate NK Cells

1999 • 856 citations

Myocarditis: The Dallas criteria

1987 • 767 citations

The familyHerpesviridae: an update

1992 • 614 citations

THE ROLE OF COMPLEMENT AND COMPLEMENT RECEPTORS IN INDUCTION AND REGULATION OF IMMUNITY

1998 • 607 citations

From Myocarditis to Cardiomyopathy: Mechanisms of Inflammation and Cell Death

1999 • 537 citations

Molecular Mimicry by Herpes Simplex Virus-Type 1: Autoimmune Disease After Viral Infection

1998 • 505 citations

Decay-Accelerating Factor: Biochemistry, Molecular Biology, and Function

1989 • 492 citations

Role of interferons and other cytokines in the regulation of the immune response

1995 • 462 citations

Characterization of early IL-12, IFN-alphabeta, and TNF effects on antiviral state and NK cell responses during murine cytomegalovirus infection.

1996 • 413 citations

Early Murine Cytomegalovirus (MCMV) Infection Induces Liver Natural Killer (NK) Cell Inflammation and Protection Through Macrophage Inflammatory Protein 1α (MIP-1α)–dependent Pathways

1998 • 375 citations

ROLE OF COMPLEMENT IN INDUCTION OF ANTIBODY PRODUCTION IN VIVO

1974 • 357 citations

The role of natural killer cells in innate resistance to infection

1993 • 330 citations

Involvement of T Lymphocytes in the Pathogenesis of Coxsackie Virus B3 Heart Disease

1974 • 310 citations

Inhibitory MHC class I receptors on NK cells and T cells

1996 • 288 citations

The role of CD8+ T lymphocytes in coxsackievirus B3-induced myocarditis

1995 • 263 citations

Arousal and inhibition of human NK cells

1997 • 249 citations

Coordinated events during bacteria-induced DC maturation

1999 • 219 citations

Linkages of innate and adaptive immunity

1998 • 214 citations

The European Study of Epidemiology and Treatment of Cardiac Inflammatory Diseases (ESETCID)

2000 • 212 citations

Interleukin 1 or tumor necrosis factor can promote Coxsackie B3-induced myocarditis in resistant B10.A mice.

1992 • 207 citations

Variations in the susceptibility to Coxsackievirus B3-induced myocarditis among different strains of mice.

1986 • 203 citations

Natural killer cells determine the outcome of B cell–mediated autoimmunity

2000 • 187 citations

Enteroviral infection of mice with severe combined immunodeficiency. Evidence for direct viral pathogenesis of myocardial injury.

1992 • 186 citations

Cytotoxic and viral neutralizing antibodies crossreact with streptococcal M protein, enteroviruses, and human cardiac myosin.

1992 • 178 citations

Direct Myocardial Injury by Enterovirus: A Central Role in the Evolution of Murine Myocarditis

1993 • 172 citations

The tyrosine kinase p56lck is essential in coxsackievirus B3-mediated heart disease

2000 • 166 citations

Immune regulation: a critical link between NK cells and CTLs

1996 • 164 citations

Pancreatic expression of interferon-γ protects mice from lethal coxsackievirus B3 infection and subsequent myocarditis

2000 • 164 citations

Molecular mimicry: a critical look at exemplary instances in human diseases

2000 • 160 citations

Enteroviruses and Myocarditis: Viral Pathogenesis Through Replication, Cytokine Induction, and Immunopathogenicity

1998 • 144 citations

NK Cells Cause Liver Injury and Facilitate the Induction of T Cell-Mediated Immunity to a Viral Liver Infection

2000 • 140 citations

Coxsackievirus B-3 myocarditis. Identification of different pathogenic mechanisms in DBA/2 and Balb/c mice.

1986 • 138 citations

Natural killer cells and natural killer T cells

2000 • 130 citations

Murine natural killer cells limit coxsackievirus B3 replication.

1987 • 126 citations

Involvement of natural killer cells in coxsackievirus B3-induced murine myocarditis.

1986 • 121 citations

Immune responses in the absence of costimulation: viruses know the trick.

1998 • 119 citations

Control of Infections by NK Cells

1998 • 118 citations

The European Study of Epidemiology and Treatment of Cardiac Inflammatory Disease (ESETCID)

1995 • 109 citations

The Pathogenesis of Postinfectious Myocarditis

1996 • 105 citations

Molecular mimicry between a viral peptide and a myelin oligodendrocyte glycoprotein peptide induces autoimmune demyelinating disease in mice

1999 • 104 citations

Coxsackievirus induced myocarditis in mice: cardiac myosin autoantibodies do not cross-react with the virus.

1987 • 103 citations

Streptococcal M protein peptide with similarity to myosin induces CD4+ T cell-dependent myocarditis in MRL/++ mice and induces partial tolerance against coxsakieviral myocarditis.

1996 • 102 citations

Augmentation of pathogenesis of coxsackievirus B3 infections in mice by exogenous administration of interleukin-1 and interleukin-2

1994 • 101 citations

The immunoregulatory effects of NK cells: the role of TGF-β and implications for autoimmunity

1997 • 99 citations

Cutting Edge Commentary: Immune Responses in the Absence of Costimulation: Viruses Know the Trick

1998 • 99 citations

Cardiac injury in myocarditis induced by coxsackievirus group B, type 3 in Balb/c mice is mediated by Lyt 2+ cytolytic lymphocytes

1984 • 98 citations

The role of complement in the induction of antibody responses.

