PSA markers in prostate cancer detection

Comparison of Digital Rectal Examination and Serum Prostate Specific Antigen in the Early Detection of Prostate Cancer: Results of a Multicenter Clinical Trial of 6,630 Men

1994 • 1,171 citations

Use of the Percentage of Free Prostate-Specific Antigen to Enhance Differentiation of Prostate Cancer From Benign Prostatic Disease

1998 • 1,148 citations

Serum prostate-specific antigen in a community-based population of healthy men. Establishment of age-specific reference ranges

1993 • 1,118 citations

A complex between prostate-specific antigen and alpha 1-antichymotrypsin is the major form of prostate-specific antigen in serum of patients with prostatic cancer: assay of the complex improves clinical sensitivity for cancer.

1991 • 954 citations

Prostate-specific antigen in serum occurs predominantly in complex with alpha 1-antichymotrypsin

1991 • 947 citations

Prostate Cancer Detection in a Clinical Urological Practice by Ultrasonography, Digital Rectal Examination and Prostate Specific Antigen

1990 • 767 citations

A Prospective Evaluation of Plasma Prostate-Specific Antigen for Detection of Prostatic Cancer

1995 • 735 citations

Prostate Cancer Detection in Men With Serum PSA Concentrations of 2.6 to 4.0 ng/mL and Benign Prostate Examination

1997 • 675 citations

Biology of Prostate-Specific Antigen

2003 • 673 citations

Enzymatic activity of prostate‐specific antigen and its reactions with extracellular serine proteinase inhibitors

1990 • 663 citations

Serum Prostate Specific Antigen Complexed toα1-Antichymotrypsin as an Indicator of Prostate Cancer

1993 • 660 citations

Screening for Prostatic Carcinoma with Prostate Specific Antigen

1992 • 631 citations

PROSTATE SPECIFIC ANTIGEN: A DECADE OF DISCOVERY-WHAT WE HAVE LEARNED AND WHERE WE ARE GOING

1999 • 618 citations

Comparison of percent free PSA, PSA density, and age-specific PSA cutoffs for prostate cancer detection and staging

2000 • 331 citations

PROSTATE CANCER DETECTION AT LOW PROSTATE SPECIFIC ANTIGEN

2000 • 323 citations

OPTIMAL PREDICTORS OF PROSTATE CANCER ON REPEAT PROSTATE BIOPSY: A PROSPECTIVE STUDY OF 1,051 MEN

2000 • 321 citations

Selection of Optimal Prostate Specific Antigen Cutoffs for Early Detection of Prostate Cancer: Receiver Operating Characteristic Curves

1994 • 318 citations

Molecular forms of prostate-specific antigen and the human kallikrein gene family: A new era

1995 • 317 citations

Comparison of Prostate Specific Antigen Concentration Versus Prostate Specific Antigen Density in the Early Detection of Prostate Cancer: Receiver Operating Characteristic Curves

1994 • 270 citations

Analysis of percent free prostate-specific antigen (PSA) for prostate cancer detection: Influence of total psa, prostate volume, and age

1996 • 255 citations

Estimation of prostatic growth using serial prostate-specific antigen measurements in men with and without prostate disease.

1992 • 242 citations

A prospective evaluation of plasma prostate-specific antigen for detection of prostatic cancer

1995 • 206 citations

INTERPRETATION OF FREE PROSTATE SPECIFIC ANTIGEN CLINICAL RESEARCH STUDIES FOR THE DETECTION OF PROSTATE CANCER

1998 • 204 citations

Immunoreactive prostate-specific antigen levels in female and male breast tumors and its association with steroid hormone receptors and patient age

1994 • 196 citations

A truncated precursor form of prostate-specific antigen is a more specific serum marker of prostate cancer.

