Soluble type II interleukin 1 (IL-1) receptor binds and blocks processing of IL-1 beta precursor and loses affinity for IL-1 receptor antagonist.

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

1992 • 2,495 citations

Interleukin-1 and interleukin-1 antagonism

1991 • 2,276 citations

Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor

1990 • 1,143 citations

Molecular Cloning of the Interleukin-1β Converting Enzyme

1992 • 1,115 citations

Viral inhibition of inflammation: Cowpox virus encodes an inhibitor of the interleukin-1β converting enzyme

1992 • 981 citations

Interleukin-1 Type II Receptor: A Decoy Target for IL-1 That Is Regulated by IL-4

1993 • 972 citations

cDNA Expression Cloning of the IL-1 Receptor, a Member of the Immunoglobulin Superfamily

1988 • 896 citations

A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types.

1991 • 677 citations

Interleukin 1 signaling occurs exclusively via the type I receptor.

1993 • 609 citations

A soluble receptor for interleukin-1β encoded by vaccinia virus: A novel mechanism of virus modulation of the host response to infection

1992 • 475 citations

The interleukin-1 receptor binds the human interleukin-1 alpha precursor but not the interleukin-1 beta precursor.

1987 • 342 citations

Interleukin-1 receptor antagonist competitively inhibits the binding of interleukin-1 to the type II interleukin-1 receptor

1991 • 262 citations

The kinetics of interleukin 1 secretion from activated monocytes. Differences between interleukin 1 alpha and interleukin 1 beta.

1988 • 249 citations

Processing of precursor interleukin 1 beta and inflammatory disease.

1990 • 217 citations

Interleukin 1 induces NF-kappa B through its type I but not its type II receptor in lymphocytes.

1992 • 212 citations

Purification and characterization of a novel soluble receptor for interleukin 1.

1991 • 173 citations

Crystal structure of the cytokine interleukin-1 beta.

1988 • 151 citations

Recombinant human interleukin-1 receptor antagonist in the treatment of steroid-resistant graft-versus-host disease

1994 • 141 citations

Identification of soluble interleukin-1 binding protein in cell-free supernatants. Evidence for soluble interleukin-1 receptor.

1990 • 115 citations

Retention of ligand binding activity by the extracellular domain of the IL-1 receptor.

1989 • 111 citations

Independent binding of interleukin-1 alpha and interleukin-1 beta to type I and type II interleukin-1 receptors.

1993 • 108 citations

Determination of the minimum polypeptide lengths of the functionally active sites of human interleukins 1 alpha and 1 beta.

1987 • 99 citations

Identification of the discontinuous binding site in human interleukin 1 beta for the type I interleukin 1 receptor.

1991 • 71 citations

A soluble binding protein specific for interleukin 1β is produced by activated mononuclear cells

1990 • 53 citations

A soluble form of the interleukin‐1 receptor produced by a human B cell line

1990 • 50 citations

Identification of an interleukin‐1 beta binding protein in human plasma

1990 • 39 citations

Cloning of rabbit interleukin-1β: differential evolution of IL-1α and IL-1β proteins

1989 • 29 citations

Mapping of neutralizing epitopes and the receptor binding site of human interleukin 1 beta

1993 • 26 citations

Structure-activity studies of human IL-1 beta with mature and truncated proteins expressed in Escherichia coli.

1988 • 24 citations

Human recombinant interleukin-1β isolated from Escherichia coli by simple osmotic shock

1990 • 22 citations

Further aspects of IL-1β secretion revealed by transfected monkey kidney cells

1992 • 2 citations