Clostridium difficile toxin A and its effects on cells

The nuclear lamina is a meshwork of intermediate-type filaments

1986 • 957 citations

Tau protein function in living cells.

1986 • 727 citations

Clostridium difficile: its disease and toxins

1988 • 574 citations

Cyclic Adenosine Monophosphate and Alteration of Chinese Hamster Ovary Cell Morphology: a Rapid, Sensitive In Vitro Assay for the Enterotoxins of Vibrio cholerae and Escherichia coli

1974 • 572 citations

Clostridium difficile toxin A perturbs cytoskeletal structure and tight junction permeability of cultured human intestinal epithelial monolayers.

1988 • 398 citations

Purification and characterization of toxins A and B of Clostridium difficile

1982 • 366 citations

Diphtheria toxin fragment forms large pores in phospholipid bilayer membranes.

1981 • 341 citations

Actin-specific ADP-ribosyltransferase produced by a Clostridium difficile strain

1988 • 324 citations

Comparison of two toxins produced by Clostridium difficile

1981 • 298 citations

Molecular characterization of the Clostridium difficile toxin A gene

1990 • 279 citations

Biological activities of toxins A and B of Clostridium difficile

1982 • 259 citations

Cell surface binding site for Clostridium difficile enterotoxin: evidence for a glycoconjugate containing the sequence Gal alpha 1-3Gal beta 1-4GlcNAc

1986 • 242 citations

Clostridium difficile: Clinical Considerations

1990 • 213 citations

Differential effects of Clostridium difficile toxins A and B on rabbit ileum

1987 • 204 citations

Pertussis toxin inhibition of chemotactic factor-induced calcium mobilization and function in human polymorphonuclear leukocytes.

1985 • 192 citations

Chemotactic peptide-induced changes in neutrophil actin conformation.

1984 • 186 citations

Nucleotide sequence ofClostridium difficiletoxin B gene

1990 • 177 citations

Effects of Clostridium difficile toxins A and B in rabbit small and large intestine in vivo and on cultured cells in vitro

1988 • 159 citations

Biochemical Characterization and Biologic Actions of Two Toxins (D-l and D-2) from Clostridium difficile

1984 • 155 citations

Clostridium spiroforme toxin is a binary toxin which ADP-ribosylates cellular actin

1988 • 153 citations

Induction of human interleukin-1 by a product of Staphylococcus aureus associated with toxic shock syndrome.

1984 • 152 citations

The cytoskeleton : an introductory survey

1986 • 151 citations

Entry of the toxic proteins abrin, modeccin, ricin, and diphtheria toxin into cells. I. Requirement for calcium.

1982 • 150 citations

Nuclear lamina and organization of nuclear architecture

1986 • 138 citations

Epidermal growth factor receptors associated to cytoskeletal elements of epidermoid carcinoma (A431) cells.

1986 • 133 citations

Action of drugs on microtubules

1975 • 122 citations

Clostridium difficile toxin A stimulates intracellular calcium release and chemotactic response in human granulocytes.

1988 • 115 citations

Characterization of toxins A and B of Clostridium difficile with monoclonal antibodies

1986 • 112 citations

Purification of two high molecular weight toxins of Clostridium difficile which are antigenically related

1987 • 112 citations

Botulinum C2 toxin ADP-ribosylates actin and disorganizes the microfilament network in intact cells.

1987 • 109 citations

The cytoskeleton. An introductory survey

1986 • 104 citations

Comparative study of Clostridium difficile toxin a and cholera toxin in rabbit ileum

1989 • 102 citations

Molecular basis for the pathological actions of Clostridium perfringens iota toxin

1987 • 101 citations

Cytoskeletal changes induced in HEp-2 cells by the cytotoxic necrotizing factor of Escherichia coli

1988 • 98 citations

Virulence Factors of Clostridium difficile

1990 • 97 citations

Growth of Clostridium difficile and production of toxins A and B in complex and defined media

1986 • 95 citations

Differential Effects of Clostridium difficile Toxins on Tissue-Cultured Cells

1982 • 87 citations

Cellular internalisation of Clostridium difficile toxin A

1987 • 83 citations

Neutralization of Clostridium difficile toxin by Clostridium sordellii antitoxins

1978 • 79 citations

Purification and properties of toxins A and B ofClostridium difficile

1986 • 79 citations

Purification of Clostridium difficile toxin A by affinity chromatography on immobilized thyroglobulin

1987 • 70 citations

Toxin a from Clostridium difficile binds to rabbit erythrocyte glycolipids with terminal Galα1–3Galβ1–4GlcNAc sequences

1987 • 70 citations

Myoelectric Effects of Clostridium difficile: Motility-Altering Factors Distinct From Its Cytotoxin and Enterotoxin in Rabbits

1982 • 69 citations

Second Cytotoxic Pathway of Diphtheria Toxin Suggested by Nuclease Activity

1989 • 66 citations

Lysosomal involvement in cellular intoxication with Clostridium difficile toxin B

1986 • 66 citations

Production of Antitoxins to Two Toxins of Clostridium difficile and Immunological Comparison of the Toxins by Cross-Neutralization Studies

1982 • 65 citations

Specific disruption of vimentin filament organization in monkey kidney CV-1 cells by diphtheria toxin, exotoxin A, and cycloheximide.