2001 • 194 citations

Prostate cancer detection in men with serum PSA concentrations of 2.6 to 4.0 ng/mL and benign prostate examination. Enhancement of specificity with free PSA measurements

1997 • 192 citations

Free prostate-specific antigen in serum is becoming more complex

2002 • 191 citations

Prostate-specific antigen in milk of lactating women

1995 • 186 citations

Diagnosis of Prostatic Carcinoma: The Yield of Serum Prostate Specific Antigen, Digital Rectal Examination and Transrectal Ultrasonography

1994 • 184 citations

Purification and characterization of different molecular forms of prostate-specific antigen in human seminal fluid

1995 • 178 citations

Complex formation between protein C inhibitor and prostate‐specific antigen in vitro and in human semen

1994 • 178 citations

NONPROSTATIC SOURCES OF PROSTATE-SPECIFIC ANTIGEN

1997 • 178 citations

“BPSA,” a specific molecular form of free prostate-specific antigen, is found predominantly in the transition zone of patients with nodular benign prostatic hyperplasia

2000 • 174 citations

PSA, PSA density, PSA density of transition zone, free/total PSA ratio, and PSA velocity for early detection of prostate cancer in men with serum PSA 2.5 to 4.0 ng/mL

1999 • 171 citations

A precursor form of PSA (pPSA) is a component of the free PSA in prostate cancer serum

1997 • 162 citations

COMPLEXED PROSTATE SPECIFIC ANTIGEN PROVIDES SIGNIFICANT ENHANCEMENT OF SPECIFICITY COMPARED WITH TOTAL PROSTATE SPECIFIC ANTIGEN FOR DETECTING PROSTATE CANCER

2000 • 149 citations

PSA density (PSAD). Role in patient evaluation and management.

1993 • 146 citations

Serum PSA adjusted for volume of transition zone (PSAT) is more accurate than PSA adjusted for total gland volume (PSAD) in detecting adenocarcinoma of the prostate

1994 • 144 citations

CHARACTERISTICS OF SCREENING DETECTED PROSTATE CANCER IN MEN 50 TO 66 YEARS OLD WITH 3 TO 4 NG./ML. PROSTATE SPECIFIC ANTIGEN

1998 • 141 citations

Prostate‐Specific antigen expression by various tumors

1995 • 138 citations

Prostate cancer trends in the era of prostate-specific antigen

2002 • 136 citations

Complexed Prostate Specific Antigen Improves Specificity for Prostate Cancer Detection: Results of a Prospective Multicenter Clinical Trial

2003 • 128 citations

Determination of the “reflex range” and appropriate cutpoints for percent free prostatespecific antigen in 413 men referred for prostatic evaluation using the AxSYM system

1997 • 125 citations

Proenzyme psa for the early detection of prostate cancer in the 2.5–4.0 ng/ml total psa range: preliminary analysis

2003 • 123 citations

Identification of precursor forms of free prostate-specific antigen in serum of prostate cancer patients by immunosorption and mass spectrometry.

2001 • 121 citations

Novel immunoassay for the measurement of complexed prostate-specific antigen in serum.

1998 • 113 citations

Complexed prostate-specific antigen, complexed prostate-specific antigen density of total and transition zone, complexed/total prostate-specific antigen ratio, free-to-total prostate-specific antigen ratio, density of total and transition zone prostate-specific antigen: results of the prospective multicenter European trial

2002 • 112 citations

The Use of Age-Specific Reference Ranges for Serum Prostate Specific Anitgen in Men 60 years Old or Older

1995 • 109 citations

The influence of prostate volume on the ratio of free to total prostate specific antigen in serum of patients with prostate carcinoma and benign prostate hyperplasia

1997 • 106 citations

Prostate-specific antigen immunoreactivity in amniotic fluid

1995 • 102 citations

PSA DENSITY (PSAD)

1993 • 99 citations

Discrimination of Prostate Cancer from Benign Disease by Plasma Measurement of Intact, Free Prostate-specific Antigen Lacking an Internal Cleavage Site at Lys145-Lys146

2001 • 99 citations

Novel immunoassay for the measurement of complexed prostate-specific antigen in serum

1998 • 96 citations

USE OF LOWER PROSTATE SPECIFIC ANTIGEN CUTOFFS FOR PROSTATE CANCER SCREENING IN BLACK AND WHITE MEN

1998 • 93 citations

Original Articles: Prostate Cancer: Measurement of Serum Prostate Specific Antigen Levels in Women and in Prostatectomized Men With an Ultrasensitive Immunoassay Technique

1995 • 90 citations

Rapid Exponential Elimination of Free Prostate-Specific Antigen Contrasts the Slow, Capacity-Limited Elimination of PSA Complexed to Alpha1-Antichymotrypsin From Serum

1998 • 81 citations

Prevalence and Pathological Extent of Prostate Cancer in Men with Prostate Specific Antigen Levels of 2.9 to 4.0 NG./ML.

