The vertebrate organizer: structure and molecules

Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse.

1995 • 1,782 citations

The Spemann Organizer Signal noggin Binds and Inactivates Bone Morphogenetic Protein 4

1996 • 1,604 citations

Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos

1992 • 1,176 citations

Dorsoventral Patterning in Xenopus: Inhibition of Ventral Signals by Direct Binding of Chordin to BMP-4

1996 • 1,126 citations

Xenopus chordin: A novel dorsalizing factor activated by organizer-specific homeobox genes

1994 • 1,114 citations

HNF-3β is essential for node and notochord formation in mouse development

1994 • 985 citations

Requirement for LIml in head-organizer function

1995 • 801 citations

Molecular nature of Spemann's organizer: the role of the Xenopus homeobox gene goosecoid

1991 • 799 citations

The winged-helix transcription factor HNF-3β is required for notochord development in the mouse embryo

1994 • 786 citations

Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis.

1995 • 784 citations

Induction of epidermis and inhibition of neural fate by Bmp-4

1995 • 782 citations

A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse

1994 • 769 citations

Follistatin, an antagonist of activin, is expressed in the Spemann organizer and displays direct neuralizing activity

1994 • 759 citations

Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus

1995 • 731 citations

Nodal is a novel TGF-β-like gene expressed in the mouse node during gastrulation

1993 • 606 citations

Multiple defects and perinatal death in mice deficient in follistatin

1995 • 586 citations

Expression cloning of Siamois, a xenopus homeobox gene expressed in dorsal-vegetal cells of blastulae and able to induce a complete secondary axis

1995 • 521 citations

A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain

1996 • 502 citations

Studies with a Xenopus BMP receptor suggest that ventral mesoderm-inducing signals override dorsal signals in vivo

1994 • 463 citations

A homeobox gene essential for zebrafish notochord development

1995 • 462 citations

The Xenopus homologue of Otx2 is a maternal homeobox gene that demarcates and specifies anterior body regions

1995 • 435 citations

Induction of a second neural axis by the mouse node

1994 • 420 citations

Developmental biology

2010 • 409 citations

On the function of BMP-4 in patterning the marginal zone of the Xenopus embryo.

1994 • 396 citations

Disruption of BMP signals in embryonic Xenopus ectoderm leads to direct neural induction.

1995 • 368 citations

Pintallavis, a gene expressed in the organizer and midline cells of frog embryos: involvement in the development of the neural axis

1992 • 332 citations

A nodal-related gene defines a physical and functional domain within the Spemann organizer

1995 • 332 citations

Anterior neurectoderm is progressively induced during gastrulation: the role of the Xenopus homeobox gene orthodenticle

1995 • 317 citations

Tail formation as a continuation of gastrulation: the multiple cell populations of the Xenopus tailbud derive from the late blastopore lip

1993 • 314 citations

The homeobox gene goosecoid and the origin of organizer cells in the early chick blastoderm

1993 • 292 citations

goosecoid is not an essential component of the mouse gastrula organizer but is required for craniofacial and rib development

1995 • 263 citations

Targeted mutation of the murine goosecoid gene results in craniofacial defects and neonatal death

1995 • 262 citations

Molecular mechanisms of Spemann's organizer formation: conserved growth factor synergy between Xenopus and mouse.

1995 • 225 citations

Characterizing the zebrafish organizer: microsurgical analysis at the early-shield stage

1996 • 224 citations

The homeobox gene Siamois is a target of the Wnt dorsalisation pathway and triggers organiser activity in the absence of mesoderm

1996 • 211 citations

A truncated FGF receptor blocks neural induction by endogenous Xenopus inducers

1996 • 198 citations

The homeobox gene goosecoid controls cell migration in Xenopus embryos

1993 • 186 citations

Role of the LIM class homeodomain protein Xlim-1 in neural and muscle induction by the Spemann organizer in Xenopus

1994 • 184 citations

Foundations of experimental embryology

1964 • 183 citations

Induction by the Primitive Streak and its Derivatives in the Chick

1933 • 167 citations

nodal induces ectopic goosecoid and lim 1 expression and axis duplication in zebrafish

1995 • 163 citations

Basic FGF as an inducer of anteroposterior neural pattern

1995 • 145 citations

Anti-Dorsalizing Morphogenetic Protein is a novel TGF-β homolog expressed in the Spemann organizer

1995 • 145 citations

Bone morphogenetic protein-4 (BMP-4) acts during gastrula stages to cause ventralization of Xenopus embryos

1996 • 143 citations

The role of gsc and BMP-4 in dorsal-ventral patterning of the marginal zone in Xenopus: a loss-of-function study using antisense RNA.

1995 • 137 citations

Growth factors in development: the role of TGF-β related polypeptide signalling molecules in embryogenesis

1994 • 124 citations

Distribution of tissue progenitors within the shield region of the zebrafish gastrula

1995 • 112 citations

Blastomere derivation and domains of gene expression in the Spemann Organizer of Xenopus laevis

1995 • 105 citations

Hensen’s node induces neural tissue in Xenopus ectoderm. Implications for the action of the organizer in neural induction

1991 • 98 citations

Gastrulation : movements, patterns, and molecules

1991 • 97 citations

The epithelium of the dorsal marginal zone of Xenopus has organizer properties

1992 • 84 citations

The evolution of vertebrate gastrulation

1994 • 75 citations

XlPOU 2, a noggin-inducible gene, has direct neuralizing activity

1995 • 65 citations

The homeobox-containing gene XANF-1 may control development of the Spemann organizer

1995 • 61 citations

Overexpression of the Homeobox GeneXnot-2Leads to Notochord Formation inXenopus

1996 • 49 citations