A multistep molecular mimicry hypothesis for the pathogenesis of rheumatoid arthritis

The shared epitope hypothesis. an approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis

1987 • 2,539 citations

Rheumatoid Arthritis

1990 • 1,565 citations

MHC-dependent antigen processing and peptide presentation: Providing ligands for T lymphocyte activation

1994 • 1,448 citations

Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen

1992 • 1,200 citations

Association of the B-Cell Alloantigen DRw4 with Rheumatoid Arthritis

1978 • 1,170 citations

Heat shock proteins and the immune response

1990 • 944 citations

Negative selection of lymphocytes

1994 • 810 citations

Predominant naturally processed peptides bound to HLA-DR1 are derived from MHC-related molecules and are heterogeneous in size

1992 • 763 citations

Evidence for a differential avidity model of T cell selection in the thymus

1994 • 679 citations

Peptides Presented to the Immune System by the Murine Class II Major Histocompatibility Complex Molecule I-A _d

1992 • 654 citations

Positive Selection of Thymocytes

1995 • 604 citations

Positive selection of lymphocytes

1994 • 563 citations

Positive and Negative Thymocyte Selection Induced by Different Concentrations of a Single Peptide

1994 • 497 citations

Apoptosis in rheumatoid arthritis synovium.

1995 • 378 citations

Peptide binding specificity of HLA-DR4 molecules: correlation with rheumatoid arthritis association.

1995 • 310 citations

HLA DRB4 0101-restricted immunodominant T cell autoepitope of pyruvate dehydrogenase complex in primary biliary cirrhosis: evidence of molecular mimicry in human autoimmune diseases.

1995 • 301 citations

Anti-CD44 treatment abrogates tissue aedema and leukocyte infiltration in murine arthrtis

1995 • 283 citations

On the complexity of self

1991 • 261 citations

Correlation between disease phenotype and genetic heterogeneity in rheumatoid arthritis.

1995 • 252 citations

Studies on T cell maturation on defined thymic stromal cell populations in vitro.

1992 • 249 citations

A differential-avidity model for T-cell selection

1994 • 239 citations

Pool sequencing of natural HLA-DR, DQ, and DP ligands reveals detailed peptide motifs, constraints of processing, and general rules

1994 • 234 citations

Specificity and flexibility in thymic selection

1994 • 221 citations

Positive selection of CD8+ T cells induced by major histocompatibility complex binding peptides in fetal thymic organ culture.

1993 • 221 citations

Rheumatoid synovium is enriched in mature antigen-presenting dendritic cells.

1994 • 209 citations

HLA-DQ8 transgenic mice are highly susceptible to collagen-induced arthritis: a novel model for human polyarthritis.

1996 • 203 citations

Several HLA alleles share overlapping peptide specificities.

1995 • 197 citations

Genetic typing of patients with inflammatory arthritis at presentation can be used to predict outcome

1994 • 187 citations

Positive selection in autoimmunity: Abnormal immune responses to a bacterial dnaJ antigenic determinant in patients with early rheumatoid arthritis

1995 • 180 citations

Could HLA-DRB1 be the protective locus in rheumatoid arthritis?

1995 • 178 citations

In vivo and in vitro clonal deletion of double-positive thymocytes.

1992 • 172 citations

Allelic polymorphism in transcriptional regulatory regions of HLA-DQB genes.

1991 • 116 citations

Stress proteins, arthritis, and autoimmunity

1989 • 113 citations

Human major histocompatibility complex class II-restricted T cell responses in transgenic mice.

1994 • 108 citations

The susceptibility sequence to rheumatoid arthritis is a cross-reactive B cell epitope shared by the Escherichia coli heat shock protein dnaJ and the histocompatibility leukocyte antigen DRB10401 molecule.

1992 • 107 citations

Molecular mimicry in the MHC: Hidden clues to autoimmunity?

1996 • 99 citations

Partial activation of CD8+ T cells by a self-derived peptide

1995 • 95 citations

Selecting the T Cell Receptor Repertoire

1994 • 71 citations

Autoimmune disease and molecular mimicry: an hypothesis

1993 • 66 citations

GENETIC AND ENVIRONMENTAL FACTORS IN THE IMMUNE PATHOGENESIS OF RHEUMATOID ARTHRITIS

1992 • 62 citations

Naturally processed peptides from rheumatoid arthritis associated and non-associated HLA-DR alleles.

1995 • 57 citations

The origin of CD4−CD8−TCRαβ+ thymocytes: a model based on T-cell receptor avidity

1995 • 44 citations

Progressive joint destruction in a human immunodeficiency virus‐infected patient with rheumatoid arthritis

1995 • 40 citations

Divergent T cell receptor γ repertoires in rheumatoid arthritis monozygotic twins

1993 • 20 citations

Tolerance to a self peptide from the third hypervariable region of the E chain. Implications for molecular mimicry models of autoimmune disease

1991 • 20 citations

Thymocyte-stromal-cell interactions and T-cell selection

1995 • 17 citations