Radiation-induced apoptosis

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis

1996 • 6,878 citations

Radiobiology for the Radiologist.

1974 • 3,582 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Apoptosis. Its significance in cancer and cancer Therapy

1994 • 2,148 citations

Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression

1995 • 1,863 citations

Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species

1993 • 1,692 citations

DNA Damage Produced by Ionizing Radiation in Mammalian Cells: Identities, Mechanisms of Formation, and Reparability

1988 • 1,434 citations

Apoptosis in cancer therapy: Crossing the threshold

1994 • 1,351 citations

Gene induction by gamma-irradiation leads to DNA fragmentation in lymphocytes.

1987 • 923 citations

Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis.

1994 • 890 citations

Activation of programmed cell death (apoptosis) by cisplatin, other anticancer drugs, toxins and hyperthermia

1990 • 887 citations

Apoptosis induced by anticancer drugs

1992 • 861 citations

Acid Sphingomyelinase–Deficient Human Lymphoblasts and Mice Are Defective in Radiation-Induced Apoptosis

1996 • 795 citations

Radiation Biology in Cancer Research

1980 • 782 citations

Activation of Programmed Cell Death in the Rat Ventral Prostate after Castration*

1988 • 730 citations

Role for c-myc in Activation-Induced Apoptotic Cell Death in T Cell Hybridomas

1992 • 705 citations

DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2

1994 • 671 citations

Programmed cell death and Bcl-2 protection in very low oxygen

1995 • 638 citations

Death and the cell

1986 • 616 citations

Prevention of hypoxia-induced cell death by Bcl-2 and Bcl-xL

1995 • 611 citations

The Complexity of DNA Damage: Relevance to Biological Consequences

1994 • 604 citations

X-Ray Damage and Recovery in Mammalian Cells in Culture

1959 • 513 citations

Radiation-induced apoptosis: Relevance to radiotherapy

1995 • 504 citations

Cell nucleus and DNA fragmentation are not required for apoptosis.

1994 • 436 citations

Extreme sensitivity of some intestinal crypt cells to X and γ irradiation

1977 • 417 citations

Iodine-131-anti-B1 radioimmunotherapy for B-cell lymphoma.

1996 • 410 citations

Sensitivity and selectivity of the DNA damage sensor responsible for activating p53-dependent G1 arrest.

1996 • 385 citations

Radiation biology in cancer research

1978 • 340 citations

Yttrium-90-labeled anti-CD20 monoclonal antibody therapy of recurrent B-cell lymphoma.

1996 • 336 citations

Mechanisms of Apoptosis: Integration of Genetic, Biochemical, and Cellular Indicators

1994 • 320 citations

Cell Death Induced in a Murine Mastocytoma by 42–47°C Heatingin Vitro: Evidence that the Form of Death Changes from Apoptosis to Necrosis Above a Critical Heat Load

1990 • 316 citations

The Yield of DNA Double-strand Breaks Produced Intracellularly by Ionizing Radiation: A Review

1990 • 312 citations

Regulation and Significance of Apoptosis in the Stem Cells of the Gastrointestinal Epithelium

1997 • 290 citations

Advances in Radiation Biology

1975 • 283 citations

Cell loss as a factor in the growth rate of human tumours

1967 • 281 citations

Coordinated regulation of apoptosis and cell proliferation by transforming growth factor beta 1 in cultured uterine epithelial cells.

1991 • 279 citations

Radiobiology for the Radiologist

1979 • 275 citations

Evidence for a General Relationship between the Induced Level of DNA Double-strand Breakage and Cell-killing after X-irradiation of Mammalian Cells

1985 • 271 citations

Apoptosis of vascular endothelial cells by fibroblast growth factor deprivation

1990 • 230 citations

Heterogeneity in the Development of Apoptosis in Irradiated Murine Tumours of Different Histologies

1993 • 203 citations

Apoptosis in irradiated murine tumors.

1991 • 199 citations

Chromosomal Aberrations and Mortality of X-Irradiated Mammalian Cells: Emphasis on Repair

1971 • 183 citations

Apoptosis and chemotherapy resistance

1996 • 183 citations

Radiation apoptosis of serous acinar cells of salivary and lacrimal glands

1991 • 178 citations

Loss of ceramide production confers resistance to radiation-induced apoptosis.

1997 • 162 citations

Apoptosis in Irradiated Murine Tumors

1991 • 150 citations

Sublethal damage, potentially lethal damage, and chromosomal aberrations in mammalian cells exposed to ionizing radiations

1991 • 148 citations

Time-Lapse Cinemicrographic Studies of X-Irradiated HeLa S3 Cells

1969 • 130 citations

Interleukin 1 inhibits T cell receptor-mediated apoptosis in immature thymocytes.

1990 • 125 citations

Ionizing Radiation-induced Cell Death

1994 • 119 citations

Potential molecular targets for manipulating the radiation response

1997 • 119 citations

Radiation Response of Mouse Lymphoid and Myeloid Cell Lines. Part III. Different Signals Can Lead to Apoptosis and May Influence Sensitivity to Killing by DNA Double-strand Breakage

1994 • 117 citations

Development of apoptosis in irradiated murine tumors as a function of time and dose.

1993 • 117 citations

The oxygen effect and reoxygenation

1975 • 117 citations

Radiation-induced apoptosis in a murine T-cell hybridoma.

