Prediction of steady-state plasma levels of nortriptyline from single oral dose kinetics: A study in twins

Statistical methods

1967 • 19,533 citations

Biogenic Amines and Emotion

1967 • 878 citations

Relationship between Plasma Level and Therapeutic Effect of Nortriptyline

1971 • 467 citations

Steady-state plasma levels of nortriptyline in twins: Influence of genetic factors and drug therapy

1969 • 361 citations

Influence of First-Pass Effect on Availability of Drugs on Oral Administration

1971 • 264 citations

PLASMA CONCENTRATION OF AMITRIPTYLINE AND CLINICAL RESPONSE

1972 • 263 citations

Blood Levels of Drug at the Equilibrium State after Multiple Dosing

1965 • 245 citations

Correlation of Subjective Side Effects with Plasma Concentrations of Nortriptyline

1970 • 203 citations

Relationship Between Drug Concentration in Plasma or Serum and Amount of Drug in the Body

1969 • 179 citations

PLASMA-NORTRIPTYLINE LEVELS IN ENDOGENOUS DEPRESSION

1973 • 172 citations

Plasma Levels of Imipramine and Desmethylimipramine during Therapy

1967 • 137 citations

A specific gas-chromatographic method for the measurement of “steady-state” plasma levels of amitriptyline and nortriptyline in patients

1971 • 125 citations

Pharmacokinetics of desmethylimipramine and nortriptyline in man after single and multiple oral doses ? A cross-over study

1972 • 112 citations

Pharmacokinetics of nortriptyline in man after single and multiple oral doses: The predictability of steady-state plasma concentrations from single-dose plasma-level data

1972 • 99 citations

Urinary excretion of nortriptyline and five of its metabolites in man after single and multiple oral doses

1973 • 88 citations

Genetic control of nortriptyline kinetics in man: a study of relatives of propositi with high plasma concentrations.

1971 • 86 citations

A gas chromatographic method for the quantitative determination of nortriptyline and some of its metabolites in human plasma and urine

1972 • 82 citations

The availability of orally administered nortriptyline

1973 • 55 citations

INDIVIDUAL DIFFERENCES IN THE PHARMACOKINETICS OF MONOMETHYLATED TRICYCLIC ANTIDEPRESSANTS: ROLE OF GENETIC AND ENVIRONMENTAL FACTORS AND CLINICAL IMPORTANCE*

1971 • 52 citations

Quantitative Determination of Nortriptyline And Desmethylnortriptyline In Human Plasma By Combined Gas Ciiromatography - Mass Spectrometry

1971 • 49 citations

Interindividual differences in plasma protein binding of nortriptyline in man ? A twin study

1972 • 48 citations

Pharmacokinetics and Biological Effects of Nortriptyline in Man

1971 • 39 citations

SIMULTANEOUS DETERMINATION OF PORTAL VEIN AND HEPATIC ARTERY BLOOD FLOW BY INDICATOR DILUTION TECHNIQUE IN AWAKE MAN

1972 • 22 citations

Application of Clearance and Volume of Distribution to the Plateau Principles of Drugs

1970 • 7 citations