Anticytokine Strategies in the Treatment of the Systemic Inflammatory Response Syndrome

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

1992 • 2,495 citations

Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia

1987 • 2,492 citations

Passive Immunization Against Cachectin/Tumor Necrosis Factor Protects Mice from Lethal Effect of Endotoxin

1985 • 2,380 citations

Interleukin-1 and interleukin-1 antagonism

1991 • 2,276 citations

Detection of Circulating Tumor Necrosis Factor after Endotoxin Administration

1988 • 1,711 citations

Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1.

1986 • 1,501 citations

Cachectin: More Than a Tumor Necrosis Factor

1987 • 1,457 citations

Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts.

1985 • 1,240 citations

Interleukin-1 and Its Biologically Related Cytokines

1989 • 1,180 citations

Molecular Cloning of the Interleukin-1β Converting Enzyme

1992 • 1,115 citations

Interleukin 1 induces a shock-like state in rabbits. Synergism with tumor necrosis factor and the effect of cyclooxygenase inhibition.

1988 • 990 citations

The Role of Interleukin-1 in Disease

1993 • 967 citations

Interleukin-1 receptor antagonist reduces mortality from endotoxin shock

1990 • 865 citations

Tumor necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumor necrosis factor alpha in vitro and in vivo.

1992 • 842 citations

Increased plasma levels of interleukin-6 in sepsis [see comments]

1989 • 813 citations

Circulating Interleukin-1 and Tumor Necrosis Factor in Septic Shock and Experimental Endotoxin Fever

1990 • 765 citations

Blocking IL-1: interleukin 1 receptor antagonist in vivo and in vitro

1991 • 729 citations

Activation of Coagulation after Administration of Tumor Necrosis Factor to Normal Subjects

1990 • 681 citations

Participation of tumor necrosis factor in the mediation of gram negative bacterial lipopolysaccharide-induced injury in rabbits.

1988 • 603 citations

Interleukin 1 receptor antagonist. A new member of the interleukin 1 family.

1991 • 589 citations

Cachectin/tumor necrosis factor regulates hepatic acute-phase gene expression.

1986 • 585 citations

Cellular and molecular regulation of tumor necrosis factor-alpha production by pentoxofylline

1988 • 564 citations

Two tumor necrosis factor-binding proteins purified from human urine. Evidence for immunological cross-reactivity with cell surface tumor necrosis factor receptors.

1990 • 557 citations

Prognostic Values of Tumor Necrosis Factor/Cachectin, Interleukin-l, Interferon- , and Interferon- in the Serum of Patients with Septic Shock

1990 • 555 citations

Toward an Epidemiology and Natural History of SIRS (Systemic Inflammatory Response Syndrome)

1992 • 479 citations

A tumor necrosis factor-binding protein purified to homogeneity from human urine protects cells from tumor necrosis factor toxicity

1989 • 442 citations

A specific receptor antagonist for interleukin 1 prevents Escherichia coli ‐induced shock in rabbits

1991 • 435 citations

Interleukin 1 induces prolonged L-arginine-dependent cyclic guanosine monophosphate and nitrite production in rat vascular smooth muscle cells.

1991 • 403 citations

Regulation of fibroblast cyclooxygenase synthesis by interleukin-1.

1988 • 401 citations

Antibodies to a soluble form of a tumor necrosis factor (TNF) receptor have TNF-like activity.

1990 • 396 citations

Glucocorticoids inhibit transcriptional and post-transcriptional expression of interleukin 1 in U937 cells.

1987 • 376 citations

Biological properties of interleukin 10

1992 • 359 citations

A urine inhibitor of interleukin 1 activity that blocks ligand binding.

1987 • 351 citations

Interleukin-1 receptor blockade improves survival and hemodynamic performance in Escherichia coli septic shock, but fails to alter host responses to sublethal endotoxemia.

1992 • 338 citations

Anti-tumor necrosis factor antibody therapy fails to prevent lethality after cecal ligation and puncture or endotoxemia.

1992 • 326 citations

Coordinated antiinflammatory effects of interleukin 4: interleukin 4 suppresses interleukin 1 production but up-regulates gene expression and synthesis of interleukin 1 receptor antagonist.

1992 • 324 citations

Production of interleukin-1-receptor antagonist during experimental endotoxaemia

1991 • 311 citations

Human tumor necrosis factor potentiates human interleukin 1-mediated rat pancreatic beta-cell cytotoxicity.

1987 • 305 citations

A recombinant human receptor antagonist to interleukin 1 improves survival after lethal endotoxemia in mice.

1991 • 298 citations

Tumor Necrosis Factor: A Putative Mediator of the Sick Euthyroid Syndrome in Man*

1990 • 276 citations

A low dose of recombinant interleukin 1 protects granulocytopenic mice from lethal gram-negative infection.

