The expanding role of microsomal enzyme induction, and its implications for clinical chemistry.

Identifying Environmental Chemicals Causing Mutations and Cancer

1979 • 575 citations

Chronic nonhemolytic unconjugated hyperbilirubinemia with glucuronyl transferase deficiency

1969 • 332 citations

Gamma-Glutamyl Transpeptidase

1975 • 276 citations

MORPHOLOGICAL CHANGES IN THE LIVER ACCOMPANYING STIMULATION OF MICROSOMAL DRUG METABOLIZING ENZYME ACTIVITY BY PHENOBARBITAL, CHLORDANE, BENZPYRENE OR METHYL-CHOLANTHRENE IN RATS.

1965 • 210 citations

Increased Rate of Clearance of Drugs from the Circulation of Alcoholics*

1969 • 209 citations

Effects of age and cigarette smoking on propranolol disposition

1979 • 186 citations

Stimulatory effect of cigarette smoking on the hydroxylation of 3,4‐benzpyrene and the N‐demethylation of 3‐methyl‐4‐monomethylaminoazobenzene by enzymes in human placenta

1969 • 168 citations

Effect of intensive occupational exposure to DDT on phenylbutazone and cortisol metabolism in human subiects

1970 • 153 citations

Enhanced Bioavailability and Decreased Clearance of Analgesics in Patients with Cirrhosis

1979 • 133 citations

Changes in Plasma -Glutamyl Transpeptidase Activity Associated with Alterations in Drug Metabolism in Man

1973 • 125 citations

Enhanced drug metabolism in cigarette smokers.

1976 • 125 citations

Effect of aging and cigarette smoking on antipyrine and indocyanine green elimination

1979 • 122 citations

REDUCTION IN CONCENTRATION OF TOTAL SERUM-BILIRUBIN IN OFFSPRING OF WOMEN TREATED WITH PHENOBARBITONE DURING PREGNANCY

1968 • 118 citations

Influence of Cigarette Smoking on Drug Metabolism in Man

1979 • 116 citations

Interactions between nutritional factors and drug biotransformations in man.

1976 • 106 citations

Role of γ-Glutamyl Transpeptidase Activity in the Diagnosis of Hepatobiliary Disease

1975 • 102 citations

Diagnosis of Gilbert's Syndrome: Role of Reduced Caloric Intake Test

1973 • 98 citations

The effects of phenobarbital, chloral betaine, and glutethimide administration on warfarin plasma levels and hypoprothrombinemic responses in man

1969 • 94 citations

A direct radioimmunoassay for 6β-hydroxycortisol in human urine

1978 • 83 citations

Increased Rate of Tolbutamide Metabolism in Alcoholic Patients

1969 • 81 citations

Impairment of antipyrine clearance in humans by propranolol.

1978 • 77 citations

PHENOBARBITONE THERAPY IN NEONATAL HYPERBILIRUBINÆMIA

1969 • 76 citations

Correlation of the plasma elimination of antipyrine and the appearance of 4-hydroxy antipyrine in the urine of man

1974 • 72 citations

Gamma-glutamyl transpeptidase, triglycerides, and enzyme induction.

1975 • 70 citations

Impairment of drug metabolism by disulfiram in man

1971 • 69 citations

Ethanol-induced increase in drug acetylation in man and isolated rat liver cells.

1978 • 69 citations

Drug metabolism in liver disease. Identification of patients with impaired hepatic drug metabolism.

1978 • 68 citations

Human Skin Aryl Hydrocarbon Hydroxylase

1978 • 67 citations

Evaluation ofin vivo parameters of drug metabolizing enzyme activity in man after administration of clemastine, phenobarbital or placebo

1975 • 67 citations

Effects of Smoking on Benzo(a)pyrene Metabolism by Human Placental Microsomes

1979 • 57 citations

Metabolism of <scp>d</scp>-glucuronolactone in mammalian systems. 2. Conversion of <scp>d</scp>-glucuronolactone into <scp>d</scp>-glucaric acid by tissue preparations

1963 • 56 citations

ETHANOL IN PREVENTION OF HYPERBILIRUBINÆMIA IN THE NEWBORN

1969 • 54 citations

Partial purification of human liver cytochrome P 450

1979 • 53 citations

Gas chromatographic assessment of the reproducibility of phenazone plasma half-life in young healthy volunteers

1974 • 53 citations

Prolonged survival in three brothers with severe type 2 Crigler-Najjar syndrome. Ultrastructural and metabolic studies.

1975 • 52 citations

Induction of aryl hydrocarbon hydroxylase activity and pulmonary carcinoma

1979 • 50 citations

Drug metabolism in malnourished children: a study with antipyrine.

1979 • 48 citations

Purification of human liver microsomal epoxide hydrase. Differences in the properties of the human and rat enzymes.

