Increased MCL–1 Expression Is Associated with Poor Prognosis in Ovarian Carcinomas

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1995 • 4,043 citations

Cancer statistics, 1996

1996 • 1,807 citations

The proto-oncogene Bcl-2 and its role in regulating apoptosis

1997 • 1,768 citations

A novel form of Epstein-Barr virus latency in normal B cells in vivo

1995 • 1,552 citations

Expression of the protooncogene bcl-2 in the prostate and its association with emergence of androgen-independent prostate cancer.

1992 • 1,063 citations

High expression of bcl-2 protein in acute myeloid leukemia cells is associated with poor response to chemotherapy

1993 • 738 citations

Bcl-2 Gene Family and the Regulation of Programmed Cell Death

1994 • 725 citations

bcl-2 Protein in Non-Small-Cell Lung Carcinoma

1993 • 684 citations

Association between cisplatin resistance and mutation of p53 gene and reduced bax expression in ovarian carcinoma cell systems.

1996 • 382 citations

bcl-2 in normal human breast and carcinoma, association with oestrogen receptor-positive, epidermal growth factor receptor-negative tumours and in situ cancer

1994 • 326 citations

Immunohistochemical analysis of Mcl-1 protein in human tissues. Differential regulation of Mcl-1 and Bcl-2 protein production suggests a unique role for Mcl-1 in control of programmed cell death in vivo.

1995 • 317 citations

bcl-2and Other Genomic Alterations in the Prognosis of Large-Cell Lymphoma

1989 • 309 citations

IL-6 up-regulates Mcl-1 in human myeloma cells through JAK / STAT rather than Ras / MAP kinase pathway

1999 • 249 citations

The prognostic significance of Bcl-2 and p53 expression in ovarian carcinoma.

1996 • 232 citations

mcl-1 Is an Immediate-Early Gene Activated by the Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Signaling Pathway and Is One Component of the GM-CSF Viability Response

1998 • 191 citations

The anti-apoptotic role of interleukin-6 in human cervical cancer is mediated by up-regulation of Mcl-1 through a PI 3-K/Akt pathway

2001 • 171 citations

BAX protein expression and clinical outcome in epithelial ovarian cancer.

1998 • 135 citations

bcl-2 Expression, p53 Accumulation, and Apoptosis in Ovarian Carcinomas

1996 • 131 citations

Expression and prognostic significance of Bcl-2 in ovarian tumours

1995 • 118 citations

Vascular endothelial growth factor inhibits apoptotic death in hematopoietic cells after exposure to chemotherapeutic drugs by inducing MCL1 acting as an antiapoptotic factor.

1998 • 112 citations

bcl-2, bax, bcl-XL, and bcl-XS expression in normal and neoplastic ovarian tissues.

1998 • 108 citations

Expression of the Bcl-2 homologue Mcl-1 correlates with survival of peripheral blood B lymphocytes.

1996 • 103 citations

Epidermal growth factor (EGF) suppresses staurosporine-induced apoptosis by inducing mcl-1 via the mitogen-activated protein kinase pathway

2000 • 99 citations

p53 accumulation in ovarian carcinomas and its prognostic implications

1993 • 97 citations

Reduced expression of BAX is associated with poor prognosis in patients with epithelial ovarian cancer: a multifactorial analysis of TP53, p21, BAX and BCL-2

2001 • 90 citations

BCL-2 family protein expression in human malignant glioma: a clinical-pathological correlative study

1998 • 78 citations

Expression of Apoptosis-Related Proteins Is an Independent Determinant of Patient Prognosis in Advanced Ovarian Cancer

2000 • 74 citations

P 16 Overexpression: A potential early indicator of transformation in ovarian carcinoma

1997 • 65 citations

Overexpression of Testisin, a Serine Protease Expressed by Testicular Germ Cells, in Expithelial Ovarian Tumor Cells

2000 • 41 citations

Overexpression of testisin, a serine protease expressed by testicular germ cells, in epithelial ovarian tumor cells

2000 • 29 citations

Cyclin D1 overexpression and p53 mutation status in epithelial ovarian cancer

1999 • 26 citations

Underexpression of cyclin-dependent kinase inhibitor p27 is associated with poor prognosis in serous ovarian carcinomas

2001 • 23 citations

Expression and localization of Bcl-2 related proteins in human ovarian cancers.

1998 • 20 citations

p21: a monitor of p53 dysfunction in ovarian neoplasia

1997 • 17 citations