Distributions of mRNAs for alpha‐2 adrenergic receptor subtypes in rat brain: An in situ hybridization study

REGIONAL STUDIES OF CATECHOLAMINES IN THE RAT BRAIN‐I

1966 • 5,429 citations

Stereotaxic Mapping of the Monoamine Pathways in the Rat Brain*

1971 • 3,816 citations

Unresponsiveness to Cannabinoids and Reduced Addictive Effects of Opiates in CB ₁ Receptor Knockout Mice

1999 • 3,597 citations

A STUDY OF THE ADRENOTROPIC RECEPTORS

1948 • 2,856 citations

EVIDENCE FOR THE EXISTENCE OF MONOAMINE NEURONS IN THE CENTRAL NERVOUS SYSTEM. IV. DISTRIBUTION OF MONOAMINE NERVE TERMINALS IN THE CENTRAL NERVOUS SYSTEM.

1965 • 1,543 citations

The central adrenergic system. An immunofluorescence study of the location of cell bodies and their efferent connections in the rat utilizing dopamine‐B‐hydroxylase as a marker

1975 • 1,454 citations

Distribution of substance P-like immunoreactivity in the central nervous system of the rat—I. Cell bodies and nerve terminals

1978 • 1,426 citations

Presynaptic regulation of catecholamine release

1974 • 1,145 citations

A functional basis for classification of α-adrenergic receptors

1977 • 802 citations

A new method for receptor autoradiography: [3H]Opioid receptors in rat brain

1979 • 797 citations

Cloning, Sequencing, and Expression of the Gene Coding for the Human Platelet α ₂ -Adrenergic Receptor

1987 • 792 citations

Distribution of α2 agonist binding sites in the rat and human central nervous system: Analysis of some functional, anatomic correlates of the pharmacologic effects of clonidine and related adrenergic agents

1984 • 719 citations

Studies in the Primate on the Analgetic Effects Associated with Intrathecal Actions of Opiates,α-Adrenergic Agonists and Baclofen

1981 • 533 citations

A new major projection from locus coeruleus: The main source of noradrenergic nerve terminals in the ventral and dorsal columns of the spinal cord

1977 • 476 citations

Relative pre- and postsynaptic potencies of ?-adrenoceptor agonists in the rabbit pulmonary artery

1975 • 455 citations

Cloning and expression of a human kidney cDNA for an alpha 2-adrenergic receptor subtype.

1988 • 440 citations

Spinal cord pharmacology of adrenergic agonist-mediated antinociception.

1980 • 428 citations

Noradrenergic alpha 1 and alpha 2 receptors: light microscopic autoradiographic localization.

1980 • 421 citations

Molecular cloning and expression of the cDNA for the alpha 1A-adrenergic receptor. The gene for which is located on human chromosome 5.

1991 • 401 citations

Sub types of α2-adrenoceptors: Pharmacological and molecular biological evidence converg

1988 • 379 citations

Changes in free cytosolic Ca2+ in hepatocytes following alpha 1-adrenergic stimulation. Studies on Quin-2-loaded hepatocytes.

1983 • 375 citations

Multiple apparent alpha-noradrenergic receptor binding sites in rat brain: effect of 6-hydroxydopamine.

1979 • 362 citations

Selective reduction by noradrenaline and 5-hydroxytryptamine of nociceptive responses of cat dorsal horn neurones

1978 • 332 citations

Presynaptic receptor systems on the noradrenergic neurones of rat brain

1977 • 325 citations

Activation and attenuation of adenylate cyclase. The role of GTP-binding proteins as macromolecular messengers in receptor–cyclase coupling

1981 • 322 citations

Alpha-2A and alpha-2B adrenergic receptor subtypes: antagonist binding in tissues and cell lines containing only one subtype.

1988 • 307 citations

Distinct α-noradrenergic receptors differentiated by binding and physiological relationships

1979 • 300 citations

Role of phosphatidylinositol turnover in alpha1 and of adenylate cyclase inhibition in alpha2 effects of catecholamines

1980 • 298 citations

Alpha-noradrenergic receptor binding in mammalian brain: Differential labeling of agonist and antagonist states

1976 • 298 citations

Heterogeneity of alpha-2 adrenergic receptors

1985 • 297 citations

Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2.

