Molecular mechanisms of vertebrate left–right development

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

1996 • 3,041 citations

A molecular pathway determining left-right asymmetry in chick embryogenesis

1995 • 781 citations

Different phenotypes for mice deficient in either activins or activin receptor type II

1995 • 598 citations

Functional analysis of activins during mammalian development

1995 • 579 citations

Mutation of an axonemal dynein affects left–right asymmetry in inversus viscerum mice

1997 • 549 citations

Relationship between asymmetric nodal expression and the direction of embryonic turning

1996 • 547 citations

lefty-1 Is Required for Left-Right Determination as a Regulator of lefty-2 and nodal

1998 • 539 citations

Pitx2 determines left–right asymmetry of internal organs in vertebrates

1998 • 512 citations

Reversal of Left-Right Asymmetry: a Situs Inversus Mutation

1993 • 470 citations

Conserved left–right asymmetry of nodal expression and alterations in murine situs inversus

1996 • 459 citations

The Transcription Factor Pitx2 Mediates Situs-Specific Morphogenesis in Response to Left-Right Asymmetric Signals

1998 • 445 citations

Left–right asymmetric expression of the TGFβ-family member lefty in mouse embryos

1996 • 436 citations

Cortical rotation of the Xenopus egg: consequences for the anteroposterior pattern of embryonic dorsal development

1989 • 418 citations

The development of handedness in left/right asymmetry

1990 • 402 citations

The signaling pathway mediated by the type IIB activin receptor controls axial patterning and lateral asymmetry in the mouse.

1997 • 387 citations

Pitx2, a Bicoid-Type Homeobox Gene, Is Involved in a Lefty-Signaling Pathway in Determination of Left-Right Asymmetry

1998 • 371 citations

Sonic hedgehog is not required for the induction of medial floor plate cells in the zebrafish

1998 • 355 citations

Pitx2 Participates in the Late Phase of the Pathway Controlling Left-Right Asymmetry

1998 • 330 citations

Left-right pattern of cardiac BMP4 may drive asymmetry of the heart in zebrafish

1997 • 324 citations

From cortical rotation to organizer gene expression: toward a molecular explanation of axis specification in Xenopus

1998 • 321 citations

The Expression of the MouseZic1, Zic2,andZic3Gene Suggests an Essential Role forZicGenes in Body Pattern Formation

1997 • 310 citations

Zebrafish Nodal-Related Genes Are Implicated in Axial Patterning and Establishing Left–Right Asymmetry

1998 • 279 citations

Cloning of inv, a gene that controls left/right asymmetry and kidney development

1998 • 261 citations

Two closely‐related left‐right asymmetrically expressed genes, lefty‐1 and lefty‐2: their distinct expression domains, chromosomal linkage and direct neuralizing activity in Xenopus embryos

1997 • 245 citations

Inversin, a novel gene in the vertebrate left-right axis pathway, is partially deleted in the inv mouse

1998 • 241 citations

Left/Right Patterning Signals and the Independent Regulation of Different Aspects ofSitusin the Chick Embryo

1997 • 206 citations

VISCERAL INVERSION AND ASSOCIATED ANOMALIES IN THE MOUSE

1959 • 200 citations

The Transfer of Left-Right Positional Information during Chick Embryogenesis

1998 • 199 citations

Role of Notochord in Specification of Cardiac Left–Right Orientation in Zebrafish andXenopus

1996 • 197 citations

Control of Vertebrate Left-Right Asymmetry by a Snail -Related Zinc Finger Gene

1997 • 194 citations

Left-right asymmetry of a nodal-related gene is regulated by dorsoanterior midline structures during Xenopus development

1997 • 164 citations

The Left-Right Coordinator: The Role of Vg1 in Organizing Left-Right Axis Formation

1998 • 160 citations

Functional differences among Xenopus nodal-related genes in left-right axis determination

1997 • 157 citations

Initiation of vertebrate left–right axis formation by maternal Vg1

1996 • 148 citations

Linkage of cardiac left-right asymmetry and dorsal-anterior development in Xenopus

1995 • 138 citations

Cloning and Expression Pattern of ChickenPitx2:A New Component in the SHH Signaling Pathway Controlling Embryonic Heart Looping

1998 • 115 citations

The compulsion of chirality: toward an understanding of left-right asymmetry

1998 • 110 citations

Left-right asymmetry in vertebrate embryogenesis

1997 • 107 citations

Left–Right Asymmetric Localization of Flectin in the Extracellular Matrix during Heart Looping

1996 • 94 citations

Biological asymmetry and handedness

1991 • 93 citations

Retinoic Acid Directs Cardiac Laterality and the Expression of Early Markers of Precardiac Asymmetry

1997 • 92 citations

No turning,a Mouse Mutation Causing Left–Right and Axial Patterning Defects

1998 • 86 citations

Vertebrate left-right development

1995 • 71 citations

Failure to Detectconnexin43Mutations in 38 Cases of Sporadic and Familial Heterotaxy

1996 • 60 citations

Organizer Induction Determines Left–Right Asymmetry inXenopus

1997 • 59 citations

Laterality disturbances

1996 • 21 citations

Cardiac Morphogenesis: Formation and Septation of the Primary Heart Tube

1997 • 15 citations