The influence of chemical sympathectomy on pain responsivity and α2-adrenergic antinociception in neuropathic animals

An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat

1992 • 3,001 citations

The glucose oxidase-DAB-nickel method in peroxidase histochemistry of the nervous system

1988 • 1,235 citations

The Neuron-Specific Protein PGP 9.5 Is a Ubiquitin Carboxyl-Terminal Hydrolase

1989 • 864 citations

Central changes in processing of mechanoreceptive input in capsaicin‐induced secondary hyperalgesia in humans.

1992 • 785 citations

Peripheral nerve injury triggers noradrenergic sprouting within dorsal root ganglia

1993 • 730 citations

Adrenergic Excitation of Cutaneous Pain Receptors Induced by Peripheral Nerve Injury

1991 • 599 citations

Distributions of mRNAs for alpha‐2 adrenergic receptor subtypes in rat brain: An in situ hybridization study

1993 • 458 citations

Nociceptive responses to high and low rates of noxious cutaneous heating are mediated by different nociceptors in the rat: behavioral evidence

1996 • 392 citations

Topical application of clonidine relieves hyperalgesia in patients with sympathetically maintained pain

1991 • 385 citations

Uninjured C-Fiber Nociceptors Develop Spontaneous Activity and α-Adrenergic Sensitivity Following L₆ Spinal Nerve Ligation in Monkey

1999 • 280 citations

Pathophysiology of damaged nerves in relation to chronic pain

1999 • 269 citations

Nociceptive responses to high and low rates of noxious cutaneous heating are mediated by different nociceptors in the rat: electrophysiological evidence

1996 • 267 citations

Noradrenaline-evoked pain in neuralgia

1995 • 241 citations

Reversal of nerve ligation-induced allodynia by spinal alpha-2 adrenoceptor agonists.

1995 • 216 citations

Effects of sympathectomy on a rat model of peripheral neuropathy

1993 • 212 citations

Sympathetic and afferent somata projecting in hindlimb nerves and the anatomical organization of the lumbar sympathetic nervous system of the rat

1988 • 199 citations

Sympathetic sprouting in the dorsal root ganglia of the injured peripheral nerve in a rat neuropathic pain model

1996 • 183 citations

Abnormalities of sympathetic innervation in the area of an injured peripheral nerve in a rat model of neuropathic pain

1993 • 162 citations

Expression of α₂‐adrenergic receptors in rat primary afferent neurones after peripheral nerve injury or inflammation

1999 • 145 citations

Adrenoreceptor subtype mediating sympathetic-sensory coupling in injured sensory neurons

1996 • 131 citations

Effects of electrical and mechanical stimulation on two foci of spontaneous activity which develop in primary afferent neurons after peripheral axotomy

1984 • 124 citations

Antinociception induced by alpha-2-adrenoceptor agonists, with special emphasis on medetomidine studies

1993 • 124 citations

The Analgesic Potency of Dexmedetomidine Is Enhanced After Nerve Injury

1998 • 122 citations

Abnormal spontaneous activity and responses to norepinephrine in dissociated dorsal root ganglion cells after chronic nerve constriction

1996 • 115 citations

Sensory and sympathetic contributions to nerve injury-induced sensory abnormalities in the rat

1995 • 108 citations

Lumbar sympathectomy failed to reverse mechanical allodynia- and hyperalgesia-like behavior in rats with L5 spinal nerve injury

1999 • 94 citations

Peripheral hyperalgesia in experimental neuropathy: mediation by α2-adrenoreceptors on post-ganglionic sympathetic terminals

1995 • 88 citations

Receptor Subtype Mediating the Adrenergic Sensitivity of Pain Behavior and Ectopic Discharges in Neuropathic Lewis Rats

1999 • 86 citations

Evaluation of the effects of a specific α2-adrenoceptor antagonist, atipamezole, on α1- and α2-adrenoceptor subtype binding, brain neurochemistry and behaviour in comparison with yohimbine

1997 • 83 citations

Comparison of the behavioral and neurochemical effects of the two optical enantiomers of medetomidine, a selective alpha-2-adrenoceptor agonist.

1991 • 78 citations

The α2A adrenoceptor and the sympathetic postganglionic neuron contribute to the development of neuropathic heat hyperalgesia in mice

2000 • 76 citations

Changes in the α2-adrenergic receptor subtypes gene expression in rat dorsal root ganglion in an experimental model of neuropathic pain

1997 • 72 citations

Postsympathectomy neuralgia

1974 • 69 citations

Sympathetic nervous system: contribution to chronic pain.

