Nociceptive responses to high and low rates of noxious cutaneous heating are mediated by different nociceptors in the rat: electrophysiological evidence

A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia

1988 • 4,963 citations

Pain, hyperalgesia and activity in nociceptive C units in humans after intradermal injection of capsaicin.

1992 • 597 citations

Peripheral suppression of first pain and central summation of second pain evoked by noxious heat pulses

1977 • 583 citations

Cutaneous Mechanoreceptors and Nociceptors

1973 • 561 citations

The measurement of pain; prototype for the quantitative study of subjective responses.

1957 • 496 citations

Protons selectively induce lasting excitation and sensitization to mechanical stimulation of nociceptors in rat skin, in vitro

1992 • 490 citations

Neurogenic hyperalgesia: the search for the primary cutaneous afferent fibers that contribute to capsaicin-induced pain and hyperalgesia

1991 • 453 citations

Primary afferent units from the hairy skin of the rat hind limb

1982 • 418 citations

Cutaneous sensory receptors in the rat foot

1993 • 405 citations

Nociceptive responses to high and low rates of noxious cutaneous heating are mediated by different nociceptors in the rat: behavioral evidence

1996 • 392 citations

Response properties of thin myelinated (A-delta) fibers in human skin nerves.

1983 • 342 citations

Nervous outflow from the cat's foot during noxious radiant heat stimulation

1974 • 330 citations

Perceptual changes accompanying controlled preferential blocking of A and C fibre responses in intact human skin nerves

1973 • 323 citations

Sensory receptors in mammalian skin in an in vitro preparation

1986 • 273 citations

C nociceptor activity in human nerve during painful and non painful skin stimulation.

1981 • 263 citations

Selective excitation by capsaicin of mechano-heat sensitive nociceptors in rat skin

1988 • 241 citations

Responses of single nerve fibres to capsaicin applied to the skin

1982 • 223 citations

Mutual potentiation of antinociceptive effects of morphine and clonidine on motor and sensory responses in rat spinal cord

1987 • 221 citations

Specific sensations evoked by activity in single identified sensory units in man

1980 • 213 citations

Studies of heat pain sensation in man: perception thresholds, rate of stimulus rise and reaction time

1990 • 198 citations

Differential effects of morphine on responses of dorsal horn lamina V type cells elicited by A and C fibre stimulation in the spinal cat

1976 • 185 citations

The effect of carrageenan-induced inflammation on the sensitivity of unmyelinated skin nociceptors in the rat

1987 • 140 citations

Selective reduction of second pain sensations by systemic morphine in humans

1986 • 136 citations

Differential effects of morphine and opioid analgesics on A and C fibre-evoked activity in ascending axons of the rat spinal cord

1979 • 123 citations

Single C nociceptor responses and psychophysical parameters of evoked pain: effect of rate of rise of heat stimuli in humans.

1992 • 109 citations

The Influence of Skin Temperature upon the Pain Threshold as Evoked by Thermal Radiation

1951 • 104 citations

Characterization of the foot withdrawal response to noxious radiant heat in the rat

1994 • 101 citations

Centrifugal modulation of the rat tail flick reflex evoked by graded noxious heating of the tail

1986 • 91 citations

Presynaptic excitability changes induced by morphine in single cutaneous afferent C- and A-fibers

1979 • 86 citations

Evidence that substance P selectively modulates C-fiber-evoked discharges of dorsal horn nociceptive neurons

1990 • 85 citations

Analgesic effect of intrathecal morphine demonstrated in ascending nociceptive activity in the rat spinal cord and ineffectiveness of caerulein and cholecystokinin octapeptide

1982 • 71 citations

Primary Afferents and Hyperalgesia

1986 • 55 citations

Thermal pain in humans: influence of the rate of stimulation

1978 • 51 citations

Relative effects of intrathecal administration of fentanyl and midazolam on aδ and c fibre reflexes

1992 • 27 citations