1979 • 47 citations

Effect of dietary composition on the unconjugated hyperbilirubinaemia of Gilbert's syndrome.

1976 • 46 citations

Regulation of Drug Metabolism in Man by Environmental Factors

1979 • 41 citations

Reduction in serum bilirubin by phenobarbital in adult unconjugated hyperbilirubinaemia

1968 • 39 citations

Drug‐metabolizing capacity in states of drug dependence and withdrawal

1972 • 38 citations

Osteomalacia after Prolonged Glutethimide Administration

1973 • 38 citations

Partial purification and properties of cytochrome P450 from homogenates of human fetal livers

1979 • 36 citations

Effect of enzyme induction on the metabolism and tissue distribution of benzo(alpha)pyrene.

1970 • 36 citations

Hepatic Metabolism of Aminopyrine in Patients with Chronic Renal Failure

1978 • 35 citations

Contribution of Environmental Factors to Variability in Human Drug Metabolism

1979 • 35 citations

Lack of value of serum γ-glutamyl transferase in the diagnosis of hepatobiliary disease

1979 • 34 citations

Purification and properties of cytochrome P-450 and NADPH-cytochrome c (P-450) reductase from human liver microsomes

1979 • 32 citations

Inhibition of hepatic demethylation of aminopyrine by oral contraceptive steroids in humans

1978 • 31 citations

Effect of fasting and phenobarbital on hepatic UDP-glucuronic acid formation in the rat.

1979 • 31 citations

The association between serum triglycerides and gamma glutamyl transpeptidase activity in diabetes mellitus

1976 • 30 citations

Aminopyrine breath test in alcoholic liver disease and in patients on enzyme-inducing drugs.

1977 • 29 citations

Liver Enzyme Induction by Anticonvulsant Drugs, and Its Relationship to Disturbed Calcium and Folic Acid Metabolism

1973 • 28 citations

The activity of aryl hydrocarbon hydroxylase in adult human skin.

1979 • 28 citations

Antipyrine metabolism in man

1978 • 28 citations

Smoking and Clinical Drug Effects

1974 • 27 citations

ENZYME INDUCTION AS A POSSIBLE CAUSE OF INCREASED SERUM-TRIGYLCERIDES AFTER ORAL CONTRACEPTIVES

1976 • 26 citations

Dynamic Changes of Serum Gamma-Glutamyl Transferase in Chronic Alcoholism

1979 • 26 citations

Decreased plasma half-life of phenylbutazone in workers exposed to chlorinated pesticides

1973 • 26 citations

Changes in Amylase, Hepatic Enzymes and Bilirubin in Serum upon Initiation of Alcohol Abstinence

1979 • 26 citations

Enzyme Induction by Drugs

1978 • 25 citations

Values for urinary excretion of D-glucaric acid by normal individuals.

1974 • 25 citations

Maternal cigarette smoking, placental aryl hydrocarbon hydroxylase and neonatal size

1979 • 24 citations

URINARY d‐GLUCARIC ACID EXCRETION AND PLASMA ANTIPYRINE KINETICS DURING ENZYME INDUCTION

1974 • 22 citations

Emploi de la mesure de la γ-glutamyltranspeptidase serique pour controler le succes des cures de desintoxication anti-alcoolique

1975 • 19 citations

A gas-liquid chromatographic method for the determination of d-glucaric acid in urine

1974 • 19 citations

Rate of drug metabolism in man measured by14CO2-breath analysis

1978 • 18 citations

Significance of Increased Serum Gamma-Glutamyltransferase Activity during Long-Term Anticonvulsive Treatment. Clinical and Experimental Studies^1,2

1975 • 16 citations

Hepatic function assessed (in rats) during chemotherapy with some anti-cancer drugs.

1979 • 14 citations

6-hydroxylation of cortisol and urinary 6β-hydroxycortisol

1978 • 14 citations

The Action of Drugs on Bilirubin Metabolism in Man

1971 • 13 citations

Pitfalls in assay and interpretation of serum gammaglutamyl transpeptidase activity

1975 • 12 citations

The liver microsomal hydroxylation enzyme system. Induction and properties of the functional components.

1976 • 12 citations

Oral contraceptive‐α‐tocopherol interrelationships

1974 • 12 citations

Disease as One of Many Variables Affecting Drug Disposition and Response: Alterations of Drug Disposition in Liver Disease

1978 • 11 citations

Comparison of benzo[c]pyrene metabolism by human peripheral blood lymphocytes and monocytes

1978 • 11 citations

Increased D-glucaric acid excretion by jaundiced patients.

1978 • 7 citations

Urinary excretion of D-glucaric acid, total glucuronic acid and total porphyrins in porphyria cutanea tarda.

1978 • 4 citations

ENZYME INDUCTION AND INCREASED SERUM-TRIGLYCERIDE

1976 • 3 citations