Regulation of fatty acid transporters in mammalian cells

mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer.

1994 • 2,176 citations

THE CAVEOLAE MEMBRANE SYSTEM

1998 • 1,947 citations

Oxidized LDL Regulates Macrophage Gene Expression through Ligand Activation of PPARγ

1998 • 1,819 citations

PPARγ Promotes Monocyte/Macrophage Differentiation and Uptake of Oxidized LDL

1998 • 1,771 citations

Caveolins, a Family of Scaffolding Proteins for Organizing “Preassembled Signaling Complexes” at the Plasma Membrane

1998 • 1,502 citations

CD36 is a receptor for oxidized low density lipoprotein

1993 • 1,271 citations

Starvation in Man

1970 • 1,242 citations

PPARalpha and PPARgamma activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene.

1996 • 1,169 citations

Cloning of a rat adipocyte membrane protein implicated in binding or transport of long-chain fatty acids that is induced during preadipocyte differentiation. Homology with human CD36.

1993 • 982 citations

The mouse peroxisome proliferator activated receptor recognizes a response element in the 5′ flanking sequence of the rat acyl CoA oxidase gene.

1992 • 903 citations

Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein

1994 • 854 citations

A Null Mutation in Murine CD36 Reveals an Important Role in Fatty Acid and Lipoprotein Metabolism

1999 • 758 citations

Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats

1999 • 739 citations

PPARγ2 Regulates Adipose Expression of the Phosphoenolpyruvate Carboxykinase Gene

1995 • 565 citations

Coordinate Regulation of the Expression of the Fatty Acid Transport Protein and Acyl-CoA Synthetase Genes by PPARα and PPARγ Activators

1997 • 533 citations

Expression of Putative Fatty Acid Transporter Genes Are Regulated by Peroxisome Proliferator-activated Receptor α and γ Activators in a Tissue- and Inducer-specific Manner

1998 • 526 citations

Isolation of the thrombospondin membrane receptor.

1987 • 518 citations

Identification of glycoprotein IV (CD36) as a primary receptor for platelet-collagen adhesion

1989 • 490 citations

Membrane glycoprotein CD36: a review of its roles in adherence, signal transduction, and transfusion medicine

1992 • 485 citations

CD36 directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes

1989 • 474 citations

Respiratory capacity of white, red, and intermediate muscle: adaptative response to exercise

1972 • 444 citations

A family of fatty acid transporters conserved from mycobacterium to man

1998 • 422 citations

Membrane glycoprotein CD36: a review of its roles in adherence, signal transduction, and transfusion medicine

1992 • 400 citations

Identification of the Major Intestinal Fatty Acid Transport Protein

1999 • 397 citations

Cellular uptake and intracellular trafficking of long chain fatty acids

1999 • 380 citations

Cloning of a Protein That Mediates Transcriptional Effects of Fatty Acids in Preadipocytes

1995 • 368 citations

Muscle-specific Overexpression of FAT/CD36 Enhances Fatty Acid Oxidation by Contracting Muscle, Reduces Plasma Triglycerides and Fatty Acids, and Increases Plasma Glucose and Insulin

1999 • 361 citations

Isolation and partial characterization of a fatty acid binding protein in rat liver plasma membranes.

1985 • 352 citations

Reduced uptake of oxidized low density lipoproteins in monocyte-derived macrophages from CD36-deficient subjects.

1995 • 335 citations

Membrane transport of long-chain fatty acids: evidence for a facilitated process

1998 • 323 citations

Control of Human Muscle-type Carnitine Palmitoyltransferase I Gene Transcription by Peroxisome Proliferator-activated Receptor

1998 • 318 citations

Fatty acid transport: difficult or easy?

1998 • 315 citations

The peroxisome proliferator-activated receptor mediates the induction of CYP4A6, a cytochrome P450 fatty acid omega-hydroxylase, by clofibric acid.

1992 • 312 citations

Unbound free fatty acid levels in human serum.

1995 • 310 citations

Effects of endotoxin and cytokines on lipid metabolism

1994 • 308 citations

How are free fatty acids transported in membranes? Is it by proteins or by free diffusion through the lipids?

1999 • 306 citations

Movement of fatty acids, fatty acid analogs, and bile acids across phospholipid bilayers

1993 • 301 citations

Permeation of long-chain fatty acid into adipocytes. Kinetics, specificity, and evidence for involvement of a membrane protein.

