Cell death and cancer therapy

Mitochondria and Apoptosis

1998 • 8,909 citations

Surfing the p53 network

2000 • 6,487 citations

Apoptosis by Death Factor

1997 • 5,038 citations

Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis

1998 • 4,383 citations

Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death

2001 • 3,867 citations

BCL-2 family members and the mitochondria in apoptosis

1999 • 3,657 citations

A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma

1997 • 3,167 citations

The DNA damage response: putting checkpoints in perspective

2000 • 3,147 citations

PUMA, a Novel Proapoptotic Gene, Is Induced by p53

2001 • 2,226 citations

An APAF-1·Cytochrome c Multimeric Complex Is a Functional Apoptosome That Activates Procaspase-9

1999 • 2,088 citations

Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis

2000 • 2,064 citations

Control of apoptosis and mitotic spindle checkpoint by survivin

1998 • 1,881 citations

Apoptosis in cancer

2000 • 1,826 citations

p53 Status and the Efficacy of Cancer Therapy in Vivo

1994 • 1,483 citations

PUMA Induces the Rapid Apoptosis of Colorectal Cancer Cells

2001 • 1,275 citations

p53AIP1, a Potential Mediator of p53-Dependent Apoptosis, and Its Regulation by Ser-46-Phosphorylated p53

2000 • 1,155 citations

Disruption of p53 in human cancer cells alters the responses to therapeutic agents

1999 • 1,044 citations

Apoptotic Pathways

2000 • 993 citations

Dysregulation of Apoptosis in Cancer

1999 • 983 citations

Inactivation of the apoptosis effector Apaf-1 in malignant melanoma

2001 • 960 citations

p53 Activates the CD95 (APO-1/Fas) Gene in Response to DNA Damage by Anticancer Drugs

1998 • 857 citations

Role ofBAXin the Apoptotic Response to Anticancer Agents

2000 • 854 citations

p53

2000 • 785 citations

Apoptosis, p53, and tumor cell sensitivity to anticancer agents.

1999 • 708 citations

Apaf-1 and Caspase-9 in p53-Dependent Apoptosis and Tumor Inhibition

1999 • 663 citations

Bax suppresses tumorigenesis and stimulates apoptosis in vivo

1997 • 648 citations

Chemosensitisation of malignant melanoma by BCL2 antisense therapy

2000 • 487 citations

Pidd, a new death-domain–containing protein, is induced by p53 and promotes apoptosis

2000 • 349 citations

A structural view of mitochondria-mediated apoptosis.

2001 • 307 citations

The IAP family: endogenous caspase inhibitors with multiple biological activities

2000 • 296 citations

Inhibition of melanoma tumor growth in vivo by survivin targeting

2001 • 290 citations

Genetic analysis of chemoresistance in primary murine lymphomas

2000 • 276 citations

p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage

2000 • 252 citations

Mutational inactivation of the proapoptotic gene BAX confers selective advantage during tumor clonal evolution

2000 • 234 citations

Malignant melanoma: modern black plague and genetic black box

1998 • 198 citations

A transactivation-deficient mouse model provides insights into Trp53 regulation and function

2000 • 197 citations

Essential Role for Caspase-8 in Transcription-independent Apoptosis Triggered by p53

2000 • 147 citations

The TRAIL Decoy Receptor TRUNDD (DcR2, TRAIL-R4) Is Induced by Adenovirus-p53 Overexpression and Can Delay TRAIL-, p53-, and KILLER/DR5-Dependent Colon Cancer Apoptosis

2000 • 114 citations

Killer/DR5, A Novel DNA-Damage Inducible Death Receptor Gene, Links the p53-Tumor Suppressor to Caspase Activation and Apoptotic Death

2002 • 79 citations

Antitumor effect of adenovirus-mediated Bax gene transfer on p53-sensitive and p53-resistant cancer lines.

2000 • 77 citations

Genes involved in melanoma: an overview of INK4a and other loci.

1999 • 68 citations

p53 induction and apoptosis in response to radio- and chemotherapy in vivo is tumor-type-dependent.

2001 • 65 citations

Evidence against apoptosis as a major mechanism for reproductive cell death following treatment of cell lines with anti-cancer drugs

2001 • 62 citations

Enhancement of antitumor effect by intratumoral administration of bax gene in combination with anticancer drugs in gastric cancer

2001 • 20 citations