On the Regulation and Control of Fibrinolysis

Atlas of protein sequence and structure

1965 • 4,462 citations

Plasminogen: Purification from Human Plasma by Affinity Chromatography

1970 • 2,160 citations

THE FIBRINOLYTIC ACTIVITY OF HEMOLYTIC STREPTOCOCCI

1933 • 617 citations

THE MECHANISM OF CLOT DISSOLUTION BY PLASMIN*

1959 • 581 citations

The Peptide Chains of Human Plasmin

1967 • 478 citations

Isolation and characterization of alpha2-plasmin inhibitor from human plasma. A novel proteinase inhibitor which inhibits activator-induced clot lysis.

1976 • 474 citations

Molecular mechanism of physiological fibrinolysis

1978 • 410 citations

Identification and Some Properties of a New Fast‐Reacting Plasmin Inhibitor in Human Plasma

1976 • 341 citations

On the Kinetics of the Reaction between Human Antiplasmin and Plasmin

1978 • 340 citations

Measurement of the binding of antifibrinolytic amino acids to various plasminogens

1972 • 308 citations

Analytical Review: Fibrinolysis in the Organism

1956 • 305 citations

1 A Treatise on the Blood, Inflammation, and Gun-Shot Wounds

1963 • 290 citations

Purification and partial characterization of plasminogen activator from human uterine tissue

1979 • 282 citations

The primary inhibitor of plasmin in human plasma

1976 • 274 citations

On the specific interaction between the lysine-binding sites in plasmin and complementary sites in α2-antiplasmin and in fibrinogen

1979 • 269 citations

A PROTEOLYTIC ENZYME OF SERUM: CHARACTERIZATION, ACTIVATION, AND REACTION WITH INHIBITORS

1945 • 267 citations

Fibrinolysis in the Animal Organism

1947 • 265 citations

Abnormal Plasminogen

1978 • 259 citations

STREPTOCOCCAL FIBRINOLYSIS: A PROTEOLYTIC REACTION DUE TO A SERUM ENZYME ACTIVATED BY STREPTOCOCCAL FIBRINOLYSIN

1945 • 252 citations

Role of surface in surface-dependent activation of Hageman factor (blood coagulation Factor XII)

1978 • 251 citations

Differences in the binding to fibrin of native plasminogen and plasminogen modified by proteolytic degradation influence of ω-aminocarboxylic acids

1975 • 250 citations

Characterization of human plasminogen II. Separation and partial characterization of different molecular forms of human plasminogen

1972 • 241 citations

Abnormal Plasminogen-Plasmin System Activity (Fibrinolysis) in Patients with Hepatic Cirrhosis: Its Cause and Consequences*

1964 • 238 citations

Purification and Characterization of Human Antiplasmin, the Fast-Acting Plasmin Inhibitor in Plasma

1977 • 228 citations

Preoperative prediction of postoperative deep vein thrombosis.

1976 • 210 citations

Determination of a new rapid plasmin inhibitor in human blood by means of a plasmin specific tripeptide substrate

1977 • 206 citations

Fibrinogenolysis and Fibrinolysis with Tissue Plasminogen Activator, Urokinase, Streptokinase-Activated Human Globulin, and Plasmin

1971 • 201 citations

Inhibition of activated factor XII by antithrombin-heparin cofactor.

1976 • 200 citations

The specific interaction between plasminogen and fibrin. A physiological role of the lysine binding site in plasminogen

1977 • 193 citations

Activation of Human Plasminogen by an Insoluble Derivative of Urokinase

1973 • 193 citations

Quantitative determination of the binding of epsilon-aminocaproic acid to native plasminogen.

1978 • 192 citations

The lysis of artificially induced intravascular clots in man by intravenous infusions of purified streptokinase.

1958 • 186 citations

Mechanism of the urokinase-catalyzed activation of human plasminogen.

1976 • 176 citations

Characterization of human plasminogen. I. On the relationship between different molecular forms of plasminogen demonstrated in plasma and found in purified preparations.

1970 • 170 citations

Tissue activators of plasminogen.

1966 • 167 citations

Physico-chemical and proenzyme properties of NH2-terminal glutamic acid and NH2-terminal lysine human plasminogen

1974 • 158 citations

Severe Thrombotic Disease in a Young Man with Bone Marrow and Skeletal Changes and with a High Content of an Inhibitor in the Fibrinolytic System

1961 • 155 citations

Thrombosis and urokinase

1977 • 152 citations

Protease Inhibitors in Plasma

1975 • 150 citations

Fibrinolytic Activity of Normal Urine

1947 • 142 citations

THE DEVELOPMENT OF UROKINASE AS A THROMBOLYTIC AGENT. MAINTENANCE OF A SUSTAINED THROMBOLYTIC STATE IN MAN BY ITS INTRAVENOUS INFUSION.