1984 • 287 citations

Differentiation-Dependent Expression of the Brown Adipocyte Uncoupling Protein Gene: Regulation by Peroxisome Proliferator-Activated Receptor γ

1996 • 271 citations

Native and Modified Low Density Lipoproteins Increase the Functional Expression of the Macrophage Class B Scavenger Receptor, CD36

1997 • 266 citations

Identification of a Functional Peroxisome Proliferator-responsive Element in the Murine Fatty Acid Transport Protein Gene

1999 • 266 citations

Mechanism of long chain fatty acid permeation in the isolated adipocyte.

1981 • 262 citations

Oxidized LDL Binds to CD36 on Human Monocyte-Derived Macrophages and Transfected Cell Lines

1995 • 261 citations

Regulated expression of CD36 during monocyte-to-macrophage differentiation: potential role of CD36 in foam cell formation

1996 • 260 citations

Book ReviewObesity.

1970 • 244 citations

Identification of a peroxisome proliferator-responsive element upstream of the gene encoding rat peroxisomal enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase.

1992 • 233 citations

Expression of the CD36 homolog (FAT) in fibroblast cells: effects on fatty acid transport.

1996 • 233 citations

The Fatty Acid Transport Protein (FATP1) Is a Very Long Chain Acyl-CoA Synthetase

1999 • 227 citations

Identification, isolation, and partial characterization of a fatty acid binding protein from rat jejunal microvillous membranes.

1985 • 227 citations

Uptake of fatty acids by jejunal mucosal cells is mediated by a fatty acid binding membrane protein.

1988 • 219 citations

Reversible Binding of Long-chain Fatty Acids to Purified FAT, the Adipose CD36 Homolog

1996 • 217 citations

Fatty acid uptake by isolated rat heart myocytes represents a carrier-mediated transport process.

1988 • 214 citations

Hepatocellular uptake of oleate is energy dependent, sodium linked, and inhibited by an antibody to a hepatocyte plasma membrane fatty acid binding protein.

1986 • 210 citations

Localization and Regulation of the Putative Membrane Fatty‐Acid Transporter (FAT) in the Small Intestine

1996 • 204 citations

Binding of sulfosuccinimidyl fatty acids to adipocyte membrane proteins: Isolation and ammo-terminal sequence of an 88-kD protein implicated in transport of long-chain fatty acids

1993 • 202 citations

Protein-mediated palmitate uptake and expression of fatty acid transport proteins in heart giant vesicles

1999 • 202 citations

Identification of Caveolin-1 as a Fatty Acid Binding Protein

1999 • 200 citations

Two -acting regulatory sequences in the peroxisome proliferator-responsive enhancer region of rat acyl-CoA oxidase gene

1991 • 198 citations

Glycoprotein IV mediates thrombospondin-dependent platelet-monocyte and platelet-U937 cell adhesion.

1989 • 198 citations

Labeling of adipocyte membranes by sulfo-N-succinimidyl derivatives of long-chain fatty acids: Inhibition of fatty acid transport

1991 • 191 citations

Oleate uptake by cardiac myocytes is carrier mediated and involves a 40-kD plasma membrane fatty acid binding protein similar to that in liver, adipose tissue, and gut.

1988 • 190 citations

Identification and characterization of DNA elements implicated in the regulation of CYP4A1 transcription

1995 • 185 citations

Voltage—clamp analysis of the early current in frog skeletal muscle fibre using the double sucrose‐gap method

1972 • 184 citations

Uptake and metabolism of palmitate by isolated cardiac myocytes from adult rats: involvement of sarcolemmal proteins

1997 • 182 citations

Tumor necrosis factor mediates the effects of endotoxin on cholesterol and triglyceride metabolism in mice.

1993 • 181 citations

Heart CD36 expression is increased in murine models of diabetes and in mice fed a high fat diet.

1995 • 177 citations

Association and Coexpression of Fatty-Acid-Binding Protein and Glycoprotein CD36 in the Bovine Mammary Gland

1995 • 171 citations

Identification of a Peroxisome Proliferator-responsive Element Upstream of the Human Peroxisomal Fatty Acyl Coenzyme A Oxidase Gene

1996 • 167 citations

Regulation of Monocyte CD36 and Thrombospondin-1 Expression by Soluble Mediators

1996 • 166 citations

Disruption of the Saccharomyces cerevisiae Homologue to the Murine Fatty Acid Transport Protein Impairs Uptake and Growth on Long-chain Fatty Acids

1997 • 165 citations

A role for fatty acids and liver fatty acid binding protein in peroxisome proliferation?

