σ receptors

The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog.

1976 • 2,883 citations

Negative v Positive Schizophrenia

1982 • 2,003 citations

Neuropsychopharmacology

1990 • 1,545 citations

Psychotomimesis Mediated by κ Opiate Receptors

1986 • 822 citations

Sigma receptors: biology and function.

1990 • 799 citations

Pharmacology of opioids.

1983 • 627 citations

Steroid Binding at σ Receptors Suggests a Link Between Endocrine, Nervous, and Immune Systems

1988 • 531 citations

Affective and psychotic symptoms associated with anabolic steroid use

1988 • 492 citations

Evidence for sigma opioid receptor: binding of [3H]SKF-10047 to etorphine-inaccessible sites in guinea-pig brain.

1982 • 409 citations

Autoradiographic localization of sigma receptor binding sites in guinea pig and rat central nervous system with (+)3H-3-(3-hydroxyphenyl)-N-(1- propyl)piperidine

1986 • 385 citations

1,3-Di(2-[5-3H]tolyl)guanidine: a selective ligand that labels sigma-type receptors for psychotomimetic opiates and antipsychotic drugs.

1986 • 379 citations

A sigma-like binding site in rat pheochromocytoma (PC12) cells: decreased affinity for (+)-benzomorphans and lower molecular weight suggest a different sigma receptor form from that of guinea pig brain

1990 • 376 citations

Sigma opiates and certain antipsychotic drugs mutually inhibit (+)-[3H] SKF 10,047 and [3H]haloperidol binding in guinea pig brain membranes.

1984 • 348 citations

Side Effects of Corticosteroid Therapy

1981 • 345 citations

Pharmacological and autoradiographic discrimination of sigma and phencyclidine receptor binding sites in brain with (+)-[3H]SKF 10,047, (+)-[3H]-3-[3-hydroxyphenyl]-N-(1-propyl)piperidine and [3H]-1-[1-(2-thienyl)cyclohexyl]piperidine.

1986 • 339 citations

Rapid membrane effects of steroid hormones: an emerging concept in neuroendocrinology

1990 • 306 citations

Increase of proenkephalin mRNA and enkephalin content of rat striatum after daily injection of haloperidol for 2 to 3 weeks.

1983 • 286 citations

Classification and nomenclature of phencyclidine and sigma receptor sites

1987 • 272 citations

Sigma and phencyclidine-like compounds as molecular probes in biology

1988 • 251 citations

N-methyl-D-aspartate-induced neuronal activation is selectively modulated by σ receptors

1990 • 225 citations

Naloxone-inaccessible sigma receptor in rat central nervous system.

1983 • 214 citations

Cocaine binding at σ receptors

1988 • 208 citations

Psychotomimetic opiate receptors labeled and visualized with (+)-[3H]3-(3-hydroxyphenyl)-N-(1-propyl)piperidine.

1984 • 199 citations

The dopamine transporter and cytochrome P450IID1 (debrisoquine 4-hydroxylase) in brain: Resolution and identification of two distinct [3H]GBR-12935 binding proteins

1990 • 193 citations

Phencyclidine and psychotomimetic sigma opiates: recent insights into their biochemical and physiological sites of action

1988 • 189 citations

Naltrexone fails to antagonize the σ effects of PCP and SKF 10,047 in the dog

1983 • 187 citations

Evidence for a role of haloperidol‐sensitive σ‐'opiate' receptors in the motor effects of antipsychotic drugs

1988 • 183 citations

Autoradiographic visualization of haloperidol-sensitive sigma receptors in guinea-pig brain

1988 • 176 citations

Sigma receptors in post-mortem human brains.

