σ Receptors: From Molecule to Man

The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog.

1976 • 2,883 citations

Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum.

1989 • 1,850 citations

Psychotomimesis Mediated by κ Opiate Receptors

1986 • 822 citations

Opiate Receptor Binding of Agonists and Antagonists Affected Differentially by Sodium

1974 • 554 citations

Opiate Agonists and Antagonists Discriminated by Receptor Binding in Brain

1973 • 527 citations

Differentiation of delta and mu opiate receptor localizations by light microscopic autoradiography.

1980 • 463 citations

Evidence for sigma opioid receptor: binding of [3H]SKF-10047 to etorphine-inaccessible sites in guinea-pig brain.

1982 • 409 citations

Handbook of Psychopharmacology

1983 • 389 citations

Autoradiographic localization of sigma receptor binding sites in guinea pig and rat central nervous system with (+)3H-3-(3-hydroxyphenyl)-N-(1- propyl)piperidine

1986 • 385 citations

Specific [3H]phencyclidine binding in rat central nervous system.

1979 • 382 citations

1,3-Di(2-[5-3H]tolyl)guanidine: a selective ligand that labels sigma-type receptors for psychotomimetic opiates and antipsychotic drugs.

1986 • 379 citations

Neuroanatomical patterns of the mu, delta, and kappa opioid receptors of rat brain as determined by quantitative in vitro autoradiography.

1987 • 377 citations

A sigma-like binding site in rat pheochromocytoma (PC12) cells: decreased affinity for (+)-benzomorphans and lower molecular weight suggest a different sigma receptor form from that of guinea pig brain

1990 • 376 citations

Sigma opiates and certain antipsychotic drugs mutually inhibit (+)-[3H] SKF 10,047 and [3H]haloperidol binding in guinea pig brain membranes.

1984 • 348 citations

Pharmacological and autoradiographic discrimination of sigma and phencyclidine receptor binding sites in brain with (+)-[3H]SKF 10,047, (+)-[3H]-3-[3-hydroxyphenyl]-N-(1-propyl)piperidine and [3H]-1-[1-(2-thienyl)cyclohexyl]piperidine.

1986 • 339 citations

Naloxone as a GABA antagonist: Evidence from iontophoretic, receptor binding and convulsant studies

1978 • 330 citations

κ-Opioid receptors and analgesia

1990 • 318 citations

N-methyl-D-aspartate-induced neuronal activation is selectively modulated by σ receptors

1990 • 225 citations

Effects of polyamines on the binding of [3H]MK-801 to the N-methyl-D-aspartate receptor: pharmacological evidence for the existence of a polyamine recognition site.

1989 • 224 citations

Ifenprodil is a novel type of N-methyl-D-aspartate receptor antagonist: interaction with polyamines.

1989 • 215 citations

Naloxone-inaccessible sigma receptor in rat central nervous system.

1983 • 214 citations

Regional distribution of ethanol-inducible cytochrome P450 IIE1 in the rat central nervous system

1990 • 202 citations

Differential Regulation by Guanine Nucleotides of Opiate Agonist and Antagonist Receptor Interactions

1980 • 201 citations

Psychotomimetic opiate receptors labeled and visualized with (+)-[3H]3-(3-hydroxyphenyl)-N-(1-propyl)piperidine.

1984 • 199 citations

The analgesic effectiveness of nalorphine and nalorphine-morphine combinations in man.

1954 • 190 citations

Naltrexone fails to antagonize the σ effects of PCP and SKF 10,047 in the dog

1983 • 187 citations

Evidence for a role of haloperidol‐sensitive σ‐'opiate' receptors in the motor effects of antipsychotic drugs

1988 • 183 citations

(+)-[3H]SKF 10,047, (+)-[3H]ethylketocyclazocine, μ, κ, δ and phencyclidine binding sites in guinea pig brain membranes

1985 • 168 citations

Stereoisomers of N -Allylnormetazocine: Phencyclidine-Like Behavioral Effects in Squirrel Monkeys and Rats

1982 • 165 citations

N-Allylnormorphine: effects of single doses and precipitation of acute abstinence syndromes during addiction to morphine; methadone or heroin in man (post addicts).

1953 • 155 citations

Ifenprodil and SL 82.0715 are antagonists at the polyamine site of the N-methyl-D-aspartate (NMDA) receptor

1989 • 154 citations

Evidence for a multi-site model of the rat brain σ receptor

1989 • 144 citations

Receptor mechanisms in antipsychotic drug action: focus on sigma receptors

1989 • 138 citations

Structural determinants of sigma receptor affinity.

1987 • 124 citations

Subjective effects of narcotic antagonists cyclazocine and nalorphine on the Addiction Research Center Inventory (ARCI)

1970 • 124 citations

Antagonism of the subjective, behavioral, pupillary, and respiratory depressant effects of cyclazocine by naloxone

1968 • 117 citations

σ Receptors negatively modulate agonist-stimulated phosphoinositide metabolism in rat brain

1988 • 111 citations

Binding of [3H]ifenprodil, a novel NMDA antagonist, to a polyamine-sensitive site in the rat cerebral cortex

1990 • 110 citations

Kappa opiate receptors localized by autoradiography to deep layers of cerebral cortex: relation to sedative effects.

1982 • 108 citations

Characterization and autoradiographic visualization of (+)-[3H]SKF10,047 binding in rat and mouse brain: further evidence for phencyclidine/"sigma opiate" receptor commonality.

1986 • 101 citations

High-affinity dextromethorphan binding sites in guinea pig brain. II. Competition experiments.