1992 • 164 citations

Uptake of oleate by isolated rat adipocytes is mediated by a 40-kDa plasma membrane fatty acid binding protein closely related to that in liver and gut.

1988 • 163 citations

Mechanisms of cellular uptake of long chain free fatty acids.

1999 • 160 citations

[60] Antioxidant effectiveness in ischemia-reperfusion tissue injury

1994 • 159 citations

The peroxisome proliferator activated receptor regulates malic enzyme gene expression.

1994 • 157 citations

Molecular Cloning of cDNA Encoding Rat Very Long-chain Acyl-CoA Synthetase

1996 • 154 citations

Putative Membrane Fatty Acid Translocase and Cytoplasmic Fatty-Acid-Binding Protein Are Co-expressed in Rat Heart and Skeletal Muscles

1995 • 153 citations

Plasma membrane fatty acid-binding protein and mitochondrial glutamic-oxaloacetic transaminase of rat liver are related.

1990 • 151 citations

3T3 fibroblasts transfected with a cDNA for mitochondrial aspartate aminotransferase express plasma membrane fatty acid-binding protein and saturable fatty acid uptake.

1995 • 151 citations

Disruption of the Saccharomyces cerevisiae FAT1 Gene Decreases Very Long-chain Fatty Acyl-CoA Synthetase Activity and Elevates Intracellular Very Long-chain Fatty Acid Concentrations

1998 • 149 citations

Human Very-Long-Chain Acyl-CoA Synthetase: Cloning, Topography, and Relevance to Branched-Chain Fatty Acid Metabolism

1999 • 146 citations

Hepatocellular influx of [14C]oleate reflects membrane transport rather than intracellular metabolism or binding.

1986 • 143 citations

Membrane Associated Fatty Acid Binding Protein (FABPpm) in Human Skeletal Muscle Is Increased by Endurance Training

1997 • 141 citations

Structural organization of the gene for human CD36 glycoprotein.

1994 • 139 citations

Serum Activity of Mitochondrial Aspartate Aminotransferase: A Sensitive Marker of Alcoholism With or Without Alcoholic Hepatitis

1984 • 139 citations

Uptake of Long Chain Free Fatty Acids Is Selectively Up-regulated in Adipocytes of Zucker Rats with Genetic Obesity and Non-insulin-dependent Diabetes Mellitus

1997 • 138 citations

Ryanodine Receptor-Ankyrin Interaction Regulates Internal Ca2+ Release in Mouse T-lymphoma Cells

1995 • 137 citations

Fatty acids in cell signalling: Modulation by lipid binding proteins

1995 • 136 citations

Induction of the rat Cu/Zn superoxide dismutase gene through the peroxisome proliferator-responsive element by arachidonic acid

1999 • 120 citations

Transfer of oleic acid between albumin and phospholipid vesicles.

1986 • 116 citations

Regulation of FAT/CD36 gene expression: further evidence in support of a role of the protein in fatty acid binding/transport

1997 • 111 citations

Identification of an insulin-responsive element in the promoter of the human gene for insulin-like growth factor binding protein-1

1993 • 111 citations

Regulation of putative fatty acid transporters and Acyl-CoA synthetase in liver and adipose tissue in ob/ob mice.

1999 • 110 citations

Regulation of Phosphoenolpyruvate Carboxykinase Gene Expression by Insulin. Use of the Stable Transfection Approach to Locate an Insulin Responsive Sequence

1990 • 109 citations

Fatty acid uptake by Caco-2 human intestinal cells

1996 • 107 citations

Xenopus peroxisome proliferator activated receptors: Genomic organization, response element recognition, heterodimer formation with retinoid X receptor and activation by fatty acids

1993 • 106 citations

Fatty Acids Enter Cells by Simple Diffusion

1996 • 104 citations

Saturation kinetics of palmitate uptake in perfused skeletal muscle

1991 • 102 citations

Adipocyte differentiation of 3T3-L1 cells involves augmented expression of a 43-kDa plasma membrane fatty acid-binding protein.

1992 • 98 citations

Photoaffinity labeling and fatty acid permeation in 3T3-L1 adipocytes.

