The Development of Bleomycin-Induced Pulmonary Fibrosis in Mice Deficient for Components of the Fibrinolytic System

Matrix Metalloproteinases: A Review

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On the Regulation and Control of Fibrinolysis

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Activation mechanisms of matrix metalloproteinases.

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Physiological consequences of loss of plasminogen activator gene function in mice

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Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formation

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Impaired wound healing in mice with a disrupted plasminogen gene

1996 • 568 citations

Bleomycin-induced pulmonary fibrosis in transgenic mice that either lack or overexpress the murine plasminogen activator inhibitor-1 gene.

1996 • 559 citations

Metalloelastase is required for macrophage-mediated proteolysis and matrix invasion in mice.

1996 • 496 citations

The pathogenesis of bleomycin-induced pulmonary fibrosis in mice.

1974 • 469 citations

Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction.

1995 • 440 citations

Effects of Disruption of The Plasminogen Gene on Thrombosis, Growth, and Health in Mice

1995 • 390 citations

Stepwise activation mechanisms of the precursor of matrix metalloproteinase 3 (stromelysin) by proteinases and (4-aminophenyl)mercuric acetate

1990 • 381 citations

Pathobiology of pulmonary fibrosis

1990 • 326 citations

Local abnormalities in coagulation and fibrinolytic pathways predispose to alveolar fibrin deposition in the adult respiratory distress syndrome.

1989 • 325 citations

Urokinase Receptor (CD87) Regulates Leukocyte Recruitment via β2 Integrins In Vivo

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Surgical Pathology of Non-Neoplastic Lung Disease.

1983 • 253 citations

Immunohistochemical study of metalloproteinases and their tissue inhibitors in the lungs of patients with diffuse alveolar damage and idiopathic pulmonary fibrosis.

1996 • 234 citations

Generation and characterization of urokinase receptor-deficient mice.

1996 • 232 citations

The Receptor for Urokinase-type Plasminogen Activator Is Not Essential for Mouse Development or Fertility

1995 • 230 citations

Fibroblast migration in fibrin gel matrices.

1993 • 224 citations

Plasminogen Deficiency Differentially Affects Recruitment of Inflammatory Cell Populations in Mice

1998 • 222 citations

Molecular cloning, chromosomal localization, and bacterial expression of a murine macrophage metalloelastase.

1992 • 197 citations

Elastolytic Metalloproteinases Produced by Human Mononuclear Phagocytes: Potential Roles in Destructive Lung Disease

1994 • 190 citations

Urokinase is required for the pulmonary inflammatory response to Cryptococcus neoformans. A murine transgenic model.

1996 • 188 citations

Chemotaxis for Human Monocytes by Fibrinogen‐derived Peptides

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Births and deaths: United States, 1996.

1997 • 123 citations

Differential expression of extracellular matrix remodeling genes in a murine model of bleomycin-induced pulmonary fibrosis.

1998 • 122 citations

Growth and Dissemination of Lewis Lung Carcinoma in Plasminogen-Deficient Mice

1997 • 113 citations

Plasmin Is a Potent and Specific Chemoattractant for Human Peripheral Monocytes Acting Via a Cyclic Guanosine Monophosphate–Dependent Pathway

1997 • 107 citations

Pulmonary Inflammation Induced by Incomplete or Inactivated Adenoviral Particles

1995 • 103 citations

Treatment of Bleomycin-Induced Pulmonary Fibrosis by Transfer of Urokinase-Type Plasminogen Activator Genes

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Aα and Bβ chains of fibrinogen stimulate proliferation of human fibroblasts

1993 • 101 citations

Bleomycin-induced pulmonary fibrosis. Effects of steroid on lung collagen metabolism.

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Local abnormalities of coagulation and fibrinolytic pathways that promote alveolar fibrin deposition in the lungs of baboons with diffuse alveolar damage.

1989 • 79 citations

The role of fibrin degradation products in neutrophil recruitment to the lung.

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Polyoma Middle T-induced Vascular Tumor Formation: The Role of the Plasminogen Activator/Plasmin System

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Pathology of pulmonary disease

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Abnormalities of pathways of fibrin turnover in lung lavage of rats with oleic acid and bleomycin-induced lung injury support alveolar fibrin deposition.

1989 • 61 citations

Interstitial Pulmonary Fibrosis—Which Cell is the Culprit?^1,2

1983 • 59 citations

Endogenously produced urokinase amplifies tumor necrosis factor-α secretion by THP-1 mononuclear phagocytes

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Role of Urokinase in the Fibrogenic Response of the Lung to Mineral Particles

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Pathology of pulmonary disease

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Restoration of thrombolytic potential in plasminogen-deficient mice by bolus administration of plasminogen

1996 • 41 citations

Partial reversal of established bleomycin-induced pulmonary fibrosis by rh-urokinase in a rat model.

1994 • 39 citations

Polymerization of fibrinogen in murine bleomycin-induced lung injury

1996 • 34 citations

Restoration of thrombolytic potential in plasminogen-deficient mice by bolus administration of plasminogen

1996 • 33 citations

Studies of Mice Lacking Plasminogen Activator Gene Function Suggest that Plasmin Production Prior to Ovulation Exceeds the Amount Needed for Optimal Ovulation Efficiency

1997 • 25 citations

Surgical Pathology of Non-Neoplastic Lung Disease

1990 • 24 citations

Proteinases and proteinase inhibitors during the development of pulmonary fibrosis in rat

1998 • 18 citations

Early detection of bleomycin-induced lung injury in rat using indium-111-labeled antibody directed against intercellular adhesion molecule-1.

1998 • 17 citations

Idiopathic Interstitial Fibrosis

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Monocyte-macrophage release of IL-1 is inhibited by type-1 plasminogen activator inhibitors.

1990 • 14 citations

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2000 • 7 citations

The role of cell-associated interleukin-1 in bleomycin-induced pulmonary fibrosis.

1996 • 3 citations