The Molecular Basis of Susceptibility to Rheumatoid Arthritis

The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis

1988 • 19,632 citations

T-cell antigen receptor genes and T-cell recognition

1988 • 3,099 citations

The shared epitope hypothesis. an approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis

1987 • 2,539 citations

Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules

1991 • 2,447 citations

Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1

1993 • 2,360 citations

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

ANKYLOSING SPONDYLITIS AND HL-A 27

1973 • 1,801 citations

Textbook of Rheumatology

1985 • 1,671 citations

Natural history of the major histo-compatibility complex

1987 • 1,274 citations

Association of the B-Cell Alloantigen DRw4 with Rheumatoid Arthritis

1978 • 1,170 citations

Interaction of Staphylococcus aureus toxin "superantigens" with human T cells.

1989 • 1,000 citations

STRUCTURE, FUNCTION, AND DIVERSITY OF CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX MOLECULES

1990 • 693 citations

Textbook of Rheumatology.

1988 • 593 citations

The Role of the T Cell Receptor in Positive and Negative Selection of Developing T Cells

1990 • 589 citations

Histocompatibility Testing 1984

1985 • 535 citations

Superantigens interact with MHC class II molecules outside of the antigen groove

1990 • 438 citations

The contribution of H LA to rheumatoid arthritis

1989 • 386 citations

Molecular diversity of HLA-DR4 haplotypes.

1986 • 385 citations

HLA-DR4 subtype frequencies in rheumatoid arthritis indicate that DRB1 is the major susceptibility locus within the HLA class II region.

1989 • 376 citations

Association of Chronic Lyme Arthritis with HLA-DR4 and HLA-DR2 Alleles

1990 • 359 citations

HLA Genes associated with rheumatoid Arthritis. Identification of susceptibility alleles using specific oligonucleotide probes

1989 • 345 citations

Mixed lymphocyte cultures in rheumatoid arthritis.

1976 • 338 citations

Nomenclature for factors of the HLA system, 1991

1992 • 337 citations

Recognition by pregnancy serums of non-HL-A alloantigens selectively expressed on B lymphocytes.

1975 • 332 citations

Occurrence of rheumatoid arthritis in a nationwide series of twins.

1986 • 308 citations

Linkage of Mls genes to endogenous mammary tumour viruses of inbred mice

1991 • 307 citations

Genes encoding ligands for deletion of Vβ11 T cells cosegregate with mammary tumour virus genomes

1991 • 297 citations

HLA-DR Antigens and Toxic Reaction to Sodium Aurothiomalate and D-Penicillamine in Patients with Rheumatoid Arthritis

1980 • 295 citations

Nomenclature for Factors of the HLA System, 1991

1992 • 290 citations

An endogenous retrovirus mediating deletion of αβ T cells?

1991 • 278 citations

The Human la System

1980 • 272 citations

Timing of Pregnancy in Relation to the Onset of Rheumatoid Arthritis

1992 • 239 citations

Homozygosity for the HLA-DRB1 allele selects for extraarticular manifestations in rheumatoid arthritis.

1992 • 229 citations

The effect of pregnancy on rheumatoid arthritis.

1976 • 227 citations

Susceptibility to rheumatoid arthritis maps to a T-cell epitope shared by the HLA-Dw4 DR beta-1 chain and the Epstein-Barr virus glycoprotein gp110.

1989 • 200 citations

Disease associations of the Ia-like human alloantigens. Contrasting patterns in rheumatoid arthritis and systemic lupus erythematosus.

1978 • 198 citations

POPULATION GENETICS OF RHEUMATOID ARTHRITIS

1992 • 195 citations

Analyses of Lymphocytes from Patients with Rheumatoid Arthritis and Systemic Lupus Erythematosus OCCURRENCE OF INTERFERING COLD-REACTIVE ANTILYMPHOCYTE ANTIBODIES

1974 • 194 citations

HLA heterozygosity contributes to susceptibility to rheumatoid arthritis

2001 • 192 citations

Heberden Oration, 1969. Rheumatoid arthritis--nature or nurture?

