Mechanism of V(D)J recombination

The DNA-dependent protein kinase: Requirement for DNA ends and association with Ku antigen

1993 • 1,219 citations

Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation

1995 • 862 citations

DNA-dependent protein kinase catalytic subunit: A relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

1995 • 742 citations

Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps

1995 • 703 citations

Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination

1994 • 637 citations

DNA-Dependent Kinase (p350) as a Candidate Gene for the Murine SCID Defect

1995 • 610 citations

The Mechanism of V(D)J Joining: Lessons from Molecular, Immunological, and Comparative Analyses

1994 • 579 citations

Absence of p350 Subunit of DNA-Activated Protein Kinase from a Radiosensitive Human Cell Line

1995 • 530 citations

The scid mutation in mice causes a general defect in DNA repair

1990 • 525 citations

PIK-Related Kinases: DNA Repair, Recombination, and Cell Cycle Checkpoints

1995 • 509 citations

scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair.

1991 • 509 citations

Human DNA-Activated Protein Kinase Phosphorylates Serines 15 and 37 in the Amino-Terminal Transactivation Domain of Human p53

1992 • 473 citations

Impairment of V(D)J Recombination in Double-Strand Break Repair Mutants

1993 • 457 citations

The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination

1995 • 449 citations

V(D)J recombination: Broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes

1992 • 449 citations

Double-strand signal sequence breaks in V(D)J recombination are blunt, 5'-phosphorylated, RAG-dependent, and cell cycle regulated.

1993 • 381 citations

Ku autoantigen is the regulatory component of a template-associated protein kinase that phosphorylates RNA polymerase II.

1992 • 367 citations

Restoration of X-ray Resistance and V(D)J Recombination in Mutant Cells by Ku cDNA

1994 • 351 citations

DNA double-strand break repair and V(D)J recombination: involvement of DNA-PK

1995 • 344 citations

DNA-dependent protein kinase activity is absent in xrs-6 cells: implications for site-specific recombination and DNA double-strand break repair.

1995 • 342 citations

Binding of Ku protein to DNA. Measurement of affinity for ends and demonstration of binding to nicks.

1993 • 311 citations

A link between double-strand break-related repair and V(D)J recombination: the scid mutation.

1991 • 295 citations

Initiation of V(D)J recombination in a cell-free system

1995 • 286 citations

Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53.

1992 • 255 citations

Absence of a Ku-like DNA end binding activity in the xrs double-strand DNA repair-deficient mutant.

1994 • 238 citations

Human DNA helicase II: a novel DNA unwinding enzyme identified as the Ku autoantigen.

1994 • 225 citations

Analysis of the mechanism of interaction of simian Ku protein with DNA

1991 • 207 citations

What to do at an end: DNA double-strand-break repair

1995 • 195 citations

V(D)J recombination in mammalian cell mutants defective in DNA double-strand break repair.

1993 • 193 citations

V(D)J recombination in mouse thymocytes: Double-strand breaks near T cell receptor δ rearrangement signals

1992 • 189 citations

A DNA end-binding factor involved in double-strand break repair and V(D)J recombination.

1994 • 164 citations

Characterization of broken DNA molecules associated with V(D)J recombination.

1993 • 163 citations

Equine severe combined immunodeficiency: a defect in V(D)J recombination and DNA-dependent protein kinase activity.

1995 • 156 citations

Formation and resolution of double-strand break intermediates in V(D)J rearrangement.

1995 • 151 citations

DNA-dependent protein kinase is activated by nicks and larger single-stranded gaps

1994 • 139 citations

Complementation of the ionizing radiation sensitivity, DNA end binding, and V(D)J recombination defects of double-strand break repair mutants by the p86 Ku autoantigen.

1995 • 138 citations

DNA-dependent protein kinase: a potent inhibitor of transcription by RNA polymerase I.

1995 • 121 citations

Characterization of coding ends in thymocytes of scid mice: Implications for the mechanism of V(D)J recombination

1995 • 113 citations

scid Cells Are Deficient in Ku and Replication Protein A Phosphorylation by the DNA-Dependent Protein Kinase

1995 • 109 citations

Repair and Recombination: How to make ends meet

1995 • 101 citations

V(D)J recombination and the cell cycle

1995 • 98 citations

P nucleotide insertions and the resolution of hairpinDNA structures in mammalian cells.

1994 • 80 citations

P nucleotides in V(D)J recombination: a fine-structure analysis.

1993 • 79 citations

rag-1 and rag-2 Are Components of a High-Molecular-Weight Complex, and Association of rag-2 with This Complex Is rag-1 Dependent

1995 • 76 citations

RAG-1 mutations that affect the target specificity of V(D)j recombination: a possible direct role of RAG-1 in site recognition.

1995 • 70 citations

DNA-dependent protein kinase specifically represses promoter-directed transcription initiation by RNA polymerase I.

1995 • 63 citations

Protein kinases and DNA damage

1994 • 55 citations

Isolation of mammalian cell mutants that are X-ray sensitive, impaired in DNA double-strand break repair and defective for V(D)J recombination

1995 • 55 citations

X-ray sensitive mutants of Chinese hamster ovary cell line: radio-sensitivity of DNA synthesis

1985 • 47 citations

Asymmetric processing of coding ends and the effect of coding end nucleotide composition on V(D)J recombination

1995 • 41 citations

Hairpin opening by single-strand-specific nucleases

1995 • 21 citations

seid Cells Efficiently Integrate Hairpin and Linear DNA Substrates

1994 • 18 citations

scid cells efficiently integrate hairpin and linear DNA substrates.

1994 • 9 citations