1992 • 116 citations

Apoptosis — Molecular mechanisms and biomedical implications

1996 • 113 citations

Radiation Response of Mouse Lymphoid and Myeloid Cell Lines. Part II. Apoptotic Death is Shown by all Lines Examined

1994 • 111 citations

Modulation of Radiation-Induced Apoptosis and G 2 /M Block in Murine T-Lymphoma Cells

1995 • 89 citations

Radiation induced apoptosis

1996 • 89 citations

Radiation inactivation of human prostate cancer cells: the role of apoptosis.

1996 • 83 citations

A Role for Calcium in Regulating Apoptosis in Rat Thymocytes Irradiatedin Vitro

1992 • 82 citations

Development of Apoptosis in Irradiated Murine Tumors as a Function of Time and Dose

1993 • 80 citations

Kinetic and Physical Studies of Cell Death Induced By Chemotherapeutic Agents Or Hyperthermia

1986 • 79 citations

Programmed cell death and radioresistance

1996 • 76 citations

The Picture Has Changed in the 1980s

1989 • 76 citations

Why are some human tumours more radiosensitive than others?

1989 • 75 citations

Review: The molecular regulation of apoptosis and implications for radiation oncology

1997 • 71 citations

Radiation-induced apoptosis in sensitive and resistant cells isolated from a mouse lymphoma.

1994 • 70 citations

Evidence for the Internucleosomal Breakage of Chromatin in Rat Thymocytes Irradiated in Vitro

1981 • 70 citations

Increasing the susceptibility of the rat 208F fibroblast cell line to radiation-induced apoptosis does not alter its clonogenic survival dose-response

1995 • 68 citations

Cell cycle alterations, apoptosis, and response to low-dose-rate radioimmunotherapy in lymphoma cells

1993 • 65 citations

Analysis of Mitotic Cell Death Caused by Radiation in Mouse Leukaemia L5178Y Cells: Apoptosis is the Ultimate Form of Cell Death Following Mitotic Failure

1994 • 62 citations

Response of Parotid Gland Organ Culture to Radiation

1989 • 62 citations

Radiation Inactivation of Human Prostate Cancer Cells: The Role of Apoptosis

1996 • 56 citations

Apoptosis induced by X-irradiation of rec-myc cells is postmitotic and not predicted by the time after irradiation or behavior of sister cells.

1996 • 53 citations

Apoptosis induced at different dose rates: implication for the shoulder region of cell survival curves

1994 • 53 citations

Transfected c-myc and c-Ha-ras Modulate Radiation-Induced Apoptosis in Rat Embryo Cells

1994 • 52 citations

Two-stage Cell Shrinkage and the OER for Radiation-induced Apoptosis of Rat Thymocytes

1993 • 51 citations

Apoptosis induced by high- and low-LET radiations

1995 • 51 citations

The Radiation Sensitivities of R3327-H and R3327-AT Rat Prostate Adenocarcinomas

1985 • 49 citations

Radiation Response of Mouse Lymphoid and Myeloid Cell Lines. Part I. Sensitivity to Killing by Ionizing Radiation, Rate of Loss of Viability, and Cell Type of Origin

1994 • 49 citations

Biochemical Modulation of Radiation-Induced Apoptosis in Murine Lymphoma Cells

1993 • 48 citations

Radiation-induced Apoptosis: Its Role in a MADCaT (Mitosis-opoptosis-differentiation-calcium Toxicity) Scheme of Cytotoxicity Mechanisms

1992 • 48 citations

Radiation-induced apoptosis in a murine lymphoma in vivo

1994 • 48 citations

Radiation-induced apoptosis: effects of cell age and dose fractionation.

1995 • 47 citations

Manifestations of Damage from Ionizing Radiation in Mammalian Cells in the Postirradiation Generations

1979 • 43 citations

In vivo induction of apoptosis in human lymphocytes by therapeutic fractionated total body irradiation

1995 • 41 citations

G2M arrest and apoptosis in murine T lymphoma cells following exposure to 212Bi alpha particle irradiation

1993 • 41 citations

Suppression of programmed death and G₁ arrest in B‐cell hybridomas by interleukin‐6 is not accompanied by altered expression of immediate early response genes

1990 • 41 citations

Characterization of radiation-induced apoptosis in rodent cell lines.

1997 • 39 citations

Reemergence of apoptotic cells between fractionated doses in irradiated murine tumors

1994 • 39 citations

Radiation Effects on Death and Migration of Tumor Cells in Mice

1970 • 29 citations

Radiation induced membrane changes and programmed cell death: possible interrelationships.

1994 • 29 citations

Characterization of Radiation-Induced Apoptosis in Rodent Cell Lines

1997 • 27 citations

Cinemicrographic Observations and Theoretical Considerations on Reactions of Lymphocytes to X-Rays

1955 • 26 citations

Programmed Cell Death in Whole Body and Organ Systems by Low Dose Radiation

1992 • 26 citations

Survival of Mammalian Cells Irradiated in Different Phases of the Life-Cycle as Examined by Autoradiography

1963 • 21 citations

Residual DNA damage: What is left over and how does this determine cell fate?

1992 • 21 citations

Early postirradiation changes leading to the loss of nuclear structure in rat thymocytes

1967 • 17 citations

Cyclic Responses of Cultured 9L Cells to Radiation

1982 • 15 citations

Clinical relevance of bcl-2(MBR)/JH rearrangement detected by polymerase chain reaction in the peripheral blood of patients with follicular lymphoma

1997 • 13 citations

Implications of Radiation Induced Apoptosis on Calculated Radial Cell Inactivation for a Linear¹⁹²Ir Source

1997 • 2 citations

Curative treatment of prostate cancer with the combination of radiation and hormone therapies

1996 • 2 citations

Deleted Work

1955 • 0 citations