1970 • 189 citations

HLA and disease associations

1986 • 185 citations

Immunobiology of HLA

1989 • 175 citations

Map of the human MHC

1991 • 174 citations

Structural organization of the DR subregion of the human major histocompatibility complex.

1985 • 173 citations

Samter's Immunologic Diseases

2001 • 169 citations

Five HLA-D clusters associated with HLA-DR4

1982 • 168 citations

Association of HLA-Aw31 and HLA-DR1 with adult rheumatoid arthritis.

1982 • 168 citations

Association of HLA–DR4 with a more progressive disease course in patients with rheumatoid arthritis. Results of a followup study

1991 • 163 citations

Association of HLA–Dw16 with rheumatoid arthritis in Yakima Indians. Further evidence for the “shared epitope” hypothesis

1991 • 157 citations

IDENTIFICATION OF HLA-Dw14 GENES IN DR4+ RHEUMATOID ARTHRITIS

1986 • 150 citations

T Cell Reactivity to MHC Molecules: Immunity Versus Tolerance

1990 • 148 citations

Nomenclature for factors of the HLA system, 1991

1992 • 148 citations

Absence of rheumatoid arthritis in a rural Nigerian population.

1993 • 147 citations

The molecular basis for HLA class II associations with rheumatoid arthritis

1987 • 142 citations

Association between HLA and Japanese patients with rheumatoid arthritis

1982 • 138 citations

DR antigens and rheumatoid arthritis: a study of two populations.

1981 • 128 citations

The effects of MHC gene dosage and allelic variation on T cell receptor selection

1990 • 123 citations

Altered reactivity in mixed lymphocyte culture of lymphocytes from patients with rheumatoid arthritis

1969 • 121 citations

Samter's immunologic diseases

1997 • 119 citations

The Epstein-Barr Virus Glycoprotein gp110, a Molecular Link between HLA DR4, HLA DR1, and Rheumatoid Arthritis

1988 • 118 citations

DNA sequence and characterization of human class II major histocompatibility complex beta chains from the DR1 haplotype.

1985 • 109 citations

The susceptibility sequence to rheumatoid arthritis is a cross-reactive B cell epitope shared by the Escherichia coli heat shock protein dnaJ and the histocompatibility leukocyte antigen DRB10401 molecule.

1992 • 107 citations

Hla‐dr alleles with naturally occurring amino acid substitutions and risk for development of rheumatoid arthritis

1990 • 103 citations

Investigating the HLA component in rheumatoid arthritis: An additive (dominant) mode of inheritance is rejected, a recessive mode is preferred

1991 • 102 citations

Functionally distinct subsites on a class II major histocompatibility complex molecule

1987 • 95 citations

The potential aggressiveness of synovial tissue in rheumatoid arthritis

1983 • 95 citations

PREDICTION OF SUSCEPTIBILITY TO RHEUMATOID ARTHRITIS BY HUMAN LEUKOCYTE ANTIGEN GENOTYPING

1992 • 94 citations

Structure-function analysis of the Abm12 beta mutation using site-directed mutagenesis and DNA-mediated gene transfer.

1987 • 86 citations

The human HLA-DR antigens are encoded by multiple beta-chain loci.

1982 • 84 citations

HLA—Dw4 and Rheumatoid Arthritis

1979 • 79 citations

Serological and cellular definition of a new HLA-DR associated determinant, MC1, and its association with rheumatoid arthritis

1984 • 75 citations

INCIDENCE OF RHEUMATOID ARTHRITIS IN A GENETICALLY PREDISPOSED POPULATION

1992 • 71 citations

HLA‐DRwlO confers the highest susceptibility to rheumatoid arthritis in a Spanish population

1990 • 69 citations

GENETIC AND ENVIRONMENTAL FACTORS IN THE IMMUNE PATHOGENESIS OF RHEUMATOID ARTHRITIS

1992 • 62 citations

Rheumatoid arthritis in Israeli Jews: shared sequences in the third hypervariable region of DRB1 alleles are associated with susceptibility.