1991 • 98 citations

Pathophysiology of Reperfusion Injury

1992 • 97 citations

Identification of a Domain (155–183) on CD36 Implicated in the Phagocytosis of Apoptotic Neutrophils

1996 • 96 citations

Cellular cholesterol regulates expression of the macrophage type B scavenger receptor, CD36

1999 • 92 citations

Lovastatin reduces expression of the combined adhesion and scavenger receptor CD36 in human monocytic cells

1996 • 90 citations

Molecular mechanism of cellular uptake and intracellular translocation of fatty acids

1997 • 88 citations

Substitution of Alanine for Serine 250 in the Murine Fatty Acid Transport Protein Inhibits Long Chain Fatty Acid Transport

1998 • 86 citations

CD36 mediates long-chain fatty acid transport in human myocardium: Complete myocardial accumulation defect of radiolabeled long-chain fatty acid analog in subjects with CD36 deficiency

1999 • 86 citations

Cardiac SPECT with iodine-123-labeled fatty acids: evaluation of myocardial viability with BMIPP.

1995 • 85 citations

Ethanol up-regulates fatty acid uptake and plasma membrane expression and export of mitochondrial aspartate aminotransferase in HepG2 cells

1998 • 81 citations

Chronic muscle stimulation increases lactate transport in rat skeletal muscle

1996 • 79 citations

Evidence that the lipid moiety of oxidized low density lipoprotein plays a role in its interaction with macrophage receptors

1998 • 79 citations

Untitled

1999 • 75 citations

Alterations in Lipid and Carbohydrate Metabolism in Sepsis

1988 • 73 citations

Regulation of the murine adipocyte fatty acid transporter gene by insulin.

1996 • 72 citations

Fasting increases plasma membrane fatty acid-binding protein (FABP(PM)) in red skeletal muscle.

1997 • 71 citations

A sensitive immunoassay for rat fatty acid translocase (CD36) using phage antibodies selected on cell transfectants: abundant presence of fatty acid translocase/CD36 in cardiac and red skeletal muscle and up-regulation in diabetes

1999 • 68 citations

Regulated expression of the human acetylated low density lipoprotein receptor gene and isolation of promoter sequences.

1992 • 66 citations

Membrane‐associated and cytoplasmic fatty acid‐binding proteins

1996 • 63 citations

Recombinant Glutathione S-Transferase/CD36 Fusion Proteins Define an Oxidized Low Density Lipoprotein-binding Domain

1998 • 63 citations

The cyclic adenosine 3',5'-monophosphate- and the glucocorticoid-dependent enhancers are targets for insulin repression of tyrosine aminotransferase gene transcription.

1994 • 61 citations

Human very long-chain acyl-CoA synthetase and two human homologs: initial characterization and relationship to fatty acid transport protein

1999 • 59 citations

Selective inhibition of long-chain fatty acid uptake in short-term cultured rat hepatocytes by an antibody to the rat liver plasma membrane fatty acid-binding protein

1986 • 59 citations

Tumor necrosis factor mediates the effects of endotoxin on cholesterol and triglyceride metabolism in mice

1993 • 57 citations

Fatty acid transporters in animal cells

1997 • 55 citations

Selective Up-regulation of Fatty Acid Uptake by Adipocytes Characterizes Both Genetic and Diet-induced Obesity in Rodents

1999 • 55 citations

Mitochondrial Aspartate Aminotransferase Expressed on the Surface of 3T3-L1 Adipocytes Mediates Saturable Fatty Acid Uptake

1995 • 53 citations

Characterization of the Murine Fatty Acid Transport Protein Gene and Its Insulin Response Sequence

1998 • 52 citations

Enhanced myocardial glucose use in patients with a deficiency in long-chain fatty acid transport (CD36 deficiency).

1999 • 50 citations

A Single Nucleotide Insertion in Codon 317 of the CD36 Gene Leads to CD36 Deficiency

1996 • 49 citations

Cooperative Formation of Higher Order Peroxisome Proliferator-activated Receptor and Retinoid X Receptor Complexes on the Peroxisome Proliferator Responsive Element of the Rat Hydratase-Dehydrogenase Gene

1995 • 47 citations

Lipoproteins modulate expression of the macrophage scavenger receptor.

1998 • 47 citations

Fatty acids bound to unilamellar lipid vesicles as substrates for microsomal acyl-CoA ligase

1985 • 46 citations

A Novel Relative of the Very-Long-Chain Acyl-CoA Synthetase and Fatty Acid Transporter Protein Genes with a Distinct Expression Pattern

1998 • 46 citations

In vivo effects of interferon-alpha and interferon-gamma on lipolysis and ketogenesis.

1992 • 44 citations

CD36 Abnormality and Impaired Myocardial Long-Chain Fatty Acid Uptake in Patients With Hypertrophic Cardiomyopathy

1998 • 44 citations

Tissue distribution and cDNA cloning of a human fatty acid transport protein (hsFATP4)

1998 • 42 citations

Absent myocardial iodine-123-BMIPP uptake and platelet/monocyte CD36 deficiency.

