Ethnic Differences in Drug Metabolism

Benzo[alpha]pyrene metabolism, activation and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes.

1980 • 1,277 citations

Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity.

1980 • 1,185 citations

Genetic Control of Isoniazid Metabolism in Man

1960 • 792 citations

Defective N-oxidation of sparteine in man: A new pharmacogenetic defect

1979 • 647 citations

A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population.

1980 • 544 citations

Comparison of normal and asthmatic circadian rhythms in peak expiratory flow rate.

1980 • 530 citations

Kinetics and metabolism of paracetamol and phenacetin.

1980 • 425 citations

Developmental changes and polymorphism in human alcohol dehydrogenase

1971 • 375 citations

The evolution of genetic diversity

1979 • 323 citations

Two aldehyde dehydrogenases from human liver. Isolation via affinity chromatography and characterization of the isozymes

1977 • 314 citations

Drug Metabolism: Chemical and Biochemical Aspects

1976 • 310 citations

Therapeutic Drug Monitoring in Saliva

1978 • 300 citations

Enzyme Polymorphism and Metabolism

1974 • 284 citations

Metabolic Activation of Drugs to Toxic Substances

1975 • 281 citations

Racial differences in alcohol sensitivity: A new hypothesis

1979 • 259 citations

Metabolism of cocaine in man

1978 • 251 citations

Inheritance of low erythrocyte catechol-o-methyltransferase activity in man.

1977 • 248 citations

Genic variation within and between the three major races of man, Caucasoids, Negroids, and Mongoloids.

1974 • 246 citations

Liver alcohol dehydrogenase and aldehyde dehydrogenase in the Japanese: isozyme variation and its possible role in alcohol intoxication.

1980 • 236 citations

FREE-RADICAL OXIDATION AND ANTIOXIDANTS

1978 • 234 citations

Genetic Control of Drug Levels in Man: Antipyrine

1968 • 225 citations

Hydrolysis of cocaine in human plasma by cholinesterase

1977 • 223 citations

The rate of decline of diphenylhydantoin in human plasma

1970 • 213 citations

Drug Metabolism under Pathological and Abnormal Physiological States in Animals and Man

1977 • 212 citations

Isolation and purification of cytochrome P-450, and the existence of multiple forms

1979 • 210 citations

Constancy of urinary creatinine excretion.

1958 • 203 citations

AN ATYPICAL HUMAN ALCOHOL DEHYDROGENASE

1965 • 191 citations

Alcohol Sensitivity and Ethnic Background

1974 • 190 citations

Pharmacokinetics of isoniazid metabolism in man

1976 • 183 citations

Liver alcohol dehydrogenase in Japanese: high population frequency of atypical form and its possible role in alcohol sensitivity.

1975 • 173 citations

E- and Z-10-hydroxylation of nortriptyline: Relationship to polymorphic debrisoquine hydroxylation

1981 • 171 citations

Assay of Antipyrine and Its Primary Metabolites in Plasma, Saliva and Urine by High-Performance Liquid Chromatography and Some Preliminary Results in Man

1979 • 168 citations

Polymorphisms of Oxidation at Carbon Centers of Drugs and Their Clinical Significance

1979 • 163 citations

Electrophoretic and biochemical studies of human aldehyde dehydrogenase isozymes in various tissues

1980 • 159 citations

The Plasma Cholinesterases: A New Perspective

1981 • 158 citations

Isoniazid hepatoxicity: the relationship between covalent binding and metabolism in vivo.

1980 • 157 citations

Genetic polymorphism and interethnic variability of plasma paroxonase activity.

1976 • 145 citations

Multiple forms of inducible drug-metabolizing enzymes: A reasonable mechanism by which any organism can cope with adversity

1979 • 142 citations

Hydrolysis of diacetylmorphine (heroin) by human serum cholinesterase.

1980 • 141 citations

Variations between individuals and populations in the acetylation of isoniazid and its significance for the treatment of pulmonary tuberculosis

1976 • 134 citations

Genetic and environmental factors affecting drug disposition in man

1977 • 130 citations

Ethanol Metabolism in Various Racial Groups

1976 • 125 citations

Enzymology of Human Alcohol Metabolism

1977 • 125 citations

Clinical Pharmacokinetics of Hypnotics

1977 • 123 citations

Polymorphism of carbon oxidation of drugs and clinical implications.