1965 • 137 citations

Studies on a complex mechanism for the activation of plasminogen by kaolin and by chloroform: the participation of Hageman factor and additional cofactors

1969 • 129 citations

Metabolism and Distribution of Fibrinogen. I. FIBRINOGEN TURNOVER IN PHYSIOLOGICAL CONDITIONS IN HUMANS

1972 • 123 citations

FIBRINOLYSIS FOLLOWING OPERATION

1937 • 121 citations

On the biological significance of the specific interaction between fibrin, plasminogen and antiplasmin

1978 • 118 citations

Kinetics of the Reactions between Streptokinase, Plasmin and alpha2-Antiplasmin

1979 • 116 citations

Supraoptic Neurosecretory Cells: Adrenergic and Cholinergic Sensitivity

1971 • 113 citations

Thrombolytic Therapy with Streptokinase Using a Standard Dosage Scheme

1966 • 111 citations

Streptokinase

1973 • 109 citations

Turnover of antiplasmin, the fast-acting plasmin inhibitor of plasma

1979 • 109 citations

Plasmin-antiplasmin complex as a reservoir of fibrinolytic enzyme

1960 • 107 citations

The fibrinolytic activity of urine.

1951 • 103 citations

STUDIES ON THE THROMBOLYTIC ACTIVITY OF HUMAN PLASMA *

1960 • 102 citations

Structural Relationship between "Glutamic Acid" and "Lysine" Forms of Human Plasminogen and Their Interaction with the NH2-Terminal Activation Peptide as Studied by Affinity Chromatography

1975 • 101 citations

[52] Human α2-macroglobulin

1976 • 96 citations

Studies on the Isolation of the Multiple Molecular Forms of Human Plasminogen and Plasmin by Isoelectric Focusing Methods

1972 • 95 citations

Kinetic properties of the primary inhibitor of plasmin from human plasma

1977 • 94 citations

A New Method of Isolation and Some Properties of the Heavy Chain of Human Plasmin

1975 • 91 citations

Inhibitors of Kallikrein in Human Plasma

1972 • 91 citations

Plasmin, Plasmin Inhibitors and Degradation Products of Fibrinogen in Human Serum during and after Intravenous Infusion of Streptokinase

1967 • 90 citations

Isolation and purification of a tissue plasminogen activator and its comparison with urokinase

1969 • 89 citations

α2-PLASMIN-INHIBITOR DEFICIENCY (MIYASATO DISEASE)

1978 • 88 citations

Fibrinolytic Enhancement by Stanozolol: A Double Blind Trial

1972 • 85 citations

Fast-acting plasmin inhibitor in human plasma

1978 • 82 citations

Metabolism of plasminogen in healthy subjects: effect of tranexamic acid

1972 • 81 citations

Isolation of plasminogen activator from human plasma by chromatography on lysine-Sepharose

1978 • 79 citations

Treatment Of Menorrhagia With An Antifibrinolytic Agent, Tranexamic Acid (Amca): A Double Blind Investigation

1967 • 78 citations

A Plasminogen Activator in Spontaneously Active Human Blood.

1953 • 74 citations

Release of an N-terminal peptide from human plasminogen during activation with urokinase

1973 • 68 citations

Natural inhibitors of fibrinolysis

1979 • 68 citations

Impairment of the Diurnal Fibrinolytic Response in Man

1973 • 68 citations

Turnover of fibrinogen, plasminogen, and prothrombin during exercise in man

1977 • 67 citations

Purification and properties of a plasminogen activator from pig heart.

1977 • 67 citations

Changes in Blood Catecholamine Levels and. Blood Coagulation and Fibrinolytic Activity in Response to Graded Exercise in Man

1975 • 66 citations

Different molecular forms of plasminogen and plasmin produced by urokinase in human plasma and their relation to protease inhibitors and lysis of fibrinogen and fibrin

1974 • 66 citations

Steady state kinetics of activation of human and bovine plasminogens by streptokinase and its equimolar complexes with various activated forms of human plasminogen.

1978 • 64 citations

Studies on the Active Center of Human Plasmin

1969 • 61 citations

Nature and Role of the Lytic Factor in Hemolytic Streptococcal Fibrinolysis.

1944 • 60 citations

Molecular Biology of Human Plasminogen

1975 • 59 citations

Molecular biology of human plasminogen. I. Physiochemical properties and microheterogeneity.

1975 • 57 citations

Rate of Activation and Electrophoretic Mobility of Unmodified and Partially Degraded Plasminogen Effects of 6-Aminohexanoic Acid and Related Compounds

1974 • 53 citations

Studies on an Inhibitor of Plasminogen Activation in Human Serum

1973 • 52 citations

A Comparative Study of Coagulation and Fibrinolysis in Blood from Normal Men and Women

1966 • 51 citations

The Extraction of Vascular Plasminogen Activator from Human Cadavers and a Description of Some of Its Properties

1971 • 51 citations

TREATMENT OF DEEP-VEIN THROMBOSIS WITH INTERMITTENT STREPTOKINASE AND PLASMINOGEN INFUSION

1975 • 51 citations

Studies on the release of plasminogen activator

1976 • 49 citations

Kinetic studies of the urokinase-catalysed conversion of NH2-terminal glutamic acid plasminogen to plasmin

1977 • 48 citations

Investigations on the Fibrinolytic System in Liver Cirrhosis

1968 • 47 citations

SURFACE-MEDIATED REACTIONS IN THE FORMATION OF THROMBIN, PLASMIN AND KALLIKREIN

1978 • 46 citations

[Role of the contact factor (Hageman factor) in fibrinolysis].