1991 • 61 citations

The molecular basis of susceptibility to rheumatoid arthritis: The conformational equivalence hypothesis

1988 • 60 citations

The peptidic self model: a hypothesis on the molecular nature of the immunological self.

1986 • 60 citations

Rheumatoid arthritis may be primarily associated with HLA‐DR4 molecules sharing a particular sequence at residues 67–74

1990 • 59 citations

HLA-D region genes and rheumatoid arthritis (RA): importance of DR and DQ genes in conferring susceptibility to RA.

1992 • 58 citations

The Immunogenetics of Juvenile Rheumatoid Arthritis

1991 • 58 citations

Molecular Basis of Human Leukocyte Antigen Class II

1990 • 58 citations

Influence of non-inherited maternal HLA antigens on occurrence of rheumatoid arthritis

1993 • 57 citations

Sequence similarity between HLA-DR1 and DR4 subtypes associated with rheumatoid arthritis and proteus/serratia membrane haemolysins.

1992 • 56 citations

Nucleotide sequence of a DRw10 beta chain cDNA clone. Identity of the third D region with that of the DRw53 allele of the beta 2 locus and as the probable site encoding a polymorphic MHC class II epitope.

1988 • 55 citations

Dw subtypes of DR4 in rheumatoid arthritis: Evidence for a preferential association with Dw4

1986 • 53 citations

Contrasting patterns of newer histocompatibility determinants in patients with rheumatoid arthritis and systemic lupus erythematosus

1978 • 53 citations

Contribution of inherited factors to rheumatoid arthritis.

1992 • 49 citations

A variant of HLA–DR4 determines susceptibility to rheumatoid arthritis in a subset of Israeli Jews

1991 • 49 citations

HLA antigens in Tlingit Indians with rheumatoid arthritis

1992 • 46 citations

HLA‐DR1 and rheumatoid arthntis in Israeli Jews: Sequencing reveals that DRB1*0102 is the predominant HLA‐DR1 subtype

1993 • 45 citations

HLA-DR4-DQw8, but not DR4-DQw7 haplotypes occur in Indian patients with rheumatoid arthritis

1992 • 45 citations

Genetic aspects of rheumatoid arthritis

1981 • 44 citations

Association of rheumatoid arthritis with a dominant DR1/Dw4/Dw14 sequence motif, but not with t cell receptor β chain gene alleles or haplotypes

1991 • 42 citations

T cell recognition of self-human histocompatibility leukocyte antigens (HLA)-DR peptides in context of syngeneic HLA-DR molecules.

1992 • 41 citations

Immunogenetics of rheumatoid arthritis in Israel

1986 • 41 citations

Interplay of T lymphocytes and HLA-DR molecules in rheumatoid arthritis

1993 • 40 citations

Differences in t cell receptor restriction fragment length polymorphisms in patients with rheumatoid arthritis

1992 • 40 citations

Distribution of HLA‐DQA1, ‐DQB1 and DRB1 alleles in black IDDM patients and controls from Zimbabwe

1992 • 40 citations

HLA-DR genotype risks in seropositive rheumatoid arthritis.

1984 • 40 citations

HLA Dr Antigens in Rheumatoid Arthritis

1983 • 40 citations

Is rheumatoid arthritis in Indians associated with HLA antigens sharing a DR beta 1 epitope?