1978 • 119 citations

ATYPICAL HUMAN LIVER ALCOHOL DEHYDROGENASE

1968 • 116 citations

Alcohol Metabolism in American Indians and Whites

1976 • 114 citations

Nortriptyline and antipyrine clearance in relation to debrisoquine hydroxylation in man

1980 • 111 citations

Alcohol and acetaldehyde metabolism in Caucasians, Chinese and Amerinds.

1976 • 109 citations

Polymorphism and the subunit structure of enzymes: a contribution to the neutralist-selectionist controversy.

1977 • 96 citations

Isozyme variations in acetaldehyde dehydrogenase (E.C.1.2.1.3) in human tissues

1978 • 95 citations

Evidence for an enzymatic defect in the 4‐hydroxylation of debrisoquine by human liver.

1981 • 93 citations

Debrisoquin hydroxylation polymorphism among Ghanaians and Caucasians

1979 • 85 citations

Ethanol metabolism in subiects possessing typical and atypical liver alcohol dehydrogenase

1967 • 84 citations

Michaelis-Menten pharmacokinetics of diphenylhydantoin and application in the pediatric age patient

1980 • 82 citations

Pharmacogenetic covariation of defective N-oxidation of sparteine and 4-hydroxylation of debrisoquine

1980 • 82 citations

Heterogeneous heterozygosities in Mus musculus populations

1977 • 81 citations

Some observations on the oxidation phenotype status of Nigerian patients presenting with cancer

1981 • 79 citations

Antipyrine metabolism in the rat by three hepatic monooxygenases

1980 • 73 citations

Diphenhydramine in Orientals and Caucasians

1980 • 72 citations

Alcohol metabolizing enzymes: Studies of isozymes in human biopsies and cultured fibroblasts

1979 • 72 citations

Human liver alcohol dehydrogenase isoenzyme variations

1978 • 68 citations

Influence of the defective metabolism of sparteine on its pharmacokinetics

1979 • 67 citations

The effects of age, race and heredity on glomerular filtration rate following volume expansion and contraction in normal man

1980 • 67 citations

Predicting Phenytoin Dose—A Revised Nomogram

1979 • 66 citations

Intraindividual variation in drug disposition

1979 • 66 citations

Plasma aspirin esterases in normal individuals, patients with alcoholic liver disease and rheumatoid arthritis: characterization and the importance of the enzymic components

1980 • 65 citations

Environmental factors affecting paracetamol metabolism in London factory and office workers.

1980 • 65 citations

Metabolic fate of phenobarbital in man. N-Glucoside formation.

1979 • 64 citations

Prediction of steady-state plasma levels of nortriptyline from single oral dose kinetics: A study in twins

1973 • 64 citations

A study of the debrisoquine hydroxylation polymorphism in a Nigerian population

1980 • 63 citations

Deficient metabolism of debrisoquine and sparteine

1980 • 63 citations

DIPHENYLHYDANTOIN HALF‐LIFE IN MAN AND ITS INHIBITION BY PHENYLBUTAZONE: THE ROLE OF GENETIC FACTORS

1973 • 59 citations

The polymorphic 4-hydroxylation of debrisoquine in a Saudi arab population

1980 • 59 citations

A Population and Familial Study of the Defective Alicyclic Hydroxylation of Debrisoquine among Egyptians

1979 • 57 citations

Prolonged Apnoea after Suxamethonium: An Analysis of the First 225 Cases Reported to the Danish Cholinesterase Research Unit

1978 • 55 citations

Human alcohol dehydrogenase ADH2 and ADH3 polymorphisms in ethnic Chinese and Indians of West Malaysia

1979 • 54 citations

Gas chromatographic assessment of the reproducibility of phenazone plasma half-life in young healthy volunteers

1974 • 53 citations

The kinetics of amylobarbitone metabolism in healthy men and women

1970 • 51 citations

Genetic study of amobarbital elimination based on its kinetics in twins

1976 • 51 citations

Ethnic difference in drug metabolism: debrisoquine 4-hydroxylation in Caucasians and Orientals