1959 • 45 citations

Impairment of hemostasis in the urinary tract: the role of urokinase.

1961 • 43 citations

Mechanism of activation and effect of plasmin in blood.

1956 • 43 citations

Amino terminal amino acid sequences and carbohydrate of the two major forms of rabbit plasminogen

1973 • 43 citations

α2-antiplasmin consumption and fibrinogen breakdown during thrombolytic therapy

1979 • 42 citations

Reversible and irreversible alterations of human plasminogen indicated by changes in susceptibility to plasminogen activators and in response to epsilon-aminocaproic acid.

1974 • 40 citations

FIBRINOLYTIC ACTIVITY RELATED TO AGE IN SURVIVORS OF MYOCARDIAL INFARCTION

1966 • 40 citations

The Inhibition of Urokinase by Alpha2-Macroglobulin

1973 • 39 citations

Quantitation of the plasma protease inhibitor antiplasmin with the chromogenic substrate S-2251

1978 • 39 citations

Abnormalities in Clotting and Thrombolysis as a Risk Factor for Stroke

1974 • 36 citations

The resistance of fibrinogen and soluble fibrin monomer in blood to degradation by a potent plasminogen activator derived from cadaver limbs

1975 • 36 citations

Inhibition of Urokinase by Complex Formation with Human Antithrombin III in Absence and Presence of Heparin

1978 • 33 citations

Elimination of Inhibition in Euglobulin Fibrinolysis by Use of Flufenamate: Involvement of C1-inactivator

1977 • 33 citations

Molecular Mechanisms of Fibrinolysis in Man

1978 • 30 citations

The Unique Nature of the Interaction of α2-Macroglobulin with Proteinases

1974 • 28 citations

Turnover of radiolabelled plasminogen and prothrombin in cirrhosis of the liver

1978 • 27 citations

Quantitation of thrombin-antithrombin III complexes in human blood

1977 • 27 citations

Emergence in plasma during activation of the coagulation or fibrinolytic systems of neoantigens, associated with the complexes of thrombin or plasmin with their inhibitors

1974 • 26 citations

Biochemical Changes Noted during Intermittent Administration of Streptokinase

1978 • 26 citations

Purification and characterization of an inhibitor of plasminogen activation from post-traumatic patients

1976 • 24 citations

A latex agglutination test for rapid quantitative estimation of the plasmin–antiplasmin complex in human plasma

1977 • 23 citations

The interaction in human plasma of antiplasmin, the fast-reacting plasmin inhibitor, with plasmin, thrombin, trypsin and chymotrypsin

1977 • 23 citations

Inhibition of activated haceman factor (factor XIIa) by an inhibitor of the plasminogen activation (PA inhibitor)

1978 • 22 citations

Altered Endogenous Fibrinolysis and Biochemical Factors in Atherosclerosis

1974 • 19 citations

THE TISSUE ACTIVATOR OF PLASMINOGEN

1978 • 18 citations

Immunochemical characterization of the plasmin-antiplasmin system. Basis for the specific detection of the plasmin-antiplasmin complex by latex agglutination assays.

1979 • 18 citations

A new approach to studies of the fibrinolytic

1968 • 17 citations

Immunochemical distinction between the inhibitors of plasminogen activation and antiplasmin in human plasma

1976 • 17 citations

Metabolism of iodine-labeled plasminogen during streptokinase and reptilase therapy in man

1973 • 17 citations

Isolation and Purification of Highly Enriched Tissue Plasminogen Activator from Pig Heart

1970 • 16 citations

Blood Catecholamine Levels, Factor VIII and Fibrinolysis after Therapeutic Electroshock

1974 • 15 citations

Comparison of the reactions of neutral granulocyte proteases with the major plasma protease inhibitors and with antiplasmin

1977 • 15 citations

A tanned red cell hemagglutination inhibition immunoassay (TRCHII) for the quantitative estimation of thrombin-antithrombin III and plasmin-alpha1-antiplasmin complexes in human plasma

1975 • 14 citations

Report on the Joint Meeting of the Task Forces on Nomenclature and Standards of Inhibitors of Coagulation and Fibrinolysis

1978 • 10 citations

Plasmin-antiplasmin complex formation during defibrase infusion in man

1977 • 9 citations

STUDIES ON THE ROLE OF PLASMINOGEN ACTIVATOR IN OVULATION AND EARLY EMBRYOGENESIS

1978 • 7 citations

An Inventory of Plasminogen Activators in Human Plasma

1977 • 6 citations

New Hypothesis for the Molecular Mechanism of Surface-Dependent Activation of Hageman Factor (Factor XII)

1977 • 3 citations