Topical application of clonidine relieves hyperalgesia in patients with sympathetically maintained pain

Permeability of the skin

1971 • 1,388 citations

Peripheral and spinal mechanisms of nociception.

1987 • 1,025 citations

Ongoing activity in peripheral nerves: the physiology and pharmacology of impulses originating from a neuroma

1975 • 610 citations

Pharmacology of spinal adrenergic systems which modulate spinal nociceptive processing

1985 • 586 citations

A hypothesis on the physiological basis for causalgia and related pains

1986 • 566 citations

α-Adrenoceptor subclassification

1981 • 492 citations

Causalgia and Other Reflex Sympathetic Dystrophies

1973 • 481 citations

Alpha-adrenoceptor subclassification.

1981 • 426 citations

Spinal noradrenergic terminal system mediates antinociception

1980 • 317 citations

Goodman and Gilman's, The Pharmacological Basis of Therapeutics

1986 • 311 citations

Systemic Alpha-adrenergic Blockade with Phentolamine

1991 • 294 citations

Noradrenaline hyperalgesia is mediated through interaction with sympathetic postgahglionic neurone terminals rather than activation of primary afferent nociceptors

1986 • 286 citations

Painful peripheral states and sympathetic blocks.

1978 • 276 citations

INTRAVENOUS REGIONAL SYMPATHETIC BLOCK WITH GUANETHIDINE

1974 • 267 citations

Activation of myelinated afferents ending in a neuroma by stimulation of the sympathetic supply in the rat

1981 • 254 citations

Association of pain relief with drug side effects in postherpetic neuralgia: A single-dose study of clonidine, codeine, ibuprofen, and placebo

1988 • 251 citations

Epidural Clonidine Analgesia for Intractable Cancer Pain

1989 • 207 citations

Characterization of coeruleospinal inhibition of the nociceptive tail-flick reflex in the rat: Mediation by spinal α2-adrenoceptors

1986 • 204 citations

Sensory Functions of the Skin in Primates

1976 • 190 citations

Discharge pattern of afferent fibers from a neuroma

1984 • 170 citations

Phenoxybenzamine in the treatment of causalgia

1984 • 151 citations

Continuous intrathecal hydromorphone and clonidine for intractable cancer pain

1986 • 151 citations

Alterations in nociceptirve threshold and morphine-induced analgesia produced by intrathecally administered amine antagonists

1981 • 145 citations

Sympathetic facilitation of sustained discharges of polymodal nociceptors

1989 • 140 citations

PRELIMINARY OBSERVATIONS ON THE PATHOPHYSIOLOGY OF HYPERALGESIA IN THE CAUSALGIC PAIN SYNDROME

1976 • 136 citations

Pain and the sympathetic nervous system

1990 • 134 citations

Sympathetic Activation of A-Delta Nociceptors

1985 • 104 citations

Electrical stimulation of the upper thoracic portion of the sympathetic chain in man.

1948 • 86 citations

Painful sequelae of nerve injury

1987 • 68 citations

Clinical trial of propranolol in post-traumatic neuralgia

1982 • 55 citations

Treatment of Long-standing Causalgia with Prazosin

1981 • 44 citations