Nuclear pore complex ion channels (Review)

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

The American Journal of Physiology

1899 • 5,863 citations

Single-Channel Recording

1995 • 2,565 citations

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

1993 • 1,902 citations

Distinct Roles for Cyclin-Dependent Kinases in Cell Cycle Control

1993 • 1,096 citations

Role of ion flux in the control of c-fos expression

1986 • 1,006 citations

Single channel recording

1984 • 981 citations

Nuclear protein import in permeabilized mammalian cells requires soluble cytoplasmic factors.

1990 • 909 citations

Nuclear envelope permeability

1975 • 808 citations

The GTP-binding protein Ran/TC4 is required for protein import into the nucleus

1993 • 760 citations

Fluorescence ratio imaging of cyclic AMP in single cells

1991 • 686 citations

The Heart and Cardiovascular System

1992 • 655 citations

NF-kappa B activation by ultraviolet light not dependent on a nuclear signal

1993 • 646 citations

A protein-conducting channel in the endoplasmic reticulum

1991 • 613 citations

Macromolecular Domains within the Cell Nucleus

1993 • 611 citations

Thapsigargin, a novel molecular probe for studying intracellular calcium release and storage

1989 • 583 citations

The pathway to signal achievement

1993 • 563 citations

How proteins enter the nucleus

1991 • 555 citations

Spatially Resolved Dynamics of cAMP and Protein Kinase A Subunits in Aplysia Sensory Neurons

1993 • 549 citations

Inhibition of nuclear protein import by nonhydrolyzable analogues of GTP and identification of the small GTPase Ran/TC4 as an essential transport factor [published erratum appears in J Cell Biol 1994 Jan;124(1-2):217]

1993 • 544 citations

Correlation between structure and mass distribution of the nuclear pore complex and of distinct pore complex components.

1990 • 510 citations

Architecture and design of the nuclear pore complex

1992 • 452 citations

Architecture of the Xenopus nuclear pore complex revealed by three-dimensional cryo-electron microscopy

1993 • 408 citations

Alternative initiation of translation determines cytoplasmic or nuclear localization of basic fibroblast growth factor.

1991 • 346 citations

Subcellular Calcium Transients Visualized by Confocal Microscopy in a Voltage-Clamped Vertebrate Neuron

1990 • 341 citations

Alteration of intracellular Fura-2 fluorescence by viscosity: A simple correction

1990 • 319 citations

ATP stimulates Ca2+ uptake and increases the free Ca2+ concentration in isolated rat liver nuclei.

1989 • 284 citations

Pulsing Electromagnetic Fields Induce Cellular Transcription

1983 • 278 citations

The Patch Clamp Technique

1992 • 272 citations

Toward a more complete 3-D structure of the nuclear pore complex

1991 • 254 citations

The nucleus is insulated from large cytosolic calcium ion changes

1994 • 249 citations

Ratiometric confocal Ca2+-measurements with visible wavelength indicators in isolated cardiac myocytes

1993 • 244 citations

Nuclear import-export: In search of signals and mechanisms

1991 • 233 citations

Requirement of GTP Hydrolysis for Dissociation of the Signal Recognition Particle from Its Receptor

1991 • 222 citations

Signal peptides open protein-conducting channels in E. coli

1992 • 216 citations

Nuclear export of proteins: The role of nuclear retention

1993 • 209 citations

The Nuclear Membrane

1992 • 206 citations

Nuclear Ca2+ concentration measured with specifically targeted recombinant aequorin.

1993 • 200 citations

Stereospecific inositol 1,4,5-[32P]trisphosphate binding to isolated rat liver nuclei: evidence for inositol trisphosphate receptor-mediated calcium release from the nucleus.

1990 • 188 citations

Ion channels in the nuclear envelope

1990 • 186 citations

Cell Physiology Source Book

1995 • 178 citations

Movement of the free catalytic subunit of cAMP-dependent protein kinase into and out of the nucleus can be explained by diffusion.

1993 • 174 citations

The nuclear pore complex

1993 • 166 citations

An inositol 1,4,5-trisphosphate-sensitive Ca2+ pool in liver nuclei.

1990 • 165 citations

Calcium and calmodulin function in the cell nucleus.

1992 • 164 citations

Chemical Nature of the System controlling Gene Activities in Insect Cells

1963 • 160 citations

Microscopic spiral waves reveal positive feedback in subcellular calcium signaling

1993 • 157 citations

Angiotensin-II-binding sites on hepatocyte nuclei.

1992 • 152 citations

Plant, Cell and Environment.