1983 • 96 citations

The epidemiology of infectious myocarditis, lymphocytic myocarditis and dilated cardiomyopathy

1995 • 95 citations

Mechanisms for virus-induced liver disease: tumor necrosis factor-mediated pathology independent of natural killer and T cells during murine cytomegalovirus infection

1997 • 95 citations

Viral Myocarditis Leading to Cardiomyopathy: Do Cytokines Contribute to Pathogenesis?

1993 • 93 citations

Cardiovirulent Coxsackieviruses and the Decay-Accelerating Factor (CD55) Receptor

1998 • 91 citations

New Concepts in Viral Heart Disease

1988 • 90 citations

Autoimmunity in Myocarditis: Relevance of Animal Models

1997 • 85 citations

Evidence for mimicry by viral antigens in animal models of autoimmune disease including myocarditis

2000 • 84 citations

Perforin-mediated myocardial damage in acute myocarditis

1990 • 81 citations

Mouse cytomegalovirus infection induces antibodies which cross-react with virus and cardiac myosin: a model for the study of molecular mimicry in the pathogenesis of viral myocarditis.

1992 • 78 citations

Triggering of Murine NK Cells by CD40 and CD86 (B7-2)

1999 • 76 citations

TheCmv1Host Resistance Locus Is Closely Linked to theLy49Multigene Family within the Natural Killer Cell Gene Complex on Mouse Chromosome 6

1997 • 73 citations

LPS promotes CB3-induced myocarditis in resistant B10.A mice

1991 • 70 citations

Characterization and myocarditic capabilities of coxsackievirus B3 variants in selected mouse strains

1984 • 68 citations

Antiviral activities of individual murine IFN-alpha subtypes in vivo: intramuscular injection of IFN expression constructs reduces cytomegalovirus replication.

1998 • 68 citations

Age-Dependent Pathogenicity of Group B Coxsackieviruses in Swiss-Webster Mice: Infectivity for Myocardium and Pancreas

1980 • 64 citations

A Clinicopathologic Description of Myocarditis

1993 • 61 citations

Effect of host genotype in determining the relative roles of natural killer cells and T cells in mediating protection against murine cytomegalovirus infection

1996 • 58 citations

The role of enterovirus replication in the development of acute and chronic heart muscle disease in different immunocompetent mouse strains.

1993 • 57 citations

Antiviral Activities of Individual Murine IFN-α Subtypes In Vivo: Intramuscular Injection of IFN Expression Constructs Reduces Cytomegalovirus Replication

1998 • 57 citations

The BALB.B6-Cmv1 r mouse: a strain congenic for Cmv1 and the NK gene complex

1995 • 55 citations

Wild isolates of murine cytomegalovirus induce myocarditis and antibodies that cross‐react with virus and cardiac myosin

1998 • 53 citations

Dependence of the adaptive immune response on innate immunity: Some questions answered but new paradoxes emerge

1997 • 46 citations

Myocardial changes after infection with Coxsackie virus B3 in nude mice.

1978 • 44 citations

Sex-related differences in the rapid production of cytotoxic spleen cells active against uninfected myofibers during Coxsackievirus B-3 infection.

1981 • 44 citations

NK cell proliferation and inflammation

1996 • 42 citations

Studies on immunosuppression by cobra venom factor. II. On responses to DNP-Ficoll and DNP-Polyacrylamide.

1978 • 39 citations

The Coxsackie B Viruses

1997 • 39 citations

The forces driving autoimmune disease

1992 • 36 citations

Persistence of virus and viral genome in myocardium after Coxsackievirus B3-induced murine myocarditis

1994 • 35 citations

Innate immunity—beginning to fulfill its promise?

2000 • 30 citations

Genetic control of mouse cytomegalovirus-induced myocarditis.

1990 • 29 citations

Studies on Immunosuppression by Cobra Venom Factor

1978 • 29 citations

Studies on immunosuppression by cobra venom factor. III. On early responses to sheep erythrocytes in C5-deficient mice.

1978 • 28 citations

Complement component 3 interactions with coxsackievirus B3 capsid proteins: innate immunity and the rapid formation of splenic antiviral germinal centers

1997 • 28 citations

Arthritis and Rheumatism

2001 • 26 citations

Cytokines are critical in linking the innate and adaptive immune responses to bacterial, fungal, and parasitic infection.

1999 • 26 citations

The role and mechanism of cobra venom factor-induced suppression of the humoral immune response in guinea pigs.

1986 • 25 citations

In VivoExpression of an Interferon-α Gene by Intramuscular Injection of Naked DNA

1997 • 24 citations

The role of T cells in mouse cytomegalovirus myocarditis.

1989 • 22 citations

Genetic determination of cytomegalovirus-induced and age-related cardiopathy in inbred mice. Characterization of infiltrating cells.

1991 • 21 citations

Murine anti-cytomegalovirus monoclonal antibodies with autoreactivity.

1991 • 19 citations

Involvement of Epitope Mimicry in Potentiation But Not Initiation of Autoimmune Disease

1999 • 18 citations

The role of self-recognition in receptor repertoire development

1999 • 16 citations

Infectious myocarditis and dilated cardiomyopathy

1997 • 14 citations

The pathogenesis of dilated cardiomyopathy.

1992 • 13 citations

Identification and Biology of Cellular Receptors for the Coxsackie B Viruses Group

1997 • 12 citations

In vivo expression of an interferon-α gene by intramuscular injection of naked DNA

1997 • 11 citations

Replication, Molecular Biology, and Pathogenesis of Coxsackieviruses

1988 • 1 citations

Deleted Work

1955 • 0 citations