Biased reading frames of pre-existing DH--JH coding joints and preferential nucleotide insertions at VH--DJH signal joints of excision products of immunoglobulin heavy chain gene rearrangements.

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

1988 • 17,059 citations

Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes

1980 • 803 citations

Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines

1984 • 644 citations

Determination of Nucleotide Sequences in DNA

1981 • 593 citations

Junctional sequences of T cell receptor γδ genes: Implications for γδ T cell lineages and for a novel intermediate of V-(D)-J joining

1989 • 572 citations

Limited diversity of γδ antigen receptor genes of thy-1+ dendritic epidermal cells

1988 • 522 citations

Expression and regulation of immunoglobulin heavy chain gene transfected into lymphoid cells.

1983 • 457 citations

Lack of N regions in fetal and neonatal mouse immunoglobulin V-D-J junctional sequences.

1990 • 414 citations

Organization, structure, and assembly of immunoglobulin heavy chain diversity DNA segments.

1982 • 411 citations

Regulation of the Assembly and Expression of Variable-Region Genes

1986 • 402 citations

Sequence homologies, N sequence insertion and JH gene utilization in VHDJH joining: implications for the joining mechanism and the ontogenetic timing of Ly1 B cell and B-CLL progenitor generation.

1990 • 396 citations

Differential expression of two distinct T-cell receptors during thymocyte development

1987 • 360 citations

Molecular and cellular origins of B lymphocyte diversity

1991 • 346 citations

The adult T-cell receptor 5-chain is diverse and distinct from that of fetal thymocytes

1988 • 320 citations

Novel immunoglobulin heavy chains are produced from DJH gene segment rearrangements in lymphoid cells

1984 • 261 citations

Circular DNA is excised by immunoglobulin class switch recombination

1990 • 244 citations

Separate elements control DJ and VDJ rearrangement in a transgenic recombination substrate.

1990 • 224 citations

B cell development regulated by gene rearrangement: Arrest of maturation by membrane-bound Dμ protein and selection of DH element reading frames

1991 • 203 citations

Biased expression of JH-proximal VH genes occurs in the newly generated repertoire of neonatal and adult mice.

1990 • 203 citations

VHDJH formation and DJH replacement during pre-B differentiation: non-random usage of gene segments.

1986 • 186 citations

Lymphoid V(D)J recombination: nucleotide insertion at signal joints as well as coding joints.

1988 • 174 citations

Characterization of productive and sterile transcripts from the immunoglobulin heavy-chain locus: processing of micron and muS mRNA.

1983 • 165 citations

Excision products of the T cell receptor gene support a progressive rearrangement model of the alpha/delta locus.

1989 • 162 citations

Comparison of D, JH, and junctional diversity in the fetal, adult, and aged B cell repertoires.

1991 • 155 citations

Ontogeny of terminal deoxynucleotidyl transferase-positive cells in lymphohemopoietic tissues of rat and mouse.

1979 • 137 citations

Characterization of an Episome Produced in Hamster Cells that Amplify a Transfected CAD Gene at High Frequency: Functional Evidence for a Mammalian Replication Origin

1987 • 137 citations

Only d_fl16, d_sp2, and d_q52 gene families exist in mouse immunoglobulin heavy chain diversity gene loci, of which d_fl16 and d_sp2 originate from the same primordial d_h gene

1989 • 137 citations

One heavy chain variable region gene segment subfamily in the BALBc mouse contains 500–1000 or more members

1986 • 132 citations

Isolation of an excision product of T-cell receptor α-chain gene rearrangments

1987 • 124 citations

The organization of the mouse Igh-V locus. Dispersion, interspersion, and the evolution of VH gene family clusters.

1988 • 116 citations

A special repertoire of alpha:beta T cells in neonatal mice.

1991 • 108 citations

Analysis of Junctional Diversity During B Lymphocyte Development

1990 • 107 citations

Adult B-cell repertoire is biased toward two heavy-chain variable-region genes that rearrange frequently in fetal pre-B cells.

1987 • 100 citations

Small circular DNA in Drosophila melanogaster

1976 • 99 citations

Dispersed localization of D segments in the human immunoglobulin heavy-chain locus.

1988 • 81 citations

Lack of feedback inhibition of V kappa gene rearrangement by productively rearranged alleles.

1991 • 80 citations

Sequence complexity of circular Epstein-Bar virus DNA in transformed cells

1981 • 79 citations

Clonal proliferation unlinked to terminal deoxynucleotidyl transferase synthesis in thymocytes of young mice.

1983 • 74 citations

Extrachromosomal DNA in eucaryotes

1985 • 63 citations

Characterization of Productive and Sterile Transcripts from the Immunoglobulin Heavy-Chain Locus: Processing of μ_m and μ_s mRNA

1983 • 63 citations

Biased distribution of recombination sites within S regions upon immunoglobulin class switch recombination induced by transforming growth factor beta and lipopolysaccharide.

1992 • 57 citations

B lymphocyte-associated antigens on terminal deoxynucleotidyl transferase-positive cells and pre-B cells in bone marrow of the rat.

1986 • 55 citations

Cell surface expression of the short immunoglobulin μ chain (Dμ protein) in murine pre-B cells is differently regulated from that of the intact μ chain

1991 • 52 citations

Purification of small polydisperse circular DNA of eukaryotic cells by use of ATP-dependent deoxyribonuclease

1983 • 44 citations

The D-J_Hcomplex is an intermediate to the complete immunoglobulin beavy-chain V-region gene

1983 • 43 citations

Immunoglobulin V gene replacement is caused by the intramolecular DNA deletion mechanism.

1992 • 37 citations

A T15-idiotype-positive T suppressor hybridoma does not use the T15 VH gene segment.

1982 • 36 citations

Novel excision products of T cell receptor γ gene rearrangements and developmental stage specificity implied by the frequency of nucleotide insertions at signal joints

1992 • 27 citations

Excision products of immunoglobulin gene rearrangements

1989 • 17 citations

Identification of a defective mouse immunoglobulinD (diversity) element which can undergoDJ H, but notV HD, recombination

1989 • 9 citations

Biased Expression of Variable Region Gene Families of the Immunoglobulin Heavy Chain in Autoimmune-Prone Mice1

1988 • 9 citations

Immunoglobulin JH rearrangement in a T-cell line reflects fusion to the D H locus at a sequence lacking the nonamer recognition signal

1988 • 7 citations