1988 • 169 citations

Neuropsychopharmacology

1979 • 159 citations

σ-Receptors in Endocrine Organs: Identification, Characterization, and Autoradiographic Localization in Rat Pituitary, Adrenal, Testis, and Ovary

1989 • 158 citations

Classification of Opioids on the Basis of Change in Seizure Threshold in Rats

1979 • 152 citations

Selective loss of cerebral cortical Sigma, but not PCP binding sites in schizophrenia

1991 • 148 citations

Evidence for a multi-site model of the rat brain σ receptor

1989 • 144 citations

Synthesis and evaluation of optically pure [³H]‐(+)‐pentazocine, a highly potent and selective radioligand for σ receptors

1989 • 141 citations

Receptor mechanisms in antipsychotic drug action: focus on sigma receptors

1989 • 138 citations

Potential antipsychotic BMY 14802 selectively binds to sigma sites

1987 • 128 citations

Structural determinants of sigma receptor affinity.

1987 • 124 citations

Antagonism of the subjective, behavioral, pupillary, and respiratory depressant effects of cyclazocine by naloxone

1968 • 117 citations

Neuroleptic-sensitive binding sites in the nigrostriatal system: evidence for differential distribution of sigma sites in the substantia nigra, pars compacta of the cat.

1989 • 116 citations

Subcellular distribution of cytochrome P-450 in the brain

1986 • 116 citations

σ Receptors negatively modulate agonist-stimulated phosphoinositide metabolism in rat brain

1988 • 111 citations

Neuroleptic-sensitive binding sites in the nigrostriatal system: evidence for differential distribution of sigma sites in the substantia nigra, pars compacta of the cat

1989 • 108 citations

Sigma binding states in the brain; An emerging concept for multiple sites and their relevance for psychiatric disorders

1990 • 99 citations

Drug specificity of pharmacological dystonia

1990 • 97 citations

σ-Ligands and non-competitive NMDA antagonists inhibit glutamate release during cerebral ischemia

1990 • 95 citations

Narcotic Antagonists as Analgesics

1962 • 95 citations

High affinity dextromethorphan binding sites in guinea pig brain. Effect of sigma ligands and other agents.

1989 • 93 citations

Autoradiographic distribution of non-dopaminergic binding sites labeled by [3H]haloperidol in rat brain

1987 • 92 citations

Regulation of σ‐Receptors: High‐ and Low‐Affinity Agonist States, GTP Shifts, and Up‐Regulation by Rimcazole and 1,3‐Di(2‐Tolyl)guanidine

1989 • 90 citations

Sigma receptors modulate both A9 and A10 dopaminergic neurons in the rat brain: functional interaction with NMDA receptors

1990 • 88 citations

Ifenprodil potently interacts with [3H](+)-3-PPP-labeled σ binding sites in guinea pig brain membranes

1990 • 85 citations

Multiple affinity binding states of the sigma receptor: effect of GTP-binding protein-modifying agents.

1989 • 85 citations

The sigma receptor: a novel site implicated in psychosis and antipsychotic drug efficacy.

1988 • 83 citations

Substrate specificities and functions of the P450 cytochromes

1990 • 79 citations

Narcotic Antagonists as Analgesics

1964 • 78 citations

Initial identification and characterization of sigma receptors on human peripheral blood leukocytes.

1988 • 77 citations

JO 1784, a potent and selective ligand for rat and mouse brain σ-sites

1990 • 77 citations

The Sigma Receptor

1988 • 76 citations

Motor effects of two sigma ligands mediated by nigrostriatal dopamine neurons

1989 • 75 citations

Sigma receptors regulate contractions of the guinea pig ileum longitudinal muscle/myenteric plexus preparation elicited by both electrical stimulation and exogenous serotonin

1989 • 75 citations

Neuropeptide Y and peptide YY interact with rat brain σ and PCP binding sites

1989 • 74 citations

Haloperidol-sensitive (+)[3H]SKF-10,047 binding sites (σ sites) exhibit a unique distribution in rat brain subcellular fractions

1990 • 72 citations

Stereoisomers of [3H]-N-allylnormetazocine bind to different sites in mouse brain.

1984 • 71 citations

Electrophysiological and binding studies on intact NCB-20 cells suggest presence of a low affinity sigma receptor.

