(125I)iodoazidococaine, a photoaffinity label for the haloperidol-sensitive sigma receptor.

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

1980 • 8,534 citations

The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog.

1976 • 2,883 citations

Cocaine Receptors on Dopamine Transporters Are Related to Self-Administration of Cocaine

1987 • 2,189 citations

Expression cloning of a cocaine-and antidepressant-sensitive human noradrenaline transporter

1991 • 928 citations

Peptide and protein molecular weight determination by electrophoresis using a high-molarity tris buffer system without urea

1986 • 926 citations

Sigma receptors: biology and function.

1990 • 799 citations

Cocaine Addiction: Psychology and Neurophysiology

1991 • 753 citations

Steroid Binding at σ Receptors Suggests a Link Between Endocrine, Nervous, and Immune Systems

1988 • 531 citations

Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain.

1976 • 499 citations

Evidence for sigma opioid receptor: binding of [3H]SKF-10047 to etorphine-inaccessible sites in guinea-pig brain.

1982 • 409 citations

1,3-Di(2-[5-3H]tolyl)guanidine: a selective ligand that labels sigma-type receptors for psychotomimetic opiates and antipsychotic drugs.

1986 • 379 citations

Structural requirements for cocaine congeners to interact with dopamine and serotonin uptake sites in mouse brain and to induce stereotyped behavior

1986 • 289 citations

Sodium‐Sensitive Cocaine Binding to Rat Striatal Membrane: Possible Relationship to Dopamine Uptake Sites

1983 • 258 citations

Cocaine binding at σ receptors

1988 • 208 citations

Novel antipsychotic drugs share high affinity for σ receptors

1988 • 206 citations

Purification of the major GTP-binding proteins from human placental membranes.

1986 • 190 citations

σ-Receptors in Endocrine Organs: Identification, Characterization, and Autoradiographic Localization in Rat Pituitary, Adrenal, Testis, and Ovary

1989 • 158 citations

Debrisoquine 4-Hydroxylase: Characterization of a New P450 Gene Subfamily, Regulation, Chromosomal Mapping, and Molecular Analysis of the DA Rat Polymorphism

1987 • 139 citations

MPTP, the neurotoxin inducing parkinson's disease, is a potent competitive inhibitor of human and rat cytochrome P450 isozymes (P450bufI, P450db1) catalyzing debrisoquine 4-hydroxylation

1987 • 130 citations

Neuronal cytochrome P450IID1 (debrisoquine/sparteine-type): potent inhibition of activity by (-)-cocaine and nucleotide sequence identity to human hepatic P450 gene CYP2D6.

1991 • 125 citations

High Affinity Stereospecific Binding of [³H] Cocaine in Striatum and its Relationship to the Dopamine Transporter

1987 • 120 citations

Cocaine inhibits muscarinic cholinergic receptors in heart and brain.

1988 • 118 citations

Labeling by [3H]1,3-di(2-tolyl)guanidine of two high affinity binding sites in guinea pig brain: evidence for allosteric regulation by calcium channel antagonists and pseudoallosteric modulation by sigma ligands.

1991 • 111 citations

High-affinity dextromethorphan binding sites in guinea pig brain. II. Competition experiments.

1983 • 96 citations

Dextromethorphan and sigma ligands: Common sites but diverse effects

1989 • 93 citations

Initial identification and characterization of sigma receptors on human peripheral blood leukocytes.

1988 • 77 citations

Haloperidol-sensitive (+)[3H]SKF-10,047 binding sites (σ sites) exhibit a unique distribution in rat brain subcellular fractions

1990 • 72 citations

Cocaine-induced closures of single batrachotoxin-activated Na+ channels in planar lipid bilayers.

1988 • 70 citations

Dopamine transport sites selectively labeled by a novel photoaffinity probe: 125I-DEEP

1989 • 68 citations

Solubilization and characterization of haloperidol-sensitive (+)-[3H]SKF-10,047 binding sites (sigma sites) from rat liver membranes.

1991 • 66 citations

Iodoazidobenzylpindolol, a photoaffinity probe for the beta-adrenergic receptor.

1981 • 56 citations

Photoaffinity labeling of the mammalian dopamine transporter

1989 • 48 citations

Derivatization of the human erythrocyte glucose transporter using a novel forskolin photoaffinity label.

1987 • 43 citations

Identification of the binding subunit of the sigma-type opiate receptor by photoaffinity labeling with 1-(4-azido-2-methyl[6-3H]phenyl)-3-(2-methyl[4,6-3H]phenyl)guanidine.

1988 • 42 citations

SKF 525-A and cytochrome P-450 ligands inhibit with high affinity the binding of [3H]dextromethorpan and σ ligands to guinea pig brain.

1991 • 40 citations

2-Nitroimipramine: a photoaffinity probe for the serotonin uptake/tricyclic binding site complex.

1985 • 24 citations

Is the Sigma Opiate Receptor a Proadifen‐Sensitive Subform of Cytochrome P‐450?

1990 • 23 citations

High affinity binding of [3H] cocaine to rat liver microsomes

1988 • 17 citations

Characterization of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) binding sites in C57BL/6 mouse brain: mutual effects of monoamine oxidase inhibitors and sigma ligands on MPTP and sigma binding sites.

1991 • 14 citations

Increased release of dopamine in vivo by BMY-14802: Contrasting pattern to clozapine

1990 • 11 citations

A structure-activity study of the transport sites for the hypothalamic and striatal catecholamine uptake systems. Similarities and differences.

1982 • 7 citations

Isoelectric analysis of 3H-Pargyline-labelled monoamine oxidase in rat and carp

1990 • 4 citations