1998 • 41 citations

Molecular cloning of fatty acid-transport protein cDNA from rat

1997 • 39 citations

Diffication of high affinity fatty acid receptors in rat myocardial sarcolemmal membranes

1987 • 38 citations

Introduction How Do Long-Chain Free Fatty Acids Cross Cell Membranes?

1996 • 38 citations

Stable transfection of fatty acid translocase (CD36) in a rat heart muscle cell line (H9c2)

1998 • 38 citations

Isolation and Partial Characterization of an Amphiphilic 56-kDa Fatty Acid Binding Protein from Rat Renal Basolateral Membrane

1987 • 37 citations

Protein-Mediated Facilitated Uptake Processes for Fatty Acids, Bilirubin, and Other Amphipathic Compounds

1996 • 37 citations

Family Studies of Type II CD36 Deficient Subjects: Linkage of a CD36 Allele to a Platelet-Specific mRNA Expression Defect(s) Causing Type II CD36 Deficiency

1995 • 35 citations

The membrane-associated 40 KD fatty acid binding protein (Berk's protein), a putative fatty acid transporter is present in human skeletal muscle

1995 • 35 citations

Characterization of Membrane Transport Processes: Lessons from the Study of BSP, Bilirubin, and Fatty Acid Uptake

1996 • 33 citations

Identification of high affinity membrane-bound fatty acid-binding proteins using a photoreactive fatty acid

1993 • 33 citations

Regulation of cytosolic aspartate aminotransferase mRNAs in the Fao rat hepatoma cell line by dexamethasone, insulin and cyclic AMP

1989 • 32 citations

Constitutive expression of a saturable transport system for non-esterified fatty acids in Xenopus laevis oocytes

1994 • 30 citations

Labelling of an 88 kDa adipocyte membrane protein by sulpho-N-succinimidyl long-chain fatty acids: inhibition of fatty acid transport

1992 • 28 citations

Regulatory elements in the promoter region of the rat gene encoding the acyl-CoA-binding protein

1996 • 26 citations

Regulation of the murine adipocyte fatty acid transporter gene by insulin

1996 • 26 citations

Expression and Regulation of mRNA for Putative Fatty Acid Transport Related Proteins and Fatty Acyl CoA Synthase in Murine Epidermis and Cultured Human Keratinocytes

1998 • 23 citations

Isolation of pig mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene promoter: characterization of a peroxisome proliferator-responsive element

1999 • 23 citations

Membrane permeation and intracellular trafficking of long chain fatty acids: insights fromEscherichia coliand 3T3-L1 adipocytes

1995 • 22 citations

The cyclic adenosine 3',5'-monophosphate- and the glucocorticoid- dependent enhancers are targets for insulin repression of tyrosine aminotransferase gene transcription

1994 • 22 citations

A sensitive immunoassay for rat fatty acid translocase (CD36) using phage antibodies selected on cell transfectants: abundant presence of fatty acid translocase/CD36 in cardiac and red skeletal muscle and up-regulation in diabetes

1999 • 21 citations

Substrate specificity of fatty-acyl-CoA ligase in liver microsomes

1985 • 21 citations

CD36 antisense expression in 3T3-F442A preadipocytes.

1999 • 21 citations

The distribution of oleic acid between chylomicron-like emulsions, phospholipid bilayers, and serum albumin. A model for fatty acid distribution between lipoproteins, membranes, and albumin.

1990 • 17 citations

An upstream region of the enoyl-coenzyme A hydratase/3-hydroxyacyl-coenzyme A dehydrogenase gene directs luciferase expression in liver in response to peroxisome proliferators in transgenic mice.

1994 • 16 citations

Scintigraphic Evidence for a Specific Long-Chain Fatty Acid Transporting System Deficit and the Genetic Background in a Patient With Hypertrophic Cardiomyopathy

1999 • 13 citations

Hepatocellular Fatty Acid Uptake Is Mediated by a Plasma Membrane Fatty Acid Binding Protein Closely Related to Mitochondrial Glutamic Oxaloacetic Transaminase^a

1990 • 10 citations

In vivo effects of interferon-alpha and interferon-gamma on lipolysis and ketogenesis

1992 • 8 citations

Isolation of pig mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene promoter: characterization of a peroxisome proliferator-responsive element

1999 • 6 citations

Molecular cloning, sequencing and expression analysis of a fatty acid transport gene in rat heart induced by ischemic preconditiong and oxidative stress

1996 • 6 citations