1991 • 68 citations

Sigma receptors are highly concentrated in the rat pineal gland

1990 • 67 citations

Sigma receptors modulate the hypothalamic-pituitary-adrenal (HPA) axis centrally: evidence for a functional interaction with NMDA receptors, in vivo

1990 • 67 citations

Solubilization and characterization of haloperidol-sensitive (+)-[3H]SKF-10,047 binding sites (sigma sites) from rat liver membranes.

1991 • 66 citations

Electrophysiological effects of BMY 14802, a new potential antipsychotic drug, on midbrain dopamine neurons in the rat: acute and chronic studies.

1988 • 62 citations

Drugs Acting on σ and Phencyclidine Receptors

1989 • 61 citations

Sigma and opioid receptors in human brain tumors

1990 • 59 citations

Psychotomimetic opiate receptors labelled and visualized with (+)[^3H]3-(3-hydroxyphenyl)-N-(1-propyl)piperidine

1984 • 57 citations

Endocrinological aspects of cyclical mood changes during the menstrual cycle or the premenstrual syndrome

1983 • 55 citations

Sertraline potently displaces (+)-[3H]3-PPP binding to σ sites in rat brain

1989 • 55 citations

Biochemical, behavioral, and electrophysiologic actions of the selective sigma receptor ligand (+)-pentazocine.

1988 • 55 citations

(+)-[3H]SK&F 10,047 sites in rat liver

1988 • 54 citations

Characterization of specific sigma opiate/phencyclidine (PCP)-binding sites in the human brain

1983 • 52 citations

Guinea-pig vas deferens preparation may contain both receptors and phencyclidine receptors

1987 • 51 citations

Effects of BMY 14802, a potential antipsychotic drug, on rat brain dopaminergic function.

1986 • 51 citations

Phencyclidine/SKF-10,047 binding sites: Evaluation of function

1989 • 50 citations

Clorgyline displays high affinity for σ binding sites in C57BL/6 mouse brain

1990 • 50 citations

High affinity dextromethorphan binding sites in guinea pig brain: further characterization and allosteric interactions.

1988 • 49 citations

The psychotomimetic effects of opiates and the sigma receptor.

1990 • 47 citations

Opipramol, a potent sigma ligand, is an anti-ischemic agent: Neurochemical evidence for an interaction with the N-methyl-D-aspartate receptor complex in vivo by cerebellar cGMP measurements

1990 • 45 citations

Evidence for a non-opioid sigma binding site in the guinea-pig myenteric plexus

1988 • 43 citations

Psychotomimetic opioid binding: specific binding of [3H]SKF-10047 to etorphine-inaccessible sites in guinea-pig brain

1981 • 43 citations

Identification of the binding subunit of the sigma-type opiate receptor by photoaffinity labeling with 1-(4-azido-2-methyl[6-3H]phenyl)-3-(2-methyl[4,6-3H]phenyl)guanidine.

1988 • 42 citations

Neuropeptide Y selectively potentiates N-methyl-D-aspartate-induced neuronal activation

1990 • 42 citations

Synthesis and structure-activity relationships of N,N'-di-o-tolylguanidine analogs, high-affinity ligands for the haloperidol-sensitive .sigma. receptor

1990 • 41 citations

SKF 525-A and cytochrome P-450 ligands inhibit with high affinity the binding of [3H]dextromethorpan and σ ligands to guinea pig brain.

1991 • 40 citations

Neuropeptide Y and peptide YY do not bind to brain σ and phencyclidine binding sites

1991 • 40 citations

The sigma enigma: biochemical and functional correlates emerge for the haloperidol-sensitive sigma binding site

1990 • 40 citations

Stereoselective behavioral effects of N-allylnormetazocine in pigeons and squirrel monkeys.

1985 • 38 citations

Sigma receptor "antagonist" BMY 14802 increases neurotensin concentrations in the rat nucleus accumbens and caudate.