1985 • 152 citations

Nuclear angiotensin receptors induce transcription of renin and angiotensinogen mRNA.

1993 • 151 citations

Nuclear protein phosphorylation and growth control

1992 • 135 citations

Intranuclear filaments containing a nuclear pore complex protein.

1993 • 131 citations

A revolution in the physiology of the living cell

1991 • 127 citations

Ion Channels for Communication Between and Within Cells

1992 • 122 citations

Some Electrical Properties of a Nuclear Membrane Examined with a Microelectrode

1963 • 122 citations

How Cells Cycle Toward Cancer

1994 • 117 citations

TRANSPORT OF NUCLEIC ACIDS THROUGH MEMBRANE CHANNELS: Snaking Through Small Holes

1993 • 115 citations

Molecular trafficking across the nuclear pore complex

1992 • 114 citations

Signal transduction and nuclear targeting: regulation of transcription factor activity by subcellular localisation

1993 • 114 citations

Calcium ion homeostasis in smooth muscle

1992 • 111 citations

Effect of cations on the condensation of hen erythrocyte nuclei and its relation to gene activation

1972 • 108 citations

Differences in regulation between nuclear and cytoplasmic Ca2+ in cultured smooth muscle cells

1992 • 108 citations

The nuclear pore complex: three-dimensional surface structure revealed by field emission, in-lens scanning electron microscopy, with underlying structure uncovered by proteolysis

1993 • 99 citations

Distribution of Na+, K+ and Cl− between nucleus and cytoplasm inChironomus salivary gland cells

1977 • 97 citations

Nuclear pore complex: structure, function, and regulation.

1991 • 97 citations

Stimulated rise in neuronal calcium is faster and greater in the nucleus than the cytosol

1991 • 97 citations

Thermostable inhibitor of cAMP-dependent protein kinase enhances the rate of export of the kinase catalytic subunit from the nucleus.

1994 • 95 citations

ULTRASTRUCTURE AND PERMEABILITY OF NUCLEAR MEMBRANES

1965 • 94 citations

The concentrations of water, sodium and potassium in the nucleus and cytoplasm of amphibian oocytes

1970 • 94 citations

Signal transduction and gene control

1991 • 94 citations

Nuclear localization of vertebrate cyclin a correlates with its ability to form complexes with cdk catalytic subunits

1993 • 90 citations

Nucleocytoplasmic movement of fluorescent tracers microinjected into living salivary gland cells.

1975 • 89 citations

The nuclear pore: at the crossroads

1992 • 83 citations

Permeability of a Nuclear Membrane: Changes during Normal Development and Changes Induced by Growth Hormone

1965 • 75 citations

The Movement of Material between Nucleus and Cytoplasm

1980 • 75 citations

Effects of electromagnetic field exposure on gene transcription

1993 • 74 citations

Chloride channels in the nuclear membrane

1991 • 74 citations

Is the Cell Membrane a Universal Rate-Limiting Barrier to the Movement of Water between the Living Cell and Its Surrounding Medium?

1967 • 73 citations

Differential effects of K+ and Na+ on specific bands of isolated polytene chromosomes of Chironomus Tentans

1970 • 71 citations

Elementary Steps in Synaptic Transmission Revealed by Currents Through Single Ion Channels

1992 • 70 citations

A study of the nucleus and cell membranes of oocytes with an intra-cellular electrode

1963 • 70 citations

High temporal resolution video imaging of intracellular calcium

1990 • 69 citations

Nuclear mRNA export

1991 • 69 citations

Change in nuclear potassium electrochemical activity and puffing of potassium-sensitive salivary chromosome regions during Chironomus development.

1979 • 63 citations

Transport across the nuclear envelope: Enigmas and explanations

1991 • 60 citations

THE ELECTRICAL CONDUCTANCE AND POTENTIAL ACROSS THE MEMBRANE OF SOME CELL NUCLEI

1963 • 56 citations

ATP‐dependent ionic permeability on nuclear envelope in in situ nuclei of Xenopus oocytes

1994 • 55 citations

Chapter 18 In Vitro Nuclear Protein Import Using Permeabilized Mammalian Cells

1991 • 51 citations

Some Electrical Properties of the Membrane of a Cell Nucleus

1962 • 50 citations

Current opinion in cell biology

1990 • 49 citations

The oocyte nucleus isolated in oil retains in vivo structure and functions.