1988 • 241 citations

Recombinant soluble tumor necrosis factor receptor proteins protect mice from lipopolysaccharide‐induced lethality

1991 • 239 citations

Release of soluble receptors for tumor necrosis factor (TNF) in relation to circulating TNF during experimental endotoxinemia.

1992 • 238 citations

Homogeneous interferon-inducing 22K factor is related to endogenous pyrogen and interleukin-1

1985 • 236 citations

Regulation of Alloreactivity in Vivo by a Soluble Form of the Interleukin-1 Receptor

1990 • 235 citations

Increased serum levels of soluble receptors for tumor necrosis factor in cancer patients.

1991 • 234 citations

Interleukin 1 receptor blockade attenuates the host inflammatory response.

1990 • 216 citations

Clinical pharmacology of recombinant human tumor necrosis factor in patients with advanced cancer.

1987 • 216 citations

Pharmacokinetics, safety and immunomodulatory effects of human recombinant interleukin-1 receptor antagonist in healthy humans

1992 • 214 citations

Interleukin-1 receptor antagonist circulates in experimental inflammation and in human disease

1992 • 209 citations

Streptococcal Toxic Shock Syndrome: Synthesis of Tumor Necrosis Factor and Interleukin-1 by Monocytes Stimulated with Pyrogenic Exotoxin A and Streptolysin O

1992 • 194 citations

Cytokines and their interactions with other inflammatory mediators in the pathogenesis of sepsis and septic shock

1991 • 188 citations

Inhibition of interleukin-1 by an interleukin-1 receptor antagonist prevents graft-versus-host disease

1991 • 180 citations

Sensitization and desensitization to lethal effects of tumor necrosis factor and IL-1.

1988 • 179 citations

Role of Interleukin‐l in Infectious Diseases

1992 • 178 citations

TGF-β Regulates Production of Growth Factors and TGF-β by Human Peripheral Blood Monocytes

1990 • 178 citations

Phase I-II trial of a monoclonal anti-tumor necrosis factor alpha antibody for the treatment of refractory severe acute graft-versus-host disease

1992 • 176 citations

Purification and characterization of a novel soluble receptor for interleukin 1.

1991 • 173 citations

The toxic and hematologic effects of interleukin-1 alpha administered in a phase I trial to patients with advanced malignancies.

1992 • 171 citations

Balance of synovial fluid IL-1β and IL-1 receptor antagonist and recovery from Lyme arthritis

1993 • 165 citations

Preliminary report: effects of interleukin-1 on platelet counts

1990 • 164 citations

The intratracheal administration of endotoxin and cytokines. III. The interleukin-1 (IL-1) receptor antagonist inhibits endotoxin- and IL-1-induced acute inflammation.

1991 • 157 citations

Circulating interleukin-1β and tumor necrosis factor-α concentrations after burn injury in humans

1992 • 141 citations

Modulation of endothelial cell functions by different molecular species of interleukin 1

1987 • 137 citations

Effects on leukocytes after injection of tumor necrosis factor into healthy humans

1992 • 135 citations

Type I IL-1 receptor blockade exacerbates murine listeriosis.

1992 • 131 citations

Modulation of cell proliferation and cytokine production in acute myeloblastic leukemia by interleukin-1 receptor antagonist and lack of its expression by leukemic cells

1991 • 128 citations

Comparison between effects of interleukin-1 alpha administration and sublethal endotoxemia in primates

1991 • 100 citations

Induction by Toxic-Shock-Syndrome Toxin-1 of a Circulating Tumor Necrosis Factor-Like Substance in Rabbits and of Immunoreactive Tumor Necrosis Factor and Interleukin-1 from Human Mononuclear Cells

1988 • 99 citations

An interleukin-1 receptor antagonist blocks lipopolysaccharide-induced colony-stimulating factor production and early endotoxin tolerance

1991 • 98 citations

Interleukin‐1 (IL‐1) receptor blockade reduces endotoxin and Borrelia burgdorferi ‐stimulated IL‐8 synthesis in human mononuclear cells

1992 • 85 citations

Detection of Tumor Necrosis Factor Soluble Receptor p55 in Blood Samples from Healthy and Endotoxemic Humans

1993 • 62 citations

Anti-tumor necrosis factor antibodies suppress cell-mediated immunity in vivo.

1992 • 61 citations

A trial of recombinant human interleukin‐1 in patients with severe refractory aplastic anaemia

1992 • 44 citations

Potential Treatment of Sepsis Syndrome with Cytokine-Specific Agents

1992 • 25 citations

Effects of arachidonic acid metabolites and interleukin‐1 on platelet activating factor production by hepatic sinusoidal endothelial cells from mice

1991 • 20 citations

The specific IL-1 inhibitor from the human M20 cell line is distinct from the IL-1 receptor antagonist.

1991 • 20 citations

Platelet-activating factor biosynthesis by cultured mesangial cells is modulated by proteinase inhibitors.

1992 • 14 citations

Interleukin — 8 and Related Cytokines

1993 • 9 citations