Functional interactions of recombinant .alpha.2 adrenergic receptor subtypes and G proteins in reconstituted phospholipid vesicles

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

Isolation of two proteins with high affinity for guanine nucleotides from membranes of bovine brain.

1984 • 1,300 citations

Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin

1986 • 1,264 citations

Cloning, sequencing and expression of complementary DNA encoding the muscarinic acetylcholine receptor

1986 • 917 citations

[71] Use of eukaryotic expression technology in the functional analysis of cloned genes

1987 • 834 citations

Cloning, Sequencing, and Expression of the Gene Coding for the Human Platelet α ₂ -Adrenergic Receptor

1987 • 792 citations

Molecular cloning of five GTP-binding protein cDNA species from rat olfactory neuroepithelium.

1987 • 751 citations

Molecular cloning and expression of the cDNA for the hamster alpha 1-adrenergic receptor.

1988 • 566 citations

The molecular basis of muscarinic receptor diversity

1989 • 544 citations

Adrenergic receptors. Models for the study of receptors coupled to guanine nucleotide regulatory proteins.

1988 • 455 citations

Cloning and expression of a human kidney cDNA for an alpha 2-adrenergic receptor subtype.

1988 • 440 citations

G-protein βγ-subunits activate the cardiac muscarinic K+-channel via phospholipase A2

1989 • 438 citations

Stimulation of phospholipase A2 activity in bovine rod outer segments by the beta gamma subunits of transducin and its inhibition by the alpha subunit.

1987 • 344 citations

Receptors linked to inhibition of adenylate cyclase: additional signaling mechanisms

1988 • 339 citations

Reconstitution of resolved muscarinic cholinergic receptors with purified GTP-binding proteins.

1985 • 314 citations

Heterogeneity of alpha-2 adrenergic receptors

1985 • 297 citations

G protein multiplicity in eukaryotic signal transduction systems

1988 • 267 citations

The avian beta-adrenergic receptor: primary structure and membrane topology.

1986 • 252 citations

Catecholamine-stimulated GTPase cycle. Multiple sites of regulation by beta-adrenergic receptor and Mg2+ studied in reconstituted receptor-Gs vesicles.

1986 • 225 citations

Specificity of the functional interactions of the beta-adrenergic receptor and rhodopsin with guanine nucleotide regulatory proteins reconstituted in phospholipid vesicles.

1985 • 213 citations

Purification and characterization of Go alpha and three types of Gi alpha after expression in Escherichia coli.

1990 • 208 citations

Functional reconstitution of the alpha 2-adrenergic receptor with guanine nucleotide regulatory proteins in phospholipid vesicles.

1986 • 199 citations

Diversity of the G-protein family: sequences from five additional alpha subunits in the mouse.

1989 • 175 citations

Specificity of receptor-G protein interactions. Discrimination of Gi subtypes by the D2 dopamine receptor in a reconstituted system.

1990 • 173 citations

Functional interaction of purified muscarinic receptors with purified inhibitory guanine nucleotide regulatory proteins reconstituted in phospholipid vesicles.

1986 • 161 citations

A novel mechanism for the inhibition of adenylate cyclase via inhibitory GTP-binding proteins. Calmodulin-dependent inhibition of the cyclase catalyst by the beta gamma-subunits of GTP-binding proteins.

1987 • 161 citations

Antibodies to the GTP binding protein, Go, antagonize noradrenaline-induced calcium current inhibition in NG108-15 hybrid cells

1989 • 159 citations

A G Protein γ Subunit Shares Homology with ras Proteins

1989 • 153 citations

Molecular cloning of beta 3 subunit, a third form of the G protein beta-subunit polypeptide.

1990 • 140 citations

G protein .beta..gamma. subunits from bovine brain and retina: equivalent catalytic support of ADP-ribosylation of .alpha. subunits by pertussis toxin but differential interactions with Gs.alpha.

1989 • 139 citations

Existence of Two γ Subunits of the G Proteins in Brain

1989 • 117 citations

The interaction between D-2 dopamine receptors and GTP-binding proteins.

1988 • 64 citations

Who carries what message?

1989 • 59 citations

Cerebral muscarinic acetylcholine receptors interact with three kinds of GTP-binding proteins in a reconstitution system of purified components.

1989 • 41 citations

Identification of the subunit-binding site of alpha 2-adrenergic receptors using [3H]phenoxybenzamine.

1984 • 29 citations

Functional reconstitution of prostaglandin E receptor from bovine adrenal medulla with guanine nucleotide binding proteins.

1988 • 22 citations