HLA Polymorphisms and T Cells in Rheumatoid Arthritis

The expanding universe of T-cell subsets: Th1, Th2 and more

1996 • 3,710 citations

The shared epitope hypothesis. an approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis

1987 • 2,539 citations

ROLE OF CYTOKINES IN RHEUMATOID ARTHRITIS

1996 • 2,527 citations

Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor α (cA2) versus placebo in rheumatoid arthritis

1994 • 1,695 citations

Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide

1994 • 1,553 citations

Association of the B-Cell Alloantigen DRw4 with Rheumatoid Arthritis

1978 • 1,170 citations

The T Lymphocyte in Experimental Allergic Encephalomyelitis

1990 • 1,005 citations

Rheumatoid Arthritis

1996 • 960 citations

Organ-Specific Disease Provoked by Systemic Autoimmunity

1996 • 880 citations

A Molecular Basis for MHC Class II—Associated Autoimmunity

1988 • 707 citations

Evidence for the Effects of a Superantigen in Rheumatoid Arthritis

1991 • 632 citations

How important are t cells in chronic rheumatoid synovitis?

1990 • 553 citations

Immunoregulatory role of interleukin 10 in rheumatoid arthritis.

1994 • 531 citations

The Influence of HLA-DRB1 Genes on Disease Severity in Rheumatoid Arthritis

1992 • 520 citations

Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-α production in rheumatoid arthritis

1997 • 513 citations

The role of interleukin–15 in T–cell migration and activation in rheumatoid arthritis

1996 • 492 citations

CD4+ CD7- CD28- T cells are expanded in rheumatoid arthritis and are characterized by autoreactivity.

1996 • 479 citations

IL-15: A Pleiotropic Cytokine with Diverse Receptor/Signaling Pathways Whose Expression Is Controlled at Multiple Levels

1996 • 459 citations

Differentiation of B cells in the nonlymphoid tissue of the synovial membrane of patients with rheumatoid arthritis.

1996 • 433 citations

Divergent T-cell cytokine patterns in inflammatory arthritis.

1994 • 388 citations

Peptide binding specificity of HLA-DR4 molecules: correlation with rheumatoid arthritis association.

1995 • 310 citations

Molecular Components of T-Cell Recognition

1992 • 304 citations

Limited T-cell receptor beta-chain heterogeneity among interleukin 2 receptor-positive synovial T cells suggests a role for superantigen in rheumatoid arthritis.

1991 • 297 citations

Clonal dominance among T-lymphocyte infiltrates in arthritis.

1988 • 268 citations

Interleukin‐10 inhibition of the progression of established collagen‐induced arthritis

1996 • 261 citations

Chronic exposure to tumor necrosis factor (TNF) in vitro impairs the activation of T cells through the T cell receptor/CD3 complex; reversal in vivo by anti-TNF antibodies in patients with rheumatoid arthritis.

1994 • 253 citations

Correlation between disease phenotype and genetic heterogeneity in rheumatoid arthritis.

1995 • 252 citations

Homozygosity for the HLA-DRB1 allele selects for extraarticular manifestations in rheumatoid arthritis.

1992 • 229 citations

T cell recognition as the target for immune intervention in autoimmune disease

1989 • 218 citations

The Molecular Basis of Susceptibility to Rheumatoid Arthritis

1994 • 218 citations

Localization of tumor necrosis factor receptors in the synovial tissue and cartilage‐pannus junction in patients with rheumatoid arthritis. Implications for local actions of tumor necrosis factor α

1992 • 216 citations

T Cell Receptor Peptide Therapy Triggers Autoregulation of Experimental Encephalomyelitis

1991 • 202 citations

Susceptibility to rheumatoid arthritis maps to a T-cell epitope shared by the HLA-Dw4 DR beta-1 chain and the Epstein-Barr virus glycoprotein gp110.

1989 • 200 citations

Disease patterns and tissue cytokine profiles in giant cell arteritis

1997 • 198 citations

Immunoelectron microscopic study of the distribution of T cell subsets in rheumatoid synovium.

1983 • 195 citations

HLA heterozygosity contributes to susceptibility to rheumatoid arthritis

2001 • 192 citations

Restricted expression of T cell receptor V_β but not V_α genes in rheumatoid arthritis

1991 • 189 citations

Genetic typing of patients with inflammatory arthritis at presentation can be used to predict outcome

1994 • 187 citations

Monoclonal anti‐TNFα Antibody as a Probe of Pathogenesis and Therapy of Rheumatoid Disease

1995 • 182 citations

Positive selection in autoimmunity: Abnormal immune responses to a bacterial dnaJ antigenic determinant in patients with early rheumatoid arthritis

1995 • 180 citations

Prevention and reversal of cartilage degradation in rheumatoid arthritis by interleukin‐10 and interleukin‐4

1996 • 174 citations

T cell response to Epstein-Barr virus transactivators in chronic rheumatoid arthritis.

1996 • 174 citations

Interleukin‐10 functions as an antiinflammatory cytokine in rheumatoid synovium

1996 • 144 citations

T Cell Receptors in Murine Autoimmune Diseases

1989 • 137 citations

Oligoclonal T cell proliferation in patients with rheumatoid arthritis and their unaffected siblings

1996 • 136 citations

PATHOGENESIS OF RHEUMATOID ARTHRITIS

1997 • 128 citations

Differential usage of T cell receptor V gene segments in CD4+ and CD8+ subsets of T lymphocytes in monozygotic twins.