1980 • 50 citations

Factors Influencing the Measurement and the Reproducibility of Aryl Hydrocarbon Hydroxylase Activity in Cultured Human Lymphocytes2

1977 • 49 citations

Inheritance of phenytoin hypometabolism: A kinetic study of one family

1980 • 48 citations

Effects of Induction of Cytochrome P-450 Enzymes on the Concentration of Foreign Compounds and Their Metabolites and on the Toxicological Effects of These Compounds

1979 • 47 citations

Genetic differences in the induction of monooxygenase activities by polycyclic aromatic compounds

1979 • 47 citations

Enzyme Induction

1976 • 46 citations

High-performance liquid chromatography technique for resolving multiple forms of hepatic membrane-bound cytochrome P-450.

1980 • 46 citations

Racial Comparisons of Alcohol Metabolism: Background, Problems, and Results

1978 • 45 citations

Environmental factors affecting antipyrine metabolism in London factory and office workers.

1979 • 43 citations

Individual Differences in the Disposition of Drugs Metabolised in the Body

1978 • 42 citations

Regulation of Drug Metabolism in Man by Environmental Factors

1979 • 41 citations

Clinical pharmacology. Possible clinical importance of genetic differences in drug metabolism.

1981 • 41 citations

Kinetic discrimination of three sulfamethazine acetylation phenotypes

1980 • 40 citations

Influence of DH/DL alleles regulating debrisoquine oxidation on phenytoin hydroxylation

1981 • 39 citations

The expanding role of microsomal enzyme induction, and its implications for clinical chemistry.

1980 • 39 citations

A method for studying drug metabolism in populations: Racial differences in amobarbital metabolism

1979 • 39 citations

On the geographical distribution of pseudocholinesterase variants

1975 • 38 citations

Ethanol Metabolism in Male American Indians and Whites

1978 • 38 citations

Prediction of drug sensitivity in individuals with atypical serum cholinesterase based on in vitro biochemical studies

1981 • 38 citations

In vitro metabolism of sparteine by human liver: competitive inhibition by debrisoquine

1982 • 38 citations

Liver alcohol dehydrogenase in a Japanese population.

1972 • 38 citations

Environmental effects on antipyrine half‐life in man

1977 • 36 citations

Further evidence for the concept of bovine plasma arylesterase as a lipoprotein

1975 • 35 citations

Acetylator phenotyping of tuberculosis patients using matrix isoniazid or sulphadimidine and its prognostic significance for treatment with several intermittent isoniazid‐containing regimens.

1977 • 35 citations

The identification of 6-methoxy 8-aminoquionoline as a metabolite of primaquine in man

1975 • 35 citations

Plasma kinetics and urinary excretion of primaquine in man.

1980 • 35 citations

Contribution of Environmental Factors to Variability in Human Drug Metabolism

1979 • 35 citations

A case of deficiency of N‐hydroxylation of amobarbital

1977 • 34 citations

Genetisch determinierter Polymorphismus der menschlichen Serum-Paraoxonase (EC 3.1.1.2)

1973 • 34 citations

Racial differences in drug metabolizing ability: A study with antipyrine in the Sudan

1978 • 34 citations

Modification of hepatic drug metabolizing enzyme activities and their induction by dietary protein

1980 • 31 citations

Metabolism of Ethanol and Alcoholism: Racial and Acquired Factors

1972 • 30 citations

Genetic structure of human populations

1979 • 30 citations

Amobarbital-a probe of hepatic drug oxidation in man

1976 • 30 citations

Metabolic Responses of Chinese, Japanese and Europeans to Alcohol

1978 • 30 citations

The Functional Roles of Cytochrome P-450 Mediated Systems: Present Knowledge and Future Areas of Investigations

1979 • 29 citations

Interactions Between Drugs and Nutrients

1979 • 29 citations

Antipyrine metabolism in man

1978 • 28 citations

Screening methods using sulfamethazine for determining acetylator phenotype

1979 • 25 citations

Distribution of serum paraoxon hydrolyzing activities in a Canadian population

1981 • 24 citations

Application of the phenotyped panel approach to the detection of polymorphism of drug oxidation in man [proceedings].

