The Effects of the alpha2-Adrenergic Agonist, Dexmedetomidine, in the Spinal Nerve Ligation Model of Neuropathic Pain in Rats

Ethical guidelines for investigations of experimental pain in conscious animals

1983 • 7,639 citations

A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man

1988 • 5,129 citations

A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia

1988 • 4,963 citations

An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat

1992 • 3,001 citations

A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury

1990 • 1,819 citations

Behavioral signs of ongoing pain and cold allodynia in a rat model of neuropathic pain

1994 • 803 citations

Pharmacology of spinal adrenergic systems which modulate spinal nociceptive processing

1985 • 586 citations

Reversal of nerve ligation-induced allodynia by spinal alpha-2 adrenoceptor agonists.

1995 • 216 citations

Effects of sympathectomy on a rat model of peripheral neuropathy

1993 • 212 citations

Spinal opioid analgesic effects are enhanced in a model of unilateral inflammation/hyperalgesia: possible involvement of noradrenergic mechanisms

1991 • 208 citations

Effects of sympathectomy in a model of causalgiform pain produced by partial sciatic nerve injury in rats

1991 • 186 citations

NMDA receptor antagonists attenuate mechanical hyperalgesia in rats with unilateral inflammation of the hindpaw

1993 • 184 citations

Spinal Antinociception by Dexmedetomidine, a Highly Selective α₂‐Adrenergic Agonist

1991 • 154 citations

Sympathectomy alleviates mechanical allodynia in an experimental animal model for neuropathy in the rat

1991 • 153 citations

Distribution and pharmacology of alpha 2-adrenoceptors in the central nervous system.

1995 • 144 citations

α 2-Adrenergic receptor subtypes in rat dorsal root and superior cervical ganglion neurons

1997 • 135 citations

Multiple alpha-2 adrenergic receptor subtypes. II. Evidence for a role of rat R alpha-2A adrenergic receptors in the control of nociception, motor behavior and hippocampal synthesis of noradrenaline.

1994 • 132 citations

The Differential Effects of Morphine and the ??2,???Adrenoceptor Agonists Clonidine and Dexrnedetornidine on the Prevention and Treatment of Experimental Neuropathic Pain

1993 • 103 citations

Effects of guanethidine on sensitization to natural stimuli and self-mutilating behaviour in rats with a peripheral neuropathy

1991 • 102 citations

Analysis of Drug Interaction between Intrathecal Clonidine and MK-801 in Peripheral Neuropathic Pain Rat Model

1995 • 75 citations

Behavioural evidence for a bidirectional effect of systemic naloxone in a model of experimental neuropathy in the rat

1989 • 53 citations

Neuropeptide FF in the Rat Spinal Cord During Carrageenan Inflammation

1997 • 52 citations

Intrathecal administration of clonidine suppresses autotomy, a behavioral sign of chronic pain in rats after sciatic nerve section

1991 • 46 citations

Adjacent neuropathic hyperalgesia in rats: A model for sympathetic independent pain

1991 • 38 citations

Analgesic Action of Acute and Chronic Intraspinally Administered Opiate and α<sub>2</sub>-Adrenergic Agonists in Chronic Neuropathic Pain

1994 • 32 citations

Pre-emptive administration of clonidine prevents development of hyperalgesia to mechanical stimuli in a model of mononeuropathy in the rat

1993 • 24 citations

Sciatic Cryoneurolysis in Rats

1995 • 22 citations

Clonidine, but Not Morphine, Delays the Development of Thermal Hyperesthesia Induced by Sciatic Nerve Constriction Injury in the Rat

1996 • 20 citations

The spinal analgesic role of α2-adrenoceptor subtypes in rats after peripheral nerve section

1994 • 17 citations

Activation of α2-adrenergic receptors decreases nerve trauma-induced afferent barrage but not autotomy

1995 • 8 citations