1993 • 124 citations

Interferon-gamma-producing T cells in giant cell vasculitis represent a minority of tissue-infiltrating cells and are located distant from the site of pathology.

1996 • 124 citations

The effects of MHC gene dosage and allelic variation on T cell receptor selection

1990 • 123 citations

Characterization of the T cell receptor repertoire causing collagen arthritis in mice.

1993 • 119 citations

Local anti—type ii collagen antibody production in rheumatoid arthritis synovial fluid

1994 • 119 citations

The Repertoire of CD4+ CD28− T Cells in Rheumatoid Arthritis

1996 • 113 citations

T cell receptor V beta gene bias in rheumatoid arthritis.

1993 • 112 citations

The repertoire of CD4+ CD28- T cells in rheumatoid arthritis.

1996 • 111 citations

Clonal heterogeneity of synovial fluid T lymphocytes from patients with rheumatoid arthritis.

1989 • 108 citations

A multistep molecular mimicry hypothesis for the pathogenesis of rheumatoid arthritis

1996 • 103 citations

Investigating the HLA component in rheumatoid arthritis: An additive (dominant) mode of inheritance is rejected, a recessive mode is preferred

1991 • 102 citations

Co‐stimulatory pathways controlling activation and peripheral tolerance of human CD4⁺CD28⁻ T cells

1997 • 100 citations

Restricted heterogeneity of T cell receptor transcripts in rheumatoid synovium.

1992 • 98 citations

PREDICTION OF SUSCEPTIBILITY TO RHEUMATOID ARTHRITIS BY HUMAN LEUKOCYTE ANTIGEN GENOTYPING

1992 • 94 citations

High frequencies of identical T cell clonotypes in synovial tissues of rheumatoid arthritis patients suggest the occurrence of common antigen‐driven immune responses

1996 • 83 citations

Characterization of T‐Cell Receptor αβ Repertoire in Synovial Tissue from Different Temporal Phases of Rheumatoid Arthritis

1992 • 80 citations

Genetic epidemiology of rheumatoid disease

1995 • 79 citations

INCREASED EXPRESSION OF INTERFERON (IFN)-GAMMA TOGETHER WITH IFN-GAMMA RECEPTOR IN THE RHEUMATOID SYNOVIAL MEMBRANE COMPARED WITH SYNOVIUM OF PATIENTS WITH OSTEOARTHRITIS

1996 • 79 citations

Structure of t cell antigen receptor β chain in synovial fluid cells from patients with rheumatoid arthritis

1988 • 78 citations

A Minority of Patients with Rheumatoid Arthritis Show a Dominant Rearrangement of T‐Cell Receptor β Chain Genes in Synovial Lymphocytes

1987 • 77 citations

Relationships among antigen presentation, cytokines, immune deviation, and autoimmune disease.

1995 • 75 citations

Mechanisms underlying the formation of the T cell receptor repertoire in rheumatoid arthritis

1995 • 66 citations

Rheumatoid Factor V Genes from Patients with Rheumatoid Arthritis are Diverse and Show Evidence of an Antigen‐Driven Response

1992 • 57 citations

An altered repertoire of T cell receptor V gene expression by rheumatoid synovial fluid T lymphocytes

1992 • 49 citations

Contribution of inherited factors to rheumatoid arthritis.

1992 • 49 citations

Identification of clonally expanded T cells in rheumatoid arthritis using a sequence enrichment nuclease assay.

1996 • 48 citations

Diversity of rheumatoid synovial tissue T cells by T cell receptor analysis. Oligoclonal expansion in interleukin‐2–responsive cells

1991 • 47 citations

Multiple Mechanisms Support Oligoclonal T Cell Expansion in Rheumatoid Synovitis

1997 • 43 citations

Immune Responses to 6 and 30‐kDa Mycobacterial Antigens in Rheumatoid Patients, and Vβ Usage by Specific Synovial T‐Cell Lines and Fresh T Cells

1991 • 43 citations

ROLE OF ADHESION MOLECULES IN THE PATHOGENESIS OF RHEUMATOID ARTHRITIS

1995 • 42 citations

Interplay of T lymphocytes and HLA-DR molecules in rheumatoid arthritis

1993 • 40 citations

Specificity of antibodies to type II collagen in early rheumatoid arthritis.

1994 • 38 citations

T CELLS IN RHEUMATOID ARTHRITIS

1995 • 32 citations

T and B cell-dependent pathways in rheumatoid arthritis

1995 • 27 citations

Genes for MHC, TCR and MIS determine susceptibility to collagen induced arthritis

1990 • 26 citations

T‐Cell Receptor β‐Chain Gene Rearrangements of T‐Cell Populations Expanded from Multiple Sites of Synovial Tissue obtained from a Patient with Rheumatoid Arthritis

1992 • 24 citations

Infectious Etiology of Rheumatoid Arthritis

1991 • 22 citations

T cell receptor variable region repertoire in lymphocytes from rheumatoid arthritis patients

1992 • 20 citations

Clonal dominance among synovial tissue-infiltrating lymphocytes in arthritis

1990 • 17 citations

Cellular immune mechanisms in rheumatoid arthritis and other inflammatory arthritides

1993 • 11 citations

Constrained V gene choice

1993 • 10 citations