1990 • 287 citations

The inhibitory action of noradrenaline and other monoamines on spinal neurones

1966 • 262 citations

An α2 receptor mediates the selective inhibition by noradrenaline of nociceptive responses of identified dorsal horn neurones

1985 • 249 citations

Vasopressin and oxytocin mRNAs in adrenalectomized and Brattleboro rats: analysis by quantitative in situ hybridization histochemistry

1986 • 246 citations

Distribution of alpha 1 adrenoceptors in rat brain revealed by in situ hybridization experiments utilizing subtype-specific probes

1994 • 245 citations

Noradrenergic inhibition of the release of substance P from the primary afferents in the rabbit spinal dorsal horn

1985 • 231 citations

Characterization of α1-and α2-Adrenergic Receptors

1983 • 230 citations

Isolation of rat genomic clones encoding subtypes of the alpha 2-adrenergic receptor. Identification of a unique receptor subtype

1991 • 220 citations

Annual review of neuroscience

1987 • 205 citations

Involvement of α-receptors in clonidine-induced inhibition of transmitter release from central monoamine neurones

1973 • 202 citations

Cellular localization of messenger RNA for beta-1 and beta-2 adrenergic receptors in rat brain: An in situ hybridization study

1993 • 202 citations

Multiple apparent alpha-noradrenergic receptor binding sites in rat brain: effect of 6-hydroxydopamine.

1979 • 199 citations

Heterogeneity of radioligand binding to alpha-adrenergic receptors. Analysis of guanine nucleotide regulation of agonist binding in relation to receptor subtypes.

1980 • 192 citations

α2-Adrenoceptor modulation of nociception in rat spinal cord: location, effects and interactions with morphine

1987 • 192 citations

[3H]rauwolscine (α-yohimbine): A specific antagonist radioligand for brain α2-adrenergic receptors

1981 • 186 citations

Anatomical evidence for alpha-2 adrenoceptor heterogeneity: differential autoradiographic distributions of [3H]rauwolscine and [3H]idazoxan in rat brain.

1987 • 185 citations

[3H]rauwolscine and [3H]yohimbine binding to rat cerebral and human platelet membranes: Possible heterogeneity of α2-adrenoceptors

1982 • 184 citations

Primary structure of rat cardiac beta-adrenergic and muscarinic cholinergic receptors obtained by automated DNA sequence analysis: further evidence for a multigene family.

1987 • 181 citations

Molecular characterization of a rat alpha 2B-adrenergic receptor.

1990 • 163 citations

Effects of lesions of locus coeruleus on regional distribution of dopamine-β-hydroxylase activity in rat brain

1974 • 153 citations

The pharmacological classification of adrenergic alpha 1 and alpha 2 receptors and their mechanisms of action.

1979 • 143 citations

Pharmacological evidence for alpha-2 adrenoceptor heterogeneity: differential binding properties of [3H]rauwolscine and [3H]idazoxan in rat brain.

1987 • 139 citations

In SituHybridization Analysis of Arginine Vasopressin Gene Transcription Using Intron-Specific Probes

1991 • 136 citations

Expression of three alpha 2-adrenergic receptor subtypes in rat tissues: implications for alpha 2 receptor classification.

1990 • 131 citations

Regulation of Pro-Opiomelanocortin Gene Transcription in Individual Cell Nuclei

1986 • 125 citations

Effects of intrathecally administered methysergide and yohimbine on microstimulation-produced antinociception in the rat

1985 • 121 citations

Molecular cloning and expression of the rat beta 1-adrenergic receptor gene.

1990 • 120 citations

Inhibition of neuronal uptake reduces the presynaptic effects of clonidine but not of α-methylnoradrenaline on the stimulation-evoked release of 3H-noradrenaline from rat occipital cortex slices

1980 • 111 citations

Distribution of α2-adrenergic receptor mRNAs in the rat CNS

1991 • 109 citations

Cloning, expression, and pharmacological characterization of a human alpha 2B-adrenergic receptor.

1990 • 108 citations

Coexistence and gene expression of phenylethanolamine N-methyltransferase, tyrosine hydroxylase, and neuropeptide tyrosine in the rat and bovine adrenal gland: effects of reserpine.

