Macrophage insulin receptor deficiency increases ER stress-induced apoptosis and necrotic core formation in advanced atherosclerotic lesions

Biochemistry and molecular cell biology of diabetic complications

2001 • 8,707 citations

Inflammation, Atherosclerosis, and Coronary Artery Disease

2005 • 8,367 citations

Inflammation in atherosclerosis

2002 • 7,873 citations

Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes

2004 • 3,671 citations

Atherosclerosis

2001 • 2,982 citations

Roles of CHOP/GADD153 in endoplasmic reticulum stress

2003 • 2,663 citations

Reactive Oxygen Species Promote TNFα-Induced Death and Sustained JNK Activation by Inhibiting MAP Kinase Phosphatases

2005 • 1,727 citations

FoxOs at the Crossroads of Cellular Metabolism, Differentiation, and Transformation

2004 • 1,294 citations

Insulin resistance and cardiovascular disease

2000 • 1,280 citations

FOXO transcription factors at the interface between longevity and tumor suppression

2005 • 1,250 citations

PI3K-Akt pathway: Its functions and alterations in human cancer

2004 • 1,201 citations

TRB3, a novel ER stress-inducible gene, is induced via ATF4–CHOP pathway and is involved in cell death

2005 • 933 citations

The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages

2003 • 851 citations

Intensive Diabetes Therapy and Carotid Intima–Media Thickness in Type 1 Diabetes Mellitus

2003 • 810 citations

TRB3: A tribbles Homolog That Inhibits Akt/PKB Activation by Insulin in Liver

2003 • 809 citations

Akt Stimulates the Transactivation Potential of the RelA/p65 Subunit of NF-κB through Utilization of the IκB Kinase and Activation of the Mitogen-activated Protein Kinase p38

2001 • 774 citations

The Forkhead Transcription Factor Foxo1 Regulates Adipocyte Differentiation

2003 • 711 citations

Consequences and Therapeutic Implications of Macrophage Apoptosis in Atherosclerosis

2005 • 623 citations

LXR-Dependent Gene Expression Is Important for Macrophage Survival and the Innate Immune Response

2004 • 549 citations

Morphologic Findings of Coronary Atherosclerotic Plaques in Diabetics

2004 • 479 citations

The survival kinases Akt and Pim as potential pharmacological targets

2005 • 399 citations

The response‐to‐retention hypothesis of atherogenesis reinforced

1998 • 392 citations

Loss of receptor-mediated lipid uptake via scavenger receptor A or CD36 pathways does not ameliorate atherosclerosis in hyperlipidemic mice

2005 • 370 citations

Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor

2005 • 339 citations

Vascular function, insulin resistance and fatty acids

2002 • 338 citations

The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance

2003 • 329 citations

Oxidized low-density lipoprotein-induced apoptosis

2002 • 323 citations

Critical Role of Endogenous Akt/IAPs and MEK1/ERK Pathways in Counteracting Endoplasmic Reticulum Stress-induced Cell Death

2004 • 319 citations

Evidence that the death of macrophage foam cells contributes to the lipid core of atheroma

1995 • 238 citations

Insulin-like Growth Factor-I Extends in VitroReplicative Life Span of Skeletal Muscle Satellite Cells by Enhancing G1/S Cell Cycle Progression via the Activation of Phosphatidylinositol 3′-Kinase/Akt Signaling Pathway

2000 • 232 citations

Increased CD36 protein as a response to defective insulin signaling in macrophages

2004 • 213 citations

Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosis

2004 • 212 citations

Effect on Tumor Cells of Blocking Survival Response to Glucose Deprivation

2004 • 211 citations

Reduced Macrophage Apoptosis Is Associated With Accelerated Atherosclerosis in Low-Density Lipoprotein Receptor-Null Mice

2004 • 210 citations

Free Cholesterol Loading of Macrophages Is Associated with Widespread Mitochondrial Dysfunction and Activation of the Mitochondrial Apoptosis Pathway

2001 • 199 citations

Oxidative stress, ER stress, and the JNK pathway in type 2 diabetes

2005 • 191 citations

Human aldose reductase expression accelerates diabetic atherosclerosis in transgenic mice

2005 • 169 citations

Apoptosis and plaque destabilization in atherosclerosis: the role of macrophage apoptosis induced by cholesterol

2004 • 167 citations

Transgenic rescue of insulin receptor–deficient mice

2004 • 145 citations

PERK (eIF2α kinase) is required to activate the stress-activated MAPKs and induce the expression of immediate-early genes upon disruption of ER calcium homoeostasis

2005 • 143 citations

Plasma free fatty acid levels and the risk of ischemic heart disease in men: prospective results from the Québec Cardiovascular Study

2002 • 140 citations

Survival and apoptosis signals in ER stress: the role of protein kinases

2004 • 137 citations

Transgenic rescue of insulin receptor–deficient mice

2004 • 131 citations

Mechanisms of oxysterol-induced apoptosis

2001 • 118 citations

Multiple CHD risk factors in type 2 diabetes: beyond hyperglycaemia

2002 • 92 citations

Localization of atherosclerosis susceptibility loci to chromosomes 4 and 6 using the Ldlr knockout mouse model

2001 • 90 citations

Epidermal growth factor and insulin inhibit cell death in pancreatic beta cells by activation of PI3-kinase/AKT signaling pathway under oxidative stress

2004 • 28 citations