2000 • 66 citations

Influence of the sympathetic nervous system in the development of abnormal pain-related behaviours in a rat model of neuropathic pain

1995 • 65 citations

Peripheral nerve injury leads to the establishment of a novel pattern of sympathetic fibre innervation in the rat skin

2000 • 64 citations

Effects of Radolmidine, A Novel α2-Adrenergic Agonist Compared with Dexmedetomidine in Different Pain Models in the Rat

2000 • 61 citations

Sympathetic nervous system: contribution to chronic pain

2000 • 61 citations

Effects of partial nerve injury on the responses of C-fiber polymodal nociceptors to adrenergic agonists

1997 • 58 citations

Strain differences in adrenergic sensitivity of neuropathic pain behaviors in an experimental rat model

1997 • 58 citations

Molecular neurobiology of pain

1998 • 57 citations

Adrenergic sensitivity of the sensory receptors modulating mechanical allodynia in a rat neuropathic pain model

1999 • 56 citations

Presence of the predicted C-flanking peptide of neuropeptide Y (CPON) in tissue extracts

1985 • 54 citations

Sympathectomy induces adrenergic excitability of cutaneous C-fiber nociceptors

1996 • 53 citations

Effects of nerve injury on sympathetic excitation of A delta mechanical nociceptors

1995 • 49 citations

Intrathecal Neostigmine, but Not Sympathectomy, Relieves Mechanical Allodynia in a Rat Model of Neuropathic Pain

1998 • 48 citations

Peripheral effects of morphine in neuropathic rats: role of sympathetic postganglionic nerve fibers

2001 • 46 citations

Mechanical hyperalgesia after spinal nerve ligation in rat is not reversed by intraplantar or systemic administration of adrenergic antagonists

1999 • 46 citations

Bildung und funktionelle Bedeutung adrenerger Ersatztransmitter

1969 • 42 citations

Spinal nerve ligation-induced neuropathy in the rat: sensory disorders and correlation between histology of the peripheral nerves

1999 • 42 citations

Postsympathectomy Neuralgia

1962 • 39 citations

PAIN IN THE LOWER LIMB AFTER SYMPATHECTOMY

1957 • 39 citations

Pathology of Peripheral Nerve

2013 • 35 citations

Involvement of α2-adrenoceptors in mediating sympathetic excitation of injured dorsal root ganglion neurons in rats with spinal nerve ligation

1997 • 33 citations

The Effects of the alpha2-Adrenergic Agonist, Dexmedetomidine, in the Spinal Nerve Ligation Model of Neuropathic Pain in Rats

1998 • 30 citations

Different roles of α2-adrenoceptors of the medulla versus the spinal cord in modulation of mustard oil-induced central hyperalgesia in rats

1996 • 27 citations

Influence of selective α2-adrenergic agents on mustard oil-induced central hyperalgesia in rats

1995 • 25 citations

Attenuation of Ascending Nociceptive Signals to the Rostroventromedial Medulla Induced by a Novel α2-Adrenoceptor Agonist, MPV-2426, following Intrathecal Application in Neuropathic Rats

2000 • 24 citations

The Effects of the alpha2-Adrenergic Agonist, Dexmedetomidine, in the Spinal Nerve Ligation Model of Neuropathic Pain in Rats

1998 • 22 citations

The Influence of Chronic Sympathectomy on Cutaneous Blood Flow in the Rat Tail.

1999 • 21 citations

Peripherally Administered alpha2-Adrenoceptor Agonist in the Modulation of Chronic Allodynia Induced by Spinal Nerve Ligation in the Rat

1997 • 17 citations

The Analgesic Potency of Dexmedetomidine Is Enhanced After Nerve Injury

1998 • 10 citations

Peripherally Administered alpha2-Adrenoceptor Agonist in the Modulation of Chronic Allodynia Induced by Spinal Nerve Ligation in the Rat

1997 • 9 citations

Can the α2-adrenoceptor agonist-mediated suppression of nocifensive reflex responses be due to action on motoneurons or peripheral nociceptors?

1995 • 9 citations

Sympathetic reflex activity and neuroeffector transmission change after chronic nerve lesions

1990 • 5 citations

Pharmacological Isolation and Characterization of NMDA Receptor-Mediated Synaptic Potential in the Dentate Gyrus of Rat Hippocampal Slices

1993 • 2 citations