Imbalance between interleukin-1 agonists and antagonists: relationship to severity of inflammatory bowel disease

Inflammatory Bowel Disease

1991 • 1,264 citations

Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor

1990 • 1,143 citations

Coated mesalazine (5-aminosalicylic acid) versus sulphasalazine in the treatment of active ulcerative colitis: a randomised trial.

1989 • 1,035 citations

The Role of Interleukin-1 in Disease

1993 • 967 citations

Cytokines and cytokine inhibitors or antagonists in rheumatoid arthritis

1990 • 963 citations

Enhand secretion of tumour necrosis factor-alpha, IL-6, and IL-1β by isolated lamina ropria monouclear cells from patients with ulcretive cilitis and Crohn's disease

1993 • 848 citations

Interleukin-1 Receptor Antagonist

1993 • 670 citations

Molecular Cloning and Characterization of a Second Subunit of the Interleukin 1 Receptor Complex

1995 • 634 citations

Cytokines in intestinal inflammation: Pathophysiological and clinical considerations

1994 • 607 citations

Tumour necrosis factor-alpha and interferon-gamma production measured at the single cell level in normal and inflamed human intestine

1990 • 489 citations

Interleukin-1 (IL-1) receptor antagonist binds to the 80-kDa IL-1 receptor but does not initiate IL-1 signal transduction

1991 • 457 citations

Enhanced production of interleukin 1-beta by mononuclear cells isolated from mucosa with active ulcerative colitis of Crohn's disease.

1989 • 430 citations

Mucosal imbalance of IL-1 and IL-1 receptor antagonist in inflammatory bowel disease. A novel mechanism of chronic intestinal inflammation.

1995 • 400 citations

Randomised controlled trial of CDP571 antibody to tumour necrosis factor-α in Crohn's disease

1997 • 400 citations

Anticytokine Strategies in the Treatment of the Systemic Inflammatory Response Syndrome

1993 • 397 citations

The IL-1 receptor/toll-like receptor superfamily: crucial receptors for inflammation and host defense

2000 • 396 citations

Functions of interleukin 1 receptor antagonist in gene knockout and overproducing mice.

1996 • 302 citations

Binding of IL-1 alpha, IL-1 beta, and IL-1 receptor antagonist by soluble IL-1 receptors and levels of soluble IL-1 receptors in synovial fluids.

1994 • 238 citations

IL-8 as an important chemoattractant for neutrophils in ulcerative colitis and Crohn's disease

1994 • 229 citations

Soluble type II interleukin 1 (IL-1) receptor binds and blocks processing of IL-1 beta precursor and loses affinity for IL-1 receptor antagonist.

1995 • 222 citations

Increased secretion of pro-inflammatory cytokines by circulating polymorphonuclear neutrophils and regulation by interleukin 10 during intestinal inflammation

1998 • 214 citations

Functional and ethnic association of allele 2 of the interleukin-1 receptor antagonist gene in ulcerative colitis

1999 • 212 citations

Production of interleukin-1 receptor antagonist and interleukin-1 beta by peripheral blood mononuclear cells is differentially regulated

1991 • 201 citations

Localization of intestinal interleukin 1 activity and protein and gene expression to lamina propria cells

1993 • 196 citations

The Soluble Form of IL-1 Receptor Accessory Protein Enhances the Ability of Soluble Type II IL-1 Receptor to Inhibit IL-1 Action

2003 • 174 citations

Purification and characterization of a novel soluble receptor for interleukin 1.

1991 • 173 citations

The inhibitory activity of human interleukin-1 receptor antagonist is enhanced by type II interleukin-1 soluble receptor and hindered by type I interleukin-1 soluble receptor.

1995 • 161 citations

Neutralization of endogenous IL-1 receptor antagonist exacerbates and prolongs inflammation in rabbit immune colitis.

1994 • 159 citations

Elevated levels of shed type II IL-1 receptor in sepsis. Potential role for type II receptor in regulation of IL-1 responses.

1994 • 148 citations

The Regulation and Functional Consequence of Proinflammatory Cytokine Binding on Human Intestinal Epithelial Cells

1998 • 136 citations

THE ROLE OF THE MUCOSAL IMMUNE SYSTEM IN INFLAMMATORY BOWEL DISEASE

1992 • 127 citations

Identification of soluble interleukin-1 binding protein in cell-free supernatants. Evidence for soluble interleukin-1 receptor.

1990 • 115 citations

IL-1 Signaling Cascade in Liver Cells and the Involvement of a Soluble Form of the IL-1 Receptor Accessory Protein

2000 • 111 citations

Biologic effects of an interleukin‐1 receptor antagonist protein on interleukin‐1–stimulated cartilage erosion and chondrocyte responsiveness

1991 • 110 citations

Physiologic role of interleukin-1 receptor antagonist.

2000 • 106 citations

Human intestinal epithelial cells secrete interleukin-1 receptor antagonist and interleukin-8 but not interleukin-1 or interleukin-6

2000 • 104 citations

Proinflammatory cytokines differentially modulate their own expression in human intestinal mucosal mesenchymal cells

1998 • 100 citations

Colonic explant production of IL-1 and its receptor antagonist is imbalanced in inflammatory bowel disease (IBD)

1998 • 85 citations

Interleukin 1 suppresses inflammation in rabbit colitis. Mediation by endogenous prostaglandins.

1990 • 84 citations

Elevated levels of soluble interleukin-1 receptor type II and interleukin-1 receptor antagonist in patients with chronic arthritis: Correlations with markers of inflammation and joint destruction

1998 • 66 citations

Further evidence for a common mechanism for shedding of cell surface proteins

1997 • 59 citations

Effects of recombinant soluble type I interleukin-1 receptor on human inflammatory responses to endotoxin

1996 • 56 citations

A soluble form of the interleukin‐1 receptor produced by a human B cell line

1990 • 50 citations

Inflammatory bowel disease

1992 • 50 citations

Influence of Interleukin-10 on the Interleukin-1 Receptor Antagonist/Interleukin-1β Ratio in the Colonic Mucosa of Ulcerative Colitis

2001 • 41 citations

Anti- and proinflammatory cytokines in the pathogenesis of tissue damage in Crohnʼs disease

2000 • 24 citations