Influence of Interleukin-10 on the Interleukin-1 Receptor Antagonist/Interleukin-1β Ratio in the Colonic Mucosa of Ulcerative Colitis

Enhand secretion of tumour necrosis factor-alpha, IL-6, and IL-1β by isolated lamina ropria monouclear cells from patients with ulcretive cilitis and Crohn's disease

1993 • 848 citations

Familial Occurrence of Inflammatory Bowel Disease

1991 • 692 citations

Cytokine production by normal human monocytes: inter-subject variation and relationship to an IL-1 receptor antagonist (IL-1Ra) gene polymorphism

1995 • 543 citations

Tumour necrosis factor-alpha and interferon-gamma production measured at the single cell level in normal and inflamed human intestine

1990 • 489 citations

Enhanced production of interleukin 1-beta by mononuclear cells isolated from mucosa with active ulcerative colitis of Crohn's disease.

1989 • 430 citations

Novel genetic association between ulcerative colitis and the anti-inflammatory cytokine interleukin-1 receptor antagonist

1994 • 412 citations

Mucosal imbalance of IL-1 and IL-1 receptor antagonist in inflammatory bowel disease. A novel mechanism of chronic intestinal inflammation.

1995 • 400 citations

Immunoregulatory role of interleukin 10 in patients with inflammatory bowel disease

1995 • 368 citations

Interleukin 1 (IL-1) gene expression, synthesis, and effect of specific IL-1 receptor blockade in rabbit immune complex colitis.

1990 • 333 citations

Tumor necrosis factor-?, interleukin-1?, and interleukin-6 expression in inflammatory bowel disease

1992 • 325 citations

Cytokine messenger RNA profiles in inflammatory bowel disease mucosa detected by polymerase chain reaction amplification

1992 • 323 citations

Influence of Polymorphism in the Genes for the Interleukin (IL)-1 Receptor Antagonist and IL-1β on Tuberculosis

1999 • 288 citations

Interleukin–1 receptor antagonist gene polymorphism as a disease severity factor in systemic lupus erythematosus

1994 • 277 citations

Distinct associations of HLA Class II genes with inflammatory bowel disease

1993 • 277 citations

Functional and ethnic association of allele 2 of the interleukin-1 receptor antagonist gene in ulcerative colitis

1999 • 212 citations

Allelic polymorphism in IL-1β and IL-1 receptor antagonist (IL-1Ra) genes in inflammatory bowel disease

1995 • 203 citations

Recombinant interleukin-1 receptor antagonist blocks the proinflammatory activity of endogenous interleukin-1 in rabbit immune colitis

1992 • 189 citations

Familial empiric risk estimates of inflammatory bowel disease in Ashkenazi Jews

1989 • 174 citations

Imbalance of the interleukin 1 system in colonic mucosa—association with intestinal inflammation and interleukin 1 receptor agonist genotype 2

1997 • 160 citations

Neutralization of endogenous IL-1 receptor antagonist exacerbates and prolongs inflammation in rabbit immune colitis.

1994 • 159 citations

In Situ Expression of Interleukin-10 in Noninflamed Human Gut and in Inflammatory Bowel Disease

1998 • 152 citations

Enhanced mucosal cytokine production in inflammatory bowel disease

1992 • 151 citations

Interleukin-1 receptor antagonist allele (ILIRN*2) associated with nephropathy in diabetes mellitus

1996 • 150 citations

Interleukin 1 receptor antagonist gene polymorphism association with lichen sclerosus

1994 • 148 citations

Ulcerative colitis: a genetically heterogeneous disorder defined by genetic (HLA class II) and subclinical (antineutrophil cytoplasmic antibodies) markers.

1993 • 143 citations

T cells of the human intestinal lamina propria are high producers of interleukin-10

1997 • 98 citations

Molecularly defined HLA-DR2 alleles in ulcerative colitis and an antineutrophil cytoplasmic antibody-positive subgroup

1995 • 75 citations

Mechanisms of IL-10 Production in Human Microglia-T Cell Interaction

1999 • 73 citations

Effects of granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-2, interferon-gamma (IFN-γ), tumour necrosis factor-alpha (TNF-α) and IL-6 on the production of immunoreactive IL-1 and TNF-α by human monocytes

1991 • 56 citations

Colonic Mucosal Interleukin 1 Receptor Antagonist in Inflammatory Bowel Disease

1994 • 44 citations

Triggering of CD23b antigen by anti‐CD23 monoclonal antibodies induces interleukin‐10 production by human macrophages

1996 • 36 citations

Regulatory effects of T cell lymphokines on cytokine gene expression in monocytes.

1993 • 29 citations

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