1980 • 65 citations

Toxin A of Clostridium difficile is a potent cytotoxin

1990 • 62 citations

Adenine nucleotides directly stimulate pertussis toxin.

1985 • 61 citations

Interaction of Clostridium difficile toxin A with cultured cells: cytoskeletal changes and nuclear polarization

1990 • 58 citations

Differential cytotoxic effects of toxins A and B isolated from Clostridium difficile

1984 • 54 citations

Enterotoxins from Clostridium difficile; diarrhoeogenic potency and morphological effects in the rat intestine.

1990 • 49 citations

Effects of Clostridium Difficile toxins A and B on cytoskeleton organization in HEp-2 cells: A comparative morphological study

1989 • 48 citations

Entry of Polypeptide Toxins into Animal Cells

1985 • 47 citations

Cytopathogenic Action of Clostridium Difficile Toxins

1984 • 41 citations

Ionic requirements for entry of Shiga toxin from Shigella dysenteriae 1 into cells

1987 • 39 citations

Macrophage-dependent stimulation of T cell-depleted spleen cells by Clostridium difficile toxin A and calcium ionophore

1990 • 38 citations

Purification and Characterisation of Clostridium Difficile Toxin A by Bovine Thyroglobulin Affinity Chromatography and Dissociation in Denaturing Conditions with or Without Reduction

1989 • 37 citations

Factors influencing the phagocytosis of Clostridium difficile by human polymorphonuclear leukocytes

1987 • 35 citations

Nucleotide sequence ofClostridium difficiletoxin A gene fragment and detection of toxigenic strains by polymerase chain reaction

1990 • 34 citations

Dual effects of pertussis toxin on lymphoid cells in culture

1986 • 34 citations

A new purification procedure for Clostridium difficile enterotoxin

1984 • 33 citations

Cloning and Characterization of Overlapping DNA Fragments of the Toxin A Gene of Clostridium difficile

1989 • 33 citations

Cholera toxin can catalyze ADP-ribosylation of cytoskeletal proteins.

1981 • 33 citations

Surface blebbing and cytoskeletal changes induced in vitro by toxin B from Clostridium difficile: An immunochemical and ultrastructural study

1990 • 33 citations

Clostridium difficile toxin

1981 • 30 citations

Clostridium difficile toxins A and B inhibit human immune response in vitro

1988 • 28 citations

Molecular cloning and expression of Clostridium difficile toxin A in Escherichia coli K 12

1987 • 26 citations

Clostridium difficile toxin A. Interactions with mucus and early sequential histopathologic effects in rabbit small intestine.

1989 • 26 citations

Effect of purified Clostridium difficile toxins on intestinal smooth muscle. II. Toxin B

1989 • 22 citations

Effect of Clostridium difficile enterotoxin A on ultrastructure of Chinese hamster ovary cells

1989 • 21 citations

Immunochemical and structural similarities in toxin A and toxin B of Clostridium difficile shown by binding to monoclonal antibodies

1988 • 21 citations

Nonspecific binding of mouse monoclonal antibodies toClostridium difficile toxins A and B

1989 • 19 citations

Comparison of methods for the production and purification of toxin A fromClostridium difficile

1988 • 14 citations

Sporogenesis and Toxin a Production by Clostridium Difficile

1986 • 14 citations

Enhancement of cell-mediated cytotoxicity by Clostridium difficile toxin A: An in vitro study

1991 • 14 citations

Cytotonic effect ofClostridium difficileenterotoxin on Chinese hamster ovary cells

1986 • 13 citations

Production of an enterotoxin different from toxin A byClostridium difficile

1988 • 12 citations

Production, purification and characterization of Clostridium difficile toxic proteins different from toxin A and from toxin B

1989 • 12 citations

Characterization of immunogenic p230 as the toxin A ofClostridium difficile

1986 • 11 citations

Interaction of Clostridium difficile toxin A with L cells in culture

1984 • 9 citations

Effect of purified Clostridium difficile toxins on intestinal smooth muscle. I. Toxin A

1989 • 9 citations

Susceptibility ofClostridium difficileToxins A and B to Trypsin and Chymotrypsin

1989 • 7 citations

The effects of Clostridium difficile toxins A and B on membrane integrity and protein synthesis in intestinal cells in vivo and in vitro and in McCoy cells in vitro

1987 • 7 citations

Analysis of purity ofClostridium difficiletoxin A derived by affinity chromatography on immobilized bovine thyroglobulin

1988 • 7 citations

Inhibition of Clostridium difficile toxin A and B by 1,2-cyclohexanedione modification of an arginine residue

1989 • 3 citations

Susceptibility ofClostridium difficileToxins A and B to Trypsin and Chymotrypsin

1989 • 3 citations