The transcription factor HNF3β is required in visceral endoderm for normal primitive streak morphogenesis

Derivation of completely cell culture-derived mice from early-passage embryonic stem cells.

1993 • 2,370 citations

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

1993 • 2,146 citations

Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5

1993 • 1,269 citations

HNF-3β is essential for node and notochord formation in mouse development

1994 • 985 citations

Clonal analysis of epiblast fate during germ layer formation in the mouse embryo

1991 • 865 citations

Requirement for LIml in head-organizer function

1995 • 801 citations

The winged-helix transcription factor HNF-3β is required for notochord development in the mouse embryo

1994 • 786 citations

Mouse Otx2 functions in the formation and patterning of rostral head.

1995 • 690 citations

Forebrain and midbrain regions are deleted in Otx2−/− mutants due to a defective anterior neuroectoderm specification during gastrulation

1995 • 683 citations

Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo

1993 • 680 citations

Six3, a murine homologue of the sine oculis gene, demarcates the most anterior border of the developing neural plate and is expressed during eye development

1995 • 662 citations

Five years on the wings of fork head

1996 • 657 citations

The formation and maintenance of the definitive endoderm lineage in the mouse: involvement of HNF3/forkhead proteins

1993 • 619 citations

Mutation of an axonemal dynein affects left–right asymmetry in inversus viscerum mice

1997 • 549 citations

Anterior primitive endoderm may be responsible for patterning the anterior neural plate in the mouse embryo

1996 • 548 citations

Relationship between asymmetric nodal expression and the direction of embryonic turning

1996 • 547 citations

Hepatocyte nuclear factor 3 alpha belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork head.

1991 • 517 citations

Segment-specific expression of a zinc-finger gene in the developing nervous system of the mouse

1989 • 511 citations

Postimplantation expression patterns indicate a role for the mouse forkhead/HNF-3 α, β and γ genes in determination of the definitive endoderm, chordamesoderm and neuroectoderm

1993 • 505 citations

A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain

1996 • 502 citations

Induction of muscle pioneers and floor plate is distinguished by the zebrafish no tail mutation

1993 • 502 citations

HNF-3A, a hepatocyte-enriched transcription factor of novel structure is regulated transcriptionally.

1990 • 466 citations

A homeobox gene essential for zebrafish notochord development

1995 • 462 citations

Left–right asymmetric expression of the TGFβ-family member lefty in mouse embryos

1996 • 436 citations

Production of homozygous mutant ES cells with a single targeting construct.

1992 • 418 citations

nodal expression in the primitive endoderm is required for specification of the anterior axis during mouse gastrulation

1997 • 384 citations

Gastrulation in the mouse: The role of the homeobox gene goosecoid

1992 • 378 citations

The DNA-binding specificity of the hepatocyte nuclear factor 3/forkhead domain is influenced by amino-acid residues adjacent to the recognition helix.

1994 • 357 citations

Expression pattern of the Brachyury gene in whole-mount T WIS/T WIS mutant embryos

1991 • 350 citations

Gastrulation in the mouse : Growth and regionalization of the epiblast

1977 • 340 citations

En-1 and En-2, two mouse genes with sequence homology to the Drosophila engrailed gene: expression during embryogenesis.

1987 • 330 citations

Hepatocyte nuclear factor 3/fork head or "winged helix" proteins: a family of transcription factors of diverse biologic function.

1993 • 329 citations

HNF-3β as a regulator of floor plate development

1994 • 287 citations

Two closely‐related left‐right asymmetrically expressed genes, lefty‐1 and lefty‐2: their distinct expression domains, chromosomal linkage and direct neuralizing activity in Xenopus embryos

1997 • 245 citations

Patterning the Xenopus blastula

1997 • 234 citations

Cell fate and cell lineage in the endoderm of the presomite mouse embryo, studied with an intracellular tracer

1986 • 224 citations

Segment-specific expression of a homoeobox-containing gene in the mouse hindbrain

1989 • 214 citations

Wild-Type Endoderm Abrogates the Ventral Developmental Defects Associated with GATA-4 Deficiency in the Mouse

1997 • 211 citations

The HNF-3 Gene Family of Transcription Factors in Mice: Gene Structure, cDNA Sequence, and mRNA Distribution

1994 • 204 citations

VISCERAL INVERSION AND ASSOCIATED ANOMALIES IN THE MOUSE

1959 • 200 citations

Role of Notochord in Specification of Cardiac Left–Right Orientation in Zebrafish andXenopus

1996 • 197 citations

Sequential expression of HNF-3β and HNF-3α by embryonic organizing centers: the dorsal lip/node, notochord and floor plate

1993 • 189 citations

Induction by the Primitive Streak and its Derivatives in the Chick

1933 • 167 citations

Left-right asymmetry of a nodal-related gene is regulated by dorsoanterior midline structures during Xenopus development

1997 • 164 citations

Anterior endoderm is a specific effector of terminal cardiac myocyte differentiation of cells from the embryonic heart forming region

1994 • 145 citations

Production of Homozygous Mutant ES Cells with a Single Targeting Construct

1992 • 140 citations

Linkage of cardiac left-right asymmetry and dorsal-anterior development in Xenopus

1995 • 138 citations

An autoradiographic analysis of the potency of embryonic ectoderm in the 8th day postimplantation mouse embryo

1981 • 128 citations

Left-right asymmetry in vertebrate embryogenesis

1997 • 107 citations

Precardiac mesoderm is specified during gastrulation in quail

1994 • 104 citations

Marginal zone cells – the primitive streak-inducing component of the primary hypoblast in the chick

1979 • 104 citations

Initiation of cardiac differentiation occurs in the absence of anterior endoderm

1995 • 101 citations

The DNA-Binding Specificity of the Hepatocyte Nuclear Factor 3/forkhead Domain Is Influenced by Amino-Acid Residues Adjacent to the Recognition Helix

1994 • 100 citations

Diversification of Cardiomyogenic Cell Lineages in Vitro

1995 • 87 citations

Interaction of epiblast and hypoblast in the formation of the primitive streak and the embryonic axis in chick, as revealed by hypoblast-rotation experiments

1981 • 84 citations

[23] Detection of messenger RNA by in Situ hybridization to postimplantation embryo whole mounts

1993 • 84 citations

The chick's marginal zone and primitive streak formation

1989 • 80 citations

Vertebrate head induction by anterior primitive endoderm

1997 • 74 citations

The chick's marginal zone and primitive streak formation

1989 • 67 citations

Establishment of the axis in chordates: facts and speculations

1997 • 66 citations

Histogenetic and neoplastic potential of different regions of the mouse embryonic egg cylinder

1983 • 52 citations

Hypoblastic cells can form a disk inducing an embryonic axis in chick epiblast

1981 • 45 citations

Cell lineage analysis of the primitive and visceral endoderm of mouse embryos cultured in vitro

1987 • 36 citations

Left—right asymmetry in vertebrates

1997 • 35 citations

Differentiation potencies of the young chick blastoderm as revealed by different manipulations

1970 • 25 citations

Embryonic asymmetry: Left TGFβ at the right time?

1997 • 25 citations

Nature of the hypoblastic influence on the chick embryo epiblast

1983 • 25 citations

Whole Mount In Situ Hybridization to Embryos and Embryonic Tissues

2003 • 6 citations