1979 • 23 citations

Digitalis metabolism and human liver alcohol dehydrogenase.

1980 • 22 citations

Amobarbital metabolism in man: N-glucoside formation.

1978 • 22 citations

Bias in calculated rate of alcohol metabolism due to variation in relative amounts of adipose tissue.

1977 • 22 citations

Pharmacogenetics

1978 • 21 citations

Determination of apparent kinetic constants of the microsomal hydroxylation of amobarbital, hexobarbital, and pentobarbital.

1973 • 21 citations

COMPARATIVE METABOLISM RATES OF ETHANOL IN ADULTS OF ABORIGINAL AND EUROPEAN DESCENT

1976 • 20 citations

Urinary primaquine excretion and red cell methaemoglobin levels in man following a primaquine:chloroquine regimen.

1980 • 20 citations

Alcohol Metabolism and Sensitivity Reactions Among the Reddis of South India

1978 • 20 citations

High incidence of the silent allele at cholinesterase locus I in Vysyas of Andhra Pradesh (S. India)

1979 • 20 citations

Intraindividual Similarity in the Metabolism of Amitriptyline and Chlorimipramine in Depressed Patients

1979 • 18 citations

A third type of serum cholinesterase deficiency in Eskimos.

1976 • 16 citations

Measurement of benzo(a)pyrene metabolism in human monocytes.

1977 • 15 citations

Identification of diphenydramine (Benadryl) metabolities in human subjects.

1974 • 15 citations

Inter‐ethnic and inter‐phenotype differences among Ghanaians and Caucasians in the metabolic hydroxylation of phenytoin [proceedings]

1980 • 14 citations

Antipyrene clearance in Indian villagers.

1980 • 14 citations

On kinetics of the paraoxon hydrolysing enzyme in human serum (EC 3.1.1.2)

1978 • 13 citations

Seasonal variation of aryl hydrocarbon hydroxylase inducibility in human lymphocytes in culture.

1978 • 13 citations

Amylobarbitone Hydroxylation Kinetics in Small Samples of Rat and Human Liver

1976 • 12 citations

Estimation of Pooled Pharmacokinetic Parameters Describing Populations

1981 • 12 citations

Prenatal programming of hepatic monoamine oxidase by 5,5-diphenylhydantoin

1979 • 10 citations

A Re-evaluation of Intersubject Variation in Enzyme Induction in Man1

1979 • 10 citations

A method for the study of N-Glucosidation invitro— amobarbital-N-glucoside formation in incubations with human liver

1980 • 9 citations

NADPH-dependent lipid peroxidation and its effects on aminopyrine N-demethylation in subcellular fractions of human neonatal liver

1976 • 7 citations

The relationship between individual dietary constituents and antipyrine metabolism in Indo‐Pakistani immigrants to Britain.

1982 • 7 citations

Antipyrine metabolites in two populations.

1981 • 7 citations

Racial Differences in Circadian Variation of Ethanol Metabolism

1978 • 7 citations

Studies on the different metabolic pathways of antipyrine as a tool in the assessment of the activity of different drug metabolizing enzyme systems in man [proceedings].

1980 • 6 citations

The metabolism of phenobarbitone, phenytoin and antipyrine in Black patients.

1977 • 6 citations

An assessment of short-cut procedures for studying drug metabolism in vivo using amobarbital as a model drug

1982 • 5 citations

INTERACTIONS BETWEEN CYTOCHROME P-450 AND NADPH-CYTOCHROME P-450 REDUCTASE IN THE MICROSOMAL MEMBRANE

1977 • 5 citations

Pharmacogenetic Investigation of Amobarbital Disposition

1979 • 5 citations

Ethanol metabolism.

1980 • 5 citations

The interaction of cigarette smoking and chronic drug ingestion on human drug metabolism

1979 • 5 citations

Die Bestimmung der Alkoholdehydrogenase- und Glutamins�ure-Oxalessigs�ure-Transaminase-Aktivit�t der menschlichen Leber nach dem Tode

1962 • 4 citations

Enhancement of antipyrine clearance and induction of antipyrine 4-hydroxylation by 3-methylcholanthrene in rats [proceedings].

1980 • 3 citations