1992 • 48 citations

Characterization of the nuclear translocation of acidic fibroblast growth factor

1993 • 47 citations

PERMEABILITY OF NUCLEAR MEMBRANES

1966 • 46 citations

Staurosporine induced Ca2+ increase in DDT1MF-2 smooth muscle cells

1993 • 45 citations

Mechanisms of the ultraviolet light response in mammalian cells*

1989 • 45 citations

Nuclear ion channels in cardiac myocytes

1992 • 43 citations

Detection of a large cation‐selective channel in nuclear envelopes of avian erythrocytes

1990 • 42 citations

Are the cytosolic components of the nuclear, ER, and mitochondrial import apparatus functionally related?

1992 • 42 citations

Nuclear envelope structure

1992 • 42 citations

The electrical properties of the nuclear envelope, and their possible role in the regulation of eukaryotic gene expression

1991 • 41 citations

The nuclear envelope and nuclear transport

1990 • 41 citations

ANALYSIS OF SODIUM TRANSPORT IN THE AMPHIBIAN OOCYTE BY EXTRACTIVE AND RADIOAUTOGRAPHIC TECHNIQUES

1970 • 41 citations

Visualization of mitochondria and nuclei in living plant cells by the use of a potential‐sensitive fluorescent dye

1986 • 40 citations

A large conductance ion channel in the nuclear envelope of a higher plant cell

1992 • 39 citations

The electrophysiological mapping of compartments within a mammalian cell.

1977 • 37 citations

Cytoplasmic exclusion as a basis for asymmetric nucleocytoplasmic solute distributions

1976 • 37 citations

Kinetics of nucleocytoplasmic Ca2+ transients in DDT1 MF-2 smooth muscle cells

1992 • 35 citations

Role of H+ ions in volume and voltage of epithelial cell nuclei

1993 • 34 citations

Ion channels in murine nuclei during early development and in fully differentiated adult cells

1991 • 34 citations

Nuclear pore structure and function

1992 • 32 citations

Norepinephrine in Neonatal Rat Ventricular Myocytes: Association with the Cell Nucleus and Binding to Nuclear α1- and β-Adrenergic Receptors

1993 • 31 citations

Identification of a nucleo-cytoplasmic ionic pathway by osmotic shock in isolated mouse liver nuclei

1993 • 31 citations

Nucleocytoplasmic traffic of proteins.

1992 • 31 citations

Differential control of free calcium and free zinc levels in isolated bovine liver nuclei

1993 • 31 citations

Restricted ion flow at the nuclear envelope of cardiac myocytes

1993 • 30 citations

Nucleus and cell membrane conductance in marine oocytes

1965 • 30 citations

Effect of calcium-binding protein regucalcin on Ca2+ transport system in rat liver nuclei: stimulation of Ca2+ release

1992 • 28 citations

Selective modification of DNA controlled by an ionic signal

1991 • 28 citations

Control of nucleocytoplasmic transport

1992 • 26 citations

Voltage clamp of the nuclear envelope

1994 • 26 citations

Subcellular imaging of calcium exchange in cultured cells with ion microscopy

1992 • 25 citations

Secretagogue‐induced calcium wave shows higher and prolonged transients of nuclear calcium concentration in mast cells

1993 • 22 citations

The nuclear pore complex

1993 • 21 citations

Plugging the nuclear pore

1990 • 20 citations

Nuclear protein accumulation by facilitated transport and intranuclear binding

1993 • 19 citations

Permeability of the Nuclear Membrane as Determined with Electrical Methods

1964 • 17 citations

Spatial and Temporal Resolution of Serotonin-Induced Changes in Intracellular Calcium in a Cultured Arterial Smooth Muscle Cell Line

1991 • 15 citations

Cell age‐related differences in the interaction of a potential‐sensitive fluorescent dye with nuclear envelopes of Acetabularia mediterranea

1988 • 14 citations

Stimulus‐Induced Nuclear Ca²⁺ Signals in Fura‐2‐Loaded Amphibian Neurons

1991 • 14 citations

The Nuclear-Cytopiasmic [Ca2+] Gradient in Single Mammalian Vascular Smooth Muscle Cells

1990 • 13 citations

Nucleoplasmin uptake by facilitated transport and intranuclear binding.

1993 • 11 citations

Can we see living structure in a cell?

1992 • 9 citations

Glucocorticoid receptor binding to rat liver nuclei occurs without nuclear transport

1993 • 6 citations

Biophysics of the Nuclear Envelope

1995 • 6 citations

A 46 kDa NTPase common to rat liver nuclear envelope, mitochondria, plasma membrane, and endoplasmic reticulum

1993 • 4 citations