Isolation of pig mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene promoter: characterization of a peroxisome proliferator-responsive element

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

1989 • 7,496 citations

Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ

1997 • 2,105 citations

Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ

1997 • 2,100 citations

CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements

1987 • 1,792 citations

Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling

1992 • 1,514 citations

Regulation of Hepatic Fatty Acid Oxidation and Ketone Body Production

1980 • 1,430 citations

Differential expression and activation of a family of murine peroxisome proliferator-activated receptors.

1994 • 1,410 citations

Activation of the Nuclear Receptor LXR by Oxysterols Defines a New Hormone Response Pathway

1997 • 1,207 citations

Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression

1996 • 1,201 citations

Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor.

1992 • 863 citations

A versatilein vivoandin vitroeukaryotic expression vector for protein engineering

1988 • 686 citations

Adaptations of glucose and fatty acid metabolism during perinatal period and suckling-weaning transition

1992 • 481 citations

Peroxisome proliferator-activated receptor mediates induction of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by fatty acids.

1994 • 380 citations

Oligodeoxyribonucleotide ligation to single-stranded cDNAs: a new tool for cloning 5′ ends of mRNAs and for constructing cDNA libraries byin vitroamplification

1991 • 312 citations

Novel Sequence Determinants in Peroxisome Proliferator Signaling

1995 • 285 citations

Target Detection Assay (TDA): a versatile procedure to determine DNA blinding sites as demonstrated on SP1 protein

1990 • 229 citations

Activity and intracellular distribution of enzymes of ketone-body metabolism in rat liver

1968 • 199 citations

Role of the peroxisome proliferator‐activated receptor in cytochrome P450 4A gene regulation

1996 • 178 citations

Peroxisome proliferator-activated receptors: finding the orphan a home

1994 • 157 citations

Fatty acid activation of peroxisome proliferator-activated receptor (PPAR)

1995 • 134 citations

Expression of liver carnitine palmitoyltransferase I and II genes during development in the rat

1994 • 95 citations

Starvation hypoglycemia in newborn pigs

1968 • 92 citations

Developmental changes in mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene expression in rat liver, intestine and kidney

1993 • 85 citations

Rat mitochondrial and cytosolic 3-hydroxy-3-methylglutaryl-CoA synthases are encoded by two different genes.

1990 • 85 citations

Regulation of the expression of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene. Its role in the control of ketogenesis

1992 • 79 citations

Crosstalk between the thyroid hormone and peroxisome proliferator-activated receptors in regulating peroxisome proliferator-responsive genes

1996 • 72 citations

Transcriptional Control of a Nuclear Gene Encoding a Mitochondrial Fatty Acid Oxidation Enzyme in Transgenic Mice: Role for Nuclear Receptors in Cardiac and Brown Adipose Expression

1996 • 70 citations

Rate-limiting function of 3-hydroxy-3-methylglutaryl-coenzyme A synthase in ketogenesis

1979 • 63 citations

Metabolic effects of starvation during neonatal period in the piglet

1970 • 59 citations

Regulation of Mitochondrial 3-Hydroxy-3-methylglutaryl-coenzyme A Synthase Protein by Starvation, Fat Feeding, and Diabetes

1993 • 53 citations

Metabolic fate of non-esterified fatty acids in isolated hepatocytes from newborn and young pigs. Evidence for a limited capacity for oxidation and increased capacity for esterification

1983 • 50 citations

Hepatic ketogenesis in newborn pigs is limited by low mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase activity

1994 • 48 citations

Developmental changes in carnitine palmitoyltransferases I and II gene expression in intestine and liver of suckling rats

1995 • 46 citations

Some Aspects of Fatty Acid Oxidation and Ketone Body Formation and Utilization during Development of the Rat

1973 • 44 citations

Plasma Levels of FFA, Glycerol, β-Hydroxybutyrate and Blood Glucose during the Postnatal Development of the Pig

1969 • 41 citations

Enzymes involved in acetoacetate formation in various bovine tissues

1970 • 40 citations

Changes in circulating fuels, pancreatic hormones and liver glycogen concentration in fasting or suckling newborn pigs.

1981 • 38 citations

Carnitine palmitoyltransferase modulation of hepatic fatty acid metabolism and radio-HPLC evidence for low ketogenesis in neonatal pigs.

1995 • 38 citations

Ketogenic Mitochondrial 3-Hydroxy 3-Methylglutaryl-CoA Synthase Gene Expression in Intestine and Liver of Suckling Rats

1993 • 36 citations

Transactivation of the peroxisome proliferator-activated receptor is differentially modulated by hepatocyte nuclear factor-4.

1994 • 36 citations

The rat mitochondrial 3‐hydroxy‐3‐methylglutaryl‐coenzyme‐A‐synthase gene contains elements that mediate its multihormonal regulation and tissue specificity

1993 • 34 citations

Chicken ovalbumin upstream-promoter transcription factor (COUP-TF) could act as a transcriptional activator or repressor of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene

1997 • 31 citations

Gene expression of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase in a poorly ketogenic mammal: effect of starvation during the neonatal period of the piglet

1997 • 24 citations

Acetate represents a major product of heptanoate and octanoate β-oxidation in hepatocytes isolated from neonatal piglets

1996 • 22 citations

Activity and expression of hepatic mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase during the starved-to-fed transition

1990 • 17 citations

Cloning and characterization of the human mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase gene

1997 • 15 citations

The effect of fasting and insulin treatment on carnitine palmitoyl transferase I and mitochondrial 3-hydroxy-3-methylglutaryl coenzyme A synthase mRNA levels in liver from suckling rats

1995 • 10 citations

Interplay of the Peroxisome Proliferator‐activated Receptor and the Thyroid Hormone Receptor‐signaling Pathways in Regulating Peroxisome Proliferator–responsive Genes^a

1996 • 9 citations