1988 • 106 citations

Differences between the α₂‐adrenoceptor in rat submaxillary gland and the α_2A‐ and α_2B‐adrenoceptor subtypes

1989 • 103 citations

Noradrenergicα1 and α2 receptors: Autoradiographic visualization

1979 • 103 citations

Relationship of Alpha-1- and Alpha-2-Adrenergic-Binding Sites to Regions of the Paraventricular Nucleus of the Hypothalamus Containing Corticotropin-Releasing Factor and Vasopressin Neurons

1988 • 100 citations

Receptor autoradiography in thoracic spinal cord: correlation of neurotransmitter binding sites with sympathoadrenal neurons

1984 • 98 citations

Sequence of a rat brain cDNA encoding an alpha-1B adrenergic receptor

1990 • 98 citations

Alpha-2 adrenergic receptor subtypes indicated by [3H]yohimbine binding in human brain

1986 • 88 citations

On the mechanism of alpha-receptor mediated modulation of 3H-noradrenaline release from slices of rat brain neocortex

1977 • 81 citations

Biochemical mapping of the noradrenergic ventral bundle projection sites: Evidence for a noradrenergic-dopaminergic interaction

1979 • 80 citations

Rat Spinal Cord α₂‐Adrenoceptors are of the α_2A‐Subtype: Comparison with α_2A‐ and α_2B‐Adrenoceptors in Rat Spleen, Cerebral Cortex and Kidney Using ³H‐RX821002 Ligand Binding

1991 • 79 citations

Identity of [3H]-dihydroalprenolol binding sites and beta-adrenergic receptors coupled with adenylate cyclase in the central nervous system: pharmacological properties, distribution and adaptive responsiveness.

1979 • 65 citations

Autoradiographic distribution of α2 adrenoceptors, NAIBS, and 5-HT1A receptors in human brain using [3H]idazoxan and [3H]rauwolscine

1991 • 64 citations

Characteristics of the [3H]-yohimbine binding on rat brain ?2

1982 • 63 citations

Presynaptic noradrenergic α-receptros and modulation of 3H-noradrenaline release from rat brain synaptosomes

1979 • 63 citations

Delineation of three pharmacological subtypes of α₂‐adrenoceptor in the rat kidney

1991 • 60 citations

Identification of structurally distinct alpha 2-adrenergic receptors.

1988 • 58 citations

α2-Adrenoceptors in rat hypothalamus and cerebral cortex: functional evidence for pharmacologically distinct subpopulations

1985 • 58 citations

Localization of GABAA-receptor γ2-subunit mRNA-containing neurons in the rat central nervous system

1992 • 57 citations

High Affinity Binding of Idazoxan to a Non‐Catecholaminergic Binding Site in the Central Nervous System: Description of a Putative Idazoxan‐Receptor

1989 • 55 citations

On the capacity of presynaptic alpha receptors to modulate norepinephrine release from slices of rat neocortex and the affinity of some agonists and antagonists for these receptors.

1979 • 55 citations

Cloning and expression of a rat brain alpha 2B-adrenergic receptor.

1991 • 54 citations

The rat α₂‐C4 adrenergic receptor gene encodes a novel pharmacological subtype

1991 • 51 citations

The small nuclear RNAs for pre-mRNA splicing are coordinately regulated during oocyte maturation and early embryogenesis in the mouse

1989 • 49 citations

Noradrenergic axon terminals in the substantia gelatinosa of the rat spinal cord

1982 • 48 citations

Distribution of alpha-1 and alpha-2 binding sites in the rat locus coeruleus

1991 • 47 citations

Primary structure of the rat beta-2 adrenergic receptor gene

1990 • 46 citations

Heterogeneos 3H-rauwolscine binding sites in rat cortex: Two alpha2-adrenoceptor subtypes or an additional non-adrenergic interaction?

1988 • 42 citations

Norepinephrine reduces excitability of single cutaneous primary afferent C-fibers in the cat spinal cord

1981 • 42 citations

Heterogeneity of α₂‐adrenoceptors in rat cortex but not human platelets can be defined by 8‐OH‐DPAT, RU 24969 and methysergide

1990 • 33 citations

Primary structure of the rat beta-1 adrenergic receptor gene

1990 • 33 citations

Relationship between alpha 2-adrenergic receptor binding sites and the functional receptors inhibiting norepinephrine release in rat cerebral cortex.

1987 • 31 citations

Effects of reserpine on phenylethanolamine N-methyltransferase mRNA levels in rat adrenal gland: Role of steroids

1990 • 26 citations

Initial observations on the localization of mRNA for α and β adrenergic receptors in brain and peripheral tissues of rat using in situ hybridization

1991 • 26 citations

Quantitative autoradiographic study on tyrosine hydroxylase mRNA with in situ hybridization and α2 adrenergic receptor binding in the locus coeruleus of the spontaneously hypertensive rat

1991 • 15 citations

Presynaptic α2-adrenoceptors modulate the release of [3H]noradrenaline from rat spinal cord dorsal horn neurones

1989 • 13 citations

Regional brain distribution and tissue ontogenic expression of a family of alpha-adrenergic receptor mRNAs in the rat

1991 • 13 citations