1990 • 36 citations

Synthesis and evaluation of N-substituted cis-N-methyl-2-(1-pyrrolidinyl)cyclohexylamines as high affinity .sigma. receptor ligands. Identification of a new class of highly potent and selective .sigma. receptor probes

1990 • 36 citations

Receptor site topographies for phencyclidine-like and sigma drugs: predictions from quantitative conformational, electrostatic potential, and radioreceptor analyses.

1988 • 36 citations

Altered haloperidol-sensitive σ receptors in the genetically dystonic (dt) rat

1988 • 36 citations

σ receptors on NCB-20 hybrid neurotumor cells labeled with (+)[3H]SKF 10,047 and (+)[3H]3-PPP

1986 • 34 citations

Respiratory and subjective effects of d- and I-pentazocine

1968 • 32 citations

Inhibition of potassium currents by the sigma receptor ligand (+)-3-(3-hydroxyphenyl)-N-(1-propyl)piperidine in sympathetic neurons of the mouse isolated hypogastric ganglion

1990 • 31 citations

Regulation of the binding of σ- and phencyclidine (PCP)-receptor ligands in rat brain membranes by guanine nucleotides and ions

1988 • 31 citations

Neuropeptide Y and JO 1784, a selective σ ligand, alter intestinal ion transport through a common, haloperidol-sensitive site

1990 • 30 citations

Interaction of σ‐Compounds with Receptor‐Stimulated Phosphoinositide Metabolism in the Rat Brain

1990 • 28 citations

BMY-14802 antagonizes harmaline- and D-serine-induced increases in mouse cerebellar cyclic GMP: neurochemical evidence for a sigma receptor-mediated functional modulation of responses mediated by the N-methyl-D-aspartate receptor complex in vivo.

1990 • 27 citations

Calcium-dependent displacement of haloperidol-sensitive σ receptor binding in rat hippocampal slices following tissues depolarization

1989 • 24 citations

Multiple vascular effects of sigma and PCP ligands: inhibition of amine uptake and contractile responses.

1990 • 24 citations

Effect of selective sigma ligands on duodenal alkaline secretion in the rat.

1990 • 24 citations

Cerebral metabolic effects of σ ligands in the rat

1989 • 24 citations

Inhibition of carbachol-induced inositol phosphate accumulation by phencyclidine, phencyclidine-like ligands and sigma agonists involves blockade of the muscarinic cholinergic receptor: a novel dioxadrol-preferring interaction.

1990 • 23 citations

Solubilization and Characterization of ?-Receptors from Guinea Pig Brain Membranes

1989 • 22 citations

Effect of trimetoquinol analogs for antagonism of endoperoxide/thromboxane A2-mediated responses in human platelets and rat aorta.

1985 • 22 citations

Double blind comparative study of remoxipride and haloperidol in acute schizophrenic patients

1990 • 22 citations

Characterization of opioid, sigma, and phencyclidine receptors in the neuroblastoma-brain hybrid cell line NCB-20.

1988 • 22 citations

H1 antihistamines interact with central sigma receptors

1990 • 20 citations

[3H]opipramol labels a novel binding site and sigma receptors in rat brain membranes.

1991 • 19 citations

Guinea pig vas deferens contains ρ but not phencyclidine receptors

1990 • 18 citations

σ Receptor blockade by BMY 14802 affects enkephalinergic and tachykinin cells differentially in the striatum of the rat

1990 • 15 citations

Synthesis and characterization of an affinity label for brain receptors to psychotomimetic benzomorphans: differentiation of σ-type and phencyclidine receptors

1987 • 14 citations

Presence of sigma and phencyclidine (PCP)-like receptors in membrane preparations of bovine adrenal medulla

1989 • 12 citations

(-)PPAP: A new and selective ligand for sigma binding sites

1990 • 12 citations

Evidence for a model of activation of central sigma systems

1989 • 11 citations

Association of progesterone with a unique particulate fraction of the human corpus luteum

1988 • 10 citations