1983 • 96 citations

Inositolphospholipid-linked glutamate receptors mediate cerebellar parallel-fiber-Purkinje-cell synaptic transmission.

1989 • 95 citations

High affinity dextromethorphan binding sites in guinea pig brain. Effect of sigma ligands and other agents.

1989 • 93 citations

Dextromethorphan and sigma ligands: Common sites but diverse effects

1989 • 93 citations

Differential regulation of σ and PCP receptors after chronic administration of haloperidol and phencyclidine in mice

1989 • 91 citations

Regulation of σ‐Receptors: High‐ and Low‐Affinity Agonist States, GTP Shifts, and Up‐Regulation by Rimcazole and 1,3‐Di(2‐Tolyl)guanidine

1989 • 90 citations

Immunohistochemical localization of cytochrome P-450 in rat brain

1987 • 87 citations

Multiple affinity binding states of the sigma receptor: effect of GTP-binding protein-modifying agents.

1989 • 85 citations

Ifenprodil potently interacts with [3H](+)-3-PPP-labeled σ binding sites in guinea pig brain membranes

1990 • 85 citations

Effects of dextromethorphan site ligands and allosteric modifiers on the binding of (+)-[3H]3-(-3-hydroxyphenyl)-N-(1-propyl)piperidine.

1989 • 82 citations

Selective σ receptor agonist and antagonist affect dopamine neuronal activity

1989 • 78 citations

Motor effects of two sigma ligands mediated by nigrostriatal dopamine neurons

1989 • 75 citations

Sigma receptors regulate contractions of the guinea pig ileum longitudinal muscle/myenteric plexus preparation elicited by both electrical stimulation and exogenous serotonin

1989 • 75 citations

Pharmacological evaluation of N-allynormetazocine (SKF 10,047) on the basis of its discriminative stimulus properties in the rat.

1983 • 70 citations

Receptor pharmacology and function

1989 • 69 citations

Reinforcing properties of stereoisomers of the putative sigma agonists N-allylnormetazocine and cyclazocine in rhesus monkeys.

1983 • 62 citations

Pharmacological analysis of the phencyclidine-like discriminative stimulus properties of narcotic derivatives in rats.

1982 • 61 citations

Biochemical, behavioral, and electrophysiologic actions of the selective sigma receptor ligand (+)-pentazocine.

1988 • 55 citations

Convulsant and anticonvulsant effects of opioids: Relationship to GABA-mediated transmission

1982 • 48 citations

The psychotomimetic effects of opiates and the sigma receptor.

1990 • 47 citations

Characterization of specific binding sites for [3H](d)-N-allylnormetazocine in rat brain membranes.

1985 • 46 citations

Opipramol, a potent sigma ligand, is an anti-ischemic agent: Neurochemical evidence for an interaction with the N-methyl-D-aspartate receptor complex in vivo by cerebellar cGMP measurements

1990 • 45 citations

An early Phase II clinical trial of BW234U in the treatment of acute schizophrenia in newly admitted patients

1984 • 44 citations

Psychotomimetic opioid binding: specific binding of [3H]SKF-10047 to etorphine-inaccessible sites in guinea-pig brain

1981 • 43 citations

σ receptors on NCB-20 hybrid neurotumor cells labeled with (+)[3H]SKF 10,047 and (+)[3H]3-PPP

1986 • 34 citations

Respiratory and subjective effects of d- and I-pentazocine

1968 • 32 citations

Regulation of the binding of σ- and phencyclidine (PCP)-receptor ligands in rat brain membranes by guanine nucleotides and ions

1988 • 31 citations

Analgesic and other effects of the d‐ and l‐isomers of pentazocine

1969 • 30 citations

The first clinical study of BW-234U in schizophrenia.

1982 • 28 citations

Divergent ontogeny of sigma and phencyclidine binding sites in the rat brain

1989 • 28 citations

BMY-14802 antagonizes harmaline- and D-serine-induced increases in mouse cerebellar cyclic GMP: neurochemical evidence for a sigma receptor-mediated functional modulation of responses mediated by the N-methyl-D-aspartate receptor complex in vivo.

1990 • 27 citations

STUDIES OF DRUGS GIVEN BEFORE ANAESTHESIA XIII: PENTAZOCINE AND OTHER OPIATE ANTAGONISTS

1967 • 26 citations

Discriminative stimulus properties of stereoisomers of cyclazocine in phencyclidine-trained squirrel monkeys

1982 • 25 citations

Studies of analgesic drugs. VII. Morphine antagonists as analgesics.

1961 • 24 citations

Is the Sigma Opiate Receptor a Proadifen‐Sensitive Subform of Cytochrome P‐450?

1990 • 23 citations

Subjective effects of nalorphine in hospitalized patients.

1957 • 21 citations

Discriminative stimulus properties of (+)-N-allylnormetazocine in the rat: Correlations with (+)-N-allylnormetazocine and phencyclidine receptor binding

1987 • 20 citations

[3H]opipramol labels a novel binding site and sigma receptors in rat brain membranes.

1991 • 19 citations

SOME EFFECTS OF N–ALLYLNORMORPHINE ON NORMAL SUBJECTS AND A REVIEW OF THE LITERATURE

1955 • 15 citations

Ontogeny of PCP and Sigma receptors in rat brain

1990 • 14 citations

Phencyclidine-like discriminative stimulus effects of the stereoisomers of alpha- and beta-cyclazocine in rats.

1988 • 12 citations

Pharmacological studies of mixtures of narcotics and N-allylnormorphine.

1954 • 7 citations