Effects of Toxin A fromClostridium difficileon Mast Cell Activation and Survival

Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids

1982 • 11,668 citations

A method for the fluorometric assay of histamine in tissues.

1959 • 2,390 citations

A highly sensitive cell line, WEHI 164 clone 13, for measuring cytotoxic factor/tumor necrosis factor from human monocytes

1986 • 1,282 citations

Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-α

1996 • 1,121 citations

New Concepts about the Mast Cell

1993 • 1,009 citations

Critical protective role of mast cells in a model of acute septic peritonitis

1996 • 942 citations

The Enteric Nervous System

1996 • 756 citations

Cytokines in intestinal inflammation: Pathophysiological and clinical considerations

1994 • 607 citations

The Enterotoxin from Clostridium difficile (ToxA) Monoglucosylates the Rho Proteins

1995 • 478 citations

Clostridium difficile: History of Its Role as an Enteric Pathogen and the Current State of Knowledge About the Organism

1994 • 311 citations

Mucosal mast cells. I. Isolation and functional characteristics of rat intestinal mast cells.

1982 • 291 citations

CP-96,345, a substance P antagonist, inhibits rat intestinal responses to Clostridium difficile toxin A but not cholera toxin.

1994 • 274 citations

Mucosal mast cells

1984 • 237 citations

Effect of Clostridium difficile toxin A on human intestinal epithelial cells: induction of interleukin 8 production and apoptosis after cell detachment.

1996 • 202 citations

Neutrophil recruitment in Clostridium difficile toxin A enteritis in the rabbit.

1994 • 196 citations

In vivo profiles of eicosanoids in ulcerative colitis, Crohn's colitis, and Clostridium difficile colitis

1988 • 185 citations

Neuronal involvement in the intestinal effects of Clostridium difficile toxin A and Vibrio cholerae enterotoxin in rat ileum

1994 • 167 citations

Cytokine response by human monocytes to Clostridium difficile toxin A and toxin B

1991 • 155 citations

Diphtheria toxin- and Pseudomonas A toxin-mediated apoptosis. ADP ribosylation of elongation factor-2 is required for DNA fragmentation and cell lysis and synergy with tumor necrosis factor-alpha.

1992 • 144 citations

Apoptosis induced by bacterial pathogens

1994 • 141 citations

The small GTPases Rac and Rho as regulators of secretion in mast cells

1995 • 137 citations

The small GTP-binding proteins, Rac and Rho, regulate cytoskeletal organization and exocytosis in mast cells by parallel pathways.

1996 • 130 citations

Substance P activation of enteric neurons in response to intraluminal Clostridium difficile toxin A in the rat ileum

1996 • 123 citations

The low molecular mass GTP-binding protein Rho is affected by toxin A from Clostridium difficile.

1995 • 122 citations

Inhibition of FcεRI-mediated Activation of Rat Basophilic Leukemia Cells by Clostridium difficile Toxin B (Monoglucosyltransferase)

1996 • 117 citations

Clostridium difficile toxin A stimulates intracellular calcium release and chemotactic response in human granulocytes.

1988 • 115 citations

Potentiation of tumor necrosis factor-alpha-mediated cytotoxicity of mast cells by their production of nitric oxide.

1991 • 100 citations

Ketotifen inhibits Clostridium difficile toxin A-induced enteritis in rat ileum

1993 • 98 citations

New concepts about the mast cell

1994 • 94 citations

Verocytotoxin-1 induces apoptosis in vero cells

1995 • 92 citations

Nitric Oxide

1991 • 83 citations

Clostridium difficile toxin A and its effects on cells

1991 • 82 citations

Ketotifen effectively prevents mucosal damage in experimental colitis.

1992 • 80 citations

Clostridium difficile toxin A-induced microvascular dysfunction. Role of histamine.

1994 • 76 citations

Nitric Oxide

1991 • 73 citations

Clostridium difficile toxin A induces the release of neutrophil chemotactic factors from rat peritoneal macrophages: role of interleukin-1beta, tumor necrosis factor alpha, and leukotrienes

1997 • 67 citations

TGF-beta1 inhibits the release of histamine and tumor necrosis factor-alpha from mast cells through an autocrine pathway.

1997 • 63 citations

Transient expression of RhoA, -B, and -C GTPases in HeLa cells potentiates resistance to Clostridium difficile toxins A and B but not to Clostridium sordellii lethal toxin

1995 • 58 citations

Enterotoxins from Clostridium difficile; diarrhoeogenic potency and morphological effects in the rat intestine.

1990 • 49 citations

Nitric oxide inhibits rat intestinal secretion by Clostridium difficile toxin A but not Vibrio cholerae enterotoxin

1996 • 48 citations

Increased substance P receptor expression by blood vessels and lymphoid aggregates inClostridium difficile-induced pseudomembranous colitis

1996 • 48 citations

Characteristics of histamine secretion from rat peritoneal mast cells sensitized to the nematode Nippostrongylus brasiliensis.

1982 • 46 citations

Trichomonas vaginalis: Ultrastructural Bases of the Cytopathic Effect

1995 • 42 citations

Role of 5-HT3 receptors and afferent fibers in the effects of mast cell degranulation on colonic motility in rats

1994 • 38 citations

Macrophage-dependent stimulation of T cell-depleted spleen cells by Clostridium difficile toxin A and calcium ionophore

1990 • 38 citations

Interaction of cadmium with actin microfilaments in vitro

1989 • 35 citations

Clostridium difficile toxins A and B inhibit human immune response in vitro

1988 • 28 citations

Clostridium difficile Toxin A-induced Microvascular Dysfunction

1994 • 26 citations

Analysis of human skin mast cell proteins by two-dimensional gel electrophoresis. Identification of tryptase as a sialylated glycoprotein.

1993 • 23 citations

Comparison of methods for the production and purification of toxin A fromClostridium difficile

1988 • 14 citations

Production, purification and characterization of Clostridium difficile toxic proteins different from toxin A and from toxin B

1989 • 12 citations

Ketotifen inhibits toxin A - induced enteritis in rat ileum.

1993 • 5 citations