1993 • 77 citations

Complexed prostate-specific antigen for early detection of prostate cancer in men with serum prostate-specific antigen levels of 2 to 4 nanograms per milliliter

2002 • 75 citations

Prospective evaluation of percent free-PSA and complexed-PSA for early detection of prostate cancer

1998 • 74 citations

Production and Characterization of Novel Anti-Prostate-specific Antigen (PSA) Monoclonal Antibodies That Do Not Detect Internally Cleaved Lys145-Lys146 Inactive PSA

2000 • 69 citations

PROSTATIC VOLUME AND RATIO OF FREE-TO-TOTAL PROSTATE SPECIFIC ANTIGEN IN PATIENTS WITH PROSTATIC CANCER OR BENIGN PROSTATIC HYPERPLASIA

1997 • 56 citations

Discrimination of Benign From Malignant Prostatic Disease by Selective Measurements of Single Chain, Intact Free Prostate Specific Antigen

2002 • 56 citations

Evaluation of common breast problems: guidance for primary care providers

1998 • 55 citations

Original Articles

1995 • 54 citations

PROSPECTIVE DETECTION OF CLINICALLY RELEVANT PROSTATE CANCER IN THE PROSTATE SPECIFIC ANTIGEN RANGE 1 TO 3 NG./ML. COMBINED WITH FREE-TO-TOTAL RATIO 20% OR LESS: THE AARAU EXPERIENCE

2001 • 52 citations

A guide to the interpretation of serum prostate specific antigen levels

1995 • 51 citations

Complexed prostate-specific antigen and its volume indexes in the detection of prostate cancer

1999 • 50 citations

Prostate-Specific Antigen: Critical Issues for the Practicing Physician

1994 • 49 citations

Different proportions of various prostate-specific antigen (PSA) and human kallikrein 2 (hK2) forms are present in noninduced and androgen-induced LNCaP cells

2000 • 47 citations

Comparison of two investigative assays for the complexed prostate-specific antigen in total prostate-specific antigen between 4.1 and 10.0 ng/mL

2000 • 47 citations

An artificial neural network considerably improves the diagnostic power of percent free prostate‐specific antigen in prostate cancer diagnosis: Results of a 5‐year investigation

2002 • 47 citations

Clearance rate of serum-free and total PSA following radical retropubic prostatectomy

1996 • 43 citations

Free/total PSA ratio improves differentiation of benign and malignant disease of the prostate: critical analysis of two different test populations

1999 • 41 citations

Cost-benefit analysis of total, free/total, and complexed prostate-specific antigen for prostate cancer screening

2002 • 33 citations

Total PSA, free PSA/total PSA ratio, and molecular PSA detection in prostate cancer: which is clinically effective and when?

2000 • 33 citations

Prostate specific antigen density in patients with histologically proven prostate carcinoma

1994 • 32 citations

Clinical Evaluation of Serum Prostate‐Specific Antigen‐Alpha₁ ‐ Antichymotrypsin Complex Values in Diagnosis of Prostate Cancer: A Cooperative Study

1998 • 28 citations

Probability of prostate cancer detection based on results of a multicenter study using the AxSYM free PSA and total PSA assays

2000 • 28 citations

Substratification of stage T1C prostate cancer based on the probability of biochemical recurrence

2002 • 28 citations

Significance of Free to Total PSA Ratio in Men with Slightly Elevated Serum PSA Levels: A Cooperative Study

1998 • 25 citations

The clinical usefulness of percent free-PSA

1996 • 24 citations

Development of an immunoassay specific for the PSA-ACT complex without the problem of high background

1998 • 23 citations

Regulation of the enzymatic activity of prostate-specific antigen and its reactions with extracellular protease inhibitors in prostate cancer.

1995 • 21 citations

Clinical Aspects of Prostate Cancer: Assessment of New Diagnostic and Management Procedures

1989 • 20 citations

Elimination of Serum Free and Total Prostate-Specific Antigen after Radical Retropubic Prostatectomy

1997 • 19 citations

A Gap Between Total Prostate-specific Antigen and the Sum of Free Prostate-specific Antigen Plus α1-Antichymotrypsin-Prostate-specific Antigen in Patients with Prostate Carcinoma but not in Those with Benign Prostate Hyperplasia

1999 • 18 citations

Bayer immuno 1™ PSA assay: An automated, ultrasensitive method to quantitate total PSA in serum

1998 • 12 citations

A comparison of three free and total PSA assays

1998 • 11 citations