1991 • 40 citations

Dwl4(DRBl*0404) is a Dw4‐dependent risk factor for rheumatoid arthritis Rethinking the “shared epitope” hypothesis

1991 • 40 citations

Remission of Rheumatoid Arthritis During Pregnancy and Maternal‐Fetal Class II Alloantigen Disparity

1992 • 40 citations

IMMUNOGENETIC HETEROGENEITY IN RHEUMATOID DISEASE AS ILLUSTRATED BY DIFFERENT MHC ASSOCIATIONS (DQ, DW AND C4) IN ARTICULAR AND EXTRA-ARTICULAR SUBSETS

1991 • 40 citations

Class ii major histocompatibility complex gene sequences in rheumatoid arthritis. The third diversity regions of both DRβ₁ genes in two DR1, DRw10–positive individuals specify the same inferred amino acid sequence as the DRβ₁ and DRβ₂ Genes of a DR4 (Dw14) haplotype

1989 • 38 citations

Lack of HLA-antigen association in Greek rheumatoid arthritis patients

1985 • 38 citations

LIMITED HETEROGENEITY OF THE HLA CLASS II CONTRIBUTION TO SUSCEPTIBILITY TO RHEUMATOID ARTHRITIS IS SUGGESTED BY POSITIVE ASSOCIATIONS WITH HLA—DR4, DR1 AND DRwlO

1991 • 37 citations

B lymphocyte alloantigens in the study of the genetic basis of rheumatoid arthritis.

1977 • 36 citations

Structural relationships between the DR beta 1 and DR beta 2 subunits in DR4, 7, and w9 haplotypes and the DRw53 (MT3) specificity.

1986 • 36 citations

HLA–D region antigens in patients with rheumatoid arthritis

1991 • 36 citations

The forces driving autoimmune disease

1992 • 36 citations

Pregnancy and its effect on the risk of developing rheumatoid arthritis.

1991 • 36 citations

Strong association of rheumatoid arthritis with the presence of a polymorphic Ia epitope defined by a monoclonal antibody: comparison with the allodeterminant DR4

1984 • 36 citations

The role of polymorphic amino acids of the MHC molecule in the selection of the T cell repertoire.

1991 • 35 citations

Weak association between HLA-DR4 and rheumatoid arthritis in Chilean patients.

1990 • 32 citations

Linkage Between Rheumatoid Arthritis Susceptibility and the Presence of HLA—DR4 and DRβ Allelic ThIrd Hypervariable Region Sequences in Southern Chinese Persons

1992 • 31 citations

HLA‐DR4 associated Dw types in rheumatoid arthritis

1989 • 30 citations

Evidence for the separate molecular expression of four distinct polymorphic Ia epitopes on cells of DR4 homozygous individuals

1984 • 30 citations

MHC class II binding of peptides derived from HLA-DR 1.

1992 • 30 citations

Protective & risk DR phenotypes in Asian Indian patients with rheumatoid arthritis.

1992 • 29 citations

Analysis of HLA DP, DQ, and DR allesles in adult Italian rheumatoid arthritis patients

1992 • 26 citations

Rheumatoid arthritis in a Chippewa band. II. Field study with clinical serologic and HLA-D correlations.

1983 • 26 citations

HLA‐DR antigens and rheumatoid arthritis in black South Africans: A study of ethc groups

1992 • 26 citations

The HLA Association with Rheumatoid Arthritis

1994 • 25 citations

Influence of HLA class I and class II antigens on the peripheral T-cell receptor repertoire

1994 • 25 citations

Genetics of rheumatoid factor and rheumatoid arthritis.

1967 • 24 citations

Analyses of hla linkage in white families with multiple cases of seropositive rheumatoid arthritis

1987 • 24 citations

Linkage studies of hla and rheumatoid arthritis in multicase families

1987 • 23 citations

Identification of the DRw10 DR beta 1-chain allele as encoding a polymorphic class II major histocompatibility complex epitope otherwise restricted to DR beta 2 molecules of the DRw53 type.

1988 • 22 citations

Rheumatoid factor detection in the unaffected first degree relatives in families with multicase rheumatoid arthritis.

1991 • 22 citations

Immunogenetics and histocompatibility

1989 • 21 citations

Antigen presentation by murine and human cells to a murine T-cell hybridoma: demonstration of a restriction element associated with a major histocompatibility complex class II determinant(s) shared by both species.

1984 • 21 citations

Divergent T cell receptor γ repertoires in rheumatoid arthritis monozygotic twins

1993 • 20 citations

DQw7 and the C4B null allele in rheumatoid arthritis and Felty's syndrome.

1990 • 19 citations

Cellular typing and functional heterogeneity of MHC-encoded products

1987 • 18 citations

What factors distinguish probands from multicase rheumatoid arthritis same sex sibships from sporadic disease?

1992 • 18 citations

Susceptibility genetics of systemic lupus erythematosus

1986 • 17 citations

DPB1 polymorphism in rheumatoid arthritis: Evidence of an association with allele DPB1 0401

1992 • 17 citations

HLA-DR antigens in rheumatoid arthritis

1981 • 17 citations

Evidence for a new HLA class II determinant present on cells from HLA‐DR1 and/or ‐DR4 individuals

1985 • 15 citations

The immunogenetic component of susceptibility to rheumatoid arthritis

1992 • 15 citations

HLA Haplotype Sharing in Rheumatoid Arthritis Sibships: Risk Estimates in Siblings

1992 • 14 citations

T-CELL RECEPTOR–MAJOR HISTOCOMPATIBILITY COMPLEX GENETIC INTERACTIONS IN RHEUMATOID ARTHRITIS

1992 • 14 citations

T cell receptor usage in rheumatic disease.

1992 • 13 citations

COMPLEMENT C4 NULL ALLELES AS A MARKER OF GOLD OR D-PENICILLAMINE TOXICITY IN THE TREATMENT OF RHEUMATOID ARTHRITIS

1992 • 12 citations

Multiple HLA associations and disease susceptibility.

1986 • 10 citations

Lack of association of the alpha-1-antitrypsin PIZ allele with rheumatoid arthritis or with its extra articular complications.

1992 • 9 citations

The HLA class II component of susceptibility to rheumatoid arthritis

1992 • 9 citations

Immunogenetics of familial rheumatoid arthritis: a study of 41 multicase families.

1993 • 8 citations

Adult rheumatoid arthritis is associated with MC1, a new HLA-D encoded determinant.

1988 • 8 citations

Definition of DRw10 specificity by restriction fragment length polymorphism

1988 • 8 citations

Ig CH AND D14S1 VARIANTS IN RHEUMATOID ARTHRITIS—LINKAGE AND ASSOCIATION STUDIES

1991 • 7 citations

Linkage of Mls genes to endogenous mammary tumour viruses of inbred mice [see comments]

1991 • 5 citations

DR4 and DR1 Define Different Subsets of Patients with Rheumatoid Arthritis

1989 • 5 citations

Interactive effect of HLA and Gm and genetic heterogeneity tested in 79 rheumatoid arthritis families.

1991 • 5 citations

CONCORDANCE RATES FOR RHEUMATOID-ARTHRITIS IN TWINS - RESULTS OF A NATIONWIDE STUDY

1992 • 5 citations

Characteristics of rheumatoid arthritis in a male population.

1980 • 4 citations

Rheumatoid arthritis-joint report

1992 • 4 citations

New aspects of HLA: perspectives for rheumatoid arthritis.

1992 • 3 citations

Association of dr4 Related Rflp Bands and Ra in Greeks

1990 • 3 citations

Association of HLA-DR antigens with disease severity in Japanese patients with rheumatoid arthritis.

1990 • 3 citations

HLA DQ beta restriction fragment length polymorphism and rheumatoid arthritis. Association between DQw7 and rheumatoid arthritis in DR4-positive subjects.

1991 • 2 citations

[Contribution of genetic factors to RA].

1992 • 1 citations

Association of HLA-DR subtypes with in vitro IgM rheumatoid factor synthesis

1993 • 1 citations

Does the locus on chromosome 11 implicated in susceptibility to HLA-DR4 dependent type I diabetes mellitus also affect susceptibility to rheumatoid arthritis?

1992 • 1 citations

Deleted Work

1955 • 0 citations