T cell receptor interaction with peptide/major histocompatibility complex (MHC) and superantigen/MHC ligands is dominated by antigen.

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

[19] Rapid and efficient site-specific mutagenesis without phenotypic selection

1987 • 5,413 citations

T Cell Growth Factor: Parameters of Production and a Quantitative Microassay for Activity

1978 • 3,314 citations

A hypothetical model of the foreign antigen binding site of Class II histocompatibility molecules

1988 • 1,161 citations

Crystal Structures of Two Viral Peptides in Complex with Murine MHC Class I H-2K ^b

1992 • 864 citations

Hybridoma cell lines secreting monoclonal antibodies to mouse H-2 and Ia antigens.

1980 • 850 citations

The outline structure of the T-cell alpha beta receptor.

1988 • 625 citations

Separation of IL-4 Production from Th Cell Proliferation by an Altered T Cell Receptor Ligand

1991 • 565 citations

Mapping T-cell receptor–peptide contacts by variant peptide immunization of single-chain transgenics

1992 • 531 citations

Structural Evidence for Induced Fit as a Mechanism for Antibody-Antigen Recognition

1992 • 519 citations

Antigen analog-major histocompatibility complexes act as antagonists of the T cell receptor

1992 • 501 citations

Superantigens interact with MHC class II molecules outside of the antigen groove

1990 • 438 citations

Correlations between T-cell specificity and the structure of the antigen receptor

1986 • 375 citations

Monoclonal antibodies against the antigen receptor on a cloned T-cell hybrid.

1983 • 293 citations

HLA-DR alleles differ in their ability to present staphylococcal enterotoxins to T cells.

1990 • 253 citations

Monoclonal antibody against an Ir gene product?

1980 • 238 citations

Intercellular Communication and Cell-Cell Adhesio n

1992 • 230 citations

Efficient cell surface expression of class II MHC molecules in the absence of associated invariant chain.

1986 • 226 citations

Expression of T Cell Antigen Receptor Heterodimers in a Lipid-Linked Form

1990 • 224 citations

Clonal analysis of B- and T-cell responses to Ia antigens

1981 • 205 citations

A single amino acid change in a myelin basic protein peptide confers the capacity to prevent rather than induce experimental autoimmune encephalomyelitis.

1991 • 165 citations

Evidence that multiple residues on both the α-helices of the class I MHC molecule are simultaneously recognized by the T cell receptor

1988 • 151 citations

Expression of a class II major histocompatibility complex (MHC) heterodimer in a lipid-linked form with enhanced peptide/soluble MHC complex formation at low pH.

1991 • 143 citations

Degenerate binding of immunogenic peptides to HLA-DR proteins on B cell Srfaces

1990 • 122 citations

Identification of the staphylococcal enterotoxin A superantigen binding site in the beta 1 domain of the human histocompatibility antigen HLA-DR.

1991 • 119 citations

Physical association of CD4 with the T cell receptor.

1992 • 116 citations

Direct evidence for functional self-protein/Ia-molecule complexes in vivo.

1988 • 111 citations

An MHC interaction site maps to the amino-terminal half of the T cell receptor α chain variable domain

1992 • 100 citations

The α1 domain of the HLA-DR molecule is essential for high-affinity binding of the toxic shock syndrome toxin-1

1990 • 100 citations

MONOCLONAL ANTI-Ia MURINE ALLOANTIBODIES CROSSREACTIVE WITH THE Ia-HOMOLOGUES OF OTHER MAMMALIAN SPECIES INCLUDING HUMANS1

1983 • 93 citations

Antigen recognition properties of mutant V beta 3+ T cell receptors are consistent with an immunoglobulin-like structure for the receptor.

1993 • 89 citations

The biologic activity of anti-T cell receptor V region monoclonal antibodies is determined by the epitope recognized.

1988 • 86 citations

The basics of binding: mechanisms of antigen recognition and mimicry by antibodies

1993 • 83 citations

The T lymphocyte response to cytochrome c. IV. Distinguishable sites on a peptide antigen which affect antigenic strength and memory.

1983 • 81 citations

Restricted V-(D)-J junctional regions in the T cell response to lambda-repressor. Identification of residues critical for antigen recognition.

1990 • 76 citations

T lymphocyte response to bacteriophage lambda repressor cI protein. Recognition of the same peptide presented by Ia molecules of different haplotypes.

1987 • 68 citations

Functionally distinct agretopic and epitopic sites. Analysis of the dominant T cell determinant of moth and pigeon cytochromes c with the use of synthetic peptide antigens.

1987 • 65 citations

Activation of Polyphosphoinositide Hydrolysis in T Cells by H-2 Alloantigen But Not MLS Determinants

1990 • 59 citations

T cell receptor gene usage in the response to lambda repressor cI protein. An apparent bias in the usage of a V alpha gene element.

1988 • 54 citations

Conventional antigen and superantigen may be coupled to distinct and cooperative T-cell activation pathways.

1991 • 46 citations

The T lymphocyte response to cytochrome c—II.

1980 • 43 citations

Functional analysis of the antigen binding site on the T cell receptor alpha chain.

1992 • 39 citations

Amino acid substitutions in the first complementarity-determining region of a murine T-cell receptor alpha chain affect antigen-major histocompatibility complex recognition.

1990 • 29 citations

Superantigen staphylococcal enterotoxin B-induced T-helper cell activation is independent of CD4 molecules and phosphatidylinositol